The redox function of APE1 is involved in the differentiation process of stem cells toward a neuronal cell fate. by Rossana Domenis, Natascha Bergamin, Giuseppe Gianfranceschi, Carlo Vascotto, Milena Romanello, Silvia Rigo, Giovanna Vagnarelli, Massimo Faggiani, Piercamillo Parodi, Mark R Kelley, Carlo Alberto Beltrami, Daniela Cesselli, Gianluca Tell, Antonio Paolo Beltrami

“…To investigate the involvement of APE1 in the differentiation process, we employed E3330, a specific inhibitor of the APE1 redox function. The addition of E3330, either to the neurogenic embryonic carcinoma cell line NT2-D1or to hAT-MASC, increases the differentiation of stem cells towards a neural phenotype, biasing the differentiation towards specific subtypes, such as dopaminergic cells. …”
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Multi-wall carbon Nanotube surface-based functional nanoparticles for stimuli-responsive dual pharmaceutical compound delivery by Masoumeh Nabitabar, Maryam Shaterian, Hossein Danafar, Morteza Enhessari

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Tendomodulin in pan-cancer analysis: exploring its impact on immune modulation and uncovering functional insights in colorectal cancer by Jingfeng Chen, Qin Hu, Cong Zhang, Aiqi Zhao, Bihua Guan, Yifan Wang, Min Zhang, Xia Li, Biao Chen, Lulu Zeng, Minjiang Chen, Bing Wu, Jianping Wang, Yang Yang, Jiansong Ji

“…However, its comprehensive impact across cancers, particularly its immunomodulatory function in CRC, remains underexplored. This study explored the role of TNMD in CRC by focusing on its immunomodulatory functions through comprehensive molecular and clinical analyses. …”
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Influencе of peptides from the bursa of Fabricius in broiler chickens on the functional activity of subpopulations of lymphocytes in immunosuppressed mice by N. A. Kolberg, S. L. Tikhonov, N. V. Tikhonova, L. S. Kudryashov

“…In this regard, the demand for immune-boosting nutraceuticals and functional foods containing biologically active peptides is growing. …”
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The Role of Chemokine (C‐C Motif) Ligand 7 (CCL7) in Hepatocellular Carcinoma: Expression, Function, and Mechanisms by Yangkun Luo, Fei Wan, Zhao Zhang, Zujun Qin, Yongjun Ren

“…This study seeks to examine the expression and functional role of CCL7 in the context of HCC. Materials & Methods Western blot and immunohistochemistry were used to detect the expression of CCL7 in HCC tissues and cell lines. …”
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APPLICATION OF VERTICAL GRADIENT METHODS OF MICROGRAVITY TIME FUNCTION TO DETERMINE GROUND WATER REDUCTION IN SEMARANG PERIOD OF 2013 by K. Khumaedi, S. Supriyadi, A. Pradana, S. Imam, M. Yusuf, M. Sarkowi

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Bacillus vallismortis acts against ginseng root rot by modifying the composition and microecological functions of ginseng root endophytes by Yang Hu, Liu-yang Yang, Meng-yuan Lei, Yi-xin Yang, Zhuo Sun, Wan Wang, Zhong-ming Han, Lin Cheng, Ze-liang Lv, Mei Han, Li-min Yang

“…IntroductionThe endophytic microbiome serves a crucial function as a secondary line of defense against pathogen invasion in plants. …”
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Soil function, properties and plant diversity–biomass patterns differ between grazed and non-grazed steppe ecosystems by Jia Mi, Jia Mi, Qianju Wang, Jun Ou, Jing Shi, Haiyan Pang, Ziheng Feng, Yongfei Bai, Yongfei Bai

“…IntroductionGrazing and enclosure are two major grassland management techniques, which are used to preserve plant variety, productivity, and ecosystem function.MethodsIn order to compare plant diversity and ecosystem function under grazing and enclosure conditions, this study observed three typical grassland locations in southeast of Inner Mongolia via medium-scale line transect surveys.ResultsOur results showed that soil nutrients in enclosed grasslands control the diversity of plant species and aboveground biomass (AGB), which in turn regulates the amount of belowground biomass (BGB) by allocation. …”
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Investigating POU3F4 in cancer: Expression patterns, prognostic implications, and functional roles in tumor immunity by Weiwei Chen, Yaya Ji, Rui Wang, Ruijie Ji, Yujian Lin, Yuhang Wu, Lehan Liu, Tianle Sha, Wen Li, Lei Zhang, Longfei Yang, Xinhua Zhang, Jianxiang Song

“…This study aims to assess the prognostic value of POU3F4 in thirty-three cancers and explore its immune-related functions. Based on data from The Cancer Genome Atlas (TCGA), Cancer Cell Line Encyclopedia (CCLE), Genotype-Tissue Expression (GTE), and Gene Set Cancer Analysis (GSCA), we employed various bioinformatics approaches to investigate the potential carcinogenic effects of POU3F4. …”
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Retinal Pigment Epithelial Cells Express a Functional Receptor for Glucagon-Like Peptide-1 (GLP-1) by Alessandra Puddu, Roberta Sanguineti, Fabrizio Montecucco, Giorgio L. Viviani

