Experimental study of cognitive function against the background of partial food derivation and its correction by A.A. Kushta

“…Of interest is cognitive function against the background of nutritional deficiency. …”
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Evaluation of the immobilized enzymes function in soil remediation following polycyclic aromatic hydrocarbon contamination by Babar Hussain, Hongqing Zhu, Chunyu Xiang, Luo Mengfei, Bowei Zhu, Shibin Liu, Hui Ma, Shengyan Pu

“…However, the practical application is limited by its instability and ease to loss function under harsh environmental conditions such as pH, temperature, and edaphic stress etc. …”
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Modulation of intracellular kinase signaling to improve TIL stemness and function for adoptive cell therapy by Hao Feng, Ling Qiu, Zixiao Shi, Yao Sheng, Peipei Zhao, Di Zhou, Fei Li, Hailin Yu, Yanan You, Hui Wang, Ming Li, Shurong Zhu, Yan Du, Jun Cui, Jingwei Sun, Yarong Liu, Hua Jiang, Xin Wu

“…Result The inhibition of either PI3K or AKT led to an increase in the population of effector CD8+ T cells with upregulation of activation markers, elevated CD39−CD69− memory T cells, and significantly enhanced cytotoxicity when cocultured with tumor cell lines and patient‐derived tumor samples. Moreover, dual knockout of AKT1 and AKT2 largely phenocopies the functional impact of AKT or PI3K inhibition on TIL. …”
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Co-dependence of HTLV-1 p12 and p8 functions in virus persistence. by Cynthia A Pise-Masison, Maria Fernanda de Castro-Amarante, Yoshimi Enose-Akahata, R Cody Buchmann, Claudio Fenizia, Robyn Washington Parks, Dustin Edwards, Martina Fiocchi, Luiz Carlos Alcantara, Izabela Bialuk, Jhanelle Graham, Jean-Claude Walser, Katherine McKinnon, Bernardo Galvão-Castro, Antoine Gessain, David Venzon, Steven Jacobson, Genoveffa Franchini

“…These results indicate that efficient viral persistence and spread require the combined functions of p12 and p8.…”
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FUNCTIONAL ACTIVITY OF ANTI-GD2 CAR-T CELLS WITH DIFFERENT ANTIGEN-RECOGNITION MODULE by Dzmitry Lutskovich, Hanna Klych, Maryia Maryia A. Keraz, Kate Lutskovich, Alexander Meleshko

“…The aim of the present study is to obtain chimeric antigenic receptors of the 2nd generation based on three antibodies, with different lengths of the extracellular domain and to evaluate their functional activity against a number of cell lines to justify further clinical trials.…”
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Validation of Novel Biomarkers for Prostate Cancer Progression by the Combination of Bioinformatics, Clinical and Functional Studies. by Saeid Alinezhad, Riina-Minna Väänänen, Jesse Mattsson, Yifeng Li, Terhi Tallgrén, Natalia Tong Ochoa, Anders Bjartell, Malin Åkerfelt, Pekka Taimen, Peter J Boström, Kim Pettersson, Matthias Nees

“…However, only few predictive markers identified in silico have also been validated for clinical, functional or mechanistic relevance in disease progression. …”
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Unraveling the cohesin-chromatin interface: identifying protein interactions that modulate chromosome structure and function by Natalie L. Rittenhouse, Riya Gohil, June E. Arricastres, Jill M. Dowen

“…Abstract Background The evolutionarily conserved cohesin complex is a pleiotropic regulator of chromosome structure and function, participating in sister chromatid cohesion, transcriptional regulation of genes, DNA replication, and DNA repair. …”
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Galectin-3 secreted by triple-negative breast cancer cells regulates T cell function by Annat Raiter, Yael Barhum, Julia Lipovetsky, Chen Menachem, Sharona Elgavish, Shmuel Ruppo, Yehudit Birger, Shai Izraeli, Orna Steinberg-Shemer, Rinat Yerushalmi

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The Function of Heat Shock Transcription Factors in Sex Differentiation in <i>Cynoglossus semilaevis</i> by Zhijie Li, Xuexue Sun, Haipeng Yan, Lijun Wang, Xihong Li, Na Wang, Min Wei, Wenteng Xu

“…After the RNA interference of <i>hsf</i> in the testis and ovarian cell lines, a series of sex-related genes, such as <i>foxl2</i> and <i>dmrt1</i>, significantly changed. …”
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Impact of PEGylation and hyaluronan functionalization on lipoplex-mediated mRNA delivery to the canine retina by Tatyana Appelbaum, David A. Smith, Kei Takahashi, Jennifer C. Kwok, Hannah Sorenson, William A. Beltran

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Novel Loss of Function Variant in SOST From Chinese Family Results in Sclerosteosis 1 by Yufan Guo, Xintao Wu, Yuting Jin, Yu Gu, Yuting Lou, Pu Miao, Ye Wang, Bijun Zhang, Xueting Lin, Chudi Zhang, Jianhua Feng

