Targeting TM4SF1 promotes tumor senescence enhancing CD8+ T cell cytotoxic function in hepatocellular carcinoma by Weifeng Zeng, Furong Liu, Yachong Liu, Ze Zhang, Haofan Hu, Shangwu Ning, Hongwei Zhang, Xiaoping Chen, Zhibin Liao, Zhanguo Zhang

“…Meanwhile, TM4SF1-mediated AKT phosphorylation enhanced PD-L1 expression while reducing major histocompatibility complex class I level on tumor cells, leading to impaired cytotoxic function of CD8+ T cells and an increased proportion of exhausted CD8+ T cells. …”
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Development and evaluation of folic acid conjugated curcumin-loaded functionalized multiwalled carbon nanotubes for enhanced efficacy in ovarian cancer treatment by Aditi Chattaraj, Yachana Mishra, Alaa A.A. Aljabali, Vijay Mishra

“…A dispersion study revealed the presence of functional groups on the outermost surface of both the functionalized MWCNT as well as formulations increased their resilience via converting the hydrophobic MWCNT surface to hydrophilic property. …”
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Expression and functional analyses of the mitogen-activated protein kinase (MPK) cascade genes in response to phytohormones in wheat (Triticum aestivum L.) by Su-fei YAO, Yan-xia WANG, Tong-ren YANG, Lin HAO, Wen-jing LU, Kai XIAO

“…TaMPK4, a MPK type gene previously characterized to mediate tolerance to phosphate (Pi) deprivation, was functionally evaluated for its role in mediation of responses of plants to exogenous GA3, ETH, SA, and JA. …”
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Temporal and Spatial Evolution and Driving Force Analysis of Water Conservation Function in Yunnan Province Based on Climate and Land Use Change by LIU Fengru, ZHAO Junsan, LIN Yilin, CHEN Guoping, ZHANG Longjiang, PENG Sufen

“…[Objective] Exploring the water-holding function is an important way to cope with future climate change. …”
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GPD2 inhibition impairs coagulation function via ROS/NF-κB/P2Y12 pathway by Jiajie Chen, Guifeng Xu, Zhipeng Xie, Shaoxia Xie, Wenwei Luo, Shilong Zhong, Weihua Lai

“…Subsequently, epigenome-wide association study (EWAS), summary data-based Mendelian randomization (SMR), and heterogeneity in dependent instruments (HEIDI) analyses were applied to pinpoint critical methylation sites that influence gene expression, platelet function recovery, and bleeding risk. After developing a targeted cellular model using the CRISPR-dCas9-DNMT3A/Tet1CD-U6-sgRNA system and integrating with transcriptomic sequencing data, we conducted mechanistic cellular experiments to elucidate how these methylation sites affect platelet function recovery and bleeding risk. …”
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Serum metabolic fingerprints encode functional biomarkers for ovarian cancer diagnosis: a large-scale cohort studyResearch in context by Wanshan Liu, Xiaoxiao Hu, Zhouzhou Bao, Yanyan Li, Juxiang Zhang, Shouzhi Yang, Yida Huang, Ruimin Wang, Jiao Wu, Xiaoyu Xu, Qi Sang, Wen Di, Huaiwu Lu, Xia Yin, Kun Qian

“…The identified metabolic biomarkers were further validated using liquid chromatography MS and their biological functions were assessed in OC cell lines. Findings: We identified a metabolic biomarker panel including glucose, histidine, pyrrole-2-carboxylic acid, and dihydrothymine. …”
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Influence of the biophosphomag preparation and biologically active substances from milk thistle seeds (Silybum marianum) on the metabolism of lymphocytes and their functional featu... by Petro Fedyshyn, Olga Pavliuk, Ivan Stupak, Taisa Dovbynchuk, Yulia Pysmenna, Volodymyr Liashenko, Natalia Senchylo, Serhii Holopura, Liliia Kalachniuk, Liudmyla Garmanchuk

“…According to preliminary data, the preparations exhibit choleretic activity and help stabilize liver and digestive functions. Their potential effects on the metabolism of immune system cells require further study. …”
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The cerebral correlates of set-shifting: an fMRI study of the trail making test by Moll Jorge, Oliveira-Souza Ricardo de, Moll Fernanda Tovar, Bramati Ivanei Edson, Andreiuolo Pedro Angelo

“…These findings are in line with clinico-anatomic and functional neuroimaging data that point to a critical role of the dorsolateral and medial prefrontal cortices as well as the intraparietal sulci in the regulation of cognitive flexibility, intention, and the covert execution of saccades/anti-saccades. …”
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PagMYB73A enhances poplar salt tolerance by facilitating adventitious roots elongation and stomata density by Xia Jin, Kai Zhao, Jia Hu, Oliver Gailing, Lieding Zhou, Shuhui Du, Youzhi Han, Shengji Wang

“…While under NaCl treatment, the OE lines displayed elongated adventitious roots but reduced plant height compared to WT. …”
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THE USE OF PARABOLIC SPLINEES IN CAD OF LINEAR STRUCTURES by V. I. Struchenkov

