PCK1 and SLC22A2 gene variants associated with response to metformin treatment in type 2 diabetes. by Sophie St-Amour, Laurence Tessier, Janie Harnois, Catherine Allard, Alexandre Lavoie, Philippe Caron, Luigi Bouchard, Patrice Perron, Karine Tremblay

“…Additional genetic and functional studies are necessary to elucidate the variants' impact in metformin's pharmacological mechanisms.…”
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The Impact of Geometric Shapes on Modern European Sculpture "An Analytical Study" by Naseer Abdul Karim Abboud

“…A lot of artistic movements appeared, especially in the twentieth century, and the content of these movements was purely geometric, plastic, looking for everything new and unique in the modern era, and starting to use these geometric shapes in the plastic arts and searching for art that is not devoid of the functional side and in line with that policy as well. …”
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Mathematical simulation of railway track and trackside contamination with silt by V. M. Belkov, M. A. Zhuravlyova

“…Transportation of ores suggests partial entrainment of dust particles from the top granular layer 10 - 15 cm thick; electrified lines add dust-like particles of copper contact wires, which turn to a fixed form as hydroxides. …”
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High-temperature terahertz quantum-cascade lasers: design optimization and experimental results by D. V. Ushakov, A. A. Afonenko, I. A. Glinskiy, R. A. Khabibullin

“…To calculate electron transport in THz QCLs, we used a system of balance equations based on wave functions with reduced dipole moments of tunnel-bound states.Results. …”
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The Effects of Extracted Peptide from Skin of Iraqi Frog (Rana ridibunda) on Human Leukemic Lymphocytes by Ali Jabbar Oleiwi Al-Khafaji

“…The peptide 4(21)E had a highest inhibitory effect(46%) on tumor cell line L20B. Furthermore , peptides effects on acute  and  chronic  myeloid  lymphocytic  leukemia  patients cell cultures  revealed  peptides selectivity  in  their  action according  to  their net charge  and functional  group as  reactant  proton  donor by the  evidence  of peptide 5(22)Y, 16.22 Dalton  so  it  was  either N—terminus (--NH2) or  C—terminus (--OH)  that  led  to  cross  cell  membrane then acted as antigen mediated and activated  cells in a high significant  value (-142.37± 47.69)for acute myeloid  lymphocytic leukemia .Both  of peptides  3(20) I  and  2(19) L were revealed  a  highly significant  differences  within  Chr.40  and Chr. 22 of  inhibition  effects  by testing  volumes 15 µl and 10 µl . …”
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Structural Design of Obstacle Deflector on Type-A City Rail Transit Train by DUAN Pengfei, ZHANG Peng, WU Yang, LI Shuai

“…［Objective］ European standard EN 15227:2020 stipulates that except the obstacle-clearing capabilities, OD (obstacle deflector) should also have energy absorption functions, specifying the energy absorption values required for trains at different speed levels. …”
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Application of Multimodal Anesthesia in Surgical Interventions for Lung Cancer by S. V. Kachur, V. T. Dolgikh, O. V. Korpacheva, O. V. Leonov

“…It is more expedient to perform surgeries to remove malignant tumors in the lungs under the multimodal anesthesia, because these interventions are distinguished by high traumatic rate and having a «fine line» between compensation and decompensation of the basic vital functions in the perioperative period.…”
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PTGS2 affects prognosis of colon cancer patients through regulation of cell proliferation and antioxidant capacity by HE Yangzhige, JIANG Xu, ZHANG Zhiwen, GONG Yiyi

“…Based on GSEA, the biological functions which were significantly activated in patients with high expression of PTGS2 were identified and the colon cancer cell line SW480 was used as an example for in vitro validation. …”
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Tumor Necrosis Factor-α Induced Cellular Stress on Trophoblastic Cells: NF-κB Signaling Could be a Potential Therapeutic Target by Erengül Tokay Varolli, Serbay Özkan, Burcu Biltekin, Meral Koyutürk

“…Deficiencies in trophoblastic functions are known to have a critical role in the progression of placental pathologies such as preeclampsia. …”
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Hypermethylation at 45S rDNA promoter in cancers. by Trang Thi Quynh Tran, Trang Hien Do, Tung The Pham, Phương Thi Thu Luu, Oanh Minh Pham, Uyen Quynh Nguyen, Linh Dieu Vuong, Quang Ngoc Nguyen, Tuan Van Mai, Son Van Ho, Than Thi Nguyen, Lan Thi Thuong Vo

“…Hence, clarifying hypo- or hypermethylation of rDNA will unravel its additional cellular functions, including organization of genome architecture and regulation of gene expression, in response to growth signaling, cellular stressors, and carcinogenesis. …”
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Modern strategy of metastatic colorectal cancer treatment (literature review) by O. I. Kit, Yu. A. Gevorkyan, N. V. Soldatkina, V. E. Kolesnikov, O. K. Bondarenko, A. V. Dashkov

