The KNAT3a1-WND2A/3A module positively regulates fiber secondary cell wall biosynthesis in Populus tomentosa by Kuan Sun, Di Fan, Yingying Peng, Chang Liu, Lingfei Kong, Ting Lan, Xianqiang Wang, Dan Li, Chaofeng Li, Keming Luo

“…Meanwhile, the studies also demonstrate that the KNAT3 has functional differentiation in xylem development. Taken together, these data suggest that the KNAT3a1-WND2A/3A module positively regulates fiber development of the secondary xylem in poplar via the WND2A/3A-mediated hierarchical regulatory network, and supplies useful information for fiber SCW formation. …”
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A‐TWinnipeg: Pathogenesis of rare ATM missense mutation c.6200C>A with decreased protein expression and downstream signaling, early‐onset dystonia, cancer, and life‐threatening rad... by Kotoka Nakamura, Francesca Fike, Sara Haghayegh, Rachel Saunders‐Pullman, Angelika J. Dawson, Thilo Dörk, Richard A. Gatti

“…This report provides the pathogenetic evidence for this mutation on cellular functions. Several patients have developed cancer and subsequently experienced life‐threatening adverse reactions to radiation (radiotoxicity) and/or chemotherapy. …”
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Selective arm-usage of pre-miR-1307 dysregulates angiogenesis and affects breast cancer aggressiveness by Oyku Ece Sumer, Korbinian Schelzig, Janine Jung, Xiaoya Li, Janina Moros, Luisa Schwarzmüller, Ezgi Sen, Sabine Karolus, Angelika Wörner, Verônica Rodrigues de Melo Costa, Nishanth Belugali Nataraj, Efstathios-Iason Vlachavas, Clarissa Gerhäuser, Karin Müller-Decker, Dominic Helm, Yosef Yarden, Birgitta Elisabeth Michels, Cindy Körner

“…Surprisingly, the overexpression of pre-miR-1307 in breast cancer cell lines resulted in reduced xenograft growth and impaired angiogenesis. …”
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Transforming Biomass Waste into Hydrochars and Porous Activated Carbon: A Characterization Study by Suhas, Monika Chaudhary, Shubham Chaudhary, Shivangi Chaubey, Isabel Pestana da Paixão Cansado, Mohammad Hadi Dehghani, Inderjeet Tyagi, Rama Gaur

“…The prepared hydrochars were rich in oxygenated functional groups. The optimized hydrochar, HC-230-4 (prepared at 230 °C, for 4 h), presented a ratio of H/C = 0.95 and O/C = 0.29, an improved degree of coalification, and a high heating value (26.53 MJ kg⁻¹), which can replace bituminous coals in the power sector. …”
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A graphical user interface for wrmXpress 2.0 streamlines helminth phenotypic screening by Zachary Caterer, Rachel V. Horejsi, Carly Weber, Blake Mathisen, Chase N. Nelson, Maggie Bagatta, Ireland Coughlin, Megan Wettstein, Ankit Kulshrestha, Hui Siang Benjamin Lee, Leonardo R. Nunn, Mostafa Zamanian, Nicolas J. Wheeler

“…Traditionally, these analyses are performed remotely on high-performance computers, often requiring an understanding of a command line interface (CLI) and the ability to write scripts to control the software or job scheduler. …”
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Bioinformatics mining and experimental validation of prognostic biomarkers in colorectal cancer by Feng Huang, Salah A. Alshehade, Wei Guo Zhao, Zhuo Ya Li, Jung Yin Fong, Chin Tat Ng, Li Chen, Sasikala Chinnappan, Mohammed Abdullah Alshawsh, Karthikkumar Venkatachalam, Malarvili Selvaraja

“…Mutational profiling showed predominant missense mutations across signature genes, with TIMP1 exhibiting the highest variant allele frequency. Functional enrichment analysis linked TIMP1 to critical CRC pathways including type I interferon receptor binding, oxidative phosphorylation, and Notch signaling pathways. …”
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Sulfatase 2 inhibition sensitizes triple-negative breast cancer cells to paclitaxel through augmentation of extracellular ATP by Jasmine M. Manouchehri, Jharna Datta, Lynn M. Marcho, Daniel Stover, Ramesh K. Ganju, Bhuvaneswari Ramaswamy, William E. Carson, Arjun Mittra, Xiaoli Zhang, Patrick M. Schnell, Yu Yue, Mark P. Rubinstein, Mathew A. Cherian

