Global biome changes over the last 21 000 years inferred from model–data comparisons by C. Li, C. Li, A. Dallmeyer, J. Ni, M. Chevalier, M. Willeit, A. A. Andreev, X. Cao, L. Schild, L. Schild, B. Heim, M. Wieczorek, U. Herzschuh, U. Herzschuh, U. Herzschuh

“…Specifically, they reveal a global shift from open glacial non-forest megabiomes to Holocene forest megabiomes since the Last Glacial Maximum (LGM), in line with the general climate warming trend and continental ice-sheet retreat. …”
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Targeted inhibition of gastric cancer progression via a chitosan-RNU11 siRNA nanoparticle delivery system: mechanistic insights and therapeutic potential by Peng Cheng, Zhengrong Zhong, Yanling Wang, Caituan Feng, Jitong Zheng, SuogaoWang, Xiangjun Meng, Dong Wang

“…Methods Chitosan nanoparticles (CH-NP) loaded with RNU11 siRNA (Si-RNU11 + CH-NP) were synthesized and characterized for size, zeta potential, and siRNA release efficiency. GC cell lines (AGS and HGC27) were treated with various formulations, and functional assays, including EdU proliferation, Transwell invasion/migration, and cell cycle/apoptosis analysis, were conducted. …”
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Optical and electron microscopy imaging of model circulating tumour cells by Марина Оленчук, Григорій Монастирський, Олена Гнатюк, А. Бойзен, Ч. Чжан, Галина Солянік, Денис Колесник, Сергій Карахім, Галина Довбешко

“…Materials and Methods: LLC cells were obtained from the National Bank of Cell Lines and Tumor Strains of the IEPOR (NAS of Ukraine) and cultured in RPMI-1640 medium under conditions of de-adhesive growth. …”
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Hepatocellular carcinoma hosts cholinergic neural cells and tumoral hepatocytes harboring targetable muscarinic receptors by Charlotte A. Hernandez, Claire Verzeroli, Armando Andres Roca Suarez, Abud-José Farca-Luna, Laurie Tonon, Roger Esteban-Fabró, Roser Pinyol, Marie-Laure Plissonnier, Ievgeniia Chicherova, Anaëlle Dubois, Pascale Bellaud, Marine Seffals, Bruno Turlin, Alain Fautrel, Gabriel Ichim, Michel Rivoire, Guillaume Passot, Zuzana Macek-Jilkova, Thomas Decaens, Alain Viari, Barbara Testoni, Sandra Rebouissou, Josep M. Llovet, Fabien Zoulim, Romain Parent

“…Its pharmacological inhibition with low concentrations of anticholinergic drugs, but not cholinomimetics, decreased anchorage-independent growth and anoikis, synergized with sorafenib and lenvatinib in HCC class 1 to 3 lines, yet not in primary human hepatocytes, and preserved mature hepatocyte functions. …”
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A consortium of seven commensal bacteria promotes gut microbiota recovery and strengthens ecological barrier against vancomycin-resistant enterococci by Alan Jan, Perrine Bayle, Nacer Mohellibi, Clara Lemoine, Frédéric Pepke, Fabienne Béguet-Crespel, Isabelle Jouanin, Marie Tremblay-Franco, Béatrice Laroche, Pascale Serror, Lionel Rigottier-Gois

“…Interestingly, five strains belong to species shared among humans and mice, and the other two have human functional equivalents. Conclusions An innovative approach based on mathematical modelling of the microbiota composition permitted to identify a mixture of commensal bacterial strains, which improves the ecological barrier effect against VRE. …”
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The cold immunological landscape of ATM-deficient cancers by Fresia Pareja, Stephen Morris, Sonali Sinha, Lorenzo Galluzzi, Fatemeh Derakhshan, Jennifer Ma, Jorge Reis-Filho, Nadeem Riaz, Shu Yazaki, Victor Ng, Ardijana Novaj, Yingjei Zhu, Xin Pei, Jeremy Setton, Flavie Naulin, Manuel Beltrán-Visiedo, Ethan Shin, Ana Leda F Longhini, Rui Gardner, Kevin Ma, Anne Roulston, Maria Koehler, Simon Powell, Ezra Rosen, Atif Khan

