Development of an Efficient and Generalized MTSCAM Model to Predict Liquid Chromatography Retention Times of Organic Compounds by Mengdie Fan, Chenhui Sang, Hua Li, Yue Wei, Bin Zhang, Yang Xing, Jing Zhang, Jie Yin, Wei An, Bing Shao

“…Next, an innovative classification system was implemented, classifying 10,905 compounds into a 3-tier hierarchy across 141 classes, based on functional group weighting. Then, data augmentation was performed within each category using simplified molecular input line entry system (SMILES) enumeration combined with structural similarity expansion. …”
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The Influence of Surface Binding Energy on Sputtering in Models of the Sodium Exosphere of Mercury by Rosemary M. Killen, Liam S. Morrissey, Matthew H. Burger, Ronald J. Vervack Jr., Orenthal J. Tucker, Daniel W. Savin

“…We describe the corresponding exosphere source functions for ion sputtering (IS), as well as for the previously studied processes of micrometeoroid impact vaporization and photon-stimulated desorption (PSD), along with their release energy distributions and spatial distributions. …”
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Revealing the Principle of Progressively Enhanced Photocatalytic Reactivity in Dual Single‐Atoms‐Mediated Electronic Interactions Optimization of Cd/Te‐TiO2 by Yihang Zhang, Hao Zhao, Shan Jiang, Yanrong Zhang, Yong Chen, Jianyu Gong

“…In essence, the free energy barriers of the benzene intermediates ring‐opening as the rate‐determining step appeared to significantly diminish tendency from 1.10 to 0.96 eV, in line with the ICOHP calculation of Cd/Te─O bonds in TS promoted from −2.43 to −3.49 eV. …”
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Teucrium polium L.: A natural source of antioxidants and a potential UV protector. by Sarra Lamari, Ahmed Dekak, Sameh Boukhedir, Chawki Bensouici, Tarek Hamel, Imededdine Kadi

“…In this study, we evaluated the total phenolic content (TPC) and biological activities of three extracts derived from its aerial parts: methanolic (MeOH), dichloromethane (DCM), and petroleum ether (EDP) extracts. The functional groups of these extracts were characterised using UV-VIS-NIR spectroscopy. …”
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Here and there: the double-side transgene localization by P. A. Salnikov, A. A. Khabarova, G. S. Koksharova, R. V. Mungalov, P. S. Belokopytova, I. E. Pristyazhnuk, A. R. Nurislamov, P. Somatich, M. M. Gridina, V. S. Fishman

“…These techniques have already been used for functional gene annotation by transposon-insertion sequencing, for identification of transcription factor binding sites and regulatory sequences, and for dissecting chromatin position effects. …”
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Exploring fatty acids from royal jelly as a source of histone deacetylase inhibitors: from the hive to applications in human well-being and health by Fernanda Aparecida dos Santos France, Debora Kazumi Maeda, Ana Beatriz Rodrigues, Mai Ono, Franciele Lopes Nogueira Marchetti, Marcos Martins Marchetti, Allana Cristina Faustino Martins, Roberto da Silva Gomes, Cláudia Aparecida Rainho

“…Biochemical assays and gene expression analyses (Reverse Transcriptase – quantitative Polymerase Chain Reaction) were performed to evaluate the functional effects of the major RJ fatty acids, 10-HDA and 10-HDAA (10-hydroxy-decanoic acid), in two human cancer cell lines (HCT116 and MDA-MB-231). …”
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Loss of cadherin 17 downregulates LGR5 expression, stem cell properties and drug resistance in metastatic colorectal cancer cells by Ruben A. Bartolomé, Laura Pintado-Berninches, Javier Robles, Tania Calvo-López, Issam Boukich, Pablo Otero-Núñez, Jose Manuel Gonzalez-Sancho, J. Ignacio Casal

“…To further elucidate the molecular mechanisms involving CDH17 functions in CRC, we examined global expression alterations following CDH17 silencing in various metastatic cell lines. …”
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The LncRNA lnc-POTEM-4:14 promotes HCC progression by interacting with FOXK1 by Bo Peng, Zhipeng Quan, Lixing Liang, Mingjiang Liu, Kai Hu, Shilian Chen, Qiuli Xie, Jing Qin, Jingzhao Chen, Lijuan Liao, Songqing He, Zeyuan Li

“…We established lnc-POTEM-4:14 knockdown and overexpression cell lines to analyse the role of lnc-POTEM-4:14 in liver cancer through functional experiments such as qPCR and WB. …”
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Ev charging management in a real-time optimization framework considering operational constraints by Hilmi Cihan Güldorum, Ayşe Kübra Erenoğlu, İbrahim Şengör, Barry P. Hayes, Ozan Erdinç

“…The model compares three widely adopted objective functions: minimization of active power loss, charging cost, and uncontrolled charging impact, which is represented by minimizing the total charging time. …”
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Three Decades of Managing Pediatric Obstructive Sleep Apnea Syndrome: What’s Old, What’s New by Beatrice Panetti, Claudia Federico, Giuseppe Francesco Sferrazza Papa, Paola Di Filippo, Armando Di Ludovico, Sabrina Di Pillo, Francesco Chiarelli, Alessandra Scaparrotta, Marina Attanasi

“…Personalized treatment plans based on anatomical, functional, and developmental characteristics are essential to optimize outcomes. …”
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VEMURAFENIB IN TREATMENT OF MELANOMA WITH BRAIN METASTASES by D. R. Naskhletashvili, V. A. Gorbunova, A. Kh. Bekyashev, L. V. Demidov, G. Yu. Kharkevich, S. M. Banov, I. V. Samoylenko, K. А. Baryshnikov, K. V. Orlova, I. А. Utyashev, N. N. Petenko, I. G. Markina, E. A. Moskvina, S. V. Medvedev

“…Over the last few years we have enhanced our understanding of brain metastasis mechanisms, principles of blood-brain barrier functioning, and  ways  of  cancer  drugs penetration into  the  central  nervous system.  …”
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Antitumor effects of natural killer cells derived from gene-engineered human-induced pluripotent stem cells on hepatocellular carcinoma by Mayuna Nakamura, Yuka Tanaka, Keishi Hakoda, Masahiro Ohira, Tsuyoshi Kobayashi, Kenji Kurachi, Kouichi Tamura, Hideki Ohdan

“…Our data suggest that eNK cells, whose functions have been enhanced by genetic engineering, have the potential to improve HCC treatment.…”
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Comparative study on the pyrolysis characteristics and gaseous release behavior of different reconstituted tobacco cut stem in processing by Miao Liang, Jiahui Zhang, Baozhi Li, Qi Fu, Yaning Hu, Zhaohui Ren, Ruili Li, Chengzhe Cui, Junsong Zhang

“…FTIR and SEM characterization indicated the surface functional groups and microstructure of RTCS samples experienced varying degrees of change during the extraction and backfilling process. …”
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Enhanced anti-tumor activity by zinc finger repressor-driven epigenetic silencing of immune checkpoints and TGFBR2 in CAR-T cells and TILs by Marion David, Phillip Schiele, Davide Monteferrario, Gaëlle Saviane, Angélique E. Martelli, Coralie F. Dupont, Caroline Jeanneau, Irène Marchetti, Satish K. Tadi, Julia Vahldick, Lynn N. Truong, Yuanyue Zhou, Igor M. Sauer, Wenzel Schöning, Il-Kang Na, Andreas Reik, Marco Frentsch, Maurus de la Rosa, David Fenard

“…PD-1 repression did not affect T cell viability, proliferation, or functionality. In a murine B cell lymphoma model, PD-1-repressed CD19-CAR-T cells exhibited enhanced anti-tumor activity and improved survival. …”
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CCT8 drives colorectal cancer progression via the RPL4-MDM2-p53 axis and immune modulation by Yangyang Teng, Hao Lin, Zijian Lin, Xichen Li, Yejiao Ruan, Binhui Pan, Jinlin Ge, Yuesheng Zhu, Daopo Lin, Qingji Ying, Zhenzhai Cai, Xuanping Xia

“…Immunohistochemistry was performed to examine CCT8 distribution in CRC tissues and adjacent non-tumor tissues. Functional assays, including CCK-8, transwell, wound-healing, and flow cytometry, were conducted using DLD-1 and HCT116 cell lines to assess the effects of CCT8 on cell proliferation, migration, invasion, and apoptosis. …”
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YAP‐TEAD inhibition is associated with upregulation of an androgen receptor mediated transcription program providing therapeutic escape by Roberto Alva‐Ruiz, Ryan D. Watkins, Jennifer L. Tomlinson, Jennifer A. Yonkus, Amro M. Abdelrahman, Caitlin B. Conboy, Erik Jessen, Nathan W. Werneburg, Hendrien Kuipers, Jack W. Sample, Gregory J. Gores, Sumera I. Ilyas, Mark J. Truty, Rory L. Smoot

“…Utilizing CCA, gastric cancer cell lines, and patient‐derived xenograft models (PDX), we demonstrate that CA3 is effective in inducing cell death and delaying tumor growth in both FGFR2 fusion and wild‐type models. …”
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Angpt2/Tie2 autostimulatory loop controls tumorigenesis by Ninelia Minaskan Karabid, Tobias Wiedemann, Sebastian Gulde, Hermine Mohr, Renu Chandra Segaran, Julia Geppert, Maria Rohm, Giovanni Vitale, Germano Gaudenzi, Alessandra Dicitore, Donna Pauler Ankerst, Yiyao Chen, Rickmer Braren, Georg Kaissis, Franz Schilling, Mathias Schillmaier, Graeme Eisenhofer, Stephan Herzig, Federico Roncaroli, Jürgen B Honegger, Natalia S Pellegata

“…We show that PitNET cells express a functional TIE2 receptor and secrete bioactive ANGPT2, which promotes, besides angiogenesis, tumor cell growth in an autocrine and paracrine fashion. …”
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Nutritional management for late complications of radiotherapy by Jiahua lyu, Yue Su, Hansong Bai, Hao Kuang, Churong Li, Xiumei Zheng, Long Liang, Lu li, Diou Cheng, Tao Li

“…The management of post-radiation trismus remains challenging, with functional training, including active jaw exercises, passive motor devices, and splints, being the primary interventions. …”
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The Spodoptera frugiperda L-aminoacylase degrades fatty acid-amino acid conjugates and promotes larvae growth on Zea mays by Bin Li, Mei Luo, Xiaofeng Liu, Wangpeng Shi, Jinfeng Qi, Shaoqun Zhou, Guirong Wang

“…Abstract Oral secretions (OS) contain diverse functional molecules that play important roles in the molecular interactions between insect herbivores and their host plants. …”
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Resolving Turbulence Drivers in Two Luminous Obscured Quasars with JWST/NIRSpec Integral Field Unit by Mandy C. Chen, Hsiao-Wen Chen, Michael Rauch, Andrey Vayner, Weizhe Liu, David S. N. Rupke, Jenny E. Greene, Nadia L. Zakamska, Dominika Wylezalek, Guilin Liu, Sylvain Veilleux, Nicole P. H. Nesvadba, Caroline Bertemes

“…Utilizing high-resolution data from the NIRSpec integral field unit onboard the James Webb Space Telescope, we analyze the velocity fields of line-emitting gas in and around these quasars and construct the second-order velocity structure functions (VSFs) to quantify turbulent motions across different spatial scales. …”
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