Telomerase inhibition targets clonogenic multiple myeloma cells through telomere length-dependent and independent mechanisms. by Sarah K Brennan, Qiuju Wang, Robert Tressler, Calvin Harley, Ning Go, Ekaterina Bassett, Carol Ann Huff, Richard J Jones, William Matsui

“…These tumor initiating B cells also share functional features with normal stem cells such as drug resistance and self-renewal potential. …”
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Dual Reporter Gene Imaging by Jiantu Che, Mikhail Doubrovin, Inna Serganova, Ludmila Ageyeva, Pat Zanzonico, Ronald Blasberg

“…The IRES-linked hNIS-eGFP dual reporter gene is functional and stable in transduced RG2-pQCNIG cells. …”
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Metal Chelation as a Powerful Strategy to Probe Cellular Circuitry Governing Fungal Drug Resistance and Morphogenesis. by Elizabeth J Polvi, Anna F Averette, Soo Chan Lee, Taeyup Kim, Yong-Sun Bahn, Amanda O Veri, Nicole Robbins, Joseph Heitman, Leah E Cowen

“…To explore this approach, we focused on a leading human fungal pathogen, Candida albicans, and screened 1,280 pharmacologically active compounds to identify those that potentiate the activity of echinocandins, which are front-line therapeutics that target fungal cell wall synthesis. …”
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Long noncoding RNAs are dynamically regulated during β-cell mass expansion in mouse pregnancy and control β-cell proliferation in vitro. by Giorgia Sisino, Alex-Xianghua Zhou, Niklas Dahr, Alan Sabirsh, Mangala M Soundarapandian, Ranjan Perera, Erik Larsson-Lekholm, Maria Chiara Magnone, Magnus Althage, Björn Tyrberg

“…Long noncoding RNAs (lncRNA) are the most abundant RNA species in the mammalian genome, yet, their functional importance is mainly elusive.<h4>Aims/hypothesis</h4>This study tests the hypothesis that lncRNAs regulate β-cell proliferation in response to prolactin in the context of β-cell mass compensation in pregnancy.…”
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Transcriptome and Proteome Analysis Identified Genes/Proteins Involved in the Regulation of Leaf Color in <i>Paulownia fortunei</i> by Hu Li, Weili Tian, Yongming Fan

“…Together, the transcriptomic and iTRAQ analyses identified 10 DEGs that were perturbed in the greening mutants in the main pathways of photosynthesis, starch and sucrose metabolism, glutathione metabolism and peroxisome functions. <i>PetJ</i>, E3.2.1.21, <i>GST</i> and <i>CAT</i> were differentially regulated in the chlorophyll-deficient mutant.…”
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Influenza preparedness in low-resource settings: a look at oxygen delivery in 12 African countries by Janeil M Belle, Hillary J Cohen, Nahoko Shindo, Matthew L Lim, Adriana Velazquez-Berumen, Jean-Bosco Ndihokubwayo, Meena N Cherian

“…Results: Ninety-nine (43.8%) of facilities surveyed reported uninterrupted access to an oxygen source and 55 (24.6%) possessed a fully functioning oxygen concentrator.  Electricity was fully available at only 81 (35.1%) health facilities. …”
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CXCR4 confers stemness and radioresistance in chordoma cells by Chan-Woong Jung, Jeong-Yub Kim, Myung-Jin Park

“…These findings underscore the functional significance of CXCR4 as a CSC marker, highlighting its potential as a therapeutic target for malignant chordomas.…”
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Individual differences in developmental trajectory leave a male polyphenic signature in bulb mite populations by Deere, Jacques A., Smallegange, Isabel M.

“…Developmental plasticity often functions to anticipate future conditions but it can also mitigate current stress conditions. …”
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Genetic interaction between DNA repair factors PAXX, XLF, XRCC4 and DNA‐PKcs in human cells by Mengtan Xing, Valentyn Oksenych

“…Moreover, ATM possesses overlapping functions with DNA‐PKcs, XLF, and XRCC4, but not with PAXX in response to DSBs. …”
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Differentiation of zebrafish melanophores depends on transcription factors AP2 alpha and AP2 epsilon. by Eric Van Otterloo, Wei Li, Gregory Bonde, Kristopher M Day, Mei-Yu Hsu, Robert A Cornell

“…We provide evidence that Tfap2e functions redundantly with Tfap2a to maintain kita expression in zebrafish embryonic melanophores. …”
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The role of ICG-fluorescence imaging in abdominal surgical oncology by V. Yu. Dubrovin, S. S. Tymchuk, V. V. Davletshina, R. V. Pavlov, V. A. Kashchenko

“…The search and analysis of publications over the last 7–10 years was carried out using RSCI (Russian Science Citation Index), E-library, PubMed, Scopus, MedLine, Elsevier, Web of Science, ScienceDirect systems. …”
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Main trends of the international market of educational services by T. I. Chinaeva

“…Creation and development of successfully functioning system of the international education, attraction of a significant amount of foreign students are not only to increase the budget of higher education institution and to lift its prestige, but also and a method of promotion of policy, culture, economy, a conduct of life of the host country home. …”
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Prostate-specific membrane antigen–directed nanoparticle targeting for extreme nearfield ablation of prostate cancer cells by Seung S Lee, Philip JR Roche, Paresa N Giannopoulos, Elliot J Mitmaker, Michael Tamilia, Miltiadis Paliouras, Mark A Trifiro

“…When combined together with a targeting moiety such as an antibody or small molecule, one can deliver highly localized temperature increases and cause extensive cellular damage. We have functionalized multi-walled carbon nanotubes by conjugating an antibody against prostate-specific membrane antigen. …”
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Predicting wildlife corridors for multiple species in an East African ungulate community. by Jason Riggio, Katie Foreman, Ethan Freedman, Becky Gottlieb, David Hendler, Danielle Radomille, