Integrated transcriptomic and functional modeling reveals AKT and mTOR synergy in colorectal cancer by Marcin Duleba, Eliza Zimoląg, Joanna Szuszkiewicz, Marcin Serocki, Joanna Szklarczyk, Olga Dracz, Alexander Kurzejamski, Izabella Więckowska, Marcelina Chmiel, Barbara Lipert, Katarzyna Sarad, Joanna Krawczyk, Oleksii Bryzghalov, Agata Stachowicz-Wałaszek, Karolina Pyziak, Joanna Drozdowska, Krzysztof Baczyński, Konrad Wojtowicz, Maurycy Chronowski, Krzysztof Rataj, Magdalena Otrocka, Michał Mikula, Paula Feliksiak, Rafał Dziadziuszko, Tomasz Rzymski, Andrew Thomason, Krzysztof Brzózka, Andrzej Mazan

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High recovery rate of adrenal function after successful surgical treatment of Cushing’s syndrome by Annenienke C van de Ven, Pepijn van Houten, Lisan Grevers, Henri J L M Timmers, Erik van Lindert, Johan F Langenhuijsen, Romana T Netea-Maier

“…Conclusion: The recovery rate of adrenal function after successful surgery as first-line treatment in patients with Cushing’s syndrome is high. …”
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Integrated analysis of gene networks and cellular functions identifies novel heart failure biomarkers by Jiang Juncheng, Chen Lei, Lin Hao, Liang Fei

“…RT-qPCR and Western blotting were used to validate gene expression in HF and normal cardiomyocyte cell lines. Functional assays (proliferation, colony formation, and wound healing) were conducted following overexpression of COL9A1 and MTIF3. miRNA regulation and immune cell infiltration were analyzed using TargetScan and CIBERSORT, respectively. …”
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Identification and functional characterization of prognosis-related ferroptosis-associated lncRNAs in colorectal cancer by Xiaoxu Ge, Xiaoxu Ge, Xiaoxu Ge, Xiaoxu Ge, Xiaoxu Ge, Jiasheng Xu, Jiasheng Xu, Jinjie He, Jinjie He, Jinjie He, Jinjie He, Jinjie He, Jian Wang, Jian Wang, Jian Wang, Jian Wang, Jian Wang, Yucheng Qian, Yucheng Qian, Yucheng Qian, Yucheng Qian

“…We assessed their expression in CRC and normal colonic epithelial cell lines using qPCR. Further functional assays included ferroptosis induction with RSL3 and Erastin, cell viability assessments, immunofluorescence staining for lipid peroxidation, and Western blot analysis of ferroptosis-related proteins.ResultsOur analysis identified 15 DEFRlncRNAs significantly associated with CRC prognosis, with Lnc-SH2D3A-2, Lnc-LSS-1, and Lnc-PEX11G-4 showing high basal expression in CRC cell lines. …”
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The functional affiliation of employees in sports management and its relationship to encouraging high performance motivation by الدكتور عزوز محمد الدكتور غزوان عزيز محسن

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Structural-functional changes of lymphoid organs under vibration and their correction with the help of essencial phospholipides by S. V. Bobrova, A. V. Efremov, G. M. Vakulin

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Reed-Sternberg cells form by abscission failure in the presence of functional Aurora B kinase. by Ana Xavier de Carvalho, Helder Maiato, André F Maia, Susana A Ribeiro, Patrícia Pontes, Wendy Bickmore, William C Earnshaw, Clara Sambade

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Functioning of Epistemic Modal Modifiers in Internet Discourse (by Material of English-Language Internet-Forums) by A. V. Troshina

“…The functioning of epistemic modal modifiers in Internet discourse is covered. …”
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Timing specific requirement of microRNA function is essential for embryonic and postnatal hippocampal development. by Qingsong Li, Shan Bian, Janet Hong, Yoko Kawase-Koga, Edwin Zhu, Yongri Zheng, Lizhuang Yang, Tao Sun

“…The adult hippocampus consists of the dentate gyrus (DG) and the CA1, CA2 and CA3 regions and is essential for learning and memory functions. During embryonic development, hippocampal neurons are derived from hippocampal neuroepithelial cells and dentate granular progenitors. …”
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Study on the mechanisms and functions of lncRNAs in regulating carboplatin resistance in ovarian cancer cells by HONG Yi, CHEN Cuilan, YIN Fuqiang, LIU Xia

“…Based on expression profiling microarrays and RT-qPCR validation, lncRNA DAPK1-IT1, which was significantly down-regulated by more than 4-fold in both two carboplatin-resistant cell lines, was selected for functional verification. …”
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Mapping Ecosystem Functional Groups in the Republic of Korea Based on the IUCN Global Ecosystem Typology by Kyungil Lee, Haedam Baek, Chul-Hyun Choi, Sang-Hak Han, Seonyoung Park

