The P2X7 receptor in depression: Novel insights and therapeutic implications by Yue-ting Zhong, Chao Pi, Ying Zuo, Yan Wei, Wen Li, Yong-qiang Jiang, Lei Tao, Wen-wu Zheng, Jun Jiang, Yan Yang, Shi-feng Chu, Bin-yan Liu, Ke-zhi Liu, Yu-meng Wei, Ling Zhao

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In-vitro modulation of glucose and lipid metabolism by Lentinula edodes extracts in obesity and type 2 diabetes models by Jasmeet Kaur, Farheen Azad, Anish Murtaja Alam Khan, Mohd. Farzaan, Javed Ahmad, Humaira Farooqi, Kailash Chandra, Bibhu Prasad Panda

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Effects of Salinity on the Growth Performance and Nutritional Composition of Artemia by Xiaodong JIANG, Ying WANG, Hongyan LI, Xinfeng ZHANG, Xiao FENG, Chen ZHONG, Yuanqin SUN

“…These factors also affect physiological functions such as osmotic pressure, oxygen consumption rate, ammonia excretion rate, and reproduction to certain extents. …”
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ASSESSMENT OF IMPACT OF ORAL HEALTH PARAMETERS ON ORAL HEALTH-RELATED QUALITY OF LIFE IN FUTURE DENTISTS by N.V. Yanko, L.F. Kaskova, O.S. Pavlenkova, Y.I. Soloshenko, L.I. Amosova

“…There were seven dimensions of negative impact on OHRQoL: functional limitation, physical pain, psychological discomfort, physical disability, psychological disability, social disability, and handicap. …”
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Antioxidant and <i>In Vitro</i> Hepatoprotective Activities of a Polyphenol-Rich Fraction from the Peel of <i>Citrus lumia</i> Risso (Rutaceae) by Vincenzo Musolino, Antonio Cardamone, Rosario Mare, Anna Rita Coppoletta, Francesca Lorenzo, Francesca Rita Noto, Angelo Galluccio, Luigi Tucci, Carmine Lupia, Cristina Carresi, Mariangela Marrelli, Samantha Maurotti, Micaela Gliozzi, Tiziana Montalcini, Arturo Pujia, Vincenzo Mollace

“…In particular, the polyphenolic fraction of <i>Citrus lumia</i> peel showed promising effects on lipid metabolism and cellular energy balance and may prove valuable in the treatment of metabolic disorders such as MASLD, where lipid accumulation disrupts normal cellular functions.…”
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A new signature associated with anoikis predicts the outcome and immune infiltration in nasopharyngeal carcinoma by Yonglin Luo, Wenyang Wei, Yaxuan Huang, Jun Li, Weiling Qin, Quanxiang Hao, Jiemei Ye, Zhe Zhang, Yushan Liang, Xue Xiao, Yonglin Cai

“…The low-risk score group exhibited features indicative of early clinical stage, immune activation, high immune checkpoint gene's expression, and low Epstein-Barr virus gene's expression. Functional analysis revealed enrichment of immune-related pathways in the low-risk group. …”
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Heterologous Immunization with Improved HIV-1 Subtype C Vaccines Elicit Autologous Tier 2 Neutralizing Antibodies with Rapid Viral Replication Control After SHIV Challenge by Gerald K. Chege, Rosamund E. Chapman, Alana T. Keyser, Craig H. Adams, Kealan Benn, Michiel T. van Diepen, Nicola Douglass, Bronwen Lambson, Tandile Hermanus, Penny L. Moore, Anna-Lise Williamson

“…These data show that the vaccines elicited robust cellular and functional humoral immune responses that resulted in a quicker control of viraemia.…”
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Alteration of vasopressin-aquaporin system in hindlimb unloading mice by Marianna Ranieri, Maria Venneri, Giuseppina Storlino, Angela Ferrulli, Mariagrazia D’Agostino, Mariangela Centrone, Annarita Di Mise, Annarita Di Mise, Roberta Zerlotin, Grazia Tamma, Maria Grano, Giovanna Valenti

