Circulating miR-200a is a novel molecular biomarker for early-stage renal cell carcinoma by Cheng Wang, Meng Ding, Yuan-Yuan Zhu, Jicheng Hu, Cuiping Zhang, Xiaolan Lu, Jingping Ge, Jun-Jun Wang, Chunni Zhang

“…E2F3 protein levels in RCC tissues and cell lines were increased and inversely associated with miR-200a levels. …”
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Comparative effects of selenium-enriched lactobacilli and selenium-enriched yeast on performance, egg selenium enrichment, antioxidant capacity, and ileal microbiota in laying hens by Jianmin Zhou, Uchechukwu Edna Obianwuna, Longfei Zhang, Yongli Liu, Haijun Zhang, Kai Qiu, Jing Wang, Guanghai Qi, Shugeng Wu

“…However, high SeL level (6.0 mg Se/kg) compromised productivity and metabolic functions while enhancing Se deposition.…”
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In Vitro Study of Antiviral Properties of Compounds Based on 1,4-Dioxane Derivative of Closo-Decaborate Anion with Amino Acid Ester Residues Against Influenza Virus A/IIV-Orenburg/... by Timur M. Garaev, Ilya I. Yudin, Natalya V. Breslav, Tatyana V. Grebennikova, Evgenii Y. Matveev, Elizaveta A. Eshtukova-Shcheglova, Varvara V. Avdeeva, Konstantin Y. Zhizhin, Nikolay T. Kuznetsov

“…Anions <b>1</b>²⁻; <b>2</b>²⁻; <b>3</b>²⁻, and <b>4</b>²⁻ contain a pendant functional group from the L-tryptophan methyl ester, L-histidine methyl ester, L-methionine methyl ester, or methyl 2-amino-3-(2-oxopyrrolidin-3-yl)propanoate (-Trp–OCH₃, -His–OCH₃, -Met–OCH₃, or -Pld–OCH₃) residue, respectively, bonded with the boron cluster anion through the oxybis[(ethane-2,1-diyl)oxy] spacer. …”
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El Aprendizaje-Servicio Universitario en la Educación Física escolar: una revisión sistemática (University Service-Learning in school Physical Education: A Systematic Review) by Olatz Bastarrica, María Teresa Vizcarra Morales, Judit Martínez-Abajo, Ana Luisa López-Vélez

“…The service proposals were mostly addressed to populations with functional or cultural diversity. Key words: systematic literature review, service learning, initial formation, motor game, body expression. …”
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FNDC5 and ACOX1 as Biomarkers of Peroxisomal Activity with Contrast Outcomes in Colon Adenocarcinoma by Yuan Hepei, Zeng Jun, Khan Muhammad, Wang Baiyao, Hu Xiaoshan, Wei Hao, Wang Zhaotong, Yuan Yawei

“…For experimental validation, qPCR and Western blotting assessed gene expression in colon cancer cell lines. FNDC5 was silenced via siRNA in SW480 and HCT116 cells, followed by CCK-8 and colony formation assays. …”
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Effects of heterologously overexpressing Manihot esculenta Crantz MeNRT2.6 gene in Arabidopsis thaliana on nitrogen utilization efficiency by Min ZHAI, Yingjie CAO, Chenyu LIN, Pingjuan ZHAO, Wenbin LI, Xiaoling YU, Wenbin LIAO, Mengbin RUAN, Liangping ZOU, Zhuang LI

“…The transgenic A. thaliana lines heterologously overexpressing MeNRT2.6 were generated via the floral dip method. …”
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<i>StMAPKK1</i> Enhances Thermotolerance in Potato (<i>Solanum tuberosum</i> L.) by Enhancing Antioxidant Defense and Photosynthetic Efficiency Under Heat Stress by Xi Zhu, Yasir Majeed, Kaitong Wang, Xiaoqin Duan, Nengkang Guan, Junfu Luo, Haifei Zheng, Huafen Zou, Hui Jin, Zhuo Chen, Yu Zhang

“…The functional role of MAPKK genes in potato (<i>Solanum tuberosum</i> L.) under high-temperature stress remains unexplored, despite their critical importance in stress signaling and yield protection. …”
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A novel mechanism of FTO modulating the progression of endometriosis through mediating the m6A methylation of GEF-H1 in a YTHDF1-dependent manner by Xin-Yu Ding, Hua-Ying Zhang, Jia-Hao Chen, Meng-Jie Yang, Zhi-Xiong Huang, Yi-Hong Lei, Qin-Kun Sun, Jian-Bin Bai, Dian-Chao Lin, Jian-Fa Lan, Lu-Lu Ren, Zheng-Yi Chen, Wei-Dong Zhou, Qiong-Hua Chen

