NK cell immunopotentiators-loaded nanoliposomes enhance ADCC effect for targeted therapy against HER2-positive breast cancer by Ruoxin Du, Changqing Cao, Dong Fan, Guodong Li, Shuangpeng Pu, Xinyao Xu, Mengmeng Liu, Gege Shi, Yuxin Wu, Qiang Hao, Yuan Gao, Juliang Zhang, Huadong Zhao, Cun Zhang

“…Abstract Trastuzumab serves as a cornerstone of first-line therapy for HER2-positive (HER2+) breast cancer; however, a significant challenge arises due to the emergence of resistance within approximately one year of commencement of treatment, particularly in advanced cases with metastatic disease where its efficacy is limited. …”
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Regulation of Stemness by NR1D2 in Colorectal Cancer by Sandra Alonso-García, Paula Sánchez-Uceta, Sara Moreno-SanJuan, Jorge Casado, Jose D. Puentes-Pardo, Huda Khaldy, David Lopez-Pérez, María Sol Zurita-Saavedra, Cristina González-Puga, Angel Carazo, Josefa León

“…In contrast, in cells lacking a functional p53 or harbouring a mutated one, NR1D2 knockout increases cell growth and stemness. …”
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LRP1 involvement in FHIT-regulated HER2 signaling in non-small cell lung cancer by Théophile Ponchel, Emma Loeffler, Julien Ancel, Audrey Brisebarre, Nathalie Lalun, Véronique Dalstein, Anne Durlach, Gaëtan Deslée, Stéphane Dedieu, Myriam Polette, Béatrice Nawrocki-Raby

“…Studying the functional role of LRP1, we showed that cell proliferation and invasion induced by FHIT silencing were LRP1-dependent. …”
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Identification and characterization of the anti-viral interferon lambda 3 as direct target of the Epstein-Barr virus microRNA-BART7-3p by Juliane Blümke, Marcus Bauer, Christoforos Vaxevanis, Andreas Wilfer, Ofer Mandelboim, Claudia Wickenhauser, Barbara Seliger, Simon Jasinski-Bergner

“…The effect of ebv-miR-BART7-3p on the IFNL3 expression was validated both in human cell lines in vitro and in human tissue specimen with known EBV status. …”
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Evaluation of the efficacy and safety of a precise thymalfasin-regulated PRaG regimen for advanced refractory solid tumours: protocol for the open-label, prospective, multicentre s... by Yong Peng, Hong Zhang, Junjun Zhang, Liyuan Zhang, Pengfei Xing, Yuehong Kong, Rongzheng Chen, Meiling Xu, Guangqiang Chen, Zhihui Hong, Xiaoxiao Dai, Yifu Ma, Xiangrong Zhao, Chenyang Zhang

“…Introduction The PRaG regimen, which consists of hypofractionated radiotherapy combined with a programmed cell death-1/programmed cell death ligand-1 (PD-1/PD-L1) inhibitor and granulocyte-macrophage colony stimulating factor (GM-CSF), has been demonstrated to have a survival benefit in patients with advanced solid tumours who have failed at least two lines of treatment. Nonetheless, lymphopenia poses an impediment to the enduring efficacy of PD-1/PD-L1 inhibitor therapy. …”
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Lotus seed (Nelumbinis semen) extract: anticancer potential and chemoprofiling by in vitro, in silico and GC-MS studies by Vijaya Jyothi Mallela, Mithun Rudrapal, D. S. N. B. K. Prasanth, Praveen Kumar Pasala, Atul R. Bendale, Soumya Bhattacharya, Sahar M. Aldosari, Sahar M. Aldosari, Johra Khan, Johra Khan

“…Lotus seeds, also known as Nelumbinis semen, has been utilized for over 7,000 years as vegetable, functional food and medicine. In this study, we primarily investigated the anticancer effects of lotus seed extracts, particularly of the methanolic extract (MELS) on cell proliferation inhibition, apoptosis induction and cell cycle arrest in ovarian cancer cell lines. …”
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REALITIES AND EFFECTIVENESS OF THE UKRAINIAN BANKING SYSTEM by Maryna Korol, Olena Bazhenova, Ihor Korol, Grygoriy Starchenko, Volodymyr Bazhenov, Oksana Banna