“…Sulfatase 2 (SULF2) removes sulfate from HS, the functional group essential for ATPase inhibition. Consequently, we propose that TNBC cell death and eATP release induced by chemotherapy would be intensified by SULF2 inhibitors. …”
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Combined targeting of TCF7L1/2, PTEN, CDK6, and BCCIP by microRNA miR‐29c‐3p is associated with reduced invasion and proliferation of endometriotic cells by Teresa Helene Wentges, Heba M. El‐Shorafa, Janine Beckmann, Michael Gabriel, Matti Poutanen, Burkhard Greve, Ludwig Kiesel, Sebastian D. Schäfer, Martin Götte

“…We aimed to identify novel molecular targets of miR‐29c‐3p functionally linked to proliferation and invasive growth in endometriosis. …”
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Consequences of Surface Composition and Aggregation Conditions of Ag Nanoparticles on Surface-Enhanced Raman Scattering (SERS) of Pesticides by Marcelo José dos Santos Oliveira, Gilia Cristine Marques Ruiz, Rafael Jesus Gonçalves Rubira, Santiago Sanchez-Cortes, Carlos José Leopoldo Constantino, Leonardo Negri Furini

“…Additionally, to obtain the SERS signal of MBC with AgCT, besides the presence of chlorinated salts, other adjustments were necessary, such as changing both the pH of the medium (from pH 5.8 to pH 8, for which MBC is in its neutral form) and the laser lines (from 785 to 514.5 nm). These findings demonstrated that although the pesticide molecules belong to the same chemical functional group, their detection was strongly influenced by the surface of the silver nanoparticles and the salts added. …”
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Hypoxia reconstructed colorectal tumor microenvironment weakening anti-tumor immunity: construction of a new prognosis predicting model through transcriptome analysis by Ruizhi Zhang, Yisong Gao, Chong Li, Ruikang Tao, Gan Mao, Tianyu Song, Wenxiang Nie, Suao Liu, Kaixiong Tao, Wei Li

“…The identified genes were validated in vitro by assessing their expression under normoxic and hypoxic conditions in normal intestinal epithelial cells and CRC tumor cell lines. Functional relevance was explored through differential gene expression analysis, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses, and protein-protein interaction (PPI) network construction. …”
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H3K14 lactylation exacerbates neuronal ferroptosis by inhibiting calcium efflux following intracerebral hemorrhagic stroke by Tingting Sun, Jian-Nan Zhang, Ting Lan, Lei Shi, Liye Hu, Liyan Yan, Chao Wei, Lisha Hei, Weihua Wu, Zhaoli Luo, Meng Liu, Xingmei Ren, Yamei Wang, Yabin Lu, Peipei Wang, Chenguang Zhang, Liheng Bian, Xingquan Zhao, Fei Yang, Qian Li

“…H3K14la/PMCA2 promoted ferroptosis by elevating intracellular calcium levels. In line with our in vitro findings, inhibiting H3K14la/PMCA2 reduced neuronal degeneration and improved functional outcomes in an ICH mouse model induced by intracranial injection of collagenase into the striatum. …”
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Implementation of the Symptom Navi © Programme for cancer patients in the Swiss outpatient setting: a study protocol for a cluster randomised pilot study (Symptom Navi© Pilot Study... by Marika Bana, Karin Ribi, Susanne Kropf-Staub, Sabin Zürcher-Florin, Ernst Näf, Tanja Manser, Lukas Bütikofer, Solange Peters, Manuela Eicher

“…We expect to include 140 adult cancer patients receiving first-line systemic anticancer treatment. Trained nurses at the intervention clusters will provide at least two semistructured consultations with the involvement of SN©Flyers. …”
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In vitro vascular differentiation system efficiently produces natural killer cells for cancer immunotherapies by Yekaterina Galat, Yuchen Du, Mariana Perepitchka, Xiao-Nan Li, Irina V Balyasnikova, William T Tse, Svetlana Dambaeva, Sylvia Schneiderman, Philip M Iannaccone, Oren Becher, Douglas K Graham, Vasiliy Galat