“…Methods A human endometrial stromal cell line (HESCs), primary eutopic endometrial stromal cells (Eu-ESCs), primary ectopic endometrial stromal cells (Ec-ESCs), and clinical samples were used in this study. …”
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Unraveling resistance mechanisms to the novel nucleoside analog RX-3117 in lung cancer: insights into DNA repair, cell cycle dysregulation and targeting PKMYT1 for improved therapy by Mahrou Vahabi, Geng Xu, Dzjemma Sarkisjan, Btissame El Hassouni, Giulia Mantini, Valentina Donati, Bing Wang, Giulia Lencioni, Richard J. Honeywell, Dongmei Deng, Sabrina Strano, Godefridus J. Peters, Giovanni Blandino, Elisa Giovannetti

“…Conclusion By integrating CRISPR-Cas9 with functional assays and transcriptomics, our study established a framework for decoding resistance mechanisms and highlights potential therapeutic strategies to enhance RX-3117 efficacy in NSCLC. …”
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Novel trispecific killer engager targeting B7-H3 enhances natural killer cell antitumor activity against head and neck cancer by Jeffrey S Miller, Martin Felices, Peter Hinderlie, James Lim, Naomi Fujioka, Shee Kwan Phung, Yvette Soignier, Joshua T Walker, Melissa A Geller, Madison Shackelford, Carly Selleck, Philippa R Kennedy, Mihir Shetty, Melissa J Khaw, Paolo P Provenzano, Nicholas A Zorko, Laura E Bendzick, Riley C Lyons, Elise L Femino, Terran Stenger, Tumpa Dasgupta, Laura E Kotz, Eng Hock Lee, Quynhanh Lu, Zachary B Davis, John E Wagner, Margaret L MacMillan

“…This TriKE is comprised of a camelid nanobody that binds to CD16 on NK cells, an interleukin (IL)-15 moiety, and another novel camelid nanobody that binds to the B7-H3 antigen, which is highly and specifically expressed on the tumor cell surface.Methods The B7H3 TriKE was generated using a mammalian expression system. Its functionality was evaluated using flow cytometry-based NK cell degranulation, cytokine production, proliferation and live cell imaging cytotoxicity assays. …”
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STRONG II trial: stereotactic body radiation therapy following chemotherapy for unresectable perihilar cholangiocarcinoma – a single-arm multicentre phase II study by Derk Jan de Groot, Luisa Vonghia, Bas Groot Koerkamp, Lydi M J W van Driel, Alejandra Méndez Romero, Anne Demols, Erik van Werkhoven, Dirk De Ruysscher, Christelle Bouchart, Marjolein Y V Homs, Joris I Erdmann, Martijn Intven, Ferry Eskens, Harm Westdorp, Timon Vandamme, Suus Y van Loosbroek, Maaike T W Milder, Rianne D W Vaes, Wilhelm den Toom, François Willemssen, Yvette Seppenwoolde, Nadia Haj Mohammad, Joep de Bruijne, Eva Versteijne, Anna M Bruynzeel, Freek Brandts, Pètra M Braam, Eric T T L Tjwa, Akos Gulyban, Jeroen Buijsen, Judith de Vos-Geelen, Maxime Dewulf, Ines Joye, Margriet Dieters, Fred J F Ubbels, Frederik J H Hoogwater, Ben Heijmen

“…In the Netherlands, recommended first-line treatment for patients with unresectable pCCA is palliative chemotherapy with gemcitabine and cisplatin. …”
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Explaining the Comprehensive Human-To-Human Marketig System in the Health Tourism Industry by Ali Pourang, Meysam Shirkhodaie, Mahmood Yahyazadeh far, Mohsen Alizadeh San, Masoomeh Tavangar

“…The aim of this research is to explain a comprehensive human-to-human marketing system in the health tourism industry in line with Iran's cultural identity and legal and institutional conditions. …”
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Predicting the Likelihood of Operational Risk Occurrence in the Banking Industry Using Machine Learning Algorithms by Hamed Naderi, Mohammad Ali Rastegar Sorkhe, Bakhtiar Ostadi, Mehrdad Kargari