“…Murine hindlimb unloading (HU) is considered a model of choice for simulating the physiological effects of microgravity on several functions, including fluid and electrolyte homeostasis. …”
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Multicentre pragmatic embedded stepped wedge cluster randomised trial comparing glucose 5% with sodium chloride 0.9% as the default drug diluent in the ICU: the sweet-water trial p... by Alexander Zarbock, Kai-Uwe Eckardt, Claudia Spies, Felix Balzer, Martin Witzenrath, Philipp Enghard, Björn Tampe, Oliver Hunsicker, Steffen Weber-Carstens, Bjoern Weiss, Jens Nee, Christian Strauss, Heiko Schenk, Jan-Hendrik Bernhard Hardenberg, Ricarda Merle Hinz, Mareen Pigorsch, Alexander Uhrig, Holger Müller-Redetzky, Tim Schroeder, Ulrike Trost, Daniel Zickler, Rainer Borgstedt, Mariam Abu-Tair, Uta Hildebrand, Dario von Wedel

“…Hypernatraemia adversely affects various physiological functions and is associated with delirium, prolonged length of stay and increased ICU and post-discharge mortality. …”
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Mechanisms of Staphylococcus aureus survival of trimethoprim-sulfamethoxazole-induced thymineless death by Lauren J. Gonsalves, Allyson Tran, Tessa Gardiner, Tiia Freeman, Angshita Dutta, Carson J. Miller, Sharon McNamara, Adam Waalkes, Dustin R. Long, Stephen J. Salipante, Lucas R. Hoffman, Daniel J. Wolter

“…Here, we report a systematic characterization of the mechanisms of S. aureus survival to treatment with the first-line antistaphylococcal antibiotic trimethoprim-sulfamethoxazole, identifying pathways and candidate targets for enhancing the efficacy of available antimicrobial agents.…”
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Prognostic model construction and immune microenvironment analysis of pyroptosis-related genes in hepatocellular carcinoma based on single-cell RNA sequencing by Haoming Shen, Yizhi Peng, Qingqing Xie, Yuxi Ren, Junping Hu, Peifang Qin, Yuanxiong Chen, Hao Zeng, Yifan Sun

“…Differential expression and functional pathway analyses revealed PRG expression dynamics across cell subtypes. …”
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A novel therapeutic approach to hemangiomas: Combining photothermal therapy and ferroptosis in a microneedle delivery system by Yiming Geng, Cancan Meng, Hanzhi Zhang, Chuan Ma, Xiao Fu, Haiwei Wu

“…The larger hemangiomas or lesions located in specific areas can cause severe complications, such as disfigurement, obstruction, or ulceration, increasing the risk of functional impairment. Propranolol, serving as the first‐line drug for IH treatment, still poses various challenges. …”
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RPL35A Downregulation Suppresses Hepatocellular Carcinoma Cell Proliferation via NCAPG2 Inactivation by Liang Chen, Yujie Lin, Yu Lai, Yanshan Li, Tao Chen, Xingxi Luo, Yibiao Ye

“…Beyond its canonical role, increasing evidence suggests that ribosomal proteins such as RPL35A may also exert extraribosomal functions that contribute to tumorigenesis. Methods We investigated RPL35A expression in HCC using tissue samples and cell lines. …”
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FTO‐mediated m6A demethylation regulates IGFBP3 expression and AKT activation through IMP3‐dependent P‐body re‐localisation in lung cancer by Haiyang Wang, Hui Peng, Zhenzhen Zhang, Yilimunuer Abulimiti, Jiayi Hu, Yongxin Zhou, Ping Ji, Dong Li

