MMP1-induced NF-κB activation promotes epithelial–mesenchymal transition and sacituzumab govitecan resistance in hormone receptor-positive breast cancer by Letian Chen, Yinghuan Cen, Keyang Qian, Wang Yang, Wenbin Zhou, Yaping Yang

“…MMP1 expression was manipulated in different BC cell lines through lentiviral transfection and small interfering RNA techniques. …”
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DNA-Containing Extracellular Structures of Tumor Cells Inhibit the Formation of Neutrophil Extracellular Traps <i>in vitro</i> by A. N. Kazimirskii, J. M. Salmasi, G. V. Poryadin, M. I. Panina, A. E. Kim, A. G. Chakhalian, O. O. Turishcheva

“…The effect of inhibition of neutrophil networks by K562 cells is probably due to the action of a soluble factor that suppresses neutrophil functions described earlier.Conclusion. The study shows that both tumor cell lines are capable of suppressing innate immune cell responses through different mechanisms. …”
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Artificial Intelligence Technology Based on Deep Learning in Building Construction Management System Modeling by Hongbo Wang, Yan Hu

“…The forecast result is the line forecast of the actual cumulative completion percentage on June 17. …”
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DHCR24 overexpression is involved in lipid metabolic reprogramming to drive cervical cancer malignant progression and is associated with immune microenvironment by Lin Cheng, Yuance Xu, Zhuo Li, Danting Sun, Yan Xu, Junqi He, Yulong Chen, Qin Yao

“…A prognostic nomogram incorporating tumor stage and DHCR24 expression levels was developed to predict clinical outcomes in patients. Functional studies using SiHa cell lines were conducted to elucidate the oncogenic properties of DHCR24. …”
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Patterns of mature woody plant species encroachment on vegetation structure, density, and diversity of the understory layer across the Marikana Thornveld by Mziwanda Mangwane, Mziwanda Mangwane, Ignacio Casper Madakadze, Tlou Julius Tjelele, Abel Ramoelo

“…IntroductionBush encroachment has a negative impact on the vegetation structure, ecosystem functions, and services of savanna rangelands. Woody plant encroachment creates an imbalance in the grass-to-tree ratio, leading to a decline in ecosystem services, including grazing capacity and soil nutrients.MethodsThis study aimed to evaluate the vegetation structure, diversity, and relationships of tree species across four different growth stages in the Marikana Thornveld. …”
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Identification of cell-type-specific, transcriptionally active transposable elements using long-read RNA-sequencing data-based comprehensive annotation by Chaemin Lim, Hyunsu An, Jihwan Park

“…Abstract Background The biological functions of transposable element (TE)-derived transcripts during physiological development, disease development, and progression have been previously reported. …”
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P. TILLICHO ONTOLOGIJA IR I. KANTO TRANSCENDENTALINĖ FILOSOFIJA by Mindaugas Briedis

“…He argues that space, time, and the twelve categories form the transcendental boundary line between what we can and cannot know. But this solution“ itself calls attention to an even more signi- ficant problem: what is the status of that which lies outside the boundary of possible empirical knowledge? …”
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Mutagenesis of Highland barley (Hordeum vulgare L. Var. nudum) using nitrogen ion beam implantation: screening of phenotypic variations and comparative transcriptome analysis by Hao-Yue Yu, You-Huan Zhang, Hang Li, Hong Feng

“…Phenotypic trait correlation analysis identified two mutation lines exhibiting significant variations: E8-38 with highly increased 1000-grain weight, and D7-67 displaying a two-row spike phenotype. …”
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P. TILLICHO ONTOLOGIJA IR I. KANTO TRANSCENDENTALINĖ FILOSOFIJA by Mindaugas Briedis

“…He argues that space, time, and the twelve categories form the transcendental boundary line between what we can and cannot know. But this solution“ itself calls attention to an even more signi- ficant problem: what is the status of that which lies outside the boundary of possible empirical knowledge? …”
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PRESTIGE study: ACE inhibitors efficacy in patients with acute myocardial infarction and left ventricular dysfunction by Yu. N. Belenkov, G. P. Arutyunov, M. G. Glezer, V. S. Zadionchenko, A. I. Martynov, V. S. Moiseev, Yu. M. Pozdnyakov, G. I. Storozakov, R. I. Stryuk, S. N. Tereshchenko

“…The secondary goal was to assess dynamics of chronic heart failure (CHF) functional classes (FC) during the treatment. Material and methods. …”
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Trypanosoma brucei Co-opts NK Cells to Kill Splenic B2 B Cells. by Deborah Frenkel, Fengqiu Zhang, Patrick Guirnalda, Carole Haynes, Viki Bockstal, Magdalena Radwanska, Stefan Magez, Samuel J Black

