Significance of Gelsolin Superfamily Genes in Diagnosis, Prognosis and Immune Microenvironment Regulation for Endometrial Cancer by Senwei Jiang, Minjuan Ye, Jing Wan, Qingjian Ye, Suli Qiu, Yuebo Yang, Xiaomao Li

“…In vitro studies showed that silencing CAPG and FLII could inhibit proliferation and metastasis in endometrial cancer cell lines. Conclusion These findings indicate the significant association of gelsolin superfamily members with prognosis and immunological status in endometrial cancer.…”
Get full text

Association of atrial fibrillation and atrial flutter with sick sinus syndrome: a review of the issue based on examples of clinical observations by O. Yu. Schmidt, D. Ye. Volkov, M. S. Brynza, К. H. Uvarova, D. Yu. Pavlova

“…Currently, radiofrequency ablation (RFA) is the first-line method in the treatment of patients with AF. …”
Get full text

Cooperation between Epstein-Barr virus immune evasion proteins spreads protection from CD8+ T cell recognition across all three phases of the lytic cycle. by Laura L Quinn, Jianmin Zuo, Rachel J M Abbott, Claire Shannon-Lowe, Rosemary J Tierney, Andrew D Hislop, Martin Rowe

“…Together, these data firstly indicate which potential immune-evasion functions are actually relevant in the context of lytic virus replication, and secondly identify lytic-cycle phase-specific effects that provide mechanistic insight into the immunodominance pattern seen for CD8+ T cell responses to EBV lytic antigens.…”
Get full text

SliC is a surface-displayed lipoprotein that is required for the anti-lysozyme strategy during Neisseria gonorrhoeae infection. by Ryszard A Zielke, Adriana Le Van, Benjamin I Baarda, Marco F Herrera, Christopher J Acosta, Ann E Jerse, Aleksandra E Sikora

“…Lysozymes are nearly omnipresent as the first line of immune defense against microbes in animals. …”
Get full text

BRAF regulates circPSD3/miR-526b/RAP2A axis to hinder papillary thyroid carcinoma progression by Chuang Li, Xiaojuan Zhao, Jingge Zhao, Jing Zhao, Lemei An, Gang Wu

“…Circular RNA PSD3 (circPSD3) is known to be highly expressed in PTC. However, the bio-functional role of circPSD3 and its possible relationship with the BRAF in PTC is not clear. …”
Get full text

ANALYSIS OF ACOUSTIC INFORMATION PROTECTION METHODS IN CRITICAL APPLICATIONS by Mykhailo Mozhaiev, Oleksandr Mozhaiev, Yurii Gnusov, Volodymyr Strukov, Petro Klimushin, Dmytro Yevstrat

“…The analysis of the functioning of the presented methods has led to the following conclusions. …”
Get full text

Illegal use of physical force and special means against prisoners: criminological characteristics and preventive measures by Alexander M. Smirnov

“…Measures taken to prevent the occurrence of negative phenomena in domestic politics can have a positive impact on improving the functioning of the penal correction system, which is in line with legal regulations of a national and international nature.…”
Get full text

A Successful Nodular Basal Cell Carcinoma Defect Closure On The Mid-Cheek Using Modified Mini Cheek Advancement Flap by Widjaya MRH, Koswara T

“…Mini-CAF offer the advantage as its ability to camouflage the excision line by utilising the natural creases of the face, thus resulting in an aesthetically and functionally favourable result.Keywords: basal cell carcinoma, defect closure, mini cheek advancement flap, nasojugal crease, palpebromalar crease…”
Get full text

Synthesis and Biological Evaluation of Herceptin-Conjugated Liposomes Loaded with Lipocalin-2 siRNA for the Treatment of Inflammatory Breast Cancer by Marienid Flores-Colón, Mariela Rivera-Serrano, Esther A. Peterson-Peguero, Pablo E. Vivas-Rivera, Fatima Valiyeva, Pablo E. Vivas-Mejía

“…However, resistance to Herceptin develops within a year, and effective second-line targeted therapies are currently unavailable for IBC patients. …”
Get full text

Emergency Medicine as a Medical Speciality in Nigeria: Challenges and Prospects by Wahab Yinusa

“…Our study revealed that inadequate funding and ambulance services, nonavailability of trained bystanders, limited infrastructure and skilled manpower, inadequate and inequitable distribution of health resources, lack of standard emergency department, high out-of-pocket expenses and substandard implementation of EMS policies, are factors militating against a functional EMS in the country. In line with the philosophy of WHA resolution72.16 of 2019, it is recommended that the central government should put in place a mechanism for full and sustainable implementation of the NHIA Act (2022), National Emergency Medical Services and Ambulance System (NEMSAS) and the patient’s bill of rights and direct the adoption of EM as a medical speciality in all federal and state hospitals. …”
Get full text

164 An algebra assessment and primer for future clinical and translational scientists entering training by Angie Mae Rodday, Vincent Costello, David M Kent, Joshua T Cohen