“…In case of widespread colorectal cancer, drug therapy lines are consistently carried out, the selection of which is based on the goals of therapy, the type and time of primary therapy, the mutation profile of the tumor, and the toxicity of drugs.Patients with metastatic liver and/or lung lesions should be considered through the prism of surgical treatment, since it is surgical intervention that can significantly improve the results of treatment of patients. …”
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Infection with endosymbiotic Spiroplasma disrupts tsetse (Glossina fuscipes fuscipes) metabolic and reproductive homeostasis. by Jae Hak Son, Brian L Weiss, Daniela I Schneider, Kiswend-Sida M Dera, Fabian Gstöttenmayer, Robert Opiro, Richard Echodu, Norah P Saarman, Geoffrey M Attardo, Maria Onyango, Adly M M Abd-Alla, Serap Aksoy

“…Herein we employed high-throughput RNA sequencing and laboratory-based functional assays to better characterize the association between Spiroplasma and the metabolic and reproductive physiologies of G. fuscipes fuscipes (Gff), a prominent vector of human disease. …”
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Comprehensive analysis of LRRC42 as a potential biomarker and key cellular processes in cancer development by Rongfu Huang, Jianfeng Yao, Lei Liu, Hua Li, Baoshan Huang

“…Focusing on LRRC42’s potential role in hepatocellular carcinoma (HCC), the study uncovered co-expression relationships with Th2 cells and identified genes enriched in mRNA processing and cell cycle regulation pathways. Functional validation through LRRC42 knockdown experiments revealed its critical involvement in promoting cell proliferation, migration, and invasion in HCC cell lines. …”
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Comprehensive GWAS and Transcriptome Analysis Discovered Candidate Gene Associated with Starch Pasting Properties of Temperate japonica rice (Oryza sativa L.) by Yoon Kyung Lee, Su Jang, Jihwan Im, Hee-Jong Koh

“…Haplotype analysis revealed significant variations in viscosity traits associated to OsGLUTN alleles, and functional validation using enhancer active tagging line showed significantly reduced starch viscosity, confirming its role in EQ regulation. …”
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Over-expression of either MECP2_e1 or MECP2_e2 in neuronally differentiated cells results in different patterns of gene expression. by Marija Orlic-Milacic, Liana Kaufman, Anna Mikhailov, Aaron Y L Cheung, Huda Mahmood, James Ellis, Peter J Gianakopoulos, Berge A Minassian, John B Vincent

“…The human neuroblastoma cell line SK-N-SH was stably infected by lentiviral vectors over-expressing MECP2_e1, MECP2_e2, or eGFP, and were then differentiated into neurons. …”
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Exploring the prognostic significance and therapeutic potential of SUCLG2 in prostate cancer by Bao Hua, Qing Yang, Shangqing Song, Wenfeng Li, Bin Xu, Yufei Gu

“…Furthermore, quantitative real-time polymerase chain reaction and immunofluorescence assays were performed to validate SUCLG2 expression in clinical samples and the prostate carcinoma epithelial cell line 22Rv1.ResultsOur findings revealed that lipid metabolism-related genes, including SUCLG2, have significant prognostic value, based on a 16-gene risk model constructed that accurately predicted PCa prognosis. …”
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Genome-wide enhancer-gene regulatory maps of liver reveal novel regulatory mechanisms underlying NAFLD pathogenesis by Ruofan Li, Kaiyan Su, Tianzhun Wu, Li Xu, Wenyu Song, Dandan Sun, Tao Zeng, Jinzhang Chen, Haibei Xin, Yuanfeng Li, Mengya Zang, Minggen Hu

“…However, numerous GWAS signals associated with NAFLD locate in non-coding regions, posing a challenge for interpreting their functional annotation. Results In this study, we utilized the Activity-by-Contact (ABC) model to construct the enhancer-gene maps of liver by integrating epigenomic data from 15 liver tissues and cell lines. …”
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A Reflux Linked GATA Factor Fulcrum Dictates Lineage Commitment Through GPRC5B During the Esophageal Dysplastic TransitionSummary by Omar Abuhussein, Sara Hosseini-Farahabadi, Corina Stewart, Stephane Flibotte, Alireza Heravi-Moussavi, David Farnell, David Schaeffer, Fergal Donnellan, Frank McKeon, Wa Xian, Dermot Kelleher, Shane Patrick Duggan

“…Conclusions: This study identifies critical GATA factor-mediated processes underlying cellular phenotype in the BE-HGD-EAC transition and identifies GATA-inducible GPRC5B as a functional marker and possible driver of progression through HGD to EAC.…”
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Construction of RNA m6A profiles in liver tissue of mice in sepsis-induced liver injury based on m6A MeRIP-seq and RNA-seq by Li Li, Penghui Li, Yuhua He, Ziyi Xu, Yitao Fan, Xueying Jia, Yingru Liu, Lijie Qin

“…Abstract Sepsis-induced liver injury (SILI) indicates liver functional or structural impairment occurring during sepsis and is one of the common complications of sepsis. …”
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Anti-Inflammatory, Anti-Hyperglycemic, and Anti-Aging Activities of Aqueous and Methanolic Fractions Obtained from <i>Cucurbita ficifolia</i> Bouché Fruit Pulp and Peel Extracts by Tiago E. Coutinho, Carlos Martins-Gomes, Liliana Machado-Carvalho, Fernando M. Nunes, Amélia M. Silva

“…Within the <i>Cucurbita</i> genus can be found <i>Cucurbita ficifolia</i> Bouché, a species that is understudied regarding its potential value for the food industry, as a functional food, and for the pharmaceutical industry, as a source of nutraceuticals. …”
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