AGD1/USP10/METTL13 complexes enhance cancer stem cells proliferation and diminish the therapeutic effect of docetaxel via CD44 m6A modification in castration resistant prostate can... by Hong Wang, Chunli Cui, Weiyi Li, Hui Wu, Jianjun Sha, Jiahua Pan, Wei Xue

“…Abstract Background Most patients with prostate cancer inevitably progress to castration-resistant prostate cancer (CRPC), at which stage chemotherapeutics like docetaxel become the first-line treatment. However, chemotherapy resistance typically develops after an initial period of therapeutic efficacy. …”
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ASCT2 inhibits HIV-1 infectivity by promoting the incorporation of a gp160/ASCT2 complex into virions by Luciana Morellatto Ruggieri, Eri Miyagi, Sandra Kao, Hideki Saito, Aymé Drake Figueredo, Haruki Kitamura, María I. Colombo, Klaus Strebel

“…ABSTRACT Restriction factors are type I interferon (IFN)-inducible proteins that provide an early line of defense against HIV-1. Our current findings propose the amino acid transporter ASCT2 as a new host plasma membrane transporter that restricts the infectivity of HIV-1 viral particles. …”
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Intervening Non-Small-Cell Lung Cancer Progression by Cell Membrane Coated Platycodin D via Regulating Hsa-miR-1246/FUT9/GSK3β Pathway by Zheng S, Xie Z, Zhou Z, Wang S, Xin Y, Lin J, Cheng K, Lu T, Qi R, Guo Y

“…Furthermore, a homologous cell membrane-based PD delivery system was established to improve the biosafety and efficacy of PD in vivo.Results: Hsa-miR-1246 was upregulated by PD treatment, and functional experiments demonstrated that the miR-1246-mimic enhanced PD’s suppressive effects on NSCLC cell proliferation, colony formation, migration, and invasion, while the miR-1246-inhibitor abrogated these effects. …”
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Construction and Brain Validation of circRNAs-miRNAs-mRNAs Regulatory Axis in Early-Onset Schizophrenia by Zhang X, Li Z, Li R, Wang X, Liu H, Du X, Gao Y, Liu S, Xu Y

“…The expression patterns of this axis in the prefrontal cortex were consistent with those observed in peripheral blood samples from clinical patients.Conclusion: This study identified a specific multi-molecular axis in early-onset schizophrenia, wherein hsa-circ-0000713 functioned as a sponge to reduce the inhibitory effects of hsa-miR-370-3p on ANK3 and MGLL. …”
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The feasibility of establishing a hamster model for HBV infection: in vitro evidence by Hu Zhang, Yanan Liu, Cheng-Der Liu, Zhongde Wang, Haitao Guo

“…Developing such models in mice has been unsuccessful due to the absence of a functional HBV receptor, human NTCP (huNTCP), and the defect in supporting viral cccDNA formation. …”
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Preliminary performance analysis using the PPP-RTK service of the National Land and Mapping Center in Taiwan by J.-Y. Lin, C.-H. Chu, F.-Y. Chu, K.-W. Chiang, M.-L. Tsai

“…However, GNSS signals in urban canyons are susceptible to multi-path effects and NLOS (Non-Line-of-Sight) issues, leading to decreased positioning accuracy. …”
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Protocol for an economic evaluation alongside a natural experiment to evaluate the impact of later trading hours for bars and clubs in the night-time economy in Scotland: The ELEPH... by Colin Angus, Emma McIntosh, Nurnabi Sheikh, Jim Lewsey, Niamh Fitzgerald, Carol Emslie, Houra Haghpanahan

“…On-trade alcohol premises (places where consumers can buy and consume alcohol such as bars, pubs, clubs and restaurants) are a significant component of this night-time economy, functioning as focal points for socialising, entertainment and cultural events. …”
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Enhancing anti-CD3 mAb-mediated diabetes remission in autoimmune diabetes through regulation of dynamin-related protein 1(Drp1)-mediated mitochondrial dynamics in exhausted CD8+T-c... by Ruiling Zhao, Zhangyao Su, Junjie Gu, Hang Zhao, Lingling Bian, Yin Jiang, Yun Cai, Tao Yang, Yong Gu, Xinyu Xu

“…Mechanistic studies were conducted using the HEK-293 T cell line and primary cells. Single-cell RNA sequencing (scRNA-seq) was applied to evaluate the characteristics of different CD8+ T cell subsets following two types of immunotherapies. …”
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A bibliometric study on body percussion based on high impact search engines (Estudio bibliométrico sobre la percusión corporal basado en motores de búsqueda de alto impacto) by Antonio Francisco Arnau-Mollá, Francisco Javier Romero-Naranjo

“…The main results are that Spain is the largest producer of literature through the BAPNE research group in the line of cognitive stimulation and executive functions. …”
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THE ANALYSIS OF THE PREVALENCE OF DENTAL ANOMALIES IN UZHHOROD SCHOOLCHILDREN by V.S. Melnyk, L.F. Horzov, O.Yu. Rivis, M.E. Izay

“…Anomalies in the size of the jaws (11.5%) and dentoalveolar anomalies of functional origin (4.1%) occur less often. However, 70.4% of all dentoalveolar anomalies are combined. …”
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Construction and characterization of chimeric FcγR T cells for universal T cell therapy by Juanjuan Zhao, Manling Chen, Xudong Li, Zhaoqi Chen, Wei Li, Rongqun Guo, Min Wang, Zhongxing Jiang, Yongping Song, Jianxiang Wang, Delong Liu

