PD-1 Bispecific Killer Engager (PD-1 BiKE) effectively depletes effector T lymphocytes in experimental autoimmune encephalomyelitis by Lauren C. Naatz, Shuyun Dong, Yujia Zhai, Brian Evavold, Mingnan Chen

“…The BiKE was characterized for its functional binding, ability to facilitate NK cell-PD-1+ cell-cell interactions, and depletion of PD-1+ cells using several in vitro assays. …”
Get full text

Flavonoids as Promising Akt1 Inhibitors in Cancer Medicine: Insights From Molecular Docking, Dynamics, DFT Calculations, and In Vitro Validation by Shokoofeh Jamshidi, Ali Eghbalian, Setareh Shojaei, Amir Taherkhani, Mehran Feizi‐Dehnayebi

“…Methods Cross‐validation and Density Functional Theory analysis were conducted utilizing the SwissDock server and the Gaussian 09 W software suite for the top‐ranked compounds. …”
Get full text

Dynamics of morphometric parameters and the glycogen content in rat hearts after аntenatal antigen influence by A. N. Lebedinets

“…These lymphocytes affect the formation of morphological and functional units of the internal organs. Features of the morphogenesis of heart after antenatal antigens exposure have not been studied. …”
Get full text

Dynamic Nomogram for Predicting the Fall Risk of Stroke Patients: An Observational Study by Wu Y, Jiang X, Wang D, Xu L, Sun H, Xie B, Tan S, Chai Y, Wang T

“…The study aimed to develop and verify a dynamic nomogram model for predicting the falls risk in stroke patients during rehabilitation.Methods: An observational study design was adopted, 488 stroke patients were treated in a tertiary hospital from March to September 2022 were investigated for fall risk factors and related functional tests. We followed up by telephone within 2 months after that to understand the occurrence of falls. …”
Get full text

Gestión de los Colegios Profesionales de Educación Física y Deporte desde una perspectiva interna (Management of Professional Colleges of Physical Education and Sport from an inte... by Roberto Silva Piñeiro, Jorge Fernando García Unanue

“…Basándonos en diferentes normativas y manuales, se diseñó un formulario on-line sobre cuestiones organizativas que fue trasladado a cada colegio autonómico. …”
Get full text

Evaluation of the relationship of immuno-inflammatory process with dyslipidemia and myocardial morphofunctional parameters in patients with chronic heart failure on the background... by A. S. Ankudinov, A. N. Kalyagin

“…The study involved 57 women with CHF-SFV, formed as a result of coronary heart disease and/or hypertension. All patients had functional class I and II according to NYHA. All patients were divided into comparable groups: the first group included 31 patients with a combination of CHF and seropositive RA of radiological stage I-III, the second group included 26 patients without RA. …”
Get full text

Research on Quantitative Analysis Method of Infrared Spectroscopy for Coal Mine Gases by Feng Zhang, Yuchen Zhu, Lin Li, Suping Zhao, Xiaoyan Zhang, Chaobo Chen

“…Spline fitting, polynomial fitting, and other curve fitting methods are used to establish a functional relationship between characteristic parameters and gas concentration. …”
Get full text

LncRNA H19 acts as a ceRNA to promote glioblastoma malignancy by sponging miR-19b-3p and upregulating SERPINE1 by Wonyi Jang, Mijung Im, Goeun Yoon, Jungwook Roh, Wanyeon Kim

“…Our results offer new insights into the regulatory interplay among H19, miR-19b-3p, and SERPINE1 in GBM cell lines, a relationship that has not been clearly defined in previous research. …”
Get full text

New approach to generating of human monoclonal antibodies specific to the proteolytic domain of botulinum neurotoxin A by Marina Vladimirovna Silkina, Alena Sergeevna Kartseva, Alena Konstantinovna Riabko, Mariia Aleksandrovna Makarova, Metkhun Madibronovich Rogozin, Yana Olegovna Romanenko, Igor Georgievich Shemyakin, Ivan Alekseevich Dyatlov, Victoria Valerievna Firstova

“…The sorted cells were then electrofused with the K6H6/B5 cell line, resulting in a producer of native human monoclonal antibodies (huMAbs). …”
Get full text

Identification and expression profile analysis of circRNAs associated with goat uterus with different fecundity during estrous cycle by Xiaolong Du, Yufang Liu, Xiaoyun He, Lin Tao, Meiying Fang, Mingxing Chu

“…During the reproductive cycle, the uterus plays a pivotal role, with its functions evolving in line with the different stages of the cycle. …”
Get full text

Exploring the causal relationship between hemoglobin and pancreatic cancer and its potential mechanisms through bioinformatics and Mendelian randomization by Shuai Wang, Shanshan Huang, Xiaohui Ren, Hengheng Zhang, Yuan Tian, Ziqi Luo, Hongbin Wang

“…The model yielded a C-index of 0.72, reflecting strong predictive power. Column-line plots further confirmed the model’s effective performance for predicting 1-, 3-, and 5-year OS. …”
Get full text