“…The BIA and SA estimate capital requirements based on annual gross income, with the key distinction being that the SA categorizes a bank’s activities into eight business lines. Under the BIA, an alpha coefficient (α) of 15% is applied, whereas in the SA, each business line has a specific beta coefficient (β) ranging between 12% and 18%. …”
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Cord blood-derived iNK T cells as a platform for allogeneic CAR T cell therapy by Maison Grefe, Abel Trujillo-Ocampo, Jelita Clinton, Hong He, Ling Yu, Dan Li, Qing Ma, Elizabeth J. Shpall, Jeffrey J. Molldrem, Jin S. Im, Jin S. Im

“…However, the phenotypic and functional heterogeneity of iNK T cells from adult donors (AD) may lead to the inconstant CAR-iNK T cell products. …”
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PD-L1 CAR effector cells induce self-amplifying cytotoxic effects against target cells by Leszek Pączek, Radoslaw Zagozdzon, Karl-Johan Malmberg, Malgorzata Bajor, Agnieszka Graczyk-Jarzynka, Katsiaryna Marhelava, Anna Burdzinska, Angelika Muchowicz, Agnieszka Goral, Andriy Zhylko, Karolina Soroczynska, Kuba Retecki, Marta Krawczyk, Marta Klopotowska, Zofia Pilch, Sébastien Wälchli, Magdalena Winiarska

“…Breast cancer MDA-MB-231 and MCF-7 cell lines or non-malignant cells (HEK293T, HMEC, MCF-10A, or BM-MSC) were used as targets to assess the reactivity or cytotoxic activity of the PD-L1–CAR-bearing immune effector cells. …”
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Engineering safe anti-CD19-CD28ζ CAR T cells with CD8a hinge domain in serum-free media for adoptive immunotherapy by Muthuganesh Muthuvel, Muthuganesh Muthuvel, Thamizhselvi Ganapathy, Trent Spencer, Sunil S. Raikar, Saravanabhavan Thangavel, Alok Srivastava, Alok Srivastava, Alok Srivastava, Sunil Martin

“…The CAR-T cells expanded (148.4 ± 29 fold; n=7) in serum free media with very high viability (87.8 ± 2.2%; n=7) on day 12. The antitumor functions of CD19 CAR T cells as gauged against percentage lysis of NALM6 cells at a 1:1 ratio is 27.68 ± 6.87% drawing up to the release criteria. …”
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SOURCES OF FINANCING INDUSTRIAL COMPLEX ENTERPRISES by Anzhela Zakhitovna Namitulina, Mikhail Nikolaevich Prokofiev, Nikolay Viktorovich Vorovsky

“…The aim of the article is to study sources of financing and investment enterprises of the military-industrial complex, study and analysis of the financing of investment sphere of defense industry enterprises; Development of the best ways of functioning of the integrated companies with a view to achieving high economic efficiency in the military and economic cooperation on the basis of military technology, defense industry places on its analysis of the global market. …”
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Artificial plasticenta: how polystyrene nanoplastics affect in-vitro cultured human trophoblast cells by Antonio Ragusa, Loredana Cristiano, Pierluigi Di Vinci, Giuseppe Familiari, Stefania Annarita Nottola, Guido Macchiarelli, Alessandro Svelato, Caterina De Luca, Denise Rinaldo, Isabella Neri, Fabio Facchinetti

“…This would lead to ER and mitochondrial stress, impairing mitochondria/ER functions and oxidative stress, thus activating the apoptotic pathway and suggesting that PS-NPs could act as a cell stressor, leading to the death of cells. …”
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Bioinformatics identification and validation of m6A/m1A/m5C/m7G/ac4 C-modified genes in oral squamous cell carcinoma by Cheng-Hui Lu, Xue-Lai Yin, Zhuo-Deng Huang, Si-Ang Lv, Jun Wu, Jie Wei

“…The four most significantly differentially expressed genes were selected for further functional analysis, and small interfering RNA (siRNA) vectors targeting these genes were transfected into OSCC CAL27 cells. …”
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Reflexions entorn la formació de formadors i formadores a Catalunya by Maria Teresa Colén, Núria Giné Freixes

“…It outlines specific skills that are required by this profession, the functions and tasks that must be assumed and the lines that can be taken in the management of its training.…”
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