Exploring MAP3K genes in gastric cancer: biomarkers, tumor microenvironment dynamics, and chemotherapy resistance by Senhui Wei, Ying Li, Jing Zhou, Yongming Xia

“…Results Utilizing RT-qPCR analysis, we observed significant up-regulation of MAP3K1, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, and MAP3K10 in GC cell lines, while MAP3K2, MAP3K3, MAP3K11, MAP3K12, MAP3K13, MAP3K14, and MAP3K15 exhibited down-regulation. …”
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Identification and validation of prognostic biomarkers in ccRCC: immune-stromal score and survival prediction by Fang Lyu, Yuxin Zhong, Qingliu He, Wen Xiao, Xiaoping Zhang

“…Gene expression was confirmed in ccRCC cell lines (786-O, Caki-1) and tumor tissues. Functional assays, such as wound healing and Transwell assays, were employed to evaluate tumor invasion and migration. …”
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Improvements in quality of life of patients with multiple sclerosis receiving alemtuzumab in clinical practice: the LEMVIDA study by José Eustasio Meca-Lallana, Sara Eichau, Bonaventura Casanova, Elena Álvarez Rodríguez, Antonio Pato, Mireia Forner, Baldo Toledo

“…Conclusions These results indicate early and substantial improvements in patients’ perception of their QoL and functioning with alemtuzumab that were sustained over three years.…”
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Title of the study: finite element analysis of five internal fixation modalities for Schatzker type IV‒C tibial plateau fractures by Zulong Zhou, Run Fang, Yulong Liu, Mingxiang Liu, Lingchao Kong, Rende Ning

“…However, balance the benefits against increased complexity, particularly in patients with compromised soft tissue or high functional demands. Selecting internal fixation based on the fracture line can optimize outcomes and speed recovery.…”
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NEAR-ABSOLUTE EQUATIONS OF STATE OF DIAMOND, Ag, Al, Au, Cu, Mo, Nb, Pt, Ta, AND W FOR QUASI-HYDROSTATIC CONDITIONS by Peter I. Dorogokupets, Tatiana S. Sokolova, Boris S. Danilov, Konstantin D. Litasov

“…In our study, reasonably accurate descriptions of all of the basic thermodynamic functions of metals are derived from a simple equation of state with a minimal set of adjustable parameters.The pressure calculated from room-temperature isotherms can be correlated with a shift of the ruby R1 line. …”
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Creation of Souvenir Products as a Means of Promotion of Historical and Cultural Heritage of the City by Uliana P. Efremova, Olga A. Tsesevichene, Anastasia A. Seldusheva

“…The design is based on the author's graphics of historical and cultural sites located mainly along the “Red Line” of the city's pedestrian route, as well as attractions chosen by respondents as a result of an Internet survey. …”
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Application of Post-Occupancy Evaluation in the Design of Collegiatae Educational Space: (Case study: Faculty of Arts and Architecture, Islamic Azad University-Tehran South Branch) by Reza Naghdbishi, Zeinab Gohari

“…By engaging users and designers in a two-way interaction, the aim is to enhance building residents' satisfaction and improve overall performance.The research focuses on assessing the alignment between user needs and the functional response of the building, comparing these responses to established design standards. …”
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“Recreated impression”: problems and technologies of integrating the audio descriptive commentary service into the system of cultural industries / «Воссозданное впечатление»: пробл... by Tatiana Denisova / Денисова Татьяна Олеговна

“…The presence of these problems and their unsystematized nature require the introduction of a technological and purposefully controlled approach, which is in line with the ideology of cultural industries development. …”
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Ultrasound-Assisted Deep Eutectic Solvent Extraction of Antioxidant and Anti-Colorectal Cancer Proteins from <i>Spirulina</i> Biomass: Process Intensification, Characterization, an... by May Thu Zin, Thida Kaewkod, Supakit Chaipoot, Gochakorn Kanthakat, Yan-Yu Chen, Benjamas Cheirsilp, Sirasit Srinuanpan

“…Apoptosis rates of 70.43% in Caco-2 and 51.33% in HT-29 cells further confirm the anticancer potential of the extract. The functional properties of the extracted protein, including high foaming capacity (100%), emulsifying capacity (94.05%), and digestibility (85.77%), underscore its potential for diverse applications in food, pharmaceutical, and nutraceutical industries. …”
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LA ADAPTACIÓN METODOLÓGICA DE LA ENSEÑANZA DE LENGUAS AL EEES: UN ESTUDIO EUROPEO by María Luisa Pérez Cañado

“…The ultimate goal is to improve the functioning of the ECTS system with a view to guaranteeing that the decisions taken in relation to the new official university studies are based on empirical data and national and international referents.…”
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Quad-Mode H-Beam Metasurface-Embedded Dual-Band Circularly-Polarized Multi-Tiered Antenna Scheme With 5G (n79) and Wi-Fi 6E Capabilities by N. Supreeyatitikul, P. Chomtong, J. Konpang, P. Thitimahatthanakusol, P. Akkaraekthalin

