CRL2LRRC41-Mediated DDX5 Ubiquitination Enhances Interaction with ELAVL1 Preventing NOG mRNA Degradation and Sustaining Proliferation and Migration of Human Spermatogonial Stem Cel... by Bing Jiang, Kehan Wang, Haoyue Hu, Wenxin Gao, Cong Shen, Xia Chen, Xiaoyan Huang, Jun Yu, Yibo Wu, Bo Zheng

“…This study aimed to investigate a novel variant of the CRL2 complex, termed CRL2LRRC41, and its role in SSC function. Methods We utilized molecular biology techniques, including gene knockdown and functional assays, to assess the effects of CRL2LRRC41 on the proliferative and migratory abilities of human spermatogonial stem cell-like cell (SSCLC) line. …”
Get full text

The use of complex structure splines in roadway design by V. I. Struchenkov, D. A. Karpov

“…A new mathematical model in the form of a modified Lagrange function is used together with a special nonlinear programming algorithm to optimize spline parameters. …”
Get full text

Wireless key generation system for internet of vehicles based on deep learning by Han WANG, Liquan CHEN, Zhongmin WANG, Tianyu LU

“…In recent years, the widespread application of internet of vehicles technology has garnered attention due to its complex nature and point-to-point communication characteristics.Critical and sensitive vehicle information is transmitted between different devices in internet of vehicles, necessitating the establishment of secure and reliable lightweight keys for encryption and decryption purposes in order to ensure communication security.Traditional key generation schemes have limitations in terms of flexibility and expandability within the vehicle network.A popular alternative is the physical layer key generation technology based on wireless channels, which offers lightweight characteristics and a theoretical basis of security in information theory.However, in the context of internet of vehicles, the movement speed of devices impacts the autocorrelation of generated keys, requiring improvements to traditional channel modeling methods.Additionally, the randomness and consistency of generated wireless keys are of higher importance in applications in internet of vehicles.This research focused on a key generation system based on the wireless physical layer, conducting channel modeling based on line-of-sight and multipath fading effects to reflect the impact of vehicle speed on autocorrelation.To enhance the randomness of key generation, a differential quantization method based on cumulative distribution function was proposed.Furthermore, an information reconciliation scheme based on neural network auto-encoder was introduced to achieve a dynamic balance between reliability and confidentiality.Compared to the implementation of Slepian-Wolf low-density parity-check codes, the proposed method reduces the bit disagreement rate by approximately 30%.…”
Get full text

Peningkatan Akurasi Estimasi Ukuran Perangkat Lunak dengan Menerapkan Logika Samar Metode Mamdani by Ristu Saptono, Galih Dian Hutama

“…Ukuran perangkat lunak biasanya disajikan dalam bentuk Lines of Code (LOC). Metode Function Point Analysis (FPA) merupakan metode yang paling sering digunakan untuk memperkirakan ukuran perangkat lunak dalam satuan LOC. …”
Get full text

Surgical treatment of disloced fracture of the scapula column and glenoid: A 22-year follow-up by Mladenović Desimir, Mladenović Marko, Stojiljković Predrag, Micić Ivan, Karalejić Saša

“…The posterior approach was used for reposition, while for fixation after reposition we used two Blunt clamps. We presented functional outcome 22 years after the injury and the surgical treatment. …”
Get full text

Characterization of Gene Expression Suppression by Bovine Coronavirus Non-Structural Protein 1 by Takehiro Ohkami, Ichika Kitashin, Riko Kawashima, Aimi Yoshida, Taizo Saito, Yasuhiro Takashima, Wataru Kamitani, Keisuke Nakagawa

“…Previous studies demonstrated that the nsp1 of various coronaviruses induces host shutoff through a variety of mechanisms; however, there is little information on the function of bovine coronavirus (BCoV) nsp1. We aimed to characterize the host gene expression suppression function of BCoV nsp1. …”
Get full text

Immune function, egg quality and production responses in layer hens fed two different lignocellulose fibre supplements during the early laying period by Sherzad Mustafa Hussein, Johnny Shumuel Yokhana, Yuko Mabuchi, Theresa Leah Frankel

“…The effects on immune function and egg productivity of 2 commercial lignocellulose supplements with similar insoluble and soluble fibre concentrations and water holding capacities, were determined in Hy-Line Brown hens from 20 weeks-of-age for 8 weeks. …”
Get full text

mRNA decapping enzyme2 DCP2 expression correlates with progression and prognosis of hepatocellular carcinoma by Tianyi Huang, Rui Wang, Cuihua Lu, Jiaying Zhang

“…Prognostic analysis confirmed high DCP2 expression as an indicator of poor overall survival (OS). Functional enrichment analyses linked DCP2 to cancer-associated pathways, including PI3K/Akt, Hippo signaling, cholesterol metabolism, and oxidative phosphorylation. …”
Get full text

Efficacy and safety of first-line PD-1/PD-L1 inhibitor in combination with CTLA-4 inhibitor in the treatment of patients with advanced non-small cell lung cancer: a systemic review... by Huimin Zhao, Shanshan Huang, Jianyu Wu, Yanlan Lu, Yue Zou, Haijian Zeng, Chunlan Li, Jin Wang, Xiaochen Zhang, Xiaochen Zhang, Siliang Duan, Siliang Duan, Weiming Liang

