Large-scale screening of HIV-1 T-cell epitopes restricted by 12 prevalent HLA-A allotypes in Northeast Asia and universal detection of HIV-1-specific CD8+ T cells by Yan Ding, Jialai Yan, Ling Huang, Jinhong Yu, Yandan Wu, Chuanlai Shen, Anning Fang

“…BackgroundAlthough the immune response of host T cells to human immunodeficiency virus (HIV) significantly influences the progression of the infection, the development of T-cell-based vaccines and therapies, as well as the clinical evaluation of specific T-cell functions, is currently markedly hindered by the absence of broad-spectrum, functionally validated HIV T-cell epitopes that account for the polymorphisms of the human leukocyte antigen (HLA) within an indicated geographic population. …”
Get full text

Integration of single-cell sequencing and drug sensitivity profiling reveals an 11-gene prognostic model for liver cancer by Qunfang Zhou, Jingqiang Wu, Jiaxin Bei, Zixuan Zhai, Xiuzhen Chen, Wei Liang, Jing Meng, Mingyu Liu

“…We constructed and validated a LASSO model based on these genes in both sets and two external datasets. Functional, immune infiltration, and mutation analyses were performed on high and low-risk groups. …”
Get full text

The effect of 1,25(OH)2D3 on Dickkopf-1 methylation in colorectal cancer by Hongyan Sun, Liehao Yang, Nan Li, Yue Hu, Qianying Hu, Zilong Zhou, Xianling Cong

“…The dual-luciferase reporter assay further confirmed that CpG island methylation (-120 to + 225) directly represses DKK1 transcription. Conclusion DKK1 functions as a tumour suppressor in colorectal cancer, and 1,25(OH)2D3 upregulates DKK1 expression by inducing demethylation of the DKK1 promoter and 5’UTR in specific colorectal cancer cell lines.…”
Get full text

Temporally resolved single-cell RNA sequencing reveals protective and pathological responses during herpes simplex virus CNS infection by Xiangning Ding, Xin Lai, Ida H. Klaestrup, Sara R. N. Jensen, Morten M. Nielsen, Kasper Thorsen, Marina Romero-Ramos, Yonglun Luo, Lin Lin, Line S. Reinert, Søren R. Paludan

Get full text

A novel thiazole-sulfonamide hybrid molecule as a promising dual tubulin/carbonic anhydrase IX inhibitor with anticancer activity by Hussam Elddin Nabeih Khasawneh, Elryah I. Ali, Ranya Mohammed Elmagzoub, Raed Fanoukh Aboqader Al-Aouadi, Wesam Taher Almagharbeh, Ghallab Alotaibi, Stefan Bräse, Abdullah Alkhammash

Get full text

Viral evolution sustains a dengue outbreak of enhanced severity by Catherine Inizan, Marine Minier, Matthieu Prot, Olivia O’Connor, Carole Forfait, Sylvie Laumond, Ingrid Marois, Antoine Biron, Ann-Claire Gourinat, Marie-Amélie Goujart, Elodie Descloux, Anavaj Sakuntabhai, Arnaud Tarantola, Etienne Simon-Lorière, Myrielle Dupont-Rouzeyrol

Get full text

Relationship between Interleukin-6 gene polymorphism and hippocampal volume in antipsychotic-naïve schizophrenia: evidence for differential susceptibility? by Sunil Vasu Kalmady, Ganesan Venkatasubramanian, Venkataram Shivakumar, S Gautham, Aditi Subramaniam, Dania Alphonse Jose, Arindam Maitra, Vasanthapuram Ravi, Bangalore N Gangadhar

“…<h4>Background</h4>Various lines of evidence including epidemiological, genetic and foetal pathogenetic models suggest a compelling role for Interleukin-6 (IL-6) in the pathogenesis of schizophrenia. …”
Get full text

The Impact of Mass-dependent Stochasticity at Cosmic Dawn by Viola Gelli, Charlotte Mason, Christopher C. Hayward

“…Since low-mass halos are more dominant in the early universe, this model naturally predicts an increase in UV luminosity functions (LFs) at high redshifts compared to models without scatter. …”
Get full text

Targeting the FOXA1/BMI1 axis to overcome chemoresistance and suppress tumor progression in nasopharyngeal carcinoma by Yaping Qin, Mingqing Yang, Yunzhu Cao, Yue Fu, Fan Yang, Xiaoling Zhang, Shengjun Xiao

“…Functional assays demonstrated that the silencing of FOXA1 significantly enhanced the proliferation, migration, and invasive capabilities of NPC cells in vitro. …”
Get full text

SPOCK1 promotes the progression of breast cancer by modulating cancer-associated fibroblasts and exerts a synergistic effect with ANXA2 by Yuan Jie, Xin Fei, Meng Fan

