Host factor PLAC8 is required for pancreas infection by SARS-CoV-2 by Lesly Ibargüen-González, Sandra Heller, Darío López-García, Hanna Dietenberger, Thomas FE Barth, Patricia Gallego, Israel Fernández-Cadenas, Sayoa Alzate-Piñol, Catalina Crespí, Julieth A. Mena-Guerrero, Eugenia Cisneros-Barroso, Alejandro P. Ugalde, Gabriel Bretones, Charlotte Steenblock, Alexander Kleger, Marta L. DeDiego, Carles Barceló

“…We perform pseudovirus infection experiments in PLAC8 knock-out PDAC and human beta cell-derived cell lines and validate results with SARS-CoV-2 virus. …”
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Predictive Role of Complete Blood Count-Derived Inflammation Indices and Optical Coherence Tomography Biomarkers for Early Response to Intravitreal Anti-VEGF in Diabetic Macular Ed... by Ece Ergin, Ana Maria Dascalu, Daniela Stana, Laura Carina Tribus, Andreea Letitia Arsene, Marina Ionela Nedea, Dragos Serban, Claudiu Eduard Nistor, Corneliu Tudor, Dan Dumitrescu, Paul Lorin Stoica, Bogdan Mihai Cristea

“…<b>Background:</b> Diabetic macular edema (DME) is the leading cause of vision impairment in diabetic patients, with intravitreal anti-vascular endothelial growth factor (anti-VEGF) injections being the first-line therapy. However, one-third of patients exhibit persistent DME despite treatment, suggesting additional pathogenic factors. …”
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Investigating broadband filtering power amplifier using multi-mode resonator-based bandpass filter by Mohamed Boumalkha, Ahmed Gamal Abdellatif, Ahmed S.I. Amar, Mohammed Lahsaini, Amir Almslmany, Shuja Ansari, Mohammed Alammar, Mahmoud A. Shawky

“…By covering these widely adopted communication bands, the proposed FPA addresses the increasing demand for wideband, multifunctional devices in next-generation wireless networks, offering an effective balance among enhanced power efficiency, broadband functionality, high-quality filtering performance, and high selectivity.…”
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Effects of Dietary Additives on Nitrogen Balance, Odor Emissions, and Yolk Corticosterone in Laying Hens Fed Low-Protein Diets by Ju-Yong Song, Yun-Ji Heo, Jina Park, Hyun-Kwan Lee, Yoo Bhin Kim, Byung-Yeon Kwon, Da-Hye Kim, Kyung-Woo Lee

“…Four commercially available functional feed additives (<i>Bacillus subtilis</i>, protease, saponin, and thyme-based essential oil) were selected for this study. …”
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Multipurpose uses of rapeseed (Brassica napus L.) crop (food, feed, industrial, medicinal, and environmental conservation uses) and improvement strategies in China by Ibrahim A.A. Mohamed, Nesma Shalby, Ali Mahmoud El-Badri, Eman F.A. Awad-Allah, Maria Batool, Muhammad Hamzah Saleem, Zongkai Wang, Jing Wen, Xianhong Ge, Zhenghua Xu, Jing Wang, Jie Kuai, Bo Wang, Guangsheng Zhou, Tingdong Fu

“…This review emphasizes the multi-functionality of rapeseed as a promising crop for sustainable development. …”
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Integrin α8 is a useful cell surface marker of alveolar lipofibroblasts by Atsuki Fukada, Yasunori Enomoto, Ryo Horiguchi, Yoichiro Aoshima, Shiori Meguro, Hideya Kawasaki, Isao Kosugi, Tomoyuki Fujisawa, Noriyuki Enomoto, Naoki Inui, Takafumi Suda, Toshihide Iwashita