“…The middle substrate is a copper plate with a horizontal Z-shaped slot at its center functioning as the ground plane, and the lower substrate contains a microstrip feed line. …”
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Energy saving in rail transport by Jan Antoš

“…Based on several partial results, emergent computing tool is functional and sufficiently accurate. The simulation program is supposed to be experimentally verified after its finishing. …”
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Deciphering the role of Hashimoto's Thyroiditis-related key genes in thyroid cancer via detailed in silico analysis followed by the experimental validation by Mostafa A. Abdel-Maksoud, Taghreed N. Almana, Saeedah Almutair, Abdulaziz Alamri, Ibrahim A. Saleh, Mohamed Y. Zaky, Wahidah H. Al-Qahtani, Yasir Hameed

“…The impact of BRAF overexpression on SW579 cells was assessed through various functional assays. Overexpression of BRAF resulted in reduced cell proliferation, colony formation, and wound healing, which may reflect context-dependent effects. …”
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Exploring exhaled breath biomarkers for lactose intolerance diagnosis: the Lactobreath pilot study protocol by Daniel Pohl, Stamatios Giannoukos, Kathryn Jane Burton-Pimentel, Roxane Guillod, Guy Vergères

“…Diagnosis is complicated as food intolerance is often associated with functional GI disorders, while FODMAPs may exert their effects individually or in combination. …”
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Trophic activity of human P2X7 receptor isoforms A and B in osteosarcoma. by Anna Lisa Giuliani, Davide Colognesi, Tiziana Ricco, Carlotta Roncato, Marina Capece, Francesca Amoroso, Qi Guang Wang, Elena De Marchi, Allison Gartland, Francesco Di Virgilio, Elena Adinolfi

“…In this study, we investigated the role of the two known human P2X7R functional splice variants, the full length P2X7RA and the truncated P2X7RB, in osteosarcoma cell growth. …”
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Green synthesis of silver nanoparticles using cocoon extract of Bombyx mori L.: therapeutic potential in antibacterial, antioxidant, anti-inflammatory, and anti-tumor applications by Ahmed H. Elsaffany, Ahmed E. M. Abdelaziz, Abdullah A. Zahra, Alsayed E. Mekky

“…Additionally, AgNPs exhibited notable cytotoxic properties against Caco-2 and PANC1 cell lines, with IC50 values of 177.24 ± 2.01 µg/ml and 208.15 ± 2.79 µg/ml, respectively. …”
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Anoikis-related genes predicts prognosis and therapeutic response in renal cell carcinoma by Lizhi Zhou, Hengcheng Lu, Bin Fu, Jianhan Fu

“…Single-cell RNA sequencing (scRNA-seq, GSE159115) was used to assess tumour heterogeneity, while in vitro experiments in RCC cell lines validated MMP9’s impact on anoikis resistance, migration and invasion.Results We collected all RNA-seq and single-cell RNA-seq (scRNA-seq) data from multiple online databases and utilized these datasets to develop a novel ARG-based prognostic model called ARGs. …”
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NFIC suppressed the epithelial ovarian cancer via modulating the balance of PTEN/TGFβ1/EGR1/BRD4 and SP1/EZH2 induced Inhibition of TBX2/MMPs signaling by Yanan Ren, Ren Xu, Di Zhang, Luyang Su, Ying Jin, Na Li, Yazhuo Wang

“…NFIC inhibited the migration and proliferation of SKOV3 cells, while TBX2 promoted it; NFIC functioned through TGFβ1 and PTEN, and their inhibition promoted the migration and proliferation of SKOV3 cells. …”
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SERPINA1 methylation as a novel diagnostic marker for early-stage papillary thyroid carcinoma via MAPK6-AKT/mTOR pathway by Junjie Li, Haixia Huang, Yifei Yin, Yizhu Mao, Mengxia Li, Hong Li, Chenxia Jiang, Rongxi Yang

“…Together, we identified SERPINA1 methylation as a functional and effective diagnostic marker for PTC and provided a novel epigenetic insight into the etiology of PTC. …”
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The genetic history of Portugal over the past 5,000 years by Xavier Roca-Rada, Roberta Davidson, Matthew P. Williams, Vanessa Villalba-Mouco, António Faustino Carvalho, Shyamsundar Ravishankar, Evelyn Collen, Christian Haarkötter, Leonard Taufik, Daniel R. Cuesta-Aguirre, Catarina Tente, Álvaro M. Monge Calleja, Rebecca Anne MacRoberts, Linda Melo, Gludhug A. Purnomo, Yassine Souilmi, Raymond Tobler, Eugénia Cunha, Sofia Tereso, Vítor M. J. Matos, Teresa Matos Fernandes, Anne-France Maurer, Ana Maria Silva, Pedro C. Carvalho, Bastien Llamas, João C. Teixeira

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