“…When herceptin was used, all three types of CFR T cells exhibited significant cytotoxicity against HER2+ cell lines of SK-BR-3, SK-OV-3, and HCC1954 (P < 0.001). …”
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Mixed Reality Ultrasound-Guided Mini-ECIRS with Apple Vision Pro™ - First Case Report by Roberto Montoro Neto, Fabio C. Vicentini, Ricardo T.S. Ugino, Alexandre Danilovic, Giovanni S. Marchini, Fabio C.M. Torricelli, Carlos A. Batagello, Anderson B. Pellanda, Alexandre Silva, William C. Nahas, Eduardo Mazzucchi

“…By providing seamless integration of digital overlays and real-world visuals, it ensures that crucial information is always within the surgeon's line of sight, thereby improving operational precision and overall outcomes. …”
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Increasing cisplatin exposure promotes small-cell lung cancer transformation after a shift from glucose metabolism to fatty acid metabolism by Qiu-yu Zhao, Wen-jun Liu, Jian-guang Wang, He Li, Jia-lu Lv, Yumeng Wang, Chun Wang

“…Comprehensive functional assays were performed to characterize A549/DDP1 μg/mL and A549/DDP3 μg/mL cells, focusing on proliferation and migratory capabilities. …”
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High-resolution genetic and physical mapping reveals a peanut spotted wilt disease resistance locus, PSWDR-1, to Tomato spotted wilt virus (TSWV), within a recombination cold-spot... by Dongliang Wu, Chuanzhi Zhao, Walid Korani, Ethan A. Thompson, Hui Wang, Gaurav Agarwal, Jake C. Fountain, Albert Culbreath, C. Corley Holbrook, Xingjun Wang, Josh P. Clevenger, Baozhu Guo

“…These findings provide a foundation for future functional studies to validate the roles of these candidate genes in resistance and application in breeding TSWV-resistant peanut cultivars.…”
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CYFIP2: potential pancreatic cancer biomarker and immunotherapeutic target by Cong Xiao, Xiaojuan Zhang, Bobo Hou, Ping Wan, Zhenjun Cao, Xuefeng Rao

“…Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Set Variation Analysis (GSVA) were used to explore the multiple biological functions and regulatory pathways in which CYFIP2 co-expressed genes co-engage in pancreatic cancer. …”
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Integrative profiling of lung cancer biomarkers EGFR, ALK, KRAS, and PD-1 with emphasis on nanomaterials-assisted immunomodulation and targeted therapy by Li Peng, Hongmei Li, Wencai Yan, Yingjie Liu, Haihao Zhu, Yingcai Hong

“…Protein–protein interaction (PPI) networks were constructed via STRING to explore functional associations and signaling networks. Molecular docking using SwissDock evaluated the binding affinities of established inhibitors. …”
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Deep immunophenotyping at the single-cell level identifies a combination of anti-IL-17 and checkpoint blockade as an effective treatment in a preclinical model of data-guided perso... by Yukari Kobayashi, Kazuhiro Kakimi, Koji Nagaoka, Akihiro Hosoi, Masashi Fujita, Masataka Shirai, Kiyomi Taniguchi, Changbo Sun, Kazuhiro Maejima, Hidewaki Nakagawa, Sachiyo Nomura

“…To demonstrate the feasibility of this kind of approach, we developed combination therapy for a preclinical model guided by deep immunophenotyping of the TME.Methods Gastric cancer cell lines YTN2 and YTN16 were subcutaneously inoculated into C57BL/6 mice. …”
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Well-posedness of the difference schemes of the high order of accuracy for elliptic equations

“…The well-posedness of these difference schemes in the difference analogy of the smooth functions is obtained. The exact almost coercive inequality for solutions in <mml:math alttext="$C(au,E)$"> <mml:mi>C</mml:mi><mml:mrow><mml:mo>(</mml:mo> <mml:mrow> <mml:mi>&#x03C4;</mml:mi><mml:mo>,</mml:mo><mml:mi>E</mml:mi> </mml:mrow> <mml:mo>)</mml:mo></mml:mrow> </mml:math> of these difference schemes is established.…”
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Deciphering key nano-bio interface descriptors to predict nanoparticle-induced lung fibrosis by Jiayu Cao, Yuhui Yang, Xi Liu, Yang Huang, Qianqian Xie, Aliaksei Kadushkin, Mikhail Nedelko, Di Wu, Noel J. Aquilina, Xuehua Li, Xiaoming Cai, Ruibin Li

“…Results The nano-bio interactions induced diverse changes in the 4 characteristics of MeONPs and had variable effects on the 14 cellular functions, which were quantitatively evaluated in chemico and in vitro. …”
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Exosomal miR-6126 as a novel therapeutic target for overcoming resistance of anti-cancer effect in hepatocellular carcinoma by Hyemin Hwang, Jimin Kim, Tae-Hun Kim, Yeonju Han, Dayoung Choi, Sua Cho, Seunghwan Kim, Sanghee Park, Taehyun Park, Filippo Piccinini, Won Jong Rhee, Jae-Chul Pyun, Misu Lee

“…Methods Sorafenib-resistant cells were generated by culturing the human HCC cell line Huh7 in a medium containing 20 µM sorafenib for six months. …”
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