IMDM-20 enhances neutrophilic features during 1.3 % DMSO-mediated differentiation of HL-60 cells by Jorge Andrés Cázares-Preciado, José Antonio Cruz-Cárdenas, Alejandra López-Arredondo, Marco V. Gallardo-Camarena, Marion E.G. Brunck

“…The promyelocytic HL-60 cell line can be differentiated toward neutrophil-like cells and has been historically used as a surrogate to study human neutrophil biology in vitro. …”
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MicroRNA-122 overexpression suppresses the colon cancer cell proliferation by downregulating the astrocyte elevated gene-1/metadherin oncoprotein by Sarubala Malayaperumal, Sushmitha Sriramulu, Ganesan Jothimani, Antara Banerjee, Hong Zhang, Shabana Thabassum Mohammed Rafi, Ilangovan Ramachandran, Rajesh Kanna NR, Xiao-Feng Sun, Surajit Pathak

“…Background MicroRNAs (miRNAs) are small non-coding RNAs that regulate essential cellular functions, such as cell adhesion, proliferation, migration, invasion, and programmed cell death, and therefore, alterations in miRNAs can contribute to carcinogenesis. …”
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Bioactive Secondary Metabolites of Two Chinese Edible Boletes, <i>Phlebopus portentosus</i> and <i>Butyriboletus roseoflavus</i> by Zhixuan Wang, Wei Zhou, Yuhang He, Zeyu Zhao, Yang Cao, Shunzhen Luo, Guangyan Ji, Kaiping Ji, Jing Chen, Jiyang Li, Juan Xiong

“…These findings underscore the therapeutic potential of the two edible boletes in addressing neurodegenerative diseases, cancer, and viral infections, paving the way for their prospective applications in the development of functional foods and pharmaceuticals.…”
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An Integrated Approach Utilizing Single-Cell and Bulk RNA-Sequencing for the Identification of a Mitophagy-Associated Genes Signature: Implications for Prognostication and Therapeu... by Yuke Zhang, Li Ding, Zhijin Zhang, Liliang Shen, Yadong Guo, Wentao Zhang, Yang Yu, Zhuoran Gu, Ji Liu, Aimaitiaji Kadier, Jiang Geng, Shiyu Mao, Xudong Yao

“…Furthermore, the cellular functions of the genes of interest were verified in vitro. …”
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Effect of testosterone treatment during puberty in boys with Klinefelter syndrome (The TIPY Study): protocol for a nationwide randomised, double-blinded, placebo-controlled study by Gary Butler, Anders Juul, Judith L Ross, Jørgen Holm Petersen, Kurt Kristensen, Ann-Margrethe Rønholt Christensen, Ida Dyhr Caspersen, Andrés Felipe Østergaard Fritzbøger, Niels Birkebæk, Anders Jørgen Schou, Shanlee Davis, Sophie van Rijn, Lise Aksglaede

“…Additionally, individuals with KS often experience mental health challenges and functional impairments that significantly impact their quality of life. …”
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Modulation of DAPK1 expression by its alternative splice variant DAPK1-215 in cancer by QingShui Wang, ShuYun Weng, WenTing Zhong, YouYu Lin, Yan Yu, YiMin Huang, LiLin Ge, XiuLi Zhang, FangQin Xue, Yehuda G. Assaraf, Yao Lin

“…Methods We examined the expression and functional impact of a DAPK1 splice variant, DAPK1-215, in multiple cancer cell lines. …”
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Endothelial Cell Senescence in Marfan Syndrome: Pathogenesis and Therapeutic Potential of TGF‐β Pathway Inhibition by Yuhao Chen, Yuankang Zhu, Xiaoli Ren, Lu Ding, Yubin Xu, Miqi Zhou, Runze Dong, Peifeng Jin, Xiufang Chen, Xiaofang Fan, Ming Li, Yongsheng Gong, Yongyu Wang