“…Since the retinal pigment epithelium (RPE), that forms the outer retinal barrier, has a key role in protecting from diabetic retinopathy (DR), we investigated the potential expression and function of GLP-1R in a RPE cell line. ARPE-19 cells were cultured in DMEM/F12 supplemented with 10% FBS. …”
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ABHD6 loss-of-function in mesoaccumbens postsynaptic but not presynaptic neurons prevents diet-induced obesity in male mice by David Lau, Stephanie Tobin, Horia Pribiag, Shingo Nakajima, Alexandre Fisette, Dominique Matthys, Anna Kristyna Franco Flores, Marie-Line Peyot, S. R. Murthy Madiraju, Marc Prentki, David Stellwagen, Thierry Alquier, Stephanie Fulton

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Dose Severity of Achilles Tendinopathy on Preoperative MRI Predict Functional Outcomes after Minimally Invasive Zadek Osteotomy? by Sarah Hall BA, Jonathan Kaplan MD, Oliver Schipper MD, A. Holly Johnson MD, Ettore Vulcano MD, J. Benjamin Jackson MD, MBA, Tyler Gonzalez MD, MBA

“…Severity of IAT on preoperative MRI may correlate with post operative functional outcomes and help guide patient selection for treatment with MIS ZO. …”
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Natural ligand 3,3’-diindolylmethane functions as an AHR agonist to modulate angiogenesis and organ development in chicken embryos by Gee-yea Lim, Hao Chen, Woo-seon Song, Dong-hee Koh, Dong-ha Kim, Hisato Iwata, Eun-Young Kim

“…Aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that is crucial for regulating various toxicological responses and physiological functions. Recent studies have highlighted that interactions between AHR and certain natural ligands can modulate inflammation and immune responses, offering therapeutic potential for a wide range of diseases. …”
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Morphological, functional and biochemical differences in cardiac adaptation to endurance exercise among male and female amateur marathon runners by Zofia Lasocka-Koriat, Zofia Lasocka-Koriat, Zuzanna Lewicka-Potocka, Zuzanna Lewicka-Potocka, Anna Kaleta-Duss, Nikola Bulman, Ewelina Marciniak, Leszek Kalinowski, Leszek Kalinowski, Ewa Lewicka, Alicja Dąbrowska-Kugacka

“…However, activities of high intensity such as marathon running may adversely affect cardiac morphology and function, especially in the heterogenous group of amateur athletes. …”
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Age-related differences of subjective visual vertical perception in adults—a functional near-infrared spectroscopy study by Jun Lu, Jun Lu, Xiang Gong, Meng-Huan Wang, Ruo-Xin Zhao, Yu-Chen Wang, Ying-Ying Shen, Rong Cao, Guang-Xu Xu, Guang-Xu Xu

“…BackgroundThe perception of Subjective Visual Vertical (SVV) is crucial for postural orientation and significantly reflects an individual’s postural control ability, relying on vestibular, visual, and somatic sensory inputs to assess the Earth’s gravity line. The neural mechanisms and aging effects on SVV perception, however, remain unclear.ObjectiveThis study seeks to examine aging-related changes in SVV perception and uncover its neurological underpinnings through functional near-infrared spectroscopy (fNIRS).MethodsIn a comparative study of 19 young and 19 older adults, the standardized SVV task executed in Eprime 3.0 software evaluated participants’ SVV orientation and uncertainty. …”
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Relationship between cognitive functions and serum neurotrophic factor levels in long-term hospitalized male patients with schizophrenia by Pan Jing, Xiaopeng Yin, Haihang Yu, Ye Fu, Fangmin Wang, Xi Mei, Qiaozhen Zhang, Qing Tian, Xiaobin Zhang

“…Methods A total of 82 male schizophrenia patients with long-term hospitalization and 52 healthy controls were recruited. Cognitive functions were evaluated in all participants, including verbal fluency function, attention function, executive function, and spatial function. …”
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PO20 | Impact of endovascular treatment on functional outcome in ischemic stroke: a real-world retrospective study

“…This study evaluated clinical and procedural predictors of functional outcomes at discharge and 90 days in patients with LVO IS treated with MT, with or without IVT, in a real-world setting. …”
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Effects of oxidative stress and GDNF on patients with bipolar disorder: a prospective study by Qun Yang, Chuanwei Li, Fei Jiang, Jiancheng Qiu, Haidong Yang, Qing Tian, Xiaobin Zhang

“…Oxidative stress and glial cell line-derived neurotrophic factor (GDNF) influence the pathophysiology of BD. …”
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Correction: Evaluation of left ventricular systolic function in patients with iron deficiency anemia based on non-invasive left ventricular pressure–strain loops by Xiuxiu Cui, Meng Jing, Liyuan Ren, Xuanning Hou, Qingfei Song, Kefeng Li, Xiaoyan Wang

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Retrograde Ret signaling controls sensory pioneer axon outgrowth by Adam Tuttle, Catherine M Drerup, Molly Marra, Hillary McGraw, Alex V Nechiporuk

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