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Neurocognitive functioning in adults with neurofibromatosis type 1- a nationwide population-based study by Karoline Doser, Jens Richardt Møllegaard Jepsen, Line Kenborg, Kamilla Woznica Miskowiak, Vanna Albieri, Susanne Oksbjerg Dalton, Anja Krøyer, Hanne Hove, John R. Østergaard, Christoffer Johansen, Sven Asger Sørensen, John Mulvihill, Jeanette Falck Winther, Pernille Envold Bidstrup

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Fc-effector functional antibody assays for SARS-CoV-2 variants of concern by Xuemin Chen, Grace Li, Caroline Ciric, Theda Gibson, Larry J. Anderson, Larry J. Anderson, Christina A. Rostad, Christina A. Rostad

“…This study evaluated the effect COVID-19 XBB.1.5 booster vaccination on Fc-effector antibody responses to SARS-CoV-2.MethodsWe developed four assays to evaluate the Fc-effector functions of SARS-CoV-2 antibodies. ADCC and CDC assays utilized stably transfected luciferase-based target cell lines expressing SARS-CoV-2 spike variants (Ancestral, Wu-1 Omicron XBB.1.5, and EG.5) to measure antibody-mediated lysis by effector cells. …”
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Analyzing body composition in living kidney donors: impact on post-transplant kidney function by Evelien E. Quint, Lisa B. Westenberg, Gertrude J. Nieuwenhuijs-Moeke, Eva A. N. van den Broek, Marcel Zorgdrager, Alain R. Viddeleer, Stephan J. L. Bakker, Ija M. Nolte, Marco van Londen, Robert A. Pol, TransplantLines Investigators

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Analysis of selenocysteine insertion sequence element, structures and functions and expression profiles of selenoprotein T in chicken by Ge Yansong, Cao Changyu, Wang Lili, Li Nan, Jiang Xiuqing, Li Jinlong

“…Selenoprotein T (SelT) was originally identified through silico studies, cloned and expressed in a mammalian cell line, confirmed as a selenoprotein. Previous studies have proved that SelT mainly occurred in Golgi apparatus and endoplasmic reticulum, with important biological function. …”
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ADAM2 interactions with mouse eggs and cell lines expressing α4/α9 (ITGA4/ITGA9) integrins: implications for integrin-based adhesion and fertilization. by Ulyana V Desiderio, Xiaoling Zhu, Janice P Evans

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Random Oscillations of Rail Vehicles with Nonlinear Spring Suspension Characteristics by A. N. Savos’Kin, H. P. Burchak, R. K. Nasyrov, A. A. Akishin

Subjects: “…random processes of the rail lines’ geometric irregularities…”
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The ETS-Domain Transcription Factor Elk-1 Regulates COX-2 Gene Expression and Inhibits Glucose-Stimulated Insulin Secretion in the Pancreatic β-Cell Line INS-1 by Xiong-Fei Zhang, Yi Zhu, Wen-Biao Liang, Jing-Jing Zhang

“…In this report, we used pancreatic β-cell line (INS-1) to explore the relationships between Elk-1 and COX-2. …”
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Effect of Curcumin on Docetaxel-Induced Apoptosis in the DU145 (Prostate) Cell Line Using the 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide Assay by Mohammad Shokrzadeh, Elahe Gharehkhani, Mahboube Rahmati Kukandeh, Mahsa Hosseini

“…Docetaxel (DTX) is proposed as a well-known compound for prostate tumor chemotherapy, and its function is based on inhibiting microtubule depolymerization, disrupting microtubule balance, and consequently delaying cell cycle progression. …”
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Effects of SNX9 on the structure and function of primary cilia in autosomal dominant polycystic kidney disease by Shen Ai-wen, Hu Wan-qian, Lin Lu, Yu Sheng-qiang

“…Objective To explore the effect and mechanism of SNX9 on primary cilia in autosomal dominant polycystic kidney disease（ADPKD）and provide theoretical rationales for seeking intervention targets.Methods The localization of SNX9 in cystic lining epithelium cell line（WT9-12）was observed by immunofluorescence.And the differential expression of SNX9 between normal renal tubular epithelial cell line（RCTEC）and WT9-12 was detected by Western blot.The expression of IFT88 was detected by Western blot and the change of cilia length examined by immunofluorescence.Results SNX9 existed in both cytoplasm and membrane of WT9-12 and its expression was lower than that in RCTEC（P<0.05）.When the expression of SNX9 was down-regulated,the expression of IFT88 declined and cilia became shorter（P<0.05）.Meanwhile,after the up-regulation of SNX9 by lentivirus,the expression of IFT88 increased and cilia became longer（P<0.01）.Conclusions In ADPKD,SNX9 exists in both membrane and cytoplasm of cyst epithelium and its expression is lower than that of normal renal tubular epithelial cell.As a result,the morphology and function of primary cilia become compromised.An up-regulation of SNX9 preserves the function of primary cilia and it may become a new target for ADPKD therapy.…”
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