Endoplasmic reticulum-localized circular RNA FAM13B restrains nasopharyngeal carcinoma lymphatic metastasis through downregulating XBP1 by Guo-Dong Jia, Si-Yi Xie, Xiao-Yun Li, Liang-Ji Li, Jing Jin, Li-Ting Liu, Xue-Song Sun, Sai-Lan Liu, Qiu-Yan Chen, Lin-Quan Tang, Li Yuan, Hai-Qiang Mai

“…Functional experiments, including cell invasion, migration, and metastasis assays, were performed in vitro and in vivo. …”
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Effect of sacha inchi oil (Plukenetia volubilis) on productive performance, egg quality and blood biochemistry of laying hens by Segundo J. Zamora, Miguel A. Arista, Paul A. Fernández, Loidy Valle, Hugo Frias, Elías Salvador-Tasayco, Yoany D. Leiva, Nilton L. Murga, Ives Yoplac, William Bardales, José Américo Saucedo-Uriarte

“…This could serve as an efficient strategy to improve animal health and produce functional eggs for consumers.…”
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SOX3 facilitates granulosa cell proliferation and suppresses cell apoptosis through modulating PI3K/AKT pathway by targeting SPP1 by Rui Cai, Cong Li, Wenhui Shi, Fenfen Xie, Mengmeng Fan, Hao Zhang, Zhuang Liu, Yuanhua Chen, Qiang Hong

“…Abstract Folliculogenesis is a crucial process for production functional female gametes in mammals. The imbalance of apoptosis and proliferation of ovarian granulosa cells has been identified as an important cause for abnormal folliculogenesis. …”
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Proteasome inhibition overcomes resistance to targeted therapies in B-cell malignancy models and in an index patient by Johanne U. Hermansen, Paschalis Athanasiadis, Yanping Yin, Anne-Sofie F. Rise, Alberto J. Arribas, Luciano Cascione, Hege G. Russnes, Åslaug Helland, Anthony R. Mato, Francesco Bertoni, Geir E. Tjønnfjord, Tero Aittokallio, Sigrid S. Skånland

“…Abstract Treatment of B-cell malignancies with the PI3K inhibitor (PI3Ki) idelalisib often results in high toxicity and resistance, with limited treatment alternatives for relapsed/refractory patients since idelalisib is recommended as a later or last line therapy. To investigate resistance mechanisms and identify alternative treatments, we studied functional phenotypes of idelalisib-resistant B-cell malignancy models. …”
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Trauma-Informed Care as a Promising Avenue for Supporting the Transition to Adulthood Among Trauma-Exposed Youth: A Scoping Review by Alexandra Matte-Landry, Annabelle Lemire-Harvey, Amélie de Serres-Lafontaine, Vanessa Fournier

“…Background/Objectives: Childhood trauma has a documented impact on development, and may also affect functioning and well-being in transition-age youth (TAY). …”
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Targeting Sodium Transport Reveals CHP1 Downregulation as a Novel Molecular Feature of Malignant Progression in Clear Cell Renal Cell Carcinoma: Insights from Integrated Multi-Omic... by Yun Wu, Ri-Ting Zhu, Jia-Ru Chen, Xiao-Min Liu, Guo-Liang Huang, Jin-Cheng Zeng, Hong-Bing Yu, Xin Liu, Cui-Fang Han

“…Functional analyses, including pseudotime trajectory, Mfuzz clustering, and cell–cell communication modeling, indicated that CHP1⁺ epithelial cells engage in immune interaction via PPIA–BSG signaling. …”
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Integrated Transcriptomic and Metabolomic Analyses Reveal the Importance of the Terpenoid, Fatty Acid, and Flavonoid Pathways in Rice Cell Death and Defense by Pengfei Bai, Yanfang Liu, Laisa Gomes-Dias, Rachel Combs-Giroir, Shaoxing Dai, Naeyeoung Choi, Yun Lin, Matthew Bernier, Emmanuel Hatzakis, Guo-Liang Wang, Joshua J. Blakeslee

“…This study provides an overall landscape of the transcriptomic and metabolomic alterations in a lesion mimic mutant, identifying candidate defense-related genes and metabolites for functional analysis in rice.…”
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Drosophila Toxicogenomics: genetic variation and sexual dimorphism in susceptibility to 4-Methylimidazole by Katelynne M. Collins, Elisabeth Howansky, Sarah C. Macon-Foley, Maria E. Adonay, Vijay Shankar, Richard F. Lyman, Nestor Octavio Nazario-Yepiz, Jordyn K. Brooks, Rachel A. Lyman, Trudy F. C. Mackay, Robert R. H. Anholt

“…Results We screened 204 DGRP lines for survival following 24-hour exposure to 4-methylimidazole. …”
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Development trend of primary healthcare after health reform in China: a longitudinal observational study by Hui Li, Jie Feng, Zuxun Lu, Yanhong Gong, Xuan Zhou, Guopeng Zhang, Xiaoxv Yin, Jianxiong Wu

“…However, compared with the indicators in 2009, excepting that the proportion of grants from the government in the whole health system has an upward trend, the proportions of other indicators had an escalating trend in 2018 by 3.66% for practicing (assistant) physicians, by 2.69% for nurses, by 3.99% for total revenues, by 5.87% for beds, by 8.39% for outpatient visits.Conclusion The primary healthcare system has developed rapidly, but its development speed lagged behind the entire health system, resulting in the weakening of its actual functions, which is not in line with the goal of health reform. …”
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The EGR1-mediated lncRNA TENM3-AS1 potentiates gastric cancer metastasis via reprogramming fatty acid metabolism by Yuhui Tang, Baiwei Zhao, Wanchuan Wang, Haoming Chen, Junsheng Zhang, Yi Xie, Yongming Chen, Feizhi Lin, Yuanfang Li, Xiaohui Zhai, Wen Zhou

“…RT-qPCR and FISH analyses revealed an increased expression of TENM3-AS1 in GC cell lines and patients. In vitro and in vivo functional experiments validated the effects of TENM3-AS1 to GC metastasis and the reprogramming of FA metabolism. …”
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SMYD2 epigenetically activates BMP4/SMAD1/5/8/ID3 axis to enhance cancer stem cell properties and drive sorafenib resistance in hepatocellular carcinoma by Shanshan Wang, Weicheng Wu, Zhen Shi, Mei Bin, Fengwei Zhang, Long Cai, Kaiqing Lin, Zhihui Li

“…To investigate the biological functions of SMYD2, we conducted a series of functional assays in vitro and in vivo. …”
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Increased antitumor efficacy of PD-1-deficient melanoma-specific human lymphocytes by Nathalie Labarrière, Lucine Marotte, Sylvain Simon, Virginie Vignard, Emilie Dupre, Malika Gantier, Jonathan Cruard, Jean-Baptiste Alberge, Melanie Hussong, Cecile Deleine, Jean-Marie Heslan, Jonathan Shaffer, Tiffany Beauvais, Joelle Gaschet, Emmanuel Scotet, Delphine Fradin, Anne Jarry, Tuan Nguyen

“…Extensive characterization of a panel of T cell clones expressing the same TCR and exhibiting similar functional avidity demonstrated superior antitumor reactivity against a PD-L1 expressing melanoma cell line. …”
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The human RNASET2 alarmin-like molecule differentially affects prostate cancer cells behavior in both cell autonomous and non-cell autonomous manners by Rossella Roncoroni, Denisa Baci, Martina Cucchiara, Annarosaria de Vito, Matteo Gallazzi, Maria Teresa Palano, Francesca Olmeo, Cristian Rubuano, Alessandra Giannatiempo, Laura Monti, Raffaella Bombelli, Daniele Mercatelli, Giovanna Finzi, Francesca Franzi, Stefano La Rosa, Douglas M. Noonan, Barbara Bassani, Lorenzo Mortara, Antonino Bruno, Francesco Acquati