“…Subgroup analysis revealed that CP provided superior OS compared with P in patients with PD-L1 expression < 1%.ConclusionCP was a feasible and safe first-line therapy for patients with advanced NSCLC. Specifically, CP may function as a therapeutic alternative for individuals with low or negative PD-L1 expression, resulting in enhanced long-term outcomes compared to chemotherapy or P. …”
Get full text

Evaluating the immune effector functions induced by humanized anti-CD99 antibody in eliminating T lymphoblastic leukemia/lymphoma cells by Kamonporn Kotemul, Ratthakorn Chaiwut, Chaochetdhapada Putpim, Supansa Pata, Witida Laopajon, Chatchai Tayapiwatana, Watchara Kasinrerk, Nuchjira Takheaw

“…In this study, we evaluated the anticancer activities of HuMT99/3 against T-ALL/T-LBL cells via immune effector functions. T-ALL/T-LBL cell lines were used as target cells, including Jurkat E6.1, MOLT-4, and SUP-T1. …”
Get full text

Interface Hazard Analysis Between Urban Rail Signal System and Platform Screen Door System Based on Functional FMEA by XUE Qiaoli, YANG Haipeng

Get full text

Optimum Equilibrium Passenger Flow Control Strategies with Delay Penalty Functions under Oversaturated Condition on Urban Rail Transit by Yonghao Yin, Dewei Li, Kai Zhao, Ruixia Yang

“…A real-world case from Batong Line corridor in Beijing subway is used to test the applicability of the model and algorithm, and the result shows that the solution with linear delay penalty functions can not only reduce the total passenger delay but also equilibrate the number of flow control passengers on spatial and temporal.…”
Get full text

Design and synthesis of antiproliferative 2-oxoindolin-3-ylidenes incorporating urea function with potential VEGFR-2 inhibitory properties by Dalia R. Aboshouk, M. Adel Youssef, Siva S. Panda, Benson M. Kariuki, Mohamed S. Bekheit, Ahmed R. Hamed, Walid Fayad, Ahmed A. F. Soliman, Adel S. Girgis

“…The current study is directed towards synthesis of novel antiproliferative 2-oxoindolin-3-ylidenes incorporating urea function with VEGFR-2 properties. The targeted agents were obtained through a two-step reaction. …”
Get full text

Uncoupling protein 2 and 4 expression pattern during stem cell differentiation provides new insight into their putative function. by Anne Rupprecht, Dana Sittner, Alina Smorodchenko, Karolina E Hilse, Justus Goyn, Rudolf Moldzio, Andrea E M Seiler, Anja U Bräuer, Elena E Pohl

“…Apart from the first family member, uncoupling protein 1 (UCP1), the functions of other UCPs (UCP2-UCP5) are still unknown. …”
Get full text

Functional analyses revealed Pinus radiata CHLOROPLAST SENSOR KINASE as a key component in UV-B stress and development by Lara García-Campa, Jesús Pascual, Mónica Meijón, Sara Guerrero, David Morales, José M. Álvarez, Luis Valledor

“…In this study, CHLOROPLAST SENSOR KINASE from Pinus radiata (PrCSK), previously identified as a potentially relevant component in UV-B stress response using a systems biology approach, was sequenced and used to generate overexpression and RNAi Arabidopsis thaliana lines to carry out functional validation studies employing phenotypical, physiological, and metabolomic analyses. …”
Get full text

Functional Characterization of <i>PtoWOX1</i> in Regulating Leaf Morphogenesis and Photosynthesis in <i>Populus tomentosa</i> by Feng Tang, Minghui He, Shi Liang, Meng Zhang, Xiaowei Guo, Yuxian Dou, Qin Song, Cunfeng Zhao, Ting Lan

“…These findings clarify the function of <i>PtoWOX1</i> in regulating mid-lateral axis development and leaf margin morphology and provide new insights for the molecular breeding of poplar.…”
Get full text

Evaluating the Influence of Different Serum‐Free Culture Conditions on the Production and Function of Natural Killer Cell‐Derived Extracellular Vesicles by Yunjie Wu, Héloïse Chollet, Amanda Sudworth, Marit Inngjerdingen

Get full text

Functionalized 1,3,5-triazine-derivatives as promising anticancer agents: synthesis and cytotoxic activity <i>in vitro</i> by A. V. Protas, O. V. Mikolaichuk, E. A. Popova, K. V. Timoshchuk, D. N. Maistrenko, O. E. Molchanov, V. V. Sharoyko, K. N. Semenov

Get full text

Research on fault location and state evaluation method of diagnostic function for power cable insulation defects based on the impedance spectrum by SI Jie, CHEN Zhi, ZHAO Jian, ZHOU Yuxiao

“…Taking XLPE coaxial cable as an example, in this paper, based on the transmission line distribution parameter model and the integral transformation theory, the impedance spectrum function of the power cable is decomposed through the e-2γx function system in the space domain, and a diagnostic function for insulation defects is proposed. …”
Get full text

Oncolytic HSV-IL27 expression improves CD8 T cell function and therapeutic activity in syngeneic glioma models by Alexia K Martin, Uksha Saini, Ilse Hernandez-Aguirre, Yeaseul Kim, Kevin A Cassady, Jack Hedberg, Doyeon Kim, Ravi Dhital

“…The antiglioma efficacy of C027 was tested in three syngeneic orthotopic glioma models derived from both chemical (CT-2A) and genetic (SB28, KR158) glioma lines. Spectral flow cytometry was used to assess immunophenotypic and functional changes in the tumor infiltrates and systemically. …”
Get full text