Second‐line treatment of hepatocellular carcinoma after sorafenib: Characterizing treatments used over the past 10 years and real‐world eligibility for cabozantinib, regorafenib, a... by Andrea S. Fung, Vincent C. Tam, Daniel E. Meyers, Hao‐Wen Sim, Jennifer J. Knox, Valeriya Zaborska, Janine Davies, Yoo‐Joung Ko, Eugene Batuyong, Haider Samawi, Winson Y. Cheung, Richard Lee‐Ying

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Dynamically Driven Evolution of Molecular Gas in the Barred Spiral Galaxy M83 Traced by CO J = 2–1/1–0 Line Ratio Variations by Jin Koda, Fumi Egusa, Akihiko Hirota, Amanda M Lee, Tsuyoshi Sawada, Fumiya Maeda

“…We show the variations of the CO J = 2–1/1–0 line ratio ( R _21/10 ) across the barred spiral galaxy M83, using the 46 pc resolution data from the Atacama Large Millimeter/submillimeter Array. …”
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Early Acute Kidney Injury and Its Association With Survival in Patients With Metastatic Non‐Small‐Cell Lung Cancer Treated With Front‐Line Immunotherapy‐Based Therapies by Mingjia Li, Po‐Lan Su, Songzhu Zhao, Grace Cheng, Nicholas Jones, Kenneth Chian, Natalie Johns, Adam Khorasanchi, Adeoluwa Adeluola, Annastasia Petouhoff, Daniel J. Spakowicz, Lai Wei, Xiaoying Wang, Christopher Coss, Mitch A. Phelps, Lingbin Meng, Yuanquan Yang, Alexa Meara, Mohamed I. Elsaid, Jinesh Gheeya, Logan Roof, Asrar Alahmadi, Regan M. Memmott, Jacob Kaufman, Kai He, Carolyn J. Presley, Peter G. Shields, David P. Carbone, Gregory A. Otterson, Jason Prosek, Dwight H. Owen

“…Although patients who recovered renal function were more likely to continue immunotherapy, 12‐month survival rates did not significantly differ (52.2% vs. 46.7%). …”
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Multivariate phenotype analysis enables genome-wide inference of mammalian gene function. by George Nicholson, Hugh Morgan, Habib Ganjgahi, Steve D M Brown, Ann-Marie Mallon, Chris Holmes

“…The function of the majority of genes in the human and mouse genomes is unknown. …”
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Reliable, scalable functional genetics in bloodstream-form Trypanosoma congolense in vitro and in vivo. by Georgina Awuah-Mensah, Jennifer McDonald, Pieter C Steketee, Delphine Autheman, Sarah Whipple, Simon D'Archivio, Cordelia Brandt, Simon Clare, Katherine Harcourt, Gavin J Wright, Liam J Morrison, Catarina Gadelha, Bill Wickstead

“…These experiments establish a base set of tools to change T. congolense from a technically challenging organism to a routine model for functional genetics and allow us to begin to address some of the fundamental questions about the biology of this important parasite.…”
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Generation of stable Cas9-EGFP expressing human induced pluripotent stem cell lines based on SeLection by Essential-gene Exon Knock-in technology by Yao Zhang, Zijun Lu, Hao Yang, Lokyu Cheng, Elena Zaklyazminskaya, Olga Sokolova, Hongmei Tan, Joe Z Zhang

“…Here, we used SeLection by Essential-gene Exon Knock-in technology to generate the iPSC line with constitutive expression of Cas9-EGFP, while retaining all functions of the essential gene. …”
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Generation of a homozygous TIGIT gene knockout (TIGIT−/−) human iPSC line (MUSIi001-A-3) using CRISPR/Cas9 system by Jakkrapatra Srisantitham, Siriwal Suwanpitak, Nontaphat Thongsin, Methichit Wattanapanitch

“…However, the expression of inhibitory receptors, such as TIGIT, may limit the functionality of these immune effector cells. In this study, we generated a homozygous TIGIT gene knockout iPSC line to potentially prevent inhibitory signaling and exhaustion, thereby creating potent “off-the-shelf” immune cell products for cellular immunotherapy applications. …”
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Knockdown of LMX1B Suppressed Cell Apoptosis and Inflammatory Response in IL-1β-Induced Human Osteoarthritis Chondrocytes through NF-κB and NLRP3 Signal Pathway by Yiping Mu, Lining Wang, Ling Fu, Qi Li

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RID: Evaluation of the Possible Inhibiting Effect of the Proinflammatory Signaling Induced by TNF-α through NF-κβ and AP-1 in Two Cell Lines of Breast Cancer by F. A. Monsalve, A. Rojas, I. Gonzalez, R. Perez, C. Añasco, J. Romero, P. Araya, L. S. Santos, F. Delgado-Lopez