“…Methods and Results We generated human induced pluripotent stem cells lines from 2 patients with MFS carrying specific Fibrillin‐1 mutations and differentiated these into ECs. …”
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Nucleotide receptor P2X7/STAT6 pathway regulates macrophage M2 polarization and its application in CAR-T immunotherapy by Qin Si, Lu Yang, Jie Liu, Hui Liu, Ruifang Bu, Na Cui

“…We engineered CAR-T cells targeting the non-functional P2X7 (nfP2X7) receptor, and co-cultured them with macrophages silencing P2X7 receptor along with OC cells. …”
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Analysis of hepatitis B virus integration identifies KMT2B as a novel cancer‐related gene in pancreatic cancer by Mengge Li, Huimin Li, Dejun Liu, Shunan Liu, Hui Yuan, Yan Wu, Min Du, Yuan Fang, Jin Li, Hui Cong, Dan Zhao, Chunsun Fan, Qing Wang, Cenkai Shen, Yu Gan, Yongwei Sun, Hong Tu

“…Methods High‐throughput sequencing‐based approach was employed to identify HBV integrations in tumour and para‐tumour tissues of PDAC. The biological functions of KMT2B were evaluated in PDAC cell lines as well as in subcutaneous and orthotopic mouse models of PDAC. …”
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Proteomic profiling identifies a stromal TGF-β1/podoplanin axis as a driver of colorectal cancer progression by Silvia Di Agostino, Davide La Padula, Vittoria Rago, Caterina Gabriele, Francesco Conforti, Elio Aprigliano, Lidia Urlandini, Elvira Parrotta, Danilo Lofaro, Francesca Vescio, Andrea Sacconi, Valeria Cernaro, Giuseppe Currò, Angela Alibrandi, Girolamo Ranieri, Valeria Zuccalà, Antonio Ieni, Marco Gaspari, Giovanni Cuda, Michele Ammendola, Vittorio Abbonante

“…Publicly available data from the Gene Expression Omnibus (GEO) database were analyzed to assess the association between PDPN expression and patient survival. Functional assays using direct and indirect co-culture systems investigated the influence of macrophage infiltration on stromal PDPN expression and its effect on colon adenocarcinoma cell growth. …”
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Human urine stem cells protect against cyclophosphamide-induced premature ovarian failure by inhibiting SLC1A4-mediated outflux of intracellular serine in ovarian granulosa cells by Hao-Cheng Gu, Ling-Fang Wang, Yu-Wei Zhang, You-Qiong Zhuo, Zhou-Hang Zhang, Xing-Yu Wei, Quan-Wen Liu, Ke-Yu Deng, Hong-Bo Xin

“…Morphological, histological, and functional alternations were examined using multiple approaches. …”
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Evaluation of anti-vibriocidal, antioxidant properties and cytotoxicity of bio fabricated/green synthesized silver nanoparticles using Euphorbia hitra L. leaf extract by Abhinash Marukurti, Alavala Matta Reddy, Silpa Rani Medapalli, Phanindra Babu Kasi, P. Tirupathi Rao, Rohini Anupoju, D. Ramachandran, B. Mallikarjuna, Kommoju Sarojani, Pangi Vijaya Nirmala

“…Furthermore, the assessment of in vitro cytotoxicity on Vero cell lines revealed minimal toxicity, as evidenced by an IC50 value of 191.51 µg mL−1. …”
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Identification and validation of DNA methylation-driven gene OSR1 as a novel tumor suppressor for the diagnosis and prognosis of breast cancer by Jian Xu, Biao Yang, Ling Cheng, Chen Gan, Runze Huang, Anlong Li, Han Ge, Longyu Hu, Meiwen Ling, Xinyi Zheng, Bao Zhao, Mingjun Zhang, Huaidong Cheng, Huaidong Cheng

“…Low OSR1 expression was significantly associated with M stage, HER2 status, PAM50 subtypes, and histological classification, and linked to poorer overall survival outcomes. Functional enrichment implicated OSR1 in pathways related to peptide hormone secretion, peptide transport, metal ion response, and forebrain development. …”
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Gene Editing Anxiety by Angelo Osofsky

