SMILES all around: structure to SMILES conversion for transition metal complexes by Maria H. Rasmussen, Magnus Strandgaard, Julius Seumer, Laura K. Hemmingsen, Angelo Frei, David Balcells, Jan H. Jensen

“…Comparing with the graphs made by Kneiding et al. where nodes and edges are featurized with DFT properties, we find that depending on the target property (polarizability, HOMO-LUMO gap or dipole moment) the SMILES based representations can perform equally well. …”
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Risk of Subclinical Hypothyroidism in Breast Cancer Patients Treated With CT-Guided Radiation Therapy: A Prospective Observational Study by Amdisen L, Brink C, Lorenzen EL, Roenlev JD, Ewertz M, Cronin-Fenton D

“…Thyroid function was measured in blood samples drawn at baseline, 6, 12, and 18 months. …”
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Dendritic cell-intrinsic PTPN22 negatively regulates antitumor immunity and impacts anti-PD-L1 efficacy by Thomas F Gajewski, Emily F Higgs, Santiago Acero-Bedoya, Anna C Martinez, Ruxandra Tonea

“…Background Individuals with a loss-of-function single-nucleotide polymorphism in the gene encoding PTPN22 have an increased risk for autoimmune diseases, and patients with cancer with such alleles may respond better to checkpoint blockade immunotherapy. …”
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Expansion of regulatory T cells in patients with Langerhans cell histiocytosis. by Brigitte Senechal, Gaelle Elain, Eric Jeziorski, Virginie Grondin, Natacha Patey-Mariaud de Serre, Francis Jaubert, Kheira Beldjord, Arielle Lellouch, Christophe Glorion, Michel Zerah, Pierre Mary, Mohammed Barkaoui, Jean Francois Emile, Liliane Boccon-Gibod, Patrice Josset, Marianne Debré, Alain Fischer, Jean Donadieu, Frederic Geissmann

“…LCH can involve various tissues such as bone, skin, lung, bone marrow, lymph nodes, and the central nervous system, and is frequently responsible for functional sequelae. …”
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Manipulation in root-associated microbiome via carbon nanosol for plant growth improvements by Lingtong Cheng, Jiemeng Tao, Peng Lu, Taibo Liang, Xutao Li, Dong Chang, Huan Su, Wei He, Zechao Qu, He Li, Wenjun Mu, Wei Zhang, Nan Liu, Jianfeng Zhang, Peijian Cao, Jingjing Jin

“…Microbial networks of CNS-treated plants had more nodes and edges, higher connectivity, and more hub microorganisms than those of control plants. …”
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Advancing immunomodulation in organ transplantation: the therapeutic potential of self-assembled rapamycin nanoparticles in allograft rejection by Ruiqi Sun, Zhi Liang, Ning Wang, Xiaona Chen, Jialing Zhao, Hong Tang, Wentao Zhao, Hangxiang Wang, Shusen Zheng, Penghong Song, Haiyang Xie

“…Mechanistic investigations indicated that these effects were mediated by the enhanced recruitment of myeloid-derived suppressor cells (MDSC) and the promotion of regulatory T cells homing to lymph nodes. This led to reduced differentiation of Th1 and Th17 cells, along with a decrease in inflammatory cytokines, resulting in significantly prolonged graft survival compared to oral RAPA. …”
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Anal metastasis of rectal cancer—adenocarcinoma of squamous cells: a case report and literature review by Shun Sasaki, Masahiko Sugiyama, Yu Nakaji, Ryota Nakanishi, Yuichiro Nakashima, Hiroshi Saeki, Eiji Oki, Yoshinao Oda, Yoshihiko Maehara

“…This is a rare report of a case with an anal metastasis of colorectal cancer on perianal squamous cells without a history of anal disease that was resected while preserving anal function.…”
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Interorgan and Transcellular Communication in Metabolic Disease: Insights From Recent CMGH Studies by Tien S. Dong, Emeran Mayer

“…Increasingly, the gut, liver, adipose tissue, immune system, and the nervous system are being understood as nodes in an integrated metabolic network rather than isolated organs. …”
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A synthetic cyclic peptide for promoting antigen presentation and immune activation by Jiahui Zhang, Harrison Y. R. Madge, Asmaa Mahmoud, Lantian Lu, Wanyi Wang, Wenbin Huang, Prashamsa Koirala, Jazmina L. Gonzalez Cruz, Wei Yang Kong, Sahra Bashiri, Ahmed O. Shalash, Waleed M. Hussein, Zeinab G. Khalil, James W. Wells, Istvan Toth, Rachel J. Stephenson

“…Notably, presence of the cyclic decapeptide in this vaccine increased accumulation in the draining inguinal lymph nodes, facilitating cellular uptake of peptide antigens. …”
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Clinical characteristics of acquired anti-IFN-γ autoantibodies in patients infected with non-tuberculous mycobacteria: a prospective cohort study by Hanlin Liang, Siqiao Liang, Yan Ning, Xuemei Huang, Ruiling Ning, Ni Chen, Limei Hong, Xiaona Liang, Siyao Wu, Ping Yan, Hongyu Wei, Zengtao Luo, Qiangxiu Zeng, Dongming Qu, Zhiyi He

