The Mystery of Certain <i>Lactobacillus acidophilus</i> Strains in the Treatment of Gastrointestinal Symptoms of COVID-19: A Review by Belén Bertola, Amparo Cotolí-Crespo, Nadia San Onofre, Jose M. Soriano

“…Some <i>L. acidophilus</i> strains show promise, and clinical validation should follow careful preclinical studies (in vitro, cell lines, and animal models), especially in vulnerable populations such as immunocompromised individuals. …”
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miR-138-5p Inhibits the Growth and Invasion of Glioma Cells by Regulating WEE1 by Jianwu Gong, Zhi Tang, Zhengtao Yu, Zhiyong Deng, Yan Liu, Nianjun Ren, Lei Wang, Zhengwen He

“…The relationship between miR-138-5p and WEE1 was explored using a luciferase reporter analysis. Results. Functional studies indicated that overexpression of miR-138-5p suppressed cell proliferation, migration, and invasion and promoted death in glioma cell lines. …”
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A broadband integrated rectenna for microwave radio energy harvesting using an integrated hybrid sandwich power divider by Milad Nosrati, Pejman Rezaei, Mohammad Danaie, Jafar Khalilpour

“…The broadband power divider section is implemented without using lossy elements such as resistors and capacitors, employing only integrated tandem line techniques and simultaneous stripline coupling with an 8.34 dB coupling factor and equal 3 dB outputs on a Ro 4003c substrate. …”
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A matter of scale: Identifying the best spatial and temporal scale of environmental variables to model the distribution of a small cetacean by Tiffany Goh, Mark Jessopp, Emer Rogan, Enrico Pirotta

“…Harbour porpoise sightings were recorded during dedicated line‐transect aerial surveys conducted in the summers of 2016, 2021 and 2022. …”
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Suppressing mitochondrial inner membrane protein (IMMT) inhibits the proliferation of breast cancer cells through mitochondrial remodeling and metabolic regulation by Li Liu, Qingqing Zhao, Daigang Xiong, Dan Li, Jie Du, Yunfei Huang, Yan Yang, Rui Chen

“…Mitochondria, as pivotal organelles, play a crucial role in the metabolic regulation of tumor cells, and their morphological and functional alterations are intricately linked to the biological characteristics of tumors. …”
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HIF-PH inhibitors induce pseudohypoxia in T cells and suppress the growth of microsatellite stable colorectal cancer by enhancing antitumor immune responses by Yuehua Chen, Toshiaki Ohara, Yusuke Hamada, Yuze Wang, Miao Tian, Kazuhiro Noma, Hiroshi Tazawa, Masayoshi Fujisawa, Teizo Yoshimura, Akihiro Matsukawa

“…Abstract Background Recent studies have revealed that CD8+ T cells can be activated via genetic upregulation of HIF-1α, thereby augmenting antitumor effector functions. HIF-1α upregulation can be attained by inhibiting HIF-prolyl hydroxylase (HIF-PH) under normoxic conditions, termed pseudohypoxia. …”
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FLL2 modulates Arabidopsis development and stress tolerance via polyadenylation and CPSF73 interaction by Saiqi Hao, Danhui Zhao, Congting Ye, Haidong Qu, Xiangming Zhou, Qingshun Q. Li

“…These results provide functional linkages between FLL2 and CPSF73 mediated by APA in critical genes for plant development and environmental responses.…”
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Uricase-Expressing Engineered Macrophages Alleviate Murine Hyperuricemia by Yu-Zhong Feng, Hao Cheng, Guo-Qing Xiong, Jia-Zhen Cui, Zhi-Li Chen, Yuan-Yuan Lu, Zhi-Xin Meng, Chen Zhu, Hao-Long Dong, Xiang-Hua Xiong, Gang Liu, Qing-Yang Wang, Hui-Peng Chen