“…The human RNASET2 protein has demonstrated both oncosuppressive and immunoregulatory functions across various cancer types, yet its role as an oncosuppressor or alarmin-like molecule in prostate cancer (PCa) is unexplored. …”
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Ginger extract inhibits c-MET activation and suppresses osteosarcoma in vitro and in vivo by Ruoping Yanzhang, Mingyang Yan, Zhaojie Yang, Huijun Zhang, Yin Yu, Xiangping Li, Ruifang Shen, Xiao Chu, Siyuan Han, Ziliang Zhang, Junyan Teng, Hao Li, Tao Li, Guoguo Jin, Zhiping Guo

“…Immunohistochemistry (IHC) staining corroborated the c-MET expression level among OS tissues relative to the controls. Functional studies involving c-MET knockdown among OS cell lines were produced to elucidate the functional role of c-MET in OS cellular processes. …”
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Pan-cancer analysis identifies CD155 as a promising target for CAR-T cell therapy by Xiaohong Liu, Yue Sun, Boxu Lin, Hao Xiong, Xinyue Lu, Binghe Tan, Chenglin Zhang, Mingyao Liu, Juliang Qin, Na Zhang, Bing Du

“…Furthermore, CD155 expression is also significantly increased in granulocytes derived from cancer patients compared to those from healthy donors. Functionally, high CD155 expression significantly inhibits the release of cytotoxic factors from T cells, thereby functioning as an immune checkpoint that mediates tumor immune evasion. …”
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Comprehensive Analysis Reveals the Potential Diagnostic Value of Biomarkers Associated With Aging and Circadian Rhythm in Knee Osteoarthritis by Hao Li, Yuze Yang, Bo Li, Jiaju Yang, Pengyu Liu, Yuanpeng Gao, Min Zhang, Guangzhi Ning

“…Additionally, the findings and functional roles of the biomarkers were further validated through experiments on human cartilage tissue and cell models. …”
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tRNA-derived small RNA 3’ tRF-Ala CGC obstructs NK cytotoxicity via cleavage of membrane protein MICA in colorectal cancer by Jing Zhang, Chunlin Ou, Xin Li, Li Fu, Qizhi Luo, Jie Wang, Yizhou Zou

“…These tsRNAs exhibit diverse biological functions, including immune modulation, metabolic disorders, and cell death. …”
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THE FEATURES OF THE FACE SKIN CONSTRUCTION THAT INFLUENCE ON THE FORMATION OF CICATRICAL TISSUES DURING SUGICAL INTERVENTIONS by K.P. Lokes, D.S. Avetikov, S.O. Stavitsky, O.O. Rozkolupa, N.S. Lutsenko

“…The overwhelming reduction of tension and accordingly the improvement of reparative processes in the skin occur when the incision lines correspond to the so-called "golden spiral". …”
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STATIC OF ORTHODONTIC APPLIANCES WITH MOVABLE INCLINED PLANE FOR MESIAL BATE TREATMENT by P.S. Flis, A.I. Hryhorenko, N.M. Doroshenko, M.M. Tormakhov, V.V. Filonenko

“…Mechanics and mathematical modeling of functionally directing appliance with a movable inclined plane static work for improving sagittal dentoalveolar anomalies and deformations treatment methods. …”
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LINC02888 promotes HGSOC progression and immune evasion via PPIB-mediated stabilization of LAPTM5 mRNA and inhibition of RIG-I-like receptor signaling by BingJie Rui, YanFeng Yang, DanBo Geng, ZiTeng Kuang, TianLi Mu, YuXi Liu, Bo Ren, RunZe He, XiaoWei Zhang, YuCi Zhang, Min Wang

“…Functional assays including CCK-8, EdU, colony formation, wound healing, Transwell migration/invasion, and flow cytometry were performed after modulating LINC02888 expression. …”
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