“…Background Mutations in genes encoding DNA repair factors, which facilitate mismatch repair, homologous recombination, or DNA polymerase functions, are known to enhance tumor immunogenicity. …”
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MicroRNA-665 and its potential role in drug response and survival outcomes in multiple myeloma: a preliminary study by Rui Bergantim, Rui Bergantim, Rui Bergantim, Rui Bergantim, Sara Peixoto da Silva, Sara Peixoto da Silva, Sara Peixoto da Silva, Vanessa Pinto, Vanessa Pinto, Joana M. Pereira, Joana M. Pereira, Diana Sousa, Diana Sousa, Diana Sousa, Fernanda Trigo, Rune Matthiesen, José E. Guimarães, José E. Guimarães, José E. Guimarães, José E. Guimarães, José E. Guimarães, M. Helena Vasconcelos, M. Helena Vasconcelos, M. Helena Vasconcelos

“…In silico analysis for target-prediction and gene ontology (GO) enrichment was performed to explore the potential biological and functional role of the identified miRNAs.ResultsNGS profiling revealed several miRNAs differently expressed between treatment-refractory and sensitive patients, as well as between PB and BM. …”
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Tricin selectively combats KRAS-mutant non-small cell lung cancer by inhibiting the PDGF-BB-induced SRC/MAPK/AP-1/PD-L1 signaling pathway and potentiating the antitumor effect of a... by Jia-Xin Li, Jia-Xin Li, Shi-Yu Tan, Li-Qi Li, Yu-Hong Zheng, Lin Zhao, Hui-Rong Zhu, Hai-Lang He, Yan-Yu Zhang, Run-Ze Li, Tian-Yu Bao, Yi-Zhong Zhang, Xiao-Man Yang, Hao Zhang, Hui-Hui Chen, Bo-Wen Wu, Xin Lin, Xiao-Sheng Lin, Xiao-Sheng Lin, Yin Cheng Lin, Xin-Bing Sui, Ying Xie, Xian-Mei Zhou, Pei-Yu Yan

“…In terms of immune regulation, tricin increased the numbers of CD8+ T lymphocytes and the levels of the functional cytokines TNFα, IFNγ, and Granzyme B. Tricin also increased the numbers of B lymphocytes and disrupted the PD-1/PD-L1 pathway. …”
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An optimized integrin α6-targeted peptide capable of delivering toxins for melanoma treatment by Zheng Zhao, Zi-Qian Li, Ying-Bin Huang, Meng-meng Liu, Fei Cao, Guo-Long Bu, Peng-Fei Xu, Qi Fang, Zhu-Long Hu, Di Wu, Guo-Kai Feng, Xue-Kui Liu

“…Methods We developed a new combination strategy for the synthesis of penetrating peptides functionalized with targeting of integrin α6. The linear peptide S5 was multimerized with 4 copies in linear sequential order spaced by GSG between each copy to yield the 4S5 peptide. …”
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Robust in vitro assay for analyzing the neutralization activity of serum specimens against hepatitis B virus by Ya-Li Zhang, Ying Gao, Jia-Li Cao, Jing-Hua Zhao, Tian-Ying Zhang, Chuan-Lai Yang, Hua-Long Xiong, Ying-Bin Wang, Shan-Hai Ou, Tong Cheng, Chang-Rong Chen, Quan Yuan, Ning-Shao Xia

“…However, little is known about the association between the qAnti-HBs determined by immunoassays and the neutralization activity (NAT) derived from functional assays. We developed an in vitro assay for direct measurement of the NAT of human sera. …”
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Single-cell transcriptomics and machine learning unveil ferroptosis features in tumor-associated macrophages: Prognostic model and therapeutic strategies for lung adenocarcinoma by Ting Ji, Ting Ji, Juanli Jiang, Juanli Jiang, Xin Wang, Xin Wang, Kai Yang, Kai Yang, Shaojin Wang, Shaojin Wang, Bin Pan, Bin Pan

“…Western blotting confirmed the expression levels of HLF, HPCAL1, and NUPR1 were remarkably lower in LUAD cell lines compared to normal bronchial epithelial cells (P < 0.05).ConclusionThe research is the first to build a LUAD prognostic model based on macrophage ferroptosis-related genes (HLF, HPCAL1, NUPR1), revealing the immune microenvironment characteristics and drug sensitivity differences in the high-risk group. …”
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Spatially varying parameters improve carbon cycle modeling in the Amazon rainforest with ORCHIDEE r8849 by L. Zhu, L. Zhu, L. Zhu, L. Zhu, P. Ciais, Y. Yao, D. Goll, S. Luyssaert, I. Martínez Cano, A. Fendrich, A. Fendrich, L. Li, H. Yang, S. Saatchi, W. Li, W. Li