“…Serum uric acid and bio-indicators for renal and hepatic functions were detected by an automatic biochemical analyzer; inflammatory cytokines were determined by ELISA; the livers and kidneys of the mice were sectioned for histological examination. …”
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Rapid-Response and Highly Sensitive Boronate Derivative-Based Fluorescence Probe for Detecting H2O2 in Living Cells by Muthusamy Selvaraj, Kanagaraj Rajalakshmi, Yun-Sik Nam, Yeonhee Lee, Byoung Chan Kim, Sung Jin Pai, Sang Soo Han, Kang-Bong Lee

“…The probe was conjugated using the TPIOP functional group acting as an excellent fluorescent enhancer. …”
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O6-methylguanine DNA methyltransferase (MGMT) expression in U1242 glioblastoma cells enhances in vitro clonogenicity, tumor implantation in vivo, and sensitivity to alisertib-carbo... by Müge Sak, Müge Sak, Brian J. Williams, Brian J. Williams, Andrew J. Hey, Mayur Sharma, Leslie Schier, Megan J. Wilson, Mahatma Ortega, Alyssa I. Lara, Mikaela N. Brentlinger, Norman L. Lehman, Norman L. Lehman, Norman L. Lehman, Norman L. Lehman, Norman L. Lehman

“…MGMT thus possesses cellular functions related to tumor cell engraftment and anchorage-independent growth beyond guanine methyltransferase repair. …”
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The Assembly of Supermassive Black Holes at z < 1 in Early-type Galaxies from Scaling Relations by D. Farrah, A. Engholm, E. Hatziminaoglou, S. Petty, F. Shankar, A. Efstathiou, K. Ejercito, K. Jones, M. Lacy, C. Lonsdale, C. Pearson, G. Tarlé, R. A. Windhorst, J. Afonso, D. L. Clements, K. S. Croker, L. K. Pitchford

“…We show, however, that this relation depends on the stellar and SMBH mass functions used to compute the selection bias, the virial relation, the virial factor, and the active fraction, which together introduce uncertainty of up to ​​​​​​∼0.6 dex in the z ∼ 0.8 relation. …”
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A novel mitochondrial autophagy and aging-related gene signature for predicting ovarian cancer by Hongyu Zhang, Qiaoying Jin, Huijuan Cao, Yunyun Wang, Yiling Zhao, Hongwen Zhu, Tiansheng Qin

“…Furthermore, we analyzed these data with unifactorial and multifactorial analyses, functional enrichment analysis, gene mutation analysis, immune infiltration, drug susceptibility analysis, cell line analysis, and immunohistochemistry data from the HPA database. …”
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Knockdown of p53 Enhances LncRNA A2M‐AS1 Inhibition of Pancreatic Cancer Progression via Regulating MAPK Pathway by Yu Cen, Yihui Luo, Yi Nan, Wenxi Kuang, Xianglian Zhang, Jiexia Lu, Chunxiao Xie, Mingzhi Xie, Enran Chen, Haixing Jiang, Shanyu Qin

“…The PANC‐1 and BxPC‐3 cell lines were used for functional assays, including cell proliferation, apoptosis, migration, and invasion assays. …”
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SAR1A Induces Cell Growth and Epithelial–Mesenchymal Transition Through the PI3K/AKT/mTOR Pathway in Head and Neck Squamous Cell Carcinoma: An In Vitro and In Vivo Study by Shizhen Fang, Jie Wang, Tianyi Liu, Yang Jiang, Qingquan Hua

“…Results: Univariate and multivariate Cox regression were conducted to screen SAR1A as a gene prognostic biomarker in HNSCC, and it was validated in the Cancer Genome Atlas (TCGA) database. Functional assays demonstrated that the depletion of SAR1A leads to suppressed proliferation, migration, and invasion of HNSCC cells. …”
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O-GlcNAcylation inhibition redirects the response of colon cancer cells to chemotherapy from senescence to apoptosis by Ingrid Loison, Adrien Pioger, Sonia Paget, Inès Metatla, OrgaRES Consortium, Audrey Vincent, Corinne Abbadie, Vanessa Dehennaut