“…This study presents a national-scale mapping of Ecosystem Functional Groups (EFGs) in the Republic of Korea using the International Union for Conservation of Nature (IUCN) Global Ecosystem Typology (GET), a hierarchical classification system, integrated with spatial datasets, satellite imagery, and a random forest (RF) classifier. …”
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Functional Morphology of Secretion by the Large Wax Glands (Sensilla Sagittiformia) Involved in Tick Defense by Jay A. Yoder, Joshua B. Benoit, Megan R. Bundy, Brian Z. Hedges, Kevin M. Gribbins

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Research on the Characteristics of Agricultural Drought Disaster in China Based on Three-Dimensional Copula Function by Dongdong Zuo, Jianbo Cheng, Hao Wu, Wei Hou

“…Based on rainfall data from 2481 stations and the drought-affected arable land of each province from 1961 to 2021, a probabilistic analysis model of drought duration, drought severity and the proportion of affected farmland area (PAFA) was constructed by a three-dimensional copula function. The results show that the distribution functions of drought duration, drought severity and the PAFA are well given based on the principle of maximum entropy and can pass the Kolmogorov–Smirnov (K-S) distribution test with a significance level of 0.05. …”
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Mammalian display to secretion switchable libraries for antibody preselection and high throughput functional screening by Ramona Gaa, Hannah Melina Mayer, Daniela Noack, Kavita Kumari, Ralf Guenther, Shang-Pu Tsai, Qingyong Ji, Achim Doerner

“…Second, a functional screen for internalization was established and comparison of autocrine versus co-encapsulation setups highlighted the advantages of an autocrine one cell approach. …”
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Improving the Accuracy of Fictitious Domain Method Using Indicator Function from Volume Intersection by Guoliang Chai, Junwei Su, Le Wang, Chunlei Yu, Yigen Zhang, Zhaolin Gu

“…In this work, a new indicator function through volume intersection is developed for FDM. …”
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KCa3.1 K+ Channel Expression and Function in Human Bronchial Epithelial Cells. by Greer K Arthur, S Mark Duffy, Katy M Roach, Rob A Hirst, Aarti Shikotra, Erol A Gaillard, Peter Bradding

“…It is expressed in epithelia but its expression and function in primary human bronchial epithelial cells (HBECs) has not been described. …”
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Progranulin sustains STAT3 hyper‐activation and oncogenic function in colorectal cancer cells by Federica Laudisi, Fabio Cherubini, Antonio Di Grazia, Vincenzo Dinallo, Davide Di Fusco, Eleonora Franzè, Angela Ortenzi, Illari Salvatori, Silvia Scaricamazza, Ivan Monteleone, Naoya Sakamoto, Giovanni Monteleone, Carmine Stolfi

“…Although STAT3 is recognized as an attractive therapeutic target in CRC, conventional approaches aimed at inhibiting its functions have met with several limitations. Moreover, the factors that sustain hyper‐activation of STAT3 in CRC are not yet fully understood. …”
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Modified pea apyrase has altered nuclear functions and enhances the growth of yeast and Arabidopsis by Manas K. Tripathy, Huan Wang, Robert D. Slocum, Han-Wei Jiang, Ji-Chul Nam, Tanya Sabharwal, Roopadarshini Veerappa, Katherine A. Brown, Katherine A. Brown, Xingbo Cai, Peter Allen Faull, Greg Clark, Stanley J. Roux

“…Apyrases (NTPDases) regulate growth and development in multiple eukaryotic organisms and function in multiple sub-cellular locales. An earlier report showed that the ectopic expression of psNTP9 (PS), a chromatin-associated pea (Pisum sativum) apyrase, enhanced the uptake of inorganic phosphate (Pi) and increased the growth of yeast and Arabidopsis. …”
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Loss of Hoxa5 function affects Hox gene expression in different biological contexts by Béatrice Frenette, Josselin Guéno, Nicolas Houde, Kim Landry-Truchon, Anthony Giguère, Theyjasvi Ashok, Abigail Ryckman, Brian R. Morton, Jennifer H. Mansfield, Lucie Jeannotte

“…We applied bulk RNA-seq assays to characterize the transcriptional impact of the loss of Hoxa5 gene function in seven different biological contexts, including developing respiratory and musculoskeletal tissues that present phenotypes in Hoxa5 mouse mutants. …”
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Probiotics and Prebiotics in the Aspect of Health Benefits and the Development of Novel Plant-Based Functional Food by Barbara Sionek, Aleksandra Szydłowska

“…It should also be mentioned that the functional food segment in question shows not only a high trend in development in terms of the diversity of the products offered but also fits into the trend of environmentally friendly production in line with sustainable development trends. …”
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