“…In contrast, infected C57BL/6 mice lacking the cytotoxic granule pore-forming protein perforin (Prf1-/-) retained splenic B2 B cells and lymphoid follicles, developed high-titer antibody responses against many trypanosome polypeptides, rapidly suppressed parasitemia and did not develop anemia or lose weight for at least 60 days. Several lines of evidence show that T. brucei infection-induced splenic B cell depletion results from natural killer (NK) cell-mediated cytotoxicity: i) B2 B cells were depleted from the spleens of infected intact, T cell deficient (TCR-/-) and FcγRIIIa deficient (CD16-/-) C57BL/6 mice excluding a requirement for T cells, NKT cell, or antibody-dependent cell-mediated cytotoxicity; ii) administration of NK1.1 specific IgG2a (mAb PK136) but not irrelevant IgG2a (myeloma M9144) prevented infection-induced B cell depletion consistent with a requirement for NK cells; iii) splenic NK cells but not T cells or NKT cells degranulated in infected C57BL/6 mice co-incident with B cell depletion evidenced by increased surface expression of CD107a; iv) purified NK cells from naïve C57BL/6 mice killed purified splenic B cells from T. brucei infected but not uninfected mice in vitro indicating acquisition of an NK cell activating phenotype by the post-infection B cells; v) adoptively transferred C57BL/6 NK cells prevented infection-induced B cell population growth in infected Prf1-/- mice consistent with in vivo B cell killing; vi) degranulated NK cells in infected mice had altered gene and differentiation antigen expression and lost cytotoxic activity consistent with functional exhaustion, but increased in number as infection progressed indicating continued generation. …”
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Aberrant angiogenesis in brain tissue in experimental Alzheimer’s disease by Ya. V. Gorina, Yu. K. Komleva, E. D. Osipova, A. V. Morgun, N. A. Malinovskaya, O. L. Lopatina, A. B. Salmina

“…The aim was to study the molecular mechanisms of the violation of the structural and functional integrity ofthe blood-brain barrier in chronic neurodegeneration of the Alzheimer’s type associated with the development of cerebral angiopathy.Materials and methods. …”
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Construction of the porcine genome mobile element variations and investigation of its role in population diversity and gene expression by Jianchao Hu, Lu Gui, Zhongzi Wu, Lusheng Huang

“…This database identified a total of 147,993 polymorphic MEVs, including 121,099 short interspersed nuclear elements (SINEs), 26,053 long interspersed nuclear elements (LINEs), 802 long terminal repeats (LTRs), and 39 other transposons, among which 54% are newly discovered. …”
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Effects of the green view index on anxiety reduction and perceived exertion during cycling in older adults by Tsai-Chiao Wang, Ta-Wei Tang, Shang-Min Ma, Tsu-Kung Lin, Chia-Liang Tsai

“…Anxiety is associated with significant functional impairments and diminished mental health and quality of life in older adults. …”
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VIBE: an R-package for VIsualization of Bulk RNA Expression data for therapeutic targeting and disease stratification by Indu Khatri, Saskia D. van Asten, Leandro F. Moreno, Brandon W. Higgs, Christiaan Klijn, Christiaan Klijn, Francis Blokzijl, Iris C. R. M. Kolder

“…VIBE’s versatility proves pivotal for disease stratification and therapeutic targeting in cancer and other diseases.ResultsVIBE offers a wide array of functions that streamline the visualization and analysis of transcriptomic data for single- and dual-targeting therapies. …”
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Zangezur and South Araz Transport Projects: Problems of Implementation in the Context of Relations between Armenia, Iran and Azerbaijan by M. M. Shumilov

“…Due to the destructive policy of the Armenian leadership, the legal framework for unblocking the Zangezur transport corridor and ensuring its functioning under Russian neutral control has been destroyed. …”
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Macrophage-mediated anti-inflammatory enhancement by biosynthesized zinc oxide nanoparticles of Quercus infectoria Olivier extract in RAW 264.7 cells by A. Umamaheswari, S. Lakshmana Prabu, K. Huthaya Prakash, A. Puratchikody

“…The FT-IR studies outlined the existence of several functional groups in the extract. The SEM analysis depicted its structure to be spongy and XRD analysis peaks at 2θ values ranging between 31.73° and 76.90° indicated the purity of zinc oxide nanoparticles. …”
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Effectiveness assessment of sulfur-containing amino acids in rats with experimental “alcohol withdrawal syndrome” with modified zoosocial interaction methods by V. I. Petrov, N. A. Osadchenko, A. S. Tarasov, A. M. Dotsenko, E. I. Morkovin

“…According to the data obtained, sulfur-containing amino acids, primarily those that had central effects, normalized neuronal functions, positively influencing a complex behavior of rats. …”
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EBV epigenetically suppresses the B cell-to-plasma cell differentiation pathway while establishing long-term latency. by Christine T Styles, Quentin Bazot, Gillian A Parker, Robert E White, Kostas Paschos, Martin J Allday

“…In vitro, about 20 days after infection with EBV lacking functional EBNA3A and EBNA3C, cells develop a PC-like phenotype. …”
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METTL14 decreases FTH1 mRNA stability via m6A methylation to promote sorafenib-induced ferroptosis of cervical cancer by Lijie Li, Jie Zeng, Sili He, Yanfei Yang, Chen Wang

“…Subsequently, METTL14 was knocked down in CC cell lines, and the effects on cell proliferation, mitochondrial morphology and ferroptosis were assessed using CCK-8, microscopy, and markers associated with ferroptosis, respectively. …”
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