“…The simulation results (mainly the analysis of impulse response functions) allow concluding that interbank lending in post-crisis conditions recovers relatively rapidly (with a lag of two years). …”
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Supporting the Development of Digitally Competent VET Teachers in Serbia and Russia by E. Burns, E. Silvennoinen, V. A. Kopnov, D. E. Shchipanova, N. Papić-Blagojević, S. Tomašević

“…The paper discusses the current state of the development of digital competencies of teachers and teachers of Serbia and Russia in line with the European Digital Competence Framework (DigComp) and the European Digital Competence Framework for Educators (DigСompЕdu). …”
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Weighted Gene Co-Expression Network Analysis Uncovers Critical Genes and Pathways Involved in Soybean Response to Soybean Mosaic Virus by Hanhan Zhu, Ruiqiong Li, Yaoyao Fang, Xue Zhao, Weili Teng, Haiyan Li, Yingpeng Han

“…We have developed an SMV-resistant soybean line, Dongnong 93-046, which has no significant changes in disease resistance identification in the adult plants and has neat grains with no obvious brown or black markings. …”
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SLC2A9 is a high-capacity urate transporter in humans. by Mark J Caulfield, Patricia B Munroe, Deb O'Neill, Kate Witkowska, Fadi J Charchar, Manuel Doblado, Sarah Evans, Susana Eyheramendy, Abiodun Onipinla, Philip Howard, Sue Shaw-Hawkins, Richard J Dobson, Chris Wallace, Stephen J Newhouse, Morris Brown, John M Connell, Anna Dominiczak, Martin Farrall, G Mark Lathrop, Nilesh J Samani, Meena Kumari, Michael Marmot, Eric Brunner, John Chambers, Paul Elliott, Jaspal Kooner, Maris Laan, Elin Org, Elin Org, Gudrun Veldre, Margus Viigimaa, Francesco P Cappuccio, Chen Ji, Roberto Iacone, Pasquale Strazzullo, Kelle H Moley, Chris Cheeseman

“…We investigated whether SLC2A9 is a functional urate transporter that contributes to the longstanding association between urate and blood pressure in man.…”
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Study protocol of sustaining home palliative care for patients with Heart Failure (HF) and their family caregivers in rural Appalachia: a mixed methods randomized clinical trial by Ubolrat Piamjariyakul, Stephanie Young, Angel Smothers, Sijin Wen, R. Osvaldo Navia, George Sokos, Ann E. Hendrickson, Peggy Fink, Diana Niland, Matthew Hottle, Angelo C. Giolzetti, Carol E. Smith

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Securing Medication Use in Pediatric Oncology Units in French-Speaking Africa: MAEva Pilot Program Results in Ivory Coast by Line Couitchere, Innocent Krasse, Léa Zaho, Marina Yao, Guy Yao, Carole Coze, Nadine Robert, Olga Molly, Max N'Doumy, Charles Akoun, Bertrand Pourroy

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Serum extracellular vesicle microRNAs as potential biomarkers to predict pembrolizumab response and prognosis in metastatic non-small cell lung cancer patients by Daniela Lamorte, Luciana De Luca, Alfredo Tartarone, Stefania Trino, Irene Giulivo, Angelo De Stradis, Maddalena Maietti, Antonella Caivano, Ilaria Laurenzana

“…All patients had tumor PD-L1≥50% and cEVs were extracted before first-line pembrolizumab treatment. cEVs were then characterized for morphology, integrity, concentration, size and protein contaminants. …”
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Hypoxia alters the response of ovarian cancer cells to the mitomycin C drug by Aleksandra Gawrylak, Aleksandra Gawrylak, Klaudia Brodaczewska, Roksana Iwanicka-Nowicka, Roksana Iwanicka-Nowicka, Marta Koblowska, Marta Koblowska, Agnieszka Synowiec, Lubomir Bodnar, Lubomir Bodnar, Cezary Szczylik, Bogdan Lesyng, Rafał Stec, Claudine Kieda, Claudine Kieda