“…These dissimilar results may be due to the different molecular and functional properties of both cell lines. Therefore, it is necessary to replicate this study in other breast cancer cell models.…”
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EVALUATION OF ADHERENCE FUNCTION FOR VARIOUS SUBPOPULATIONS OF PERIPHERAL BLOOD MONONUCLEARS TO ENDOTHELIAL CELLS by D. I. Sokolov, E. A. Starikova, A. V. Seljutin, S. A. Selkov, I. S. Freidlin

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Generation of Fractal Objects with Iterated Function System on the Developments of Trellis Ornament Designs by Kosala Dwidja Purnomo, Siti Fatimah, Bagus Juliyanto

“…The basic trellis pattern is built from basic geometry, namely line segments, rhombuses and elliptical curved lines with certain sizes. …”
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Molecular cytological analysis of alien introgressions in common wheat lines created by crossing of <i>Triticum aestivum</i> with <i>T. dicoccoides</i> and <i>T. dicoccum</i> by О. A. Orlovskaya, I. N. Leonova, L. A. Solovey, N. I. Dubovets

“…The analysis of the final stage of meiosis showed a high level of cytological stability in the vast majority of introgression wheat lines (meiotic index was 83.0–99.0 %), which ensures the formation of functional gametes in an amount sufficient for successful reproduction. …”
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A New Conjugate Gradient Method for Finding the Minimum of Non Linear Functions by Abbas Al-Bayati, Basim Hassan

“…The results obtained both theoretically and experimentally indicate that in general the new algorithm is superior an standard algorithms using seven nonlinear test-functions with (20) differs dimensions.…”
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NEW FUNCTIONALIZED QUINAZOLINES AS POTENTIAL AGENTS AGAINST HEAD AND NECK AND LUNG CANCER by Giorgio Antoniolli, Gilberto Carlos Franchi Junior, Laura Antunes, Carmen Silvia Passos Lima, Fernando Coelho

“…Objectives: Evaluate the antiproliferative activity of new functionalized quinazolines against FaDu, HaCat, SCC-25 and NCI-H460 cell lines. …”
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The Effect of the Interatomic Distances Distribution Character on the Radial Distribution Function of Amorphous Solids by G.M. Ivanitska, V.S. Kovtunenko, M.M. Ryaboschuk

“…It is proposed parabolic assignment of the radial distribution function peaks shape. It is shown that this assignment is more in line with the real structure of disordered atomic networks, in comparison with the Gauss distribution. …”
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Longitudinal graphics of patient-reported physical function in patients treated for hematologic malignancies by Gita Thanarajasingam, Vishal Bhatnagar, Brie N. Noble, Ting-Yu Chen, Mallorie H. Fiero, Ron Hoffman, Molly Jeffery, Gina L. Mazza, John Mascarenhas, Ruben Mesa, Meena Murugappan, Joseph Ross, Surbhi Sidana, Rahma Warsame, Paul G. Kluetz, Amylou C. Dueck

“…Abstract Background The US Food and Drug Administration (FDA) released a draft guidance document detailing core patient-reported outcomes in cancer clinical trials, including physical function (PF). The objectives of this study were to develop analytic methods and visualizations of patient-reported PF in patients with cancer. …”
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Regulatory effects of vitamin E nano-emulsion on blood metabolites, immunological variables, testicular architecture, and sperm ultrastructure of heat-stressed V-line rabbit bucks by Ali Ali El-Raghi, Walaa M. Essawi, Sameh A. Abdelnour, Ibrahim Talat El-Ratel, Elsayed M. Younis, Abdel-Wahab A. Abdel-Warith, Mahmoud A. E. Hassan, Maged A. A. Abd El-Hady, Maged A. Aboul-omran, Ahmed N. F. Neamat-Allah, Shimaa A. Amer, Simon J. Davies, Alaa M. A. Gad

“…The dietary NEVE significantly improved the hematological, blood protein, lipid profile, and liver functions of rabbit bucks (p < 0.05). The NEVE200 treated group showed higher levels of nitric oxide, TAC, and SOD in blood serum and seminal plasma compared to the control group (p < 0.05). …”
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HTT loss-of-function contributes to RNA deregulation in developing Huntington’s disease neurons by Emilia Kozłowska, Agata Ciołak, Grażyna Adamek, Julia Szcześniak, Agnieszka Fiszer

“…Conclusions On the basis of overlapping changes in the mRNA and miRNA profiles of HD and HTT-KO cell lines, we propose that transcriptional deregulation in HD at early neuronal stages is largely caused by a deficiency of properly functioning HTT rather than a typical gain-of-function mechanism.…”
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Joint Probability Distribution of Wind–Wave Actions Based on Vine Copula Function by Yongtuo Wu, Yudong Feng, Yuliang Zhao, Saiyu Yu

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Research on the longitudinal end effect in eddy-current braking characteristic experiment by WANG Lichao, WANG Ke, WANG Lining, GAO Liqun

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