P02 | THE C-C CHEMOKINE-RECEPTOR 2 (CCR2)/CCL2 AXIS PARTICIPATE IN PLATELET FUNCTION IN MYELOFIBROSIS

“…Both P-selectin staining and TEM observations confirmed the platelet aggregation in the MF patients, suggesting the CCR2 involvement in the residual platelet function in MF. In line with the abnormal MK phenotype, recent proof indicates that myeloproliferative disorders are associated with a high incidence of arterial and venous thrombotic events3. …”
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Analysis of p53-Independent Functions of the Mdm2-MdmX Complex Using Data-Independent Acquisition-Based Profiling by Anu Jain, Rafaela Muniz de Queiroz, Jayanta K. Chakrabarty, Karl A. T. Makepeace, Carol Prives, Lewis M. Brown

“…Results: Protein ontology and function were analyzed, revealing which pathways are affected by modulation of the proteins that form the complex. …”
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Characterization of a pathogenic gain-of-function mutation in the N-terminal domain of STAT1 which is reported to be associated with eosinophilic esophagitis by Kristin Annawald, Anke Gregus, Oliver Wirths, Thomas Meyer

“…Recently, a case report described a gain-of-function (GOF) mutation in the STAT1 (signal transducer and activator of transcription 1) protein (D65A) to be associated with this disease. …”
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IGFBP2 Modulates Trophoblast Function and Epithelial–Mesenchymal Transition in Preeclampsia via the PI3K/AKT Signaling Pathway by Shengping Meng, Yanping Qin, Chunyan Lyu, Sumei Wang

“…Moreover, the gain- and loss-of-function assays were conducted in human trophoblast cell line HTR-8/SVneo, and cellular models exhibiting overexpression and the knockdown of IGFBP2 were established. …”
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Phagocytosis is the main CR3-mediated function affected by the lupus-associated variant of CD11b in human myeloid cells. by Liliane Fossati-Jimack, Guang Sheng Ling, Andrea Cortini, Marta Szajna, Talat H Malik, Jacqueline U McDonald, Matthew C Pickering, H Terence Cook, Philip R Taylor, Marina Botto

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Triple negative breast cancer initiating cell subsets differ in functional and molecular characteristics and in γ‐secretase inhibitor drug responses by Diana J. Azzam, Dekuang Zhao, Jun Sun, Andy J. Minn, Prathibha Ranganathan, Katherine Drews‐Elger, Xiaoqing Han, Manuel Picon‐Ruiz, Candace A. Gilbert, Seth A. Wander, Anthony J. Capobianco, Dorraya El‐Ashry, Joyce M. Slingerland

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IFN-α and vitamin B6-induced galectin-9 promotes the immunomodulatory function of human clonal mesenchymal stem cells by Jee-Hoon Nam, Jeong Hyun Moon, Byeol Choi, Geun-Hyung Kang, Yunok Park, Se-Yeon Park, Tae-Hyun Ko, Donghee Shin, YoungSu Jung, Si-Na Kim, Yun-Kyoung Cho, Myung-Shin Jeon

“…Abstract Background Mesenchymal stem cells (MSCs) possess a variety of immunomodulatory functions that can vary depending on the MSC line. …”
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Functional movement screen test as an predictor for jumping tests performance and on-ice skating sprint in elite level ice hockey players. by Jakub Baron, Maciej Hołub, Arkadiusz Stanula

“…The main purpose of this research was to establish selected motor skills measured in off-ice and on-ice conditions in ice hockey players using the functional movement screen test, vertical jumps, and on-ice sprints. …”
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Natural SEL1L variants rescue a model of NGLY1 deficiency and modify ERAD function and proteasome sensitivity. by Travis K Tu'ifua, Clement Y Chow

“…We found that the SEL1LS780P and SEL1LΔ806-809 variants improve resistance to ER stress, with enhanced ERAD function as a likely contributing mechanism. This effect depends on NGLY1 activity, further implicating NGLY1 in general ERAD function. …”
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Connexin43 functions as a non-canonical phenotypic stability factor in promoting hybrid Epithelial/Mesenchymal phenotype in glioblastoma cells by Anushka Mondal, Sanchari Saha, Adrish Ghosh, Justin D Lathia, Jayasri Das Sarma

“…Using high-grade mouse astrocytoma cell lines, we found that CT2A cells had higher Cx43 gap junction assembly as compared to KR158 cells. …”
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A Causal Inference Approach to Mediation Analysis in Vitreomacular Traction: How Much Does Traction Resolution Mediate Functional Outcomes? by Benedicte Lescrauwaet, Stijn Vansteelandt, Timothy L. Jackson, SriniVas R. Sadda, Luc Duchateau