“…NK cytotoxicity was validated using in vitro and in vitro K562 assays and further corroborated on lymphoma, diffuse intrinsic pontine glioma (DIPG), and GBM cell lines in vitro.Results HPCs demonstrated engraftment in peripheral blood samples, and hPSC-NKs showcased morphology and functionality akin to same donor peripheral blood NKs (PB-NKs). …”
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Transcranial Intermittent Theta-Burst Stimulation Reverses Neurodegeneration in the Somatosensory Motor Cortex after Spinal Cord Transection in Rats by Zhenghong Chen, Yujian Lin, Jing Xu, Jiawei Sun, Rui Liu, Yue Yang, Zhen Chen, Mingyu Lv, Biqin Lai, Ling Zhang

“…Background: Complete spinal cord injury (SCI) leads to a disconnection between the brain and the body below the injury level, resulting in the functional silencing, degeneration, and apoptosis of sensorimotor cortex (SMC) neurons, which is of crucial importance to the pathological process. …”
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Isolation, characterization, and biomedical potential of phycoerythrin phycobiliprotein from Kappaphycus alvarezii (Doty) L. M. Liao: antimicrobial, antioxidant, and anticancer act... by Harinathan Balasundaram, Parthasarathy Seethapathy, Subbiah Sankaralingam, Shunmugiah Mahendran, Murugan Mareeswaran, Jeyaraj Pandiarajan, Pandiaraj Maheswari, Sakthivel Venkatesh, Malaisamy Arunkumar, Girish R. Pathade, Deepu Pandita, Anu Pandita, Fazal Ullah, Hosam O. Elansary, Muhammad Nazim, Adel A. Fickak, Mohamed A. Rashwan, Ihab Mohamed Moussa

“…Comprehensive characterization using FT-IR, HPLC, and GC-MS analysis revealed the nature of pigment and functional groups, highlighting its potential for biomedical applications. …”
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Obesity-Derived Biomolecules Promote the Differentiation of THP1 Monocytes to Macrophages In Vitro by Luis I. Terrazas, Valeria Gutiérrez-Almaraz, Valentina García-Garay, Victoria Hernández-Gómez, Nohemí Salinas-Jazmín, Mónica Graciela Mendoza-Rodríguez, Jonadab Efraín Olguín

“…Background: It is well known that the microenvironment in which an immune response develops, generally pro-inflammatory or immunosuppressive, along with other overproduced biomolecules recognized by pattern recognition receptors, may promote the stimulation and differentiation of monocytes into macrophages with effector functions. Low-density lipoprotein (LDL) plays a fundamental role in cholesterol transport. …”
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Longitudinal changes of resting-state networks in Parkinson‘s disease by Matthias Sure, Rasha Hyder, Levent Kandemir, Jan Vesper, Alfons Schnitzler, Esther Florin

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Anti-virulence strategy of diaryl chalcogenide compounds against Candida albicans infection by Shihao Song, Shuo Zhao, Xiuyun Sun, Lili Meng, Zijie Wang, Huihui Tan, Jingyun Liu, Min Zhang, Yinyue Deng

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Design of Tri-frequency Combiner Based on Inverted T-stub Combiner Network by LIU Zirui, WANG Haoyu, HUANG Kama

“…Combined with the impedance transformation of λ/4 transmission lines, this design achieves an equivalent open-circuit state at the corresponding combiner ports. …”
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KIF13B C.*3163G>A SINGLE NUCLEOTIDE VARIANT ON OROPHARYNGEAL SQUAMOUS CELL CARCINOMA SUSCEPTIBILITY AND TUMOR CHARACTERISTICS by Ericka Francislaine Dias Costa, Gustavo Jacob Lourenço, Carmen Silvia Passos Lima

“….*3163G>A influence the risk and tumor characteristics of OPSCC, as well as the expression of the KIF13B gene and the microRNA (miRNA) let-7e-3p in controls, and to functionally assess the interaction between let-7e-3p and the SNV region in the 3’-UTR of KIF13B. …”
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