Identification of a series of pyrrolo-pyrimidine-based SARS-CoV-2 Mac1 inhibitors that repress coronavirus replication by Jessica J. Pfannenstiel, Men Thi Hoai Duong, Daniel Cluff, Lavinia M. Sherrill, Iain Colquhoun, Gabrielle Cadoux, Devyn Thorne, Johan Pääkkönen, Nathaniel F. Schemmel, Joseph O’Connor, Pradtahna Saenjamsai, Mei Feng, Srivatsan Parthasarathy, Michael J. Hageman, David K. Johnson, Anuradha Roy, Lari Lehtiö, Dana V. Ferraris, Anthony R. Fehr

“…SARS-CoV-2 Mac1 promotes virus replication in the presence of interferon (IFN) and blocks the production of IFN, although the mechanisms by which it mediates these functions remain unknown. Mac1 inhibitors could help elucidate these mechanisms and serve as therapeutic agents against CoV-induced diseases. …”
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The Trend of Residential-Livelihood Changes in Nomadic Ecosystems with Environmental Sustainability Approach (Case Study: Farsimadan Tribe Ecosystem, Fars Province) by Siamak Tahmasbi, Seyed Ali Badri, Mohammad Reza Rezvani

“…In this change, a lot of structures and functions of nomadism have changed. In the past, livestock was impartible components of nomadic life having the value and dignity among nomads and well- known people who had more livestock in the tribe. …”
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Legal Challenges of Marine Insurance Laws in the Use of Unmanned Ships by Mahsa Bahadoran- Baghbaderani, Masoud Shirani, Reza Soltani

“…Furthermore, standardizing the design and functionality of unmanned ships and issuing certifications for software and systems are vital steps in minimizing risks and fostering trust among insurers and operators. …”
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Commensal microorganisms ameliorate the adverse effects of high wheat starch diet on the growth performance, glucose and lipid metabolisms in juvenile largemouth bass, Micropterus... by Bi-Yun Zhang, Hong-Ling Yang, Ze-Hui Yuan, Xiao-Ou Sun, Jia-Hao Yin, Jun-Ji Xu, Guo-He Cai, Yun-Zhang Sun

“…A 42-d feeding experiment was performed to study the functions of the seven microorganisms. A total of 810 fish (5.9 ± 0.01 g) were equally distributed into 9 groups. …”
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Screening and characterization of the scFv for chimeric antigen receptor T cells targeting CEA-positive carcinoma by Chengcheng Zhang, Linling Wang, Qianzhen Zhang, Junjie Shen, Xia Huang, Meiling Wang, Yi Huang, Jun Chen, Yanmin Xu, Wenxu Zhao, Yanan Qi, Yunyan Li, Yanjiao Ou, Zhi Yang, Cheng Qian

“…IntroductionChimeric antigen receptor T (CAR-T) cell therapy presents a promising treatment option for various cancers, including solid tumors. …”
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The African swine fever virus gene MGF_360-4L inhibits interferon signaling by recruiting mitochondrial selective autophagy receptor SQSTM1 degrading MDA5 antagonizing innate immun... by Hualin Sun, Jifei Yang, Zhonghui Zhang, Mengli Wu, Zhancheng Tian, Ying Liu, Xiaoqiang Zhang, Jianhao Zhong, Songlin Yang, Yikang Chen, Jianxun Luo, Guiquan Guan, Hong Yin, Qingli Niu

“…Multigene family (MGF) virulence genes have been shown to be crucial for ASFV’s ability to evade host innate immune responses. However, the functions of most MGF genes remain unknown, which poses significant challenges for the development of ASFV vaccines and antiviral drugs. …”
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Hybrid Integration of a Beam-Steering Leaky-Wave Antenna and Power Amplifier MMIC Using UPD Printing in 220 to 325 GHz Range by Georg Gramlich, Elizabeth Bekker, Luca Valenziano, Joel Dittmer, Martin Roemhild, Holger Baur, Fabian Thome, Axel Tessmann, Michael Kuri, Tom Neerfeld, Andreas Stohr, Sebastian Randel, Christian Koos, Norbert Fruehauf, Thomas Zwick, Akanksha Bhutani

“…This paper presents the first hybrid-integration assembly of a power amplifier (PA) monolithic microwave integrated circuit (MMIC) and a beam-steering leaky wave antenna (LWA) using an ultra-precise deposition (UPD) printed coplanar waveguide (CPW) interconnect operating in a broad sub- THz range of 220 GHz to 325 GHz. …”
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Study of anti-inflammatory, antioxidant, antimicrobial and mineralizing effects of an N-isopropenylimidazole zinc metal complex derivative in experimental endodontic-periodontal le... by Pavel A. Galenko-Yaroshevsky, Ivan I. Pavlyuchenko, Olga V. Shelemekh, Boris A. Trofimov, Lidiya N. Parshina, Viktor L. Popkov, Svetlana A. Demyanenko, Oleg V. Tsymbalov, Andrey V. Zadorozhniy, Anait V. Zelenskaya, Irina B. Nektarevskaya, Alina V. Sergeeva, Nikolay E. Korovaykin, Svetlana A. Lebedeva

“…This necessitates search for and development of new molecules with a wide range of therapeutic effects aimed to block the infectious and inflammatory process and to restore the functional ability of teeth in EPLs as much as possible (depending on a lesion severity). …”
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Innovation Ecosystem of Iran's Tourism Industry with Emphasis on Supply Chain by Azizolah Jafari, mahdi alaei kerahrudi

