Molecular cause and functional impact of altered synaptic lipid signaling due to a prg‐1 gene SNP by Johannes Vogt, Jenq‐Wei Yang, Arian Mobascher, Jin Cheng, Yunbo Li, Xingfeng Liu, Jan Baumgart, Carine Thalman, Sergei Kirischuk, Petr Unichenko, Guilherme Horta, Konstantin Radyushkin, Albrecht Stroh, Sebastian Richers, Nassim Sahragard, Ute Distler, Stefan Tenzer, Lianyong Qiao, Klaus Lieb, Oliver Tüscher, Harald Binder, Nerea Ferreiros, Irmgard Tegeder, Andrew J Morris, Sergiu Gropa, Peter Nürnberg, Mohammad R Toliat, Georg Winterer, Heiko J Luhmann, Jisen Huai, Robert Nitsch

“…PRG‐1+/− mice, which are animal correlates of human PRG‐1+/mut carriers, showed an altered cortical network function and stress‐related behavioral changes indicating altered resilience against psychiatric disorders. …”
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SUMOylation substrate encoding genes as prognostic biomarkers in pancreatic ductal adenocarcinoma with functional assessment of SAF-B2 by Xiangjun Wang, Chuanxin Yang, Yangming Liu, Jian Wang

“…SUMOylation, a reversible post-translational modification, plays a critical role in tumor progression, yet its prognostic significance in PDAC remains unclear.MethodsWe assessed SUMOylation expression patterns and function in PDAC using Western blot and the SUMOylation inhibitor TAK-981. …”
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Application of Wireless Power Transfer to Railway Parking Functionality: Preliminary Design Considerations with Series-Series and LCC Topologies by Luca Pugi, Alberto Reatti, Fabio Corti

“…In this work, proposed application is innovative with respect to existing literature: static current collection on conventional railway lines is proposed in order to replace the functionalities implemented by conventional battery chargers and the so-called railway “parking” system. …”
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Division of the large and multifunctional glycoside hydrolase family 2: high functional specificity and biochemical assays in the uncharacterized subfamilies by Annie Lebreton, Marie-Line Garron, Marlene Vuillemin, Bo Pilgaard, Bastian V. H. Hornung, Elodie Drula, Vincent Lombard, William Helbert, Bernard Henrissat, Nicolas Terrapon

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Distribution of C30 carotenoid biosynthesis genes suggests habitat adaptation function in insect-adapted and nomadic Lactobacillaceae by Tom Eilers, Marie Legein, Jari Temmermans, Jelle Dillen, Ine Vandendriessche, Koen Sandra, Peter A. Bron, Stijn Wittouck, Sarah Lebeer

“…The production of carotenoids, particularly C30 forms, has been documented in some non-photosynthetic prokaryotes. However, their function, distribution and ecology beyond photosynthesizing organisms remains understudied. …”
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Toll-like receptor 4 signaling activation domains promote CAR T cell function against solid tumors by Veronika Mikolič, Jelica Pantović-Žalig, Špela Malenšek, Matjaž Sever, Duško Lainšček, Roman Jerala

“…While the incorporation of CD28 or 4-1BB costimulatory signaling domains into CARs revolutionized immune responses, there is an exciting prospect of further enhancing CAR functionality. Here, we investigated the design of CD19 CARs enriched with distinct Toll-like receptor 4 (TLR4), myeloid differentiation primary response 88 (MyD88), or Toll/IL-1 domain-containing adaptor-inducing interferon (IFN)-β (TRIF) costimulatory domains. …”
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An Implementation of Creep Test Assisting System with Dial Gauge Needle Reading and Smart Lighting Function for Laboratory Automation by Dezheng Kong, Nobuo Funabiki, Shihao Fang, Noprianto, Mitsuhiro Okayasu, Pradini Puspitaningayu

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Characterization and functional evaluation of goat PDX1 regulatory modules through comparative analysis of conserved interspecies homologs by Naeimeh Rezaei, Kianoush Dormiani, Abbas Kiani-Esfahani, Somayeh Mirdamadian, Mohsen Rahmani, Farnoosh Jafarpour, Mohammad Hossein Nasr-Esfahani

“…Abstract PDX1 is a crucial transcription factor in pancreas development and mature β-cell function. However, the regulation of PDX1 expression in larger animals mirroring human pancreas morphogenesis and endocrine maturation remains poorly understood. …”
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The relationship of functional movement screen scores with flexibility, speed and agility in 17-15- year- old male students by Mohammad sadegh Armanfar, Reza Rajabi, Shahnaz Shahrbanian, Mohammad Hosein Alizadeh

“…Background: Functional Movement Screening (FMS) is a tool to determine the individual's potential for the possibility of sports injury.Aim: The purpose of this study was to determine the relationship between functional movement screening scores with flexibility factors, speed and agility in male students in Lorestan province.Materials and Methods: 370 male volunteer students aged 15 to 17 years participated in this study. …”
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Identification and zoning of complex ecological functions in territorial space: a case study of Huzhou City of Zhejiang Province by JIANG Fangming, XU Zhihong, WANG Jianfeng, YOU Shixue, SHEN Shaoze, CEN Qing, DENG Jingsong

“…The identification and zoning of complex ecological functions is the research focus and application difficulty of territorial spatial planning, and it is also the ecological security guarantee for the green and sustainable development model. …”
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Transcriptome-wide co-expression analysis identifies LRRC2 as a novel mediator of mitochondrial and cardiac function. by Chris McDermott-Roe, Marion Leleu, Glenn C Rowe, Oleg Palygin, John D Bukowy, Judy Kuo, Monika Rech, Steffie Hermans-Beijnsberger, Sebastian Schaefer, Eleonora Adami, Esther E Creemers, Matthias Heinig, Blanche Schroen, Zoltan Arany, Enrico Petretto, Aron M Geurts