“…Bulk RNA sequencing and single-cell RNA sequencing (scRNA-seq) analyses were conducted, including functional enrichment, immune infiltration assessments, mutation profiling, and transcription factor activity analysis. …”
Get full text

Exploring research capacity and capability in a local authority: qualitative insights from leaders and staff by James Woodall, Chloe Bracewell, Andrew Passey, Samantha Start, Jane South

“…Conversely, some departments were engaged in front-line service delivery where research was not prioritised. …”
Get full text

DENTAL IMPLANTATION AS A METHOD OF OPTIMIZING TREATMENT OF PATIENTS WITH COMPLETE DENTAL TEETH by O.V. Dobrovolskaya

“…The review and analysis of scientific-medical literature of 2013-2019 years was conducted, according to the databases Scopus, Web of Science, Med Line, The Cochrane Library, EMBASE, Global Health, CyberLeninka, RINC. …”
Get full text

Ternary amorphous oxide semiconductor of In–Ga–O system for three-dimensional integrated device application by Takanori Takahashi, Mutsunori Uenuma, Masaharu Kobayashi, Yukiharu Uraoka

“…In2O3-based oxide semiconductors are potential materials for supporting the development of next-generation integrated devices with low power consumption, such as back-end-of-line-compatible transistors and ferroelectric memories. …”
Get full text

Gene network inference and biochemical assessment delineates GPCR pathways and CREB targets in small intestinal neuroendocrine neoplasia. by Ignat Drozdov, Bernhard Svejda, Bjorn I Gustafsson, Shrikant Mane, Roswitha Pfragner, Mark Kidd, Irvin M Modlin

“…The network was confirmed to be non-random, scale-free, and highly modular. Functional analysis of gene co-expression modules revealed processes including 'Nervous system development', 'Immune response', and 'Cell-cycle'. …”
Get full text

Human Mesenchymal Stem Cells Derived from the Placenta and Chorion Suppress the Proliferation while Enhancing the Migration of Human Breast Cancer Cells by Sarawut Sirithammajak, Sirikul Manochantr, Chairat Tantrawatpan, Duangrat Tantikanlayaporn, Pakpoom Kheolamai

“…Furthermore, hMSCs from both sources also increased the expression levels of MYC, SNAI1, and TWIST, which promote the epithelial-mesenchymal transition and migration of breast cancer cells in both cell lines. The functional study suggests that the suppressive effect of CH-hMSCs and PL-hMSCs on MCF-7 and MDA-MB231 cell proliferation was mediated, at least in part, through IFN-γ. …”
Get full text

TGM2, HMGA2, FXYD3, and LGALS4 genes as biomarkers in acquired oxaliplatin resistance of human colorectal cancer: A systems biology approach. by Tayebeh Cheraghi-Shavi, Razieh Jalal, Zarrin Minuchehr

“…In the next procedure, two in vitro oxaliplatin-resistant sub-lines including HCT116/OX-R4.3 and HCT116/OX-R10 cells with OX-IR 3.93 and 10.06 were established, respectively. …”
Get full text

Influence of weather conditions on the yield and quality of spring wheat grain in the forest-steppe of the Middle Volga region by I. F. Demina

“…The content of protein and gluten in the grain were almost functionally dependent on each other – r = 0.945±0.055. …”
Get full text

Endotoxemia in immunotherapy with dendritic cell vaccine in patients with advanced cervical cancer by I. A. Goroshinskaya, A. P. Menshenina, E. M. Frantsiyants, I. V. Kaplieva, T. I. Moiseenko, E. V. Verenikina, L. A. Nemashkalova

“…CI in patients of groups 2 and 3 decreased after each DCV session. 4 and more DCVs restored the functional activity of albumin and normalized the MWM content.Conclusion. …”
Get full text

COMPUTATIONAL AND EXPERIMENTAL EVALUATION OF TECHNICAL CHARACTERISTICS OF TRUCKS TIRES by Z. A. Godzhaev, S. V. Goncharenko, D. Kh. Valeev, V. S. Karabtsev

“…In modern mechanical engineering polyamide and kapron cords for tires of line-haul trucks and buses are replaced with all-metal ones (AMC) even more often. …”
Get full text

Empirical Analysis of Vulnerabilities in Blockchain-based Smart Contracts by Dr. Kashif Mehboob Khan, Ansha Zahid

“…The Ethereum network’s computing capabilities and functionalities are founded on the basis of SC. A smart contract is a self-executing agreement between buyer and seller with the terms of the settlement between them, written directly as lines of code, existing across a distributed decentralized blockchain network. …”
Get full text