Chlorotoxin-functionalized mesoporous silica nanoparticles for pH-responsive paclitaxel delivery to Glioblastoma multiforme by Mirjana Mundžić, Amelia Ultimo, Minja Mladenović, Aleksandra Pavlović, Oliviero L. Gobbo, Eduardo Ruiz-Hernandez, Maria Jose Santos-Martinez, Nikola Ž. Knežević

“…Furthermore, we utilized a host-guest interaction between the adamantane and capping CD moieties to further functionalize the surface with a potential glioma-targeting oligopeptide chlorotoxin (CHX). …”
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Liver functions and medication adherence in tuberculosis patients after 6 months of antituberculosis treatment in Indonesia by Dyah Aryani Perwitasari, Triantoro Safaria, Didik Setiawan, Haafizah Dania, Salma Auliya Fatimah, Imaniar Noor Faridah

“…Objective The objective of this study was to assess liver functions in tuberculosis patients after 6 months of treatment and determine the difference in the level of liver enzymes based on medication adherence and patient characteristics. …”
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IntAct: A nondisruptive internal tagging strategy to study the organization and function of actin isoforms. by Maxime C van Zwam, Anubhav Dhar, Willem Bosman, Wendy van Straaten, Suzanne Weijers, Emiel Seta, Ben Joosten, Jeffrey van Haren, Saravanan Palani, Koen van den Dries

“…Mammals have 6 highly conserved actin isoforms with nonredundant biological functions. The molecular basis of isoform specificity, however, remains elusive due to a lack of tools. …”
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Protein kinase 2 of the giant sarcomeric protein UNC-89 regulates mitochondrial morphology and function by Yohei Matsunaga, Hiroshi Qadota, Nasab Ghazal, Leila Lesanpezeshki, Till Dorendorf, Jasmine C. Moody, Arnaud Ahier, Courtney J. Matheny, Siva A. Vanapalli, Steven Zuryn, Olga Mayans, Jennifer Q. Kwong, Guy M. Benian

“…Abstract UNC-89 is a giant sarcomeric M-line protein required for sarcomere organization and optimal muscle function. …”
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Isolation, identification, and production optimization of natural functional pigments produced by Talaromyces atroroseus LWT-1 by Xian Xia, Xian Xia, Li-Yu Liu, Miao Liu, Guo-Jun Hu, Wen-Ting Li, Zi-Yi Wang, Yao Pei, Yan-He Li, Jing-Jing Li, Yan-Xiang Wang, Xiao-Shan Shi, Jun-Ming Tu

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Smart fiber with overprinted patterns to function as chip-like multi-threshold logic switch circuit by Xiaofei Wei, Rui Li, Siwei Xiang, Long Qin, Xinxin Luo, Jie Xue, Xing Fan

“…Herein, we present a smart fiber with multilayers of overprinted patterns, composed of many small units with 0.3 mm long to function as a one-dimension (1D) array of chip-like multi-threshold logic-switch circuit. …”
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A cross-country analysis of feasible income equality using the sigmoid function and the Boltzmann distribution. by Thitithep Sitthiyot, Kanyarat Holasut

“…This study uses the sigmoid function in combination with the Boltzmann distribution, originally developed by Park and Kim (2021), in order to calculate the optimal income distribution that represents feasible income equality and maximizes total social welfare. …”
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GDNF overexpression in astrocytes enhances branching and partially preserves hippocampal function in an Alzheimer’s rat model by Ana Abril Vidal Escobedo, Facundo Peralta, Gustavo Ramón Morel, Martino Avallone, Tomas Björklund, Paula Cecilia Reggiani, Joaquín Pardo

“…In this study, we developed an adeno-associated viral vector (AAV9) designed to selectively overexpress glial cell line-derived neurotrophic factor (GDNF) in astrocytes, using the astrocyte-specific GFAP promoter and TdTomato for transduction tracking. …”
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Adapted physical activity: Benefit on oxidative, functional capacity and exercise tolerance of elderly people in Kinshasa by Constant Nkıama, Samuel Biduaya Bamu, Carel Busano Nduakulu, Siloé Ntumba Tshiyamba, Godefroid Kusuayi

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Incorporating Cystatin C to Predict Methotrexate Elimination in Patients with CNS Lymphoma and Suspicious Renal Function by Jason N. Barreto, Allison L. McClanahan, Andrew D. Rule, Carrie A. Thompson, Erin Frazee

