Exploring the potential of underrated yet versatile crop Lunaria annua L.: New insights into honesty plant by Jovana Petrović, Daiana Almeida, Ângela Fernandes, Dejan Stojković, Dragana Robajac, Tayse F.F. da Silveira, Lillian Barros

“…Overall, our results indicate that L. annua seeds may be considered as source of compounds used in food and pharmaceutical industry and a candidate for functional ingredient that provides additional health benefits beyond basic nutritional requirements.…”
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Streptococcus gallolyticus supernatant induces M2 macrophage polarization and activates IL-17 F signaling in colorectal tumorigenesis by Jiaqi Wang, Yan Zhang, Duo Luo, Jing Xu, Xin Nie, Chen Huang, Hailan Zhao, Minzheng Zhu, Xue Guo, Yong Zhang, Wenjing Qiu, Haoming Xu, Yuqiang Nie, Youlian Zhou

“…These findings suggest that both Sg-derived metabolites and host immune signaling may serve as potential targets for CRC intervention. Functional validation of individual metabolites is currently in progress.…”
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Assessing the prognostic and therapeutic value of cuproptosis-related genes in colon adenocarcinoma patients by Zhanhui Ye, Yixian Song, Mengqing Zhu, Fuying Zheng, Wenjie Qin, Wenjie Qin, Xue Li, Pei Wang, Zihua Li, Kequan Chen, Aimin Li

“…Using the Weighted Gene Co-expression Network Analysis (WGCNA) method, we identified the gene module most strongly linked to cuproptosis and conducted functional enrichment analysis to explore the roles of genes within this module in COAD tumorigenesis. …”
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HERV-derived epitopes represent new targets for T-cell-based immunotherapies in ovarian cancer by Qing Wang, Maha Ayyoub, Olivia Le Saux, Paola Bonaventura, Isabelle Treilleux, Nicolas Chopin, Clarisse Dubois, Virginie Mutez, Nicolas Chuvin, Yann Estornes, Jenny Valladeau-Guilemond, Stephane Depil, Nicolas Gadot, Marie Michelas, Audrey Page, Olivier Tabone, Marie Delles, Sarah Moran, Thibault Richard, Marjorie Lacourrège, Dina M Tawfik, Ema Etchegaray, Adrian Valente, Rasha E Boulos, Gabriel Jimenez Dominguez

“…Furthermore, in vitro stimulation of patient T cells induced functional epitope-specific T cells, confirming the immunogenicity of these epitopes in patients with ovarian cancer. …”
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Dynamic changes and drives of surface urban heat islands in China by Qiumeng Zhang, Baoquan Jia, Tong Li, Yarong Yang, Youxin Fang

“…This phenomenon can disrupt the functions of urban ecosystems, affect residents’ comfort and health, and even pose life-threatening risks. existing research has predominantly focused on developed cities during urbanization, often overlooking smaller towns. …”
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Helminth Coinfections Modulate Disease Dynamics and Vaccination Success in the Era of Emerging Infectious Diseases by Brice Armel Nembot Fogang, Linda Batsa Debrah, Michael Owusu, George Agyei, Julia Meyer, Jonathan Mawutor Gmanyami, Manuel Ritter, Kathrin Arndts, Derrick Adu Mensah, Tomabu Adjobimey, Achim Hörauf, Alexander Yaw Debrah

“…However, they can exacerbate disease outcomes in most bacteria and blood-borne viral conditions by impairing immune functions, such as neutrophil recruitment and antibody response, leading to more severe infections and higher viral loads. …”
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Transcriptome and DNA methylation analyses provide insight into the heterosis of growth-related traits in hybrid yellow croaker by Dan-Dan Guo, Feng Liu, Qing-Ping Xie, Ting Ye, Fu-Liang Wei, Bao-Long Niu, Bao Lou