“…The innovation ecosystem and review of global experiences will present a plan of the innovation ecosystem of Iran's tourism industry with an emphasis on the supply chain. …”
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Debut de leucemia linfoblástica aguda infantil con hipercalcemia maligna, presentación inusual: reporte de caso by Arenas-Camacho, Laura Daniela, Peña-Jiménez, Juan Camilo, Delgado-Beltrán, Angélica María, Obregón-Martínez, María del Pilar, Estupiñán-Perico, Diego Iván

“…She also presented electrolyte imbalances that required potassium and phosphorus replacement with adequate response. …”
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The Effectiveness of Using the Reggio Emilia Approach on the Experimental Science Lesson for Third-Grade Elementary Students by Batool Sabzeh, Farangis Ghalavand, Seyedamir Ghasemtabar

“…Data collection was done using a researcher-made test of the science lesson and functional checklist. Teachers and professors confirmed the validity of the tool and its reliability was obtained through Cronbach's alpha test of 0.865. …”
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Renewable Energy Sources and the New Paradigm in Energy Engineering by Eden Mamut

“…</p><p>Unfortunately, at present, the quotas for exploiting resources as forest wood or reed in wetlands or Deltas in many parts of the World are established without any scientific background. …”
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A Cross‐Linked Flexible Metaferroelectrolyte Regulated by 2D/2D Perovskite Heterostructures for High‐Performance Compact Solid‐State Sodium Batteries by Yanan Huang, Zhuo Yang, Weicheng Zhou, Liequan Liu, Chuanbao Tu, Mingyang Tang, Haijiao Xie, Yu Lu, Xu Yan, Zhihao Ding, Xiaolong Li, Tiannan Yang, Alexander S. Sigov, Wei Huang, Lijun Gao, Cheng Huang

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Investigating the relationship between the monetary policy shock through the exchange rate channel on the management quality index in the banking system: by examining the productiv... by Farhad Sharifi Bagha, Jafar Haqiqat, Zahra Karimi Takanloo

“…In their identification schemes, information on the size of the central bank's balance sheet is key to distinguishing monetary policy shocks from other shocks that reduce financial market stress. In the present study, we show that replacing ECB balance sheet size with random numbers leads to statistically indistinguishable shock response functions and time series of abnormal monetary policy shocks. …”
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Integrating plot-based methods for monitoring biodiversity in island habitats under the scope of BIODIVERSA + project BioMonI: Tree monitoring in Terceira, Tenerife and Réunion Isl... by Paulo Borges, Leila Morgado, Rosalina Gabriel, Rui Elias, Mirana Gauche, Claudine Ah-Peng, Rüdiger Otto, Lea de Nascimento, Dominique Strasberg, Nathaly Guerrero-Ramírez, Holger Kreft, José María Fernández-Palacios

“…Such data underpin the detection of subtle shifts in community composition, functional diversity and species distributions, which are critical for assessing the effectiveness of conservation actions and predicting future ecological scenarios.In summary, plot-based data are indispensable for targeted and effective biodiversity monitoring on islands. …”
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Requirements for Becoming a Startup: A Study with an Economic Sociology Approach (Case Study: Managers of Startups in Isfahan City) by Rahmatollah Torkan, Seyed Samad Beheshty, Ramin Moradi

“…To address these gaps, the present study aimed to analyze the process of becoming a startup and the associated contexts and requirements in the city of Isfahan, utilizing an economic sociology framework. …”
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SnowQM 1.0: a fast R package for bias-correcting spatial fields of snow water equivalent using quantile mapping by A. Michel, A. Michel, J. Aschauer, T. Jonas, S. Gubler, S. Kotlarski, C. Marty

“…Long-term spatial data on snow cover and snow water equivalent are scarce, due to the lack of satellite data or forcing data to run land surface models back in time. This study presents an R package, SnowQM, designed to correct for the bias in long-term spatial snow water equivalent data compared to a shorter-term and more accurate dataset, using the more accurate data to calibrate the correction. …”
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RETRACTED: In-depth systems biological evaluation of bovine alveolar macrophages suggests novel insights into molecular mechanisms underlying Mycobacterium bovis infection by Aliakbar Hasankhani, Abolfazl Bahrami, Abolfazl Bahrami, Shayan Mackie, Sairan Maghsoodi, Heba Saed Kariem Alawamleh, Negin Sheybani, Farhad Safarpoor Dehkordi, Farhad Safarpoor Dehkordi, Fatemeh Rajabi, Ghazaleh Javanmard, Hosein Khadem, Herman W. Barkema, Marcos De Donato

“…The WGCNA module preservation approach was then used to identify non-preserved modules between non-infected controls and M. bovis-infected samples (test set). Additionally, functional enrichment analysis was used to investigate the biological behavior of the non-preserved modules and to identify bTB-specific non-preserved modules. …”
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Water Diplomacy by Implementing Energy Consumption Reduction Scenarios in the Sistan Region by Fazel Ghobeyshavi, Ali Sardar Shahraki, Mahdi Safdari, Neda Aliahmadi

“…Based on the method of dynamic systems, the following steps are performed. 1- Understanding the system 2- Identification and definition of the problem 3- Conceptualization of the system (cause-effect relationships - informational feedbacks) 4- Formulation of the model (decision variables - physical flows of information) In order to build the flow model, the trends of the variables over time are taken into consideration, and based on these trends and based on mathematical laws and regression functions, the relationship between the variables was formulated.Discussion and Results The results, modeling the water, food, energy nexus (NEXUS) with several water diplomacy in the Trans Boundary River show that the current scenarios with water are After applying each of the policies separately on the model as well as applying the combined policy, the scenario of reducing energy consumption by 50%, reducing water loss (evaporation) by 50%, from the solution to improve the security of water, food and energy resources for ten. …”
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Els discent assegut by Juan A. Canal

“…Pour illustrer ce problème, l’article présente brièvement l’expérience menée au lycée Vega del Prado de Valladolid. …”
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