“…HBP provides UDP-GlcNAc, the substrate for O-GlcNAc transferase (OGT), which catalyzes O-GlcNAcylation, a post-translational modification implicated in regulating numerous cellular functions and aberrantly elevated in CRC. In this study, we demonstrated, in the p53-proficient colon cancer cell lines HCT116 and LS174T, that TIS induced by low-dose SN38 or etoposide treatment was accompanied with a decrease of GFAT (the rate limiting enzyme of the HBP), OGT and O-GlcNAcase (OGA) expression correlated with a slight reduction in O-GlcNAcylation levels. …”
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Does Aspirin Increase Risk of Bleeding in Patients Undergoing Skin Lesion Excision: A Systematic Review and Meta-Analysis by Karl A. Romain, MB, BChir, MA, David Zargaran, MBBS, MBA, PhD, Alexander Zargaran, MBBS, BSc, MBA, Elena Whiteman, MB, ChB, MSc, Norman R. Williams, PhD, BSc, Stephen Hamilton, MB, ChB, MD, Afshin Mosahebi, MBBS, PhD, MBA

“…Cutaneous lesion excision is frequently performed for diagnosis and treatment of malignancies, as well as for aesthetic or functional benefits. We must balance the risk of bleeding against the risk of discontinuing aspirin. …”
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Utilization of universal-targeting mSA2 CAR-T cells for the treatment of glioblastoma by Alexandros Kourtesakis, Eileen Bailey, Hiu Nam Hannah Chow, Hannah Rohdjeß, Normann Mussnig, Dennis Alexander Agardy, Dirk Carsten Frieder Hoffmann, Yu-Chan Chih, Rainer Will, Leon Kaulen, Melissa Hahn, Robin Wagener, Denise Reibold, Sonja Pusch, Felix Sahm, Tim Sauer, Michael Schmitt, Lukas Bunse, Michael Platten, Wolfgang Wick, Tobias Kessler

“…In vitro, mSA2 CAR-T cells specifically recognized multiple primary GB cell lines in a target- and biotinylated antibody-dependent manner. …”
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Hypoxia-related Y RNA fragments as a novel potential biomarker for distinguishing metastatic oral melanoma from non-metastatic oral melanoma in dogs by MD Nazmul Hasan, MD Mahfuzur Rahman, Al Asmaul Husna, Daiki Kato, Takayuki Nakagawa, Mohammad Arif, Naoki Miura

“…However, further investigation is required to elucidate the biological functions of Y RNA under hypoxic conditions.…”
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Targeted Delivery of Bortezomib Using Retinoid-Based Nanoparticle: Modulating Liver Fibrosis through the TGF-β1/Smad3 Pathway by Samaneh Siapoush, Mohammad Rahmati, Morteza Milani, Behzad Hatami, Nosratollah Zarghami, Abbas Ebrahimi-Kalan, Mohammad Reza Zali, Kaveh Baghaei

“…Purpose: Hepatic stellate cells (HSCs) play a crucial role in fibrosis progression. we have developed a targeted delivery approach using A-functionalized nanoparticles for bortezomib (BTZ) specifically for activated HSCs in a mouse model of liver fibrosis. …”
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Plain radiograph evaluation of concurrent filling of tibial peg holes with bone in cementless total knee arthroplasty by Kazue Hayakawa, Hideki Date, Sho Nojiri, Yosuke Kaneko, Kohei Shibata, Nobuyuki Fujita

“…Knee Society Scores and Knee Society Functional Scores did not differ significantly between groups; however, the bone filling group had a significantly lower incidence of RLLs (p ​< ​0.05) and significantly more longitudinal trabecular thickening below the pegs (p ​< ​0.05). …”
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