“…Further studies are necessary for the functional distinction between lung fibroblast subpopulations.…”
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SFB flagellin mediates cell adhesion, endocytosis and immune regulation in germ-free mice by Huahai Chen, Huahai Chen, Huahai Chen, Huahai Chen, Huahai Chen, Liu Wu, Liu Wu, Xiongyu Cao, Xiongyu Cao, Zongyan Li, Zongyan Li, Renjun Zhu, Renjun Zhu, Xiaojing Wang, Jun Li, Jun Li, Jun Li, Zuzhang Wei, Zuzhang Wei, Dengfeng Yang, Dengfeng Yang, Dengfeng Yang, Yeshi Yin, Yeshi Yin

“…Given this, the present study specifically examined the functions of SFB flagellin in bacterial adhesion, cellular internalization, and immune modulation.MethodsLactococcus lactis and Escherichia coli were engineered to express murine and rat SFB flagellin genes. …”
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p27^Kip1 and Tumors: Characterization of <i>CDKN1B</i> Variants Identified in MEN4 and Breast Cancer by Debora Bencivenga, Emanuela Stampone, Jahanzaib Azhar, Daniela Parente, Waqar Ali, Vitale Del Vecchio, Fulvio Della Ragione, Adriana Borriello

“…By transfecting breast cancer cell lines, we observed increased growth and cell motility for all the investigated mutants compared to wild-type p27^Kip1 transfected cells. …”
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Identification and validation of glycolysis-related diagnostic signatures in diabetic nephropathy: a study based on integrative machine learning and single-cell sequence by Xiaoyin Wu, Xiaoyin Wu, Buyu Guo, Buyu Guo, Xingyu Chang, Xingyu Chang, Yuxuan Yang, Yuxuan Yang, Qianqian Liu, Qianqian Liu, Jiahui Liu, Jiahui Liu, Yichen Yang, Yichen Yang, Kang Zhang, Yumei Ma, Songbo Fu, Songbo Fu, Songbo Fu

“…Differentially expressed genes (DEGs) and their functional enrichments were identified. Glycolysis-related genes (GRGs) were selected by combining DEGs, weighted gene co-expression network, and glycolysis candidate genes. …”
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GRAPHENE OXIDE NANOPARTICLES IN THE REGULATION OF THE OXIDATIVE ACTIVITY OF HUMAN MONOCYTES by S. V. Uzhviyuk, M. S. Bochkova, V. P. Timganova, P. V. Khramtsov, K. Yu. Shardina, M. D. Kropaneva, A. I. Nechaev, M. B. Rayev, S. A. Zamorina

“…Monocytes are innate immunity cells and the first line of defenсe of the human organism from microorganisms and other alien objects. …”
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The Potential Anti-Cancer Effects of Polish Ethanolic Extract of Propolis and Quercetin on Glioma Cells Under Hypoxic Conditions by Małgorzata Kłósek, Anna Kurek-Górecka, Radosław Balwierz, Grażyna Pietsz, Zenon P. Czuba

“…Tissue hypoxia is commonly observed in head cancers and contributes to both molecular and functional changes in tumour cells. It is known to stimulate erythropoiesis, angiogenesis, and metabolic alterations within tumour cells. …”
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Crosstalk between CD180-overexpression macrophages and glioma cells worsens patient survival through malignant phenotype promotion and immunosuppressive regulation by Wen Wang, Junsheng Li, Qiheng He, Chenglong Liu, Zhiyao Zheng, Bojian Zhang, Siqi Mou, Wei Sun, Jizong Zhao

“…Differentially expressed genes (DEGs) and their potential biological functions were analyzed between different CD180 expression groups. …”
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Botulinum toxin type A inhibits microglia pyroptosis by suppressing Cblb-mediated degradation of Pdlim1 to attenuate neuropathic pain by Sheng Tian, Lanxiang Wu, Heqing Zheng, Zhijuan Cheng, Jingjing Liu, Mingxu Liu, Xinping Yu, Jianglong Tu, Wei Wu