“…Our findings revealed diverse DNA methylation profiles and demonstrated a greater number of hypo-DMRs in hybrid yellow croakers than in their parental lines. The majority (86 ~ 92%) of these DMRs were observed within the CG context. …”
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CD137 and PD-L1 targeting with immunovirotherapy induces a potent and durable antitumor immune response in glioblastoma models by Hong Jiang, Sandra Hervás-Stubbs, Sara Labiano, Candelaria Gomez-Manzano, Juan Fueyo, Marta Alonso, Zhihong Chen, Montserrat Puigdelloses, Marc Garcia-Moure, Virginia Laspidea, Marisol Gonzalez-Huarriz, Marta Zalacain, Lucia Marrodan, Naiara Martinez-Velez, Daniel De la Nava, Iker Ausejo, Guillermo Herrador, Dolores Hambardzumyan, Ana Patino Garcia, Jaime Gállego Pérez-Larraya

“…The tumor microenvironment was studied by flow cytometry, immunohistochemistry and IF.Results Delta-24-ACT was able to infect and exert a cytotoxic effect on murine and human glioma cell lines. Moreover, Delta-24-ACT expressed functional 4-1BBL that was able to costimulate T lymphocytes in vitro and in vivo. …”
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A non-invasive method for screening mitochondrial diabetes by Hangyu Fang, Hangyu Fang, Xiaoe Li, Shuping Wang, Mei Zhang, Victor Wei Zhang, Chao Xu, Chao Xu, Chao Xu, Chao Xu, Chao Xu, Chao Xu, Chao Xu

“…BackgroundMitochondrial diabetes mellitus (MDM) is a special type of diabetes resulting from functional defects in mitochondria. Its incidence rate is low, and it can often be misdiagnosed as either type 1 or type 2 diabetes in clinical settings. …”
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Deuterium plasma-driven permeation in chemical vapor deposition tungsten-copper composite by Yiwen Sun, Xuechun Li, Caibin Liu, Yifan Li, Yuhao Li, Jonathan Mougenot, Long Cheng, Haodong Liu, Di Hu, Sijie Hao, Yue Yuan, Haishan Zhou, Hongbo Zhou, Guang-Hong Lu

“…Density functional theory calculations confirmed that the presence of Cu in W could reduce the HI solution energy in W. …”
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Defects in the necroptosis machinery are a cancer resistance mechanism to checkpoint inhibitor immunotherapy by Katja Steiger, Peter May, Florian Bassermann, Anna Sax, Stefan Enssle, Nardine Soliman, Tatiana Nedelko, Giada Mandracci, Fabian Stögbauer, Laura Joachim, Christof Winter, Nadia El Khawanky, Hendrik Poeck, Simon Heidegger

“…However, it is unclear to which extent functional necroptosis in tumor cells contributes to ICI immunotherapy.Methods With genetically engineered tumor cell lines that lack specific components of the necroptosis machinery (mixed lineage kinase domain-like pseudokinase (MLKL), receptor interacting protein kinase 3 (RIPK3)), we addressed the importance of necroptotic tumor cell death for the efficacy of ICI immunotherapy in murine models. …”
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A novel NFKB1 agonist remodels tumor microenvironment and activates dendritic cells to promote anti-tumor immunity in colorectal cancer by Ying Chen, Qiaoming Li, Zixiang Wang, Ling V. Sun, Steven X. Hou

“…Methods We conducted an in vivo chemical screen to identify F1929-1458, which is capable of eliciting an organism-wide response to destroy stem cell tumors in Drosophila. We then performed functional validation using a mouse colorectal cancer graft tumor model established with the CT26 cell line characterized by its high content of CSCs. …”
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A potent and broad CD4 binding site neutralizing antibody with strong ADCC activity from a Chinese HIV-1 elite neutralizer by Yingdan Wang, Ping Ji, Qianying Liu, Nannan Jia, Yunping Ma, Tianyi Yuan, Palizhati Rehati, Jiali Chen, Yumei Wen, Fan Wu, Jinghe Huang