“…” [13] Lanphier and Urnov, “Don’t Edit the Human Germ Line.” [14] Harris, “Germline Modification and the Burden of Human Existence.” …”
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The impact of intraoperative prone lumbar fluoroscopy under anesthesia on the selection of lowest instrumented vertebra and surgical outcomes in adolescent idiopathic scoliosis wit... by Lang Mai, Yankui Liu, Ruijue Zhu, Pan Zhou, Jiawei Di, Junlin Yang, Zifang Huang, Lei He

“…Further multicenter studies are needed to validate these findings and assess their long-term functional impact.…”
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ARID1A deficiency attenuates the response to EGFR-TKI treatment in lung adenocarcinoma by Fangfang Yang, Fangfang Yang, Helei Hou, Guanqun Wang, Guangming Fu, Xingfa Huo, Xueqin Duan, Na Zhou, Xiaochun Zhang

“…AT-rich interactive domain 1A (ARID1A), which is a key subunit of SWI/SNF complexes, demonstrates critical regulatory functions as a tumour suppressor gene in cancer. The aim of this study is to determine the role of ARID1A deficiency in the therapeutic efficacy of EGFR-TKIs in LUAD.MethodsWe identified the ARID1A mutation as a potential prognostic marker in EGFR-mutant LUAD by analysing data from cBioPortal. …”
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Engineered multifunctional nanoparticles for enhanced radiation therapy: three-in-one approach for cancer treatment by Tejaswini Appidi, Debarghya China, George-Răzvan Ștefan, Michele Moreau, Serena Mao, Esteban Velarde, Ngeh Toyang, Henry Lowe, Aravind Kumar Rengan, Kai Ding, Wilfred Ngwa

“…Abstract Clinical cancer treatment modalities include radiation as one of the first-line therapies used for treating almost two-thirds of cancer patients. …”
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Maternal consumption of yoghurt activating the aryl hydrocarbon receptor increases group 3 innate lymphoid cells in murine offspring by Grégory Pimentel, Thomas Roder, Cornelia Bär, Sandro Christensen, Zahra Sattari, Cristina Kalbermatter, Ueli von Ah, Christelle A. M. Robert, Pierre Mateo, Rémy Bruggmann, Stephanie C. Ganal-Vonarburg, Guy Vergères

“…Selection of LABs based on their ability to produce a fermented dairy able to activate AhR appears to be an effective approach to produce a yoghurt with immunomodulatory properties.IMPORTANCEKey progresses in the sequencing and functional annotation of microbial organisms have revolutionized research in the fields of human metabolism and food biotechnology. …”
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Characterization of lactylation modification subtypes and the promoting role of CCL20 in hepatocellular carcinoma progression by Li-Hong Wu, Liu Yang, Xiang-Xu Wang, Shuang Bai, Xi Yan, Jing Wei, Jun Wang, Fei Tian

“…The CIBERSORT algorithm was utilized to analyze immune cell infiltration. Functional validation of the lactylation-related gene CCL20 in HCC was conducted through in vitro experiments using HCC cell lines.ResultsWe identified three distinct lactylation modification patterns, with higher lactylation modification levels correlating with worse prognosis in HCC. …”
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Effects of binocularity and eye dominance on visually-driven ocular tracking by Kimia Seyedmadani, Kimia Seyedmadani, Keith A. Tucker, Mark R. Anderson, Mark R. Anderson, Yasemin M. Akay, Metin Akay, Leland S. Stone

“…Our examination of spatial/directional tuning revealed largely isotropic enhancement due to binocularity, as well as several anisotropies in retinal functional processing: (1) a Nasal-Temporal asymmetry for pursuit latency and direction noise, and a Superior–Inferior asymmetry for latency, and (2) anisotropic enhancement in initial acceleration and direction noise (primarily for nasal retina) and speed noise (primarily for superior retina) when viewing through the dominant eye. …”
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