“…Result In a mice model of NP, BTX-A administration increased the pain threshold and decreased the Cblb protein expression level, consistent with the results of in vitro experiments. Functional experiments and mouse models were respectively used to evaluate the severity of microglia pyroptosis. …”
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Advancing the Indian cattle pangenome: characterizing non-reference sequences in Bos indicus by Sarwar Azam, Abhisek Sahu, Naveen Kumar Pandey, Mahesh Neupane, Curtis P Van Tassell, Benjamin D Rosen, Ravi Kumar Gandham, Subha Narayan Rath, Subeer S Majumdar

“…These protein-coding genes were enriched for functions such as chemical synaptic transmission, cell junction organization, cell-cell adhesion, and cell morphogenesis. …”
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Investigation Into the Pathogenesis of Type 2 Cardiorenal Syndrome via the ROS–TRPM2 Signaling Axis by Yanxia Li, Fengrong Wang

“…Thus, this study aimed to explore the biological functions and mechanisms of the ROS–TRPM2 signaling axis in type 2 CRS. …”
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Solid organ transplantation originating from uncontrolled donation after circulatory death in Europe: a narrative review by Yann Pionnier, Tom Darius, Andrea Penaloza, Francoise Steenebruggen, Florence Dupriez, Arne Neyrinck, Cornelia Genbrugge

“…We summarize the studies reporting the procured organ rate and functional outcome of organs originated from uDCD. European databases indicate a high incidence of OHCA, where resuscitation efforts are initiated but the rate of return of spontaneous circulation (ROSC) remains limited. …”
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ALDOC promotes neuroblastoma progression and modulates sensitivity to chemotherapy drugs by enhancing aerobic glycolysis by Yunpeng Chen, Haixia Zhu, Yishu Luo, Tianyue Xie, Youyang Hu, Zhiwei Yan, Weichao Ji, YaXuan Wang, Qiyou Yin, Hua Xian

“…Protein expression levels of ALDOC were assessed in NB cells versus normal cells using immunoblotting. Functional experiments, including proliferation and migration assays, were conducted in ALDOC-interfered NB cell lines. …”
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Nuclear corepressor SMRT acts as a strong regulator of both β-oxidation and suppressor of fibrosis in the differentiation process of mouse skeletal muscle cells. by Hiroaki Shimizu, Yasuhiro Horibata, Izuki Amano, Megan J Ritter, Mariko Domae, Hiromi Ando, Hiroyuki Sugimoto, Ronald N Cohen, Anthony N Hollenberg

“…<h4>Conclusion</h4>Taken together, we demonstrate that SMRT functions as a pivotal transcriptional mediator for both β-oxidation and the prevention for the fibrosis via TGF-β receptor signaling in the differentiation of C2C12 myoblasts. …”
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Quand le local se saisit du volet urbain de la politique de cohésion à Varsovie : une européanisation de la gouvernance et du territoire à l’épreuve des conflits politiques by Chloé Sénécat

“…The first concerns public policies: local and European strategies are in line. The second concerns the territory: the implementation of Integrated Territorial Investments has undoubtedly encouraged metropolitan cooperation in Warsaw, and the creation of a functional urban area, as defined by the European institutions. …”
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Isocitrate Dehydrogenase-Wildtype Glioma Adapts Toward Mutant Phenotypes and Enhanced Therapy Sensitivity Under D-2-Hydroxyglutarate Exposure by Geraldine Rocha, Clara Francés-Gómez, Javier Megías, Lisandra Muñoz-Hidalgo, Pilar Casanova, Jose F. Haro-Estevez, Vicent Teruel-Martí, Daniel Monleón, Teresa San-Miguel

“…<b>Methods:</b> Experiments were conducted using <i>IDH</i>-wildtype (<i>IDH</i>-wt) and <i>IDH</i>-mutant (<i>IDH</i>-mut) glioma cell lines under controlled oxygen conditions. Functional assays included cell viability, cell cycle analysis, apoptosis profiling, migration, and surface marker expression via flow cytometry. …”
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