“…Our findings provide valuable insights into the mechanisms of FD22 in viral neutralization and ADCC. The dual functionality of FD22 enhances its potential as a promising therapeutic antibody and offers new avenues for designing CD4bs-targeting vaccines with enhanced ADCC capabilities.…”
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Exploring the mechanism of triptolide inhibiting the motility of fibroblast-like synoviocytes in rheumatoid arthritis via RhoA/Rho-associated kinase axis, based on network pharmaco... by Jiacheng Shen, Jiacheng Shen, Jiacheng Shen, Yuxuan Fang, Yuxuan Fang, Nan Xu, Nan Xu, Hongyi Chen, Hongyi Chen, Miao Zhu, Miao Zhu, Dan Li, Dan Li, Zewen Chu, Masataka Sunagawa, Yanqing Liu, Yanqing Liu, Haibo Wang, Haibo Wang, Guoqing Li, Guoqing Li

“…TPL can enter RhoA, Rock1, and Rock2 target protein binding domains with stable binding activities, and may cause conformational changes of Rock1 related to molecular functions.ConclusionTPL inhibits RA-FLS in motility by regulating actin cytoskeleton remodeling through action on the RhoA/Rho-associated kinase signaling pathway.…”
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Unveiling the chemical composition, antioxidant and antibacterial properties, and mechanistic insights of Convolvulus arvensis extract through molecular docking simulations by Fatemeh Mosallaie, Motahare Pirnia, Zahra Dehghan, Fereshteh Falah, Reihaneh Sabbaghzadeh, Behrooz Alizadeh Behbahani, Fahimeh Lavi Arab, Farideh Tabatabaei Yazdi, Alireza Vasiee

“…Furthermore, the in vitro cytotoxic activity of the extract was evaluated against the Caco-2 cell line, with the IC50 value determined to be 26.55 mg/mL. …”
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Psychosocial Support and Quality of Life in CKD Patients on Hemodialysis Amidst the Sudan Conflict: A Cross-Sectional Study by Ahmed MohammedAlhassan Ismail Abdulsamad, Ibrahim Nagmeldin Hassan, Mohamed Ibrahim

“…Socioeconomic status varied, with 45% below the poverty line. The mean Quality of Life (QoL) scores were 55 ± 15 for physical health, 48 ± 17 for mental health, 52 ± 14 for social functioning, and 50 ± 16 overall. …”
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Strong Hsp90α/β Protein Expression in Advanced Primary CRC Indicates Short Survival and Predicts Response to the Hsp90α/β-Specific Inhibitor Pimitespib by Sebastian B. M. Schmitz, Jakob Gülden, Marlene Niederreiter, Cassandra Eichner, Jens Werner, Barbara Mayer

“…Protein profiling combined with functional drug testing stratifies Hsp90α/β > 40% pCRC patients diagnosed with UICC IIb-IV for effective Pim-based therapy.…”
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ANTIPROLIFERATIVE ACTIVITIES IN VITRO OVER SQUAMOUS CELL CARCINOMAS OF A PALLADIUM(II) COMPLEX WITH AMANTADINE by Pedro Corbi, Laura Barros Silva, Fernanda Van Petten V. Azevedo, Gilberto C. Franchi Jr, Carmen Silvia P. Lima

“…Squamous cell carcinoma of tongue (SCC-4 and SCC-25) and of hypopharynx (Fadu), and a non-tumoral cell line (HaCat, immortalized keratinocyte) were used in this study. …”
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Overexpression of soybean SGF14a enhanced tolerance of transgenic tobacco plants to aluminum stress by Yang Zhili, Guo Chuanlong, Liu Lei, Wu Konghuan, Wang Lin, Li Kunzhi, Zhao Yan, Chen Limei

“…A lot of 14-3-3 gene family members are isolated in different plants. 14-3-3 proteins regulate various physiological activities and functions by interacting with phosphorylated or non-phosphorylated target proteins in plants. …”
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MAZ-mediated N6-methyladenosine modification of ZEB1 promotes hepatocellular carcinoma progression by regulating METTL3 by Di Li, Li Xu, Ruyuan Liu, Zhaonv Yao, Chuanjun Zheng, Song Jin, Xuefeng Guo, Zhengbao Zhang, Shengkui Tan, Xiaonian Zhu

“…However, the specific regulatory mechanism by which MAZ functions as an oncogene in HCC has still not been fully elucidated. …”
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