“…To understand the underlying mechanisms, it is essential to define the full complement of proteins that modulate mitochondrial function. To identify such proteins, we performed a meta-analysis of publicly available gene expression data. …”
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Formulation and evaluation of cetuximab functionalized phospholipid modified nanocrystals of paclitaxel for non-small cell lung cancer therapy by Manish Kumar, Pooja Goswami, Abhishek Jha, Manjit Manjit, Amol Parasram Satpute, Biplob Koch, Brahmeshwar Mishra

“…The findings of this study indicate the promising potential of the prepared cetuximab-functionalized phospholipid-coated paclitaxel nanocrystals in lung cancer therapy.…”
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Sporadic ALS induced pluripotent stem cell derived neurons reveal hallmarks of TDP-43 loss of function by Jeffrey D. Rothstein, Olivia Keeley, Caroline Warlick, Timothy M. Miller, Cindy V. Ly, Jonathan D. Glass, Alyssa N. Coyne

“…Induced pluripotent stem cell (iPSC)-derived neurons (iPSNs) from 180 individuals, including controls, C9orf72 ALS/FTD, and sporadic ALS (sALS) patients were used to generate and analyze ~32,500 qRT-PCR data points across 20 genes which identified variable, time-dependent signatures of TDP-43 loss of function in individual lines. Notably, the same changes were also seen in postmortem brain tissue from the same patients, confirming that iPSNs accurately model disease. …”
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Maps of open chromatin guide the functional follow-up of genome-wide association signals: application to hematological traits. by Dirk S Paul, James P Nisbet, Tsun-Po Yang, Stuart Meacham, Augusto Rendon, Katta Hautaviita, Jonna Tallila, Jacqui White, Marloes R Tijssen, Suthesh Sivapalaratnam, Hanneke Basart, Mieke D Trip, Cardiogenics Consortium, MuTHER Consortium, Berthold Göttgens, Nicole Soranzo, Willem H Ouwehand, Panos Deloukas

“…We showed that the two cell types exhibit distinct patterns of open chromatin and that cell-specific open chromatin can guide the finding of functional variants. We identified an open chromatin region at chromosome 7q22.3 in megakaryocytes but not erythroblasts, which harbors the common non-coding sequence variant rs342293 known to be associated with platelet volume and function. …”
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δ-Catenin is genetically and biologically associated with cortical cataract and future Alzheimer-related structural and functional brain changes. by Gyungah Jun, Juliet A Moncaster, Carolina Koutras, Sudha Seshadri, Jacqueline Buros, Ann C McKee, Georges Levesque, Philip A Wolf, Peter St George-Hyslop, Lee E Goldstein, Lindsay A Farrer

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Event-Type Identification in Power Grids Using a Spectral Correlation Function-Aided Convolutional Neural Network by Ozgur Alaca, Ali Riza Ekti, Jhi-Young Joo, Nils Stenvig

“…This study introduces a novel event-type identification method, utilizing a Spectral Correlation Function (SCF)-aided Convolutional Neural Network (CNN). …”
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Structural and Functional Analysis of Hemoglobin Binding to the Peritrophic Matrix During Blood Digestion in <i>Aedes aegypti</i> by Karla Barreto da Silva Orozimbo, Desiely da Silva Gusmão Tauil, Aline Melila Licurgo, Felipe Figueirôa Moreira, Jucélia da Silva Araújo, Maria Aparecida Aride Bertonceli, Sérgio Henrique Seabra, Olga Lima Tavares Machado, Francisco José Alves Lemos

“…Thus, hemoglobin may perform a function similar to that of peritrophins. Further experiments demonstrated the protective role of the PM against hemoglobin proteolysis during blood digestion. …”
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miR-449, identified through antiandrogen exposure, mitigates functional biomarkers associated with ovarian cancer risk by Xia Wang, Ho-Hyung Woo, Michelle Wei, Steven Gibson, Mitzi Miranda, Demaretta Rush, Janiel Cragun, Wenxin Zheng, Guang Yao, Setsuko K. Chambers

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Network modeling identifies molecular functions targeted by miR-204 to suppress head and neck tumor metastasis. by Younghee Lee, Xinan Yang, Yong Huang, Hanli Fan, Qingbei Zhang, Youngfei Wu, Jianrong Li, Rifat Hasina, Chao Cheng, Mark W Lingen, Mark B Gerstein, Ralph R Weichselbaum, H Rosie Xing, Yves A Lussier

“…Restoration of miR-204 function in HNSCC cell lines inhibits the expression of its functionally related gene targets, leads to the reduced adhesion, migration and invasion in vitro and attenuates experimental lung metastasis in vivo. …”
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Development of functional markers for peroxidase activity genes TaPod-7AS and TaPod-4AL in wheat by Xinyuan Liu, Yukun Cheng, Hongwei Geng, Yi Ren, Junmei Cao, Bin Bai, Yating Xue

“…The markers POD-4AL1 and POD-4AL2 for TaPod-4AL amplified 541-bp and 391-bp fragments in the cultivars with low and high POD activities, respectively. The functional markers were validated in a diverse panel of 268 winter wheat cultivars and advanced lines, indicating significant associations between genotypes and POD activity (P < 0.05). …”
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