“…In the AIGAs-positive group, lymph nodes, bones, skin, and blood were the most frequently affected sites. …”
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MicroRNA: unveiling novel mechanistic and theranostic pathways in diabetic cardiomyopathy by Akash De, Arnab Sarkar, Tanmoy Banerjee, Rudranil Bhowmik, Shuvam Sar, Md. Adil Shaharyar, Sanmoy Karmakar, Nilanjan Ghosh

“…In diabetic patients, it is a chronic condition that is characterized by ventricular hypertrophy (VH), diastolic dysfunction, alteration of systolic function, and reduced ejection fraction, ultimately leading to heart failure (HF). …”
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Increasing target engagement via customized electrode positioning for personalized transcranial electrical stimulation: A biophysical modeling study by Griffin Rodgers, Mahyar Joodaki, Alois Hopf, Emiliano Santarnecchi, Raphael Guzman, Bert Müller, Bekim Osmani

“…This is of interest for stimulation of brain networks such as the default mode network with spatially proximate correlated and anti-correlated cortical nodes.…”
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Transcriptome analysis of mesenteric arterioles changes and its mechanisms in cirrhotic rats with portal hypertension by Guangbo Wu, Min Chen, Qiang Fan, Hongjie Li, Zhifeng Zhao, Chihao Zhang, Meng Luo

“…Moreover, the top ten hub genes were screened according to the degree nodes in the protein–protein interaction (PPI) network. …”
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Acasunlimab, an Fc-inert PD-L1×4-1BB bispecific antibody, combined with PD-1 blockade potentiates antitumor immunity via complementary immune modulatory effects by Maria Jure-Kunkel, Christina Yu, Nora Pencheva, Mark Fereshteh, Alexander Muik, Aras Toker, Özlem Türeci, Tahamtan Ahmadi, Ugur Sahin, Brandon W Higgs, Jordan M Blum, Saskia M Burm, Vanessa M Spires, Angelica Sette, Sina Fellermeier-Kopf, Andrea Imle, Michela Capello, Kristin Strumane, Theo Plantinga, Craig J Thalhauser, Kristina B Nürmberger, Patricia Garrido Castro, Carol Costa Sa, Bruna de Andrade Pereira

“…Mechanistically, the combination enhanced clonal expansion of tumor-specific CD8+ T cells in tumor-draining lymph nodes and increased the density of proliferating and cytotoxic CD8+ T cells in the tumor microenvironment. …”
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ISG15 as a Potent Immune Adjuvant in MVA-Based Vaccines Against Zika Virus and SARS-CoV-2 by Juan García-Arriaza, Michela Falqui, Patricia Pérez, Rocío Coloma, Beatriz Perdiguero, Enrique Álvarez, Laura Marcos-Villar, David Astorgano, Irene Campaña-Gómez, Carlos Óscar S. Sorzano, Mariano Esteban, Carmen Elena Gómez, Susana Guerra

“…Finally, we evaluated the magnitude and functional quality of the elicited antigen-specific cellular immune responses in vivo. …”
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Integrated in vitro, microarray, and network pharmacology analysis reveals the multi-target anti-diabetic potential of Vigna unguiculata by Haseeba Sardar, Fatima Noor, Syed Mukarram Shah, Ashraf Ullah Khan, Jamelah S. Al-Otaibi, Fazal Hadi, Maria Daglia, Prof. Dr. Haroon Khan

“…Protein-protein interaction (PPI) network analysis highlighted key genes like EGFR, PTGS2, and TLR4 as central nodes in diabetes-related pathways. Molecular docking was used to study the binding affinities of compounds. …”
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Comparative transcriptome analysis reveals abscisic acid-induced bHLH transcription factors involved in saikosaponin biosynthesis in Bupleurum chinense DC by Han Wang, Shanqun Hu, Tong Li, Xuejie Qu, Jiaqi Zhang, Baoshun Wang, Yixuan Sun, Rui Cao, Yutong Yan, Ze Song, Xia’nan Zhang, Rong Luo, Yuru Tong, Changli Liu

“…Furthermore, precision engineering of the critical functional domain in BcbHLH could enhance promoter-binding activity to target genes and improve SS biosynthesis efficiency. …”
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SNX10 in autosomal recessive osteosclerosis, osteosarcoma, rheumatoid arthritis, and osteoporosis: molecular mechanisms and therapeutic implications by Sijia Liu, Huili Deng, Junjie Liu, Jun Zhang, Xier Chen, Xuchang Zhou, Chengqiang Zheng

“…Therefore, systematically analyzing the molecular pathological mechanisms of bone metabolic diseases, particularly the spatiotemporal dynamics of key regulatory nodes, has become an urgent need for developing novel therapeutic strategies. …”
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Clinical and biological significance of estrogen receptor-positive/progesterone receptor-negative in invasive breast cancer: bioinformatic analysis by Maryam Althobiti, Raef Albugami, Mohammed Alnamnakani, Samir Alharbi, Michael Toss, Rajennder Kumar, Fahad Alkhureeb

“…Multiple online tools were employed to conduct functional enrichment analysis. STRING was used to create protein-protein interaction networks for the identified DEGs. …”
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Network pharmacology-based insights into the role of gut microbiota metabolites in insulin resistance by Bing Xiao, Xin Chen, Ruiyu Zong, Yiming Guan, Zhu Zhu, Siling Bi

“…However, the pharmacological mechanisms and functional roles of gut microbiota metabolites remain insufficiently understood. …”
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