Surgical Technique, Tips, and Tricks: Medial Implantable Shock Absorber for Medial Compartment Knee Osteoarthritis by Andrew S. Bi MD, Wendell W. Cole MD, Dylan Lowe MD, Alexander Golant MD, Laith M. Jazrawi MD

“…This treatment can be technically difficult to perform, but several pearls and techniques can offer a reproducible, minimally invasive surgery and good functional results. Patient Consent Disclosure Statement: The author(s) attests that consent has been obtained from any patient(s) appearing in this publication. …”
Get full text

USP24 upregulation stabilizes PKA-Cα to promote lipogenesis, inflammation, and fibrosis during MASH progression by Beh Ning, Shao-An Wang, Ming-Jer Young, Yung-Ching Chen, Yun Hung, Tran Thu Huong, Wen-Chang Chang, Yi-Ching Wang, Ming-Lung Yu, Kai-Cheng Hsu, Jan-Jong Hung

“…Methods This study utilized CRISPR/Cas9 to create functional knockout mice (USP24C1695A) and treated HFD-fed mice with USP24 inhibitor (USP24-i-101). …”
Get full text

Sufficient conditions for convergence of positive solutions to linearized two-dimensional sediment transport problem by Alexander I. Sukhinov, Valentina V. Sidoryakina, Andrey A. Sukhinov

“…For actual coastal systems with irregular coastal configuration, the flow vector is generally not orthogonal to the tangent line for the coastline at each of its points. It also may not coincide with the wind stress vector. …”
Get full text

Development of blood-brain barrier-penetrating antibodies for neutralizing tick-borne encephalitis virus in the brain by Mizuki Fukuta, Sayo Fukano, Naoya Maekawa, Shintaro Kobayashi, Shunsuke Okamoto, Minato Hirano, Junko Nio-Kobayashi, Hiroaki Kariwa, Shigeru Kawakami, Satoru Konnai, Kentaro Yoshii

Get full text

An anti-androgen resistance-related gene signature acts as a prognostic marker and increases enzalutamide efficacy via PLK1 inhibition in prostate cancer by Ruilin Zhuang, Ruihui Xie, Shirong Peng, Qianghua Zhou, Weilong Lin, Yuan Ou, Bingliang Chen, Tong Su, Zean Li, Hai Huang, Kaiwen Li, Yu Duan

“…Methods Anti-androgen resistance-related differentially expressed genes (ARRDEGs) were identified through transcriptomic analysis of enzalutamide- and dual enzalutamide abiraterone-resistant PCa cell lines from the GEO database. Functional enrichment analysis was performed to determine the biological roles of these genes. …”
Get full text

miR-29a Negatively Affects Glucose-Stimulated Insulin Secretion and MIN6 Cell Proliferation via Cdc42/β-Catenin Signaling by Jing Duan, Xian-Ling Qian, Jun Li, Xing-Hua Xiao, Xiang-Tong Lu, Lin-Chen Lv, Qing-Yun Huang, Wen Ding, Hong-Yan Zhang, Li-Xia Xiong

“…Diabetes is a progressive metabolic disease characterized by hyperglycemia. Functional impairment of islet β cells can occur to varying degrees. …”
Get full text

In vivo CRISPR screening identifies POU3F3 as a novel regulator of ferroptosis resistance in hepatocellular carcinoma via retinoic acid signaling by Yu Tian, Xin Bao, Shan Lei, Youcai Huang, Xiaoling Wang, Yanyang Tu, Qinglian He, Feixiang Zhang, Haicheng Xu, Milad Ashrafizadeh, Gautam Sethi, Furong Wang, Zhirui Zeng

“…Abstract Background Sorafenib, a ferroptosis agonist, is a first-line treatment for advanced hepatocellular carcinoma (HCC). …”
Get full text

Neutrophil extracellular traps impede cancer metastatic seeding via protease-activated receptor 2-mediated downregulation of phagocytic checkpoint CD24 by Yu Liu, Xiaoli Zhang, Kun Chen, Hongying Wang, Junhu Yuan, Yiming Ma, Jianhui Ma, Fanyu Zhang, Bing-zhi Wang, Yinong Wang, Xinhua Zhao

“…The neutrophils isolated from human peripheral blood were stimulated with PMA to release NETs, which were collected and added to the cultures of different CRC cell lines for in vitro studies. Macrophage phagocytosis was assessed with flow cytometry in vitro and in vivo. …”
Get full text

Upregulation of TRPS1 promotes proliferation, migration, and invasion in ovarian clear cell carcinoma and correlates with poor patient prognosis by Jingfang Liu, Beier Wu, Shihan Wan, Yanlu Jin, Li Yang, Meijuan Wu, Jie Xing, Jiejie Zhang, Xin Chen, Aijun Yu

“…Functional studies were conducted by silencing TRPS1 in TOV21G cells with small interfering RNA and inducing overexpression in ES-2 cells using a plasmid. …”
Get full text