“…The ribonuclear protein IMP3 was identified as a crucial functional reader that interacted with m6A‐modified sites in the IGFBP3 3′UTR, thereby promoting IGFBP3 mRNA localisation to P‐bodies and suppressing its translation. …”
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Combining single-cell analysis and molecular docking techniques to construct a prognostic model for colon adenocarcinoma and uncovering inhibin subunit βb as a novel therapeutic ta... by Qinqing Wu, Qinqing Wu, Lu Ye, Yuwei Wu, Mengyu Zhao, Mengyu Zhao, Jiaxin Lu, Yanping Yu, Yanping Yu, Yixiao Niu, Yixiao Niu, Luxiao Zhang, Peijun Zuo, Peijun Zuo

“…Finally, we used gene knockout techniques to silence the key gene INHBB and explored its biological functions in vitro.ResultsIn our study, by analyzing the expression differences of ARGs, we successfully classified patients with COAD. …”
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Association studies for leaf rust resistance earmark differential genomic regions for silicon (Si) responsiveness in bread wheat (Triticum aestivum L.) by Prashanth Babu, Manjunath Prasad, R. Nirmalaruban, Sudhir Kumar, Rajbir Yadav, Manjeet Kumar, Kiran B. Gaikwad, Naresh Kumar Bainsla, S. Bhaskar Reddy, Nasreen Saifi, Amit Kumar Mazumder, Meda Alekya, Gaurav Kaushik, Palaparthi Dharamteja, Meghashri S. Patil, Shiv Kumar Singh, Dunna Vijay, Ranjeet Ranjan Kumar

“…Conclusions Our results provide important insights into the genetic basis of Si response and can assist in developing molecular markers for selecting and integrating Si-responsive genomic regions into wheat breeding lines.…”
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Randomized Controlled Trial of a Novel Cementless vs. Cemented Total Knee Arthroplasty: Early Clinical and Radiographic Outcomes by Enze Zhao, Xiaoyan Zhu, Haiwei Tang, Zhenyu Luo, Weinan Zeng, Zongke Zhou

“…The radiographs and computed tomography scans showed similar results, including radiolucent lines and osteolysis in either femoral or tibial. …”
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The human long noncoding RNAs CoroMarker, MALAT1, CDR1as, and LINC00460 in whole blood of individuals after controlled short-term exposure with ultrafine metal fume particles at wo... by Theresa Scheurer, Jan Steffens, Agnieszka Markert, Miriam Du Marchie Sarvaas, Christoph Roderburg, Lothar Rink, Frank Tacke, Tom Luedde, Thomas Kraus, Ralf Baumann

“…Conclusion The orientation of regulation of the lncRNAs is (except for CoroMarker) similar in the in vitro and in vivo experiments and in line with their described functions. Therefore, these results, e.g. the upregulation of the potential risk marker for cardiovascular diseases, CDR1as, contribute to understanding the underlying mechanisms of Zn/Cu-induced subclinical inflammation in metal workers.…”
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Inhibition of -type amino acid transporter 1 activity as a new therapeutic target for cholangiocarcinoma treatment by Supak Yothaisong, Hasaya Dokduang, Naohiko Anzai, Keitaro Hayashi, Nisana Namwat, Puangrat Yongvanit, Sakkarn Sangkhamanon, Promsuk Jutabha, Hitoshi Endou, Watcharin Loilome

“…Our previous study reported that l -type amino acid transporter-1 and its co-functional protein CD98 were highly expressed and implicated in cholangiocarcinoma progression and carcinogenesis. …”
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Regulations, biosecurity measures, and impact of COVID-19: A comprehensive mixed method study in traditional wet and live animal markets in Bangladesh by Sukanta Chowdhury, Tushar Kumar Das, Nurun Nahar Chisty, Sajal Kanti Biswas, Mohammed Ziaur Rahman, Jiaxin Ling, Mahmoud M. Naguib, Johanna F. Lindahl

“…Most markets (80 %, n = 8) lacked direct water supply lines for their shops, and 50 % had no functional drainage systems. …”
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