“…Current dynamic global vegetation models (DGVMs), which use one or two plant functional types for tropical rainforests, fail to capture observed biomass and mortality gradients in this region, raising concerns about their ability to predict forest responses to global change drivers. …”
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Knee-Sparing Resection and Reconstruction Surgery for Bone Sarcoma Using 3D-Surgical Approach: Average of 5-Year Follow-Up by Amit Benady, Noy Yehiel, Ortal Segal, Omri Merose, Amir Sterenheim, Osnat Sher, Ben Efrima, Eran Golden, Yair Gortzak, Solomon Dadia

“…In cases where the tumor arises in the distal femur or proximal tibia near the joint line, knee-sacrificing surgery is typically performed, followed by reconstruction with oncological megaprostheses. …”
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Altered maturation and activation state of circulating monocytes is associated with their enhanced recruitment in pulmonary arterial hypertension by Rebecca L. Harper, Xin Zhou, David P. Marciano, Aiqin Cao, Lingli Wang, Guibin Chen, Mir S. Adil, Wenyu Zhou, Peter Maguire, Shanthi Deivanayagam, Quan Yu, Vignesh Viswanathan, Dan Yang, Marcy Martin, Sarasa Isobe, Shoichiro Otsuki, Jordan Burgess, Audrey Inglis, Devon Kelley, Patricia A. del Rosario, Andrew Hsi, Francois Haddad, Roham T. Zamanian, Manfred Boehm, Michael P. Snyder, Marlene Rabinovitch

“…These changes are linked to intrinsic functional abnormalities that contribute to the monocytes’ increased propensity to invade the pulmonary circulation.…”
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Artemisinin supplementation in concentrated cottonseed protein basal diets enhances growth, antioxidant capacity, intestinal immunity and microbiota in hybrid grouper (Epinephelus... by Ling Pan, Qi Wang, Weikang Li, Xiaohui Dong, Shiwei Xie, Beiping Tan, Hongyu Liu, Yan Wang

“…In recent years, its potential in aquaculture has gained attention, but the physiological functions of its bioactive components in aquatic animal production remain underexplored and require further investigation. …”
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The role of proline P325 residue in the recognition of the MX35 epitope of the sodium-dependent phosphate transporter NaPi2b by monoclonal antibodies in ovarian carcinoma cells by L. F. Bulatova, I. A. Slidzuk, A. V. Kilunov, V. S. Skripova, R. G. Kiyamova

“…One of the key components of cell membranes are membrane proteins, which provide a wide range of functions – from transport and signal transmission to coordination of intercellular interactions. …”
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CLINICAL AND BIOCHEMICAL INDICATORS IN WHITE RATS IN THE TREATMENT OF EXPERIMENTAL GENERALIZED PARODONTITIS by Yu.I. Silenko, M.V. Khrebor, Y.M. Silenko, O.A. Pisarenko

“… A number of scientists put forward and confirmed the assumption of the presence in the body of biological regulators, polypeptides, carrying out the transfer of information necessary for the functioning, development and interaction of cell populations. …”
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Osornophryne, genero nuevo de anfibios bufonidos de Colombia y Ecuador Osornophryne, genero nuevo de anfibios bufonidos de Colombia y Ecuador by Ruíz Carranza Pedro M., Hernández Camacho Jorge I.

“…. (= Atelopus bufoniformis PERACCA,1904) from the Andes of southern Colombia and northern Ecuador, as a referred species. The functional and adaptative significance of the main characters is discussed in<br />detail. …”
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Оrgan-preserving operations in the abdominal gun-shot penetrating woundings of large bowel. Experience of the medical help delivery in military environment Аntiterroristic operatio... by O. Yu. Usenko, I. A. Lurin, K. V. Gumenuk, V. V. Nehoduiko, R. M. Mykhaylusov, R. V. Saliutin

“…Selecting the surgical treatment method for the gun-shot woundings of large bowel, it is necessary to base on complex analysis of the battle trauma character, the patient’s state and the risk for іntra- and postoperative complications. The first-line application of organ-preserving interventions as more physiological and those, which permit mostly rapid come back to the service duties functioning, is expedient. …”
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Effect of polystyrene micro/nanoplastics on mesenchymal phenotypic transformation in testicular Sertoli cells by CAI Jing, WEN Yixian, ZHANG Huilian

“…Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed to identify functions and signaling pathways enriched in the testicular transcriptome. …”
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