Solution-based manufacturing of 2D materials for memristive device applications by Kijeong Nam, Gwang Ya Kim, Dongjoon Rhee, Hyesung Park, Deep Jariwala, Joohoon Kang

“…Their excellent gate tunability in electronic properties also enables hybrid devices combining the functionality of memory devices and transistors, with the possibility of realizing large-scale memristive crossbar arrays with high integration density. …”
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Synthesis, characterization, and computational evaluation of some synthesized xanthone derivatives: focus on kinase target network and biomedical properties by Wisam Taher Muslim, Layth Jasim Mohammad, Munaf M. Naji, Isaac Karimi, Matheel D. Al-Sabti, Majid Jabir, Mazin A. A. Najm, Helgi B. Schiöth

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Gelatin/PLA-loaded gold nanocomposites synthesis using Syzygium cumini fruit extract and their antioxidant, antibacterial, anti-inflammatory, antidiabetic and anti-Alzheimer’s acti... by Manickam Rajkumar, S. I. Davis Presley, Nathiya Thiyagarajulu, Koyeli Girigoswami, Gopalarethinam Janani, Chinnaperumal Kamaraj, Bharathi Madheswaran, Bhupendra Prajapati, Nemat Ali, Mohammad Rashid Khan

“…The FTIR spectrum showed various functional groups and the XRD patterns confirmed the crystalline shape and structure of nanocomposites. …”
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Toxoplasma calcium-dependent protein kinases 3 mediates M1 macrophage polarization by targeting host Arginase-1 by Ran An, Fang Liu, Niuniu Dai, Fangmin Li, Xingyun Liu, Haijian Cai, Lijian Chen, Jian Du

“…Results The interaction between TgCDPK3 and Arginase-1 is functionally correlated and leads to a reduction in Arginase-1 activity, ultimately, contributing to the M1-biased phenotype of the host macrophages, which is related to restraining the proliferation of parasites. …”
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Genicular nerve radiofrequency ablation, phenol neurolysis or conservative medical management in patients with knee osteoarthritis: protocol for the RADIOPHENOL randomised controll... by Markus W Hollmann, Johan Haumann, Bram Thiel, Marc B Godfried, Jan-Willem Kallewaard, Paul R de Wit, Rienk van Beek, Monique Schokker, Carin Wensing, Gezina Oei, Derk A van Kampen, Lars Elzinga, Gijs Hendriks, Jeroen van de Heiden, Jan Willem Coumou

“…Introduction Guidelines for symptomatic knee osteoarthritis (OA) dictate the initiation of conservative treatment (physical therapy, analgesics and intra-articular injections with corticosteroids) as a first line defence. When conservative treatment fails, the golden standard is invasive joint replacement surgery, but for a substantial group of patients who do not respond to the current conservative treatment, this is not (yet) indicated. …”
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High expression of G-protein signaling modulator 2 in hepatocellular carcinoma facilitates tumor growth and metastasis by activating the PI3K/AKT signaling pathway by Xiao-Qin He, Yue-Feng Zhang, Jia-Jun Yu, Yuan-Yuan Gan, Na-Na Han, Mei-Xia Zhang, Wei Ge, Jun-Jian Deng, Yong-Fa Zheng, Xi-Ming Xu

“…With this study, we first assessed the expression pattern of G-protein signaling modulator 2 in hepatocellular carcinoma specimens and adjacent noncancerous tissues; clinical data were analyzed, along survival times, utilizing the Kaplan–Meier method. Moreover, the functions of G-protein signaling modulator 2 were examined using small-interfering RNAs in vitro. …”
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Polysorbates degrading enzymes in biotherapeutics – a current status and future perspectives by Marius Nicolaus Felix, Thomas Waerner, Daniel Lakatos, Bernd Reisinger, Simon Fischer, Patrick Garidel

“…Enzymatic polysorbate degradation may impair the functionality of the surfactant in stabilising therapeutic proteins, leading to the formation of visible and/or sub-visible particles in biopharmaceutical drug products. …”
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Deciphering the tumor-suppressive role of RBMS3 in lung adenocarcinoma through genomic insights into prognosis and mechanisms by Li Lv, Tengxiang Zhong, Zhenkun Li, Wenhui Zhang, Yi Zhang, Ying Liang, Rongqing Li, Mingxia Ding, Jie Lin