“…The article continues studying the problem of the calculus of variations that occurs in line structures routing, in particular, roads. The task is to find a line that satisfies all technical constraints and gives a minimum of a given functional, for example, construction costs. …”
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Spectral Characteristics of the Sturm-Liouville Problem with Spectral Parameter-Dependent Boundary Conditions by Aynur Çöl

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Multi-energy storage SoC equilibrium strategy based on the variable regulating factor by CHEN Jingwen, LIU Jiaxin, ZHANG Wenqian

“…The arccotangent function is used to associate the droop coefficient with SoC and rated capacity, and the virtual voltage drop compensation link is introduced to achieve the balance of multiple sets of energy storage SoC. …”
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Power Grid Scale Prediction and Optimization Needs Based on Policy Requirements of Modern Infrastructure System by Xin TIAN, Linyu WANG, Xingpei JI, Xinyang HAN

“…Starting from the effectiveness of infrastructure, various industries have proposed optimization directions for layout, structure, function, and system integration. This article starts from the study of the functional role of the modern infrastructure system, analyzes the important role of the power grid infrastructure in the modern infrastructure system, and uses Pearson's correlation coefficient to study the relationship between the power grid infrastructure line length and transformer capacity scale and the electricity consumption of the whole society. …”
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A Prospective Exploratory Study of Functional Immunity Assessed by Pretreatment Interferon Gamma Release Assay in Relation to Different Systemic Therapies in Patients With Advanced... by Hsu-Ching Huang, MD, Han-Jhih Chang, MS, Chi-Lu Chiang, MD, Hsin-Yi Huang, MS, Yung-Hung Luo, MD, Yuh-Min Chen, MD, Tsu-Hui Shiao, MD, Chao-Hua Chiu, MD

“…This study prospectively evaluated the interferon gamma (IFN-γ) release assay (IGRA) as a potential predictor of treatment response and a tool for assessing immune function. Methods: We enrolled patients with stage IV NSCLC undergoing first-line chemotherapy, EGFR tyrosine kinase inhibitor (TKI) therapy, or any line of single-agent immunotherapy, alongside stage I controls. …”
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Push based buffer setting strategy for high density linecard of small buffer size by LI Yu-feng1, QIU Han1, LAN Ju-long1, WANG Bin-qiang1

“…Much of the previous work on buffer design of router linecard mainly focus on how to implement large and fast packet buffers,however,lots of recent theories suggest that the optimal buffer size would no longer be a large one as expected,and a small buffer should be sufficient.A push based buffer setting strategy for high density linecard of small buffer size was presented,and a buffer-revenue function was introduced to give an evaluation on using efficiency of the small buffer.It is proved that the strategy can completely eliminate the HOL（header of line） blocking problem and the back-pressure mechanism of the existing strategies,moreover,the strategy can also get a better revenue when the buffer-revenue function is used to give an evaluation.…”
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BVP for the heat equation with a fractional integro-differentiation operator by M.T. Kosmakova, N.T. Orumbayeva, D.M. Akhmanova, L.Zh. Kasymova

“…The problem is reduced to a Volterra integral equation of the second kind, the kernel of which contains a special function, namely, a Wright-type function. The kernel of the resulting integral equation is estimated, and it is shown, under certain restrictions on the line along which the load moves, that the kernel of the equation has a weak singularity, which is the basis for the assertion that the loaded term in the equation of the problem is a weak perturbation of its differential part. …”
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Deciphering the dynamic expression network of fiber elongation and the functional role of the GhTUB5 gene for fiber length in cotton based on an introgression population of upland... by Jianjiang Ma, Liupeng Yang, Yuanyue Dang, Kashif Shahzad, Jikun Song, Bing Jia, Li Wang, Juanjuan Feng, Nuohan Wang, Wenfeng Pei, Man Wu, Xuexian Zhang, Jinfa Zhang, Jianyong Wu, Jiwen Yu

“…The function of GhTUB5 was determined by ectopic expression of two TUB5 alleles in Arabidopsis and knockout of GhTUB5 in upland cotton. …”
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Self-Correction in Free-Running Dual-Comb Spectroscopy With Varying Interferogram Refresh Rates by Xiangze Ma, Wei Long, Jie Cheng, Yujia Ji, Teng Huang, Dijun Chen

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Hybrid genre in persuasive communication by Valeria E. Chernyavskaya, Natalia E. Gorschkova

“…The analysis is based on advertisement texts functioning as hybrid genres in modern Russian socio-cultural prac­tice. …”
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Enhancement of Sansevieria Trifasciata Laurentii Fiber Properties with Liquid Smoke Treatment by Mukhlis Muslimin, Willy Artha Wirawan, Mohammad Muzni Harbelubun, Abdul Rifais Mujawal, R. A. Ilyas, Mohd Nor Faiz Norrrahim, Victor Feizal Knight

“…In addition, LS treatment introduces C=C and C=O functional groups into the STLF molecular chain, potentially improving the interfacial bonding between the fiber and the polymer matrix.…”
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