“…Outcomes, assessed at month 24, included visual acuity improvement (VA-I): ≥2-line increase in VA; visual function questionnaire improvement (VFQ-I): ≥5-point increase in the 25-item visual function questionnaire composite score (VFQ-25cs); visual function improvement (VF-I): defined as either a VA-I or a clinically meaningful improvement in the VFQ-25cs. …”
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An exploratory study of the mandate and functions of national pharmaceutical services units: global trends and the cases of Côte d’Ivoire, Kenya, and Nepal by Augustina Koduah, Ndinda Kusu, Herodias Ahimon, Andrew Brown, Nancy Njeru, Tom Menge, Mahama Ouattara, Nijan Upadhyay, Madan Kumar Upadhyaya, Melissa Jiha, Robbie Hodgson, Emmanuel Nfor, Francis Aboagye-Nyame, Tamara Hafner

“…We triangulated and synthesised the findings to identify NPSUs by level in the health ministry’s hierarchy and reporting line, mandate, and function.Results We identified medicine regulation, procurement and supply chain management, selection and rational use of medicines, and pharmacy practice regulation as four broad sets of functions that NPSUs commonly have as their mandate. …”
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Identification and Functional Characterization of P159L Mutation in in a Family with Maturity-Onset Diabetes of the Young 5 (MODY5) by Eun Ky Kim, Ji Seon Lee, Hae Il Cheong, Sung Soo Chung, Soo Heon Kwak, Kyong Soo Park

“…To investigate the functional consequences of this HNF1B mutation, we generated a P159L HNF1B construct. …”
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Dietary Puerariae Lobatae Radix polysaccharides improve ovarian function and reproductive efficiency in laying hens with fatty liver hemorrhagic syndrome by Anqi Wang, Hui Ren, Yanyan Zhang, Hongfan Ge, Zhenlei Zhou

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Sorafenib enhanced the function of myeloid-derived suppressor cells in hepatocellular carcinoma by facilitating PPARα-mediated fatty acid oxidation by Chunxiao Li, Liting Xiong, Yuhan Yang, Ping Jiang, Junjie Wang, Mengyuan Li, Shuhua Wei, Suqing Tian, Yuexuan Wang, Mi Zhang, Jie Tang

“…MDSCs were analyzed for chemotaxis, immunosuppressive functions, fatty acid oxidation (FAO), and PPARα expression. …”
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Functional Attributes of Synovial Fluid from Osteoarthritic Knee Exacerbate Cellular Inflammation and Metabolic Stress, and Fosters Monocyte to Macrophage Differentiation by Vanshika Srivastava, Abhay Harsulkar, Shama Aphale, Aare Märtson, Sulev Kõks, Priya Kulkarni, Shantanu Deshpande

“…<b>Background:</b> Besides conventional norms that recognize synovial fluid (SF) as a joint lubricant, nutritional channel, and a diagnostic tool in knee osteoarthritis (kOA), based on the authors previous studies, this study aims to define functional role of SF in kOA. <b>Methods:</b> U937, a monocytic, human myeloid cell line, was induced with progressive grades of kOA SF, and the induction response was assessed on various pro-inflammatory parameters. …”
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Effect of SGLT2 inhibitors on cardiac structure and function assessed by cardiac magnetic resonance: a systematic review and meta-analysis by Isabella Leo, Nadia Salerno, Stefano Figliozzi, Angelica Cersosimo, Jessica Ielapi, Kamil Stankowski, Giandomenico Bisaccia, Santo Dellegrottaglie, Giovanni Canino, Salvatore De Rosa, Sabato Sorrentino, Chiara Bucciarelli-Ducci, Daniele Torella

“…Cardiac magnetic resonance (CMR) is key in evaluating cardiac structure and function, enabling accurate assessment of reverse remodeling. …”
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Magnaporthe Rab5 homologs show distinct functions in nerve growth factor (NGF)-mediated neurite outgrowth and cell differentiation by Yao-yao QI, Zhi-min LIANG, Jie ZHOU, Zong-hua WANG, Guo-dong LU, Guang-pu LI

“…Two Rab5 homologs (MoRab5A: MGG_06241 and MoRab5B:MGG_01185) were characterized from the rice blast fungus Magnaporthe oryzae, and MoRab5B was identified as the Rab5 ortholog promoting early endosomal fusion, while MoRab5A specialized to perform a non-redundant function in endosomal sorting. In this study, we examined whether MoRab5A and MoRab5B play different roles in NGF-induced neurite outgrowth and cell differentiation in PC12 cells (a rat pheochromocytoma cell line). …”
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Variability in grain, flour, functional properties and protein profiling in newly developed wheat genotypes grown in temperate climate of Western Himalayas by Taha Mukhtar, Abida Jabeen, Syed Zameer Hussain, Raashid Ahmad Siddiqi, Shabir H. Wani, Anju Mahendru-Singh, Tawheed Amin, Quraazah A. Amin, Mohmad Sayeed Bhat

“…These wheat genotypes were studied for their functional, structural and protein profiling characteristics as per the approved AACC and AOAC standard methods of analysis.ResultsThe various physical parameters varied significantly (p ≤ 0.05) between wheat genotypes. …”
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GYY4137-induced p65 sulfhydration protects synovial macrophages against pyroptosis by improving mitochondrial function in osteoarthritis development by Jun Ma, Peng Yang, Zhibin Zhou, Tengfei Song, Liang Jia, Xiaofei Ye, Wei Yan, Jiuyi Sun, Tianwen Ye, Lei Zhu

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