“…High-dose methotrexate (MTX; ≥1 g/m2) is a renally eliminated and nephrotoxic first-line therapy for central nervous system (CNS) lymphoma. …”
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Oncogenic functions of the cancer-testis antigen SSX on the proliferation, survival, and signaling pathways of cancer cells. by Padraig D'Arcy, Wessen Maruwge, Barry Wolahan, Limin Ma, Bertha Brodin

“…SSX is a transcription factor with elusive oncogenic functions expressed in a variety of human tumors of epithelial and mesenchymal origin. …”
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Adiabatic state conversion for (a)cyclic non-Hermitian quantum Hamiltonians of generalized functional form by Nicholas S. Nye, Nikolaos V. Kantartzis

“…Analytical solutions in terms of Airy and modified Bessel functions have been retrieved for linear and hyperbolic temporal dependencies in parity-time-symmetric-like systems, which were subsequently studied in the slowly varying limit to show conversion to one of the instantaneous eigenstates. …”
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MS CETSA deep functional proteomics uncovers DNA repair programs leading to gemcitabine resistance by Ying Yu Liang, Khalidah Khalid, Hai Van Le, Hui Min Vivian Teo, Mindaugas Raitelaitis, Marc-Antoine Gerault, Jane Jia Hui Lee, Jiawen Lyu, Allison Chan, Anand Devaprasath Jeyasekharan, Wai Leong Tam, Pär Nordlund, Nayana Prabhu

“…Here we use a deep functional proteomics implementation of the Cellular Thermal Shift Assay to reveal a range of induced biochemical responses to gemcitabine in resistant and sensitive diffuse large B cell lymphoma cell lines. …”
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Genomic Analysis of Indel and SV Reveals Functional and Adaptive Signatures in Hubei Indigenous Cattle Breeds by Liangyu Shi, Pu Zhang, Bo Yu, Lei Cheng, Sha Liu, Qing Liu, Yuan Zhou, Min Xiang, Pengju Zhao, Hongbo Chen

“…This study investigates the distribution and functional impact of insertions and deletions in five Hubei indigenous cattle breeds. …”
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Functional interaction of fibroblast growth factor 8b and androgen in prostate cancer cell proliferation by Wen-jun Xiao, Gui-ming Zhang, Ding-wei Ye

“…We investigated the effects of fibroblast growth factor 8b and androgen on the proliferation of prostate cell lines and the corresponding intracellular mechanisms. …”
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ARF6-dependent regulation of P2Y receptor traffic and function in human platelets. by Venkateswarlu Kanamarlapudi, Sian E Owens, Keya Saha, Robert J Pope, Stuart J Mundell

“…Further blockade of ARF6 function either in cell lines or human platelets blocks P2Y purinoceptor internalization. …”
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Ship path planning based on improved multi-scale A* algorithm of collision risk function by Chunyu Song, Teer Guo, Jianghua Sui

“…Moreover, in order to improve the efficiency of optimal path planning in the context of complex sea areas while ensuring path safety, the paper proposes a collision risk function to optimize the determination of the cost of A* algorithm nodes, thereby enhancing the heuristic function of the A* algorithm. …”
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Dopamine Treatment and Cognitive Functioning in Individuals with Parkinson’s Disease: The “Cognitive Flexibility” Hypothesis Seems to Work by Alberto Costa, Antonella Peppe, Ilenia Mazzù, Mariachiara Longarzo, Carlo Caltagirone, Giovanni A. Carlesimo

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Discussion on the Function and Interface Schemes for Interlocking System of Multi-level Railway Network Junction Station by ZHANG Minhui, WU Ruhan, LIU Huaxiang, SONG Rui

“…Objective In the multi-level road network, junction stations of lines with different signal systems face quite a number of challenges. …”
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Construction of multi-targeted CRISPR libraries in tomato to overcome functional redundancy at genome-scale level by Amichai Berman, Ning Su, Zhuorong Li, Udi Landau, Joydeep Chakraborty, Natali Gerbi, Jia Liu, Yuntai Qin, Boxi Yuan, Wei Wei, Osnat Yanai, Itay Mayrose, Yuqin Zhang, Eilon Shani

“…These sgRNAs are classified into 10 sub-libraries based on gene function. We generate approximately 1300 independent CRISPR lines and successfully identify mutants with distinct phenotypes related to fruit development, fruit flavor, nutrient uptake, and pathogen response. …”
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