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CAR-T cells and TRUCKs that recognize an EBNA-3C-derived epitope presented on HLA-B*35 control Epstein-Barr virus-associated lymphoproliferation by Michael Hudecek, Anna Christina Dragon, Katharina Zimmermann, Thomas Nerreter, Deborah Sandfort, Julia Lahrberg, Stephan Klöß, Christina Kloth, Caroline Mangare, Agnes Bonifacius, Sabine Tischer-Zimmermann, Rainer Blasczyk, Britta Maecker-Kolhoff, Barbara Uchanska-Ziegler, Hinrich Abken, Axel Schambach, Britta Eiz-Vesper

“…Of note, TÜ165 TRUCKs with inducible IL-12 showed highly improved effector functions and additionally led to recruitment of monocyte and NK cell lines.Conclusions Our results demonstrate that TÜ165 CAR-Ts recognize EBV peptide/HLA complexes in a TCR-like manner and thereby allow for recognizing an intracellular EBV target. …”
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N-glycosylation of PD-L1 modulates the efficacy of immune checkpoint blockades targeting PD-L1 and PD-1 by Bar Kaufman, Muhammad Abu-Ahmad, Olga Radinsky, Eman Gharra, Tal Manko, Baisali Bhattacharya, Daniela Gologan, Nofar Erlichman, Tsipi Meshel, Yoav Nuta, Tomer Cooks, Moshe Elkabets, Adit Ben-Baruch, Angel Porgador

“…Methods Human PD-L1 glycosylation mutants—at each individual site or at all four sites together (Nx4)—were tested for their functional interaction with PD-1 using an artificial immune checkpoint reporter assay (IcAR-PD1). …”
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Internal structure, reliability and cross-cultural validity of the Warwick-Edinburgh Mental Wellbeing Scale in three European populations by Jose M Valderas, Katherine Pérez, Ioannis Bakolis, Gemma Vilagut, Jordi Alonso, Antonio J Molina, Vicente Martin, Philippe Mortier, Sarah Stewart-Brown, Alex Dregan, Xavier Bartoll, Amy Ronaldson, Antoni Serrano-Blanco, Jorge Arias de la Torre, Prateek Yadav, Cristina Casajuana Kogel, Joan Colom Farran, Carlos Garcia Forero, Lorena Botella-Juan, Line Nielsen, Beatriz Puertolas, Ziggi Santini, Ana Schiaffino

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How mindfulness-based training improves stress-related health: a selective review of randomized clinical trials comparing psychological mechanisms of action by Lara M. C. Puhlmann, Lara M. C. Puhlmann, Lara M. C. Puhlmann, Veronika Engert, Veronika Engert, Veronika Engert

“…., activity of the autonomic nervous system, the hypothalamic-pituitary-adrenal axis and proinflammatory activity), each in two different states of the stress system: acutely stressful challenges and more long-term basal functioning. In line with MAT, we find that monitoring needs to be coupled with acceptance for beneficial effects on stress-related physiological activity in states of acute challenge. …”
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The translatome of glioblastoma by Fleur M. G. Cornelissen, Zhaoren He, Edward Ciputra, Richard R. deHaas, Ammarina Beumer‐Chuwonpad, David Noske, W. Peter Vandertop, Sander R. Piersma, Connie R. Jiménez, Cornelis Murre, Bart A. Westerman

“…We investigated inter‐cell‐line differences through differential expression analysis at both the translatome and transcriptome levels. …”
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Cytotoxic and Antioxidant Properties and Profile of Active Compounds in Kale and Lupine Sprouts Supplemented with γ-Polyglutamic Acid During Sprouting by Agnieszka Galanty, Paulina Kłos, Ewelina Prochownik, Paweł Paśko, Tomasz Skalski, Robert Podsiadły, Paweł Zagrodzki

“…These results provide a foundation for developing functional foods and sustainable agricultural practices.…”
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