“…Clinically, elevated RBMS3 expression was independently associated with improved overall survival (HR = 0.766, 95% CI 0.602–0.973, P = 0.029), validated by Kaplan–Meier analysis (Log-rank P = 0.027). Functionally, RBMS3 overexpression in A549 and PC-9 LUAD cells suppressed invasion (66.53% and 52.46% reduction, respectively; P < 0.01) and induced apoptosis (total apoptosis increased by 6.53% and 8.57%; P < 0.05). …”
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A Novel Metallo‐β‐Lactamase AMM‐1 From Alteromonas mangrovi Reveals a Cryptic Environmental Reservoir of Carbapenem Resistance by Xuan Wu, Xinjing Han, Lu Zhu, Ningning Pi, Yi Li, Rong Xiang

“…ABSTRACT Carbapenem resistance driven by metallo‐β‐lactamases (MBLs) poses a formidable global challenge as these enzymes can degrade a wide range of β‐lactam antibiotics, including last‐line carbapenems. Despite extensive documentation of MBL‐producing pathogens, their evolutionary origins and ecological reservoirs are still poorly understood. …”
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Genome-wide analysis of the laccase gene family in tossa jute (Corchorus olitorius): insights into stem development, lignification, and responses to abiotic stress by Deepak Kumar Jha, Deepak Kumar Jha, Subhadarshini Parida, Seema Pradhan, Nrisingha Dey, Shuvobrata Majumder

“…Understanding ColLAC functions could facilitate the development of low-lignin jute fibres, meeting the growing industrial demand for high-quality natural fibres of jute.…”
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Genetic Polymorphisms on TNFA, TNFRSF1A, and TNFRSF1B Genes Predict the Effectiveness of Anti-TNF-α Treatment in Inflammatory Bowel Disease Patients by Michelangelo Rottura, Igor Pirrotta, Domenico Antonio Giorgi, Natasha Irrera, Vincenzo Arcoraci, Federica Mannino, Rosario Campisi, Chiara Bivacqua, Laura Patanè, Giuseppe Costantino, Socrate Pallio, Walter Fries, Anna Viola, Giovanni Pallio

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Culturing of Giardia lamblia under microaerobic conditions can impact metronidazole susceptibility by inducing increased expression of antioxidant enzymes by Kateryna Starynets, Ana Paunkov, Anja Wagner, Klaus Kratochwill, Christian Klotz, David Leitsch

“…All three proteins are known, or can be predicted to have antioxidant functions. Indeed, overexpression of pyridoxamine 5′-phosphate oxidase in WB C6 from a plasmid carrying the respective gene behind the arginine deiminase promoter significantly improved growth of the transfected cell line under microaerobic conditions. …”
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Decoding the hypoxic tumor microenvironment in colorectal cancer for prognostic modeling and therapeutic target discovery by Xiao-Cui Duan, Yan Zhou, Fan Feng, Hai-Bo Jiang, Mei-Lin Wang, Zhe Han, Hong-Fei Pang, Yu-Hang Liu, Heng-Zhe Jia, Meng- He, Hong-Pan Xu, Yuan-Yuan Wang

“…Finally, in vitro assays assessed the functional role of GIPC2, a model gene, in CRC cell lines.ResultsSingle-cell profiling uncovered eight distinct hypoxic clusters, with H3 exhibiting the highest hypoxia scores and enrichment in glycoprotein metabolic and angiogenesis pathways. …”
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Evaluation of antimicrobial, anticancer, and neuroprotective activities of silver nanoparticles (AgNPs) green-synthesized using a red pigment produced by Streptomyces sp. A23 strai... by Mokhnache Mohamed, Hani Belhadj, Koca Fatih Dogan, Unal Gokhan, Rahman Nasrat Abdul, Basma Aysegul, Bozkurt Nuh Mehmet, Bachir Ahmed Alien Mohamed, Daoud Harzallah

“…Furthermore, FT-IR analysis revealed the specific functional groups at 3471 to 478 cm-1. In addition, FE-SEM showed that the mean size of the spherical AgNPs was 54.5 nm in diameter. …”
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Leveraging a disulfidptosis-based signature to characterize heterogeneity and optimize treatment in multiple myeloma by Bingxin Zhang, Dong Zheng, Shuxia Zhu, Xinyi Zhang, Quanqiang Wang, Zhili Lin, Ziwei Zheng, Shujuan Zhou, Zixing Chen, Sisi Zheng, Enqing Lan, Luning Cui, Hansen Ying, Yu Zhang, Xuanru Lin, Qiang Zhuang, Honglan Qian, Xudong Hu, Yan Zhuang, Qianying Zhang, Zhouxiang Jin, Songfu Jiang, Yongyong Ma, Yongyong Ma, Yongyong Ma

“…We further explored genetic mutation mapping, protein-protein interactions, functional enrichment, drug sensitivity, drug prediction, and immune infiltration analysis among subtypes and risk subgroups. …”
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Genetic Mapping of a QTL Controlling Fruit Size in Melon (<i>Cucumis melo</i> L.) by Fazle Amin, Nasar Ali Khan, Sikandar Amanullah, Shusen Liu, Zhao Liu, Zhengfeng Song, Shi Liu, Xuezheng Wang, Xufeng Fang, Feishi Luan

“…These results provide a better understanding for further fine mapping and functional gene analysis related to melon fruit size.…”
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A nanoencapsulated oral formulation of fenretinide promotes local and metastatic breast cancer dormancy in HER2/neu transgenic mice by Maria Laura De Angelis, Federica Francescangeli, Eleonora Aricò, Paola Verachi, Massimo Zucchetti, Cristina Matteo, Elena Petricci, Emanuela Pilozzi, Isabella Orienti, Alessandra Boe, Adriana Eramo, Rachele Rossi, Tiberio Corati, Daniele Macchia, Anna Maria Pacca, Ann Zeuner, Marta Baiocchi

“…Methods We used BC cell lines for in vitro analyses of cell viability, cell cycle and migratory capacity. …”
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A 314-bp SINE insertion in the ZNF2 promoter region may act as a repressor related to regulation of fat deposition in pigs by Hao GU, Zhan-yu DU, Eduard MURANI, Enrico D'ALESSANDRO, Cai CHEN, Xiao-yan WANG, Jiu-de MAO, Klaus WIMMERS, Cheng-yi SONG

“…Zinc finger proteins (ZNFs) are among the most abundant proteins in eukaryotic animals, and their functions are extraordinarily diverse and particularly important in gene regulation. …”
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Metabolic and nutritional effects of vitamin A on growth, lipid metabolism, antioxidant capacity and hepatopancreas health of juvenile mud crab (Scylla paramamosain) by Zheng Tang, Shichao Xie, Yao Deng, Wenhao Zhan, Hongyu Peng, Yinqiu Tian, Haiqing Cao, Min Jin, Binjie Zhou, Yushan Zou, Juntao Gu, Peng Sun, Qicun Zhou

“…The correlation analysis results showed that fatp4 and gpx both have a significant positive correlation with growth performance related parameters, suggesting they may be crucial for VA's physiological functions. In conclusion, the broken-line equations of PWG relative to the dietary VA level indicated that the optimal dietary VA requirement for juvenile mud crab was established as 2.96 mg/kg. …”
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TRAF7 knockdown induces cellular senescence and synergizes with lomustine to inhibit glioma progression and recurrence by Yu Chen, Tongyu Zhou, Rongrong Zhou, Wen Sun, Yan Li, Qiyi Zhou, Dongcheng Xu, Yuxin Zhao, Peihao Hu, Jingrui Liang, Yumeng Zhang, Bin Zhong, Juncheng Yao, Di Jing

“…The expression of TRAF7, cellular senescence and cell cycle arrest pathways in glioma tissues and cell lines was detected by real-time quantitative PCR (RT-qPCR), western blotting and immunohistochemistry. …”
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