“…Results/Anticipated Results: We developed a 20-item quantitative assessment covering properties of operators; identity elements and inverses; simplification of arithmetic and algebraic expressions; solving algebraic equations; functions; equations of a line; and exponents/logarithms. …”
Get full text

UXT enhances melanoma proliferation, migration, and invasion through modulation of the P53 signaling pathway by Kaifen Xiong, Chong Wang, Bingqian Hu, Jianglin Zhang, Min Qi

“…We employed Western blotting, quantitative RT-PCR, immunohistochemistry, CCK-8 assays, colony formation, flow cytometry, wound healing, and invasion assays to explore these functions. Results indicate that UXT is aberrantly upregulated in melanoma cell lines. …”
Get full text

SEMA3A, a gene involved in axonal pathfinding, is mutated in patients with Kallmann syndrome. by Naresh Kumar Hanchate, Paolo Giacobini, Pierre Lhuillier, Jyoti Parkash, Cécile Espy, Corinne Fouveaut, Chrystel Leroy, Stéphanie Baron, Céline Campagne, Charlotte Vanacker, Francis Collier, Corinne Cruaud, Vincent Meyer, Alfons García-Piñero, Didier Dewailly, Christine Cortet-Rudelli, Ksenija Gersak, Chantal Metz, Gérard Chabrier, Michel Pugeat, Jacques Young, Jean-Pierre Hardelin, Vincent Prevot, Catherine Dodé

“…Here, we report that Nrp1(sema/sema) mutant mice that lack a functional semaphorin-binding domain in neuropilin-1, an obligatory coreceptor of semaphorin-3A, have a KS-like phenotype. …”
Get full text

MiR-181a-driven downregulation of cholesterol biosynthesis through SREBP2 inhibition suppresses uveal melanoma metastasis by Rui Wang, Claudia Gilbert, Houda Tahiri, Chun Yang, Solange Landreville, Pierre Hardy

“…Functional assays, including migration, invasion, and cancer stem-like cell (CSC) formation, were performed. …”
Get full text

Stage-specific inhibition of MHC class I presentation by the Epstein-Barr virus BNLF2a protein during virus lytic cycle. by Nathan P Croft, Claire Shannon-Lowe, Andrew I Bell, Daniëlle Horst, Elisabeth Kremmer, Maaike E Ressing, Emmanuel J H J Wiertz, Jaap M Middeldorp, Martin Rowe, Alan B Rickinson, Andrew D Hislop

“…We have recently identified an immune evasion protein encoded by EBV, BNLF2a, which is expressed in early phase lytic replication and inhibits peptide- and ATP-binding functions of the transporter associated with antigen processing. …”
Get full text

Soluble human macrophage factors are able to inhibit TGF-β-induced differentiation of lung fibroblasts by A. A. Maksimova, E. Ya. Shevela, L. V. Sakhno

“…Some studies have shown the antifibrotic effect of macrophages on dermal fibroblasts, but the effect of macrophages on the lung fibroblast functions remains unexplored. Therefore, the purpose of this study was to examine the influence of conditioned media of human macrophage differentiated by M-CSF/GM-CSF and further dexamethasone polarized/unpolarized on the TGF-β-induced lung fibroblast differentiation. …”
Get full text

Roles of ACSL4/GPX4 and FSP1 in oxalate-induced acute kidney injury by Keng Ye, Ruilong Lan, Zhimin Chen, Kunmei Lai, Yankun Song, Guoping Li, Huabin Ma, Hong Chen, Yanfang Xu

“…Furthermore, renal tubule-specific deficiency of Acsl4 conferred significant protection against oxalate-induced AKI, as evidenced by alleviated structural and functional renal damage, reduced oxidative stress and decreased inflammatory cell infiltration, all of which collectively contribute to a reduction in ferroptosis. …”
Get full text

Synthesizing hybrid copper phosphate (Cu3(PO4)2) nanoflowers using Cu+2 and shed snakeskin: antioxidant, antibacterial, anticancer, guaiacol, anionic, and cationic dye degradation... by Cagri Caglar Sinmez, Fatih Doğan Koca

“…The use of bio-extracts containing these functional groups instead of expensive organic inputs such as DNA, enzymes, and protein creates advantages in terms of cost and applicability. …”
Get full text

Risk Assessment Model for Metro Station Stair and Escalator Operation Systems Based on Bayesian Network by HOU Xiangyu, HU Hua, FANG Yong, MENG Yanli, HAO Yanxi, LIU Zhigang

“…[Method] The SEO system is divided into two subsystems—stairs and escalators—and three functional units: buffering, walking, and dispersing. …”
Get full text

Immunotropic Effect of Bursal Peptides on Mice with Experimental Immunodeficiency by Natalia A. Kolberg, Natalia V. Tikhonova, Sergei L. Tikhonov, Svetlana A. Leontieva, Irina Yu. Sergeeva

“…The article offers a new technology for obtaining peptides with a pronounced immunotropic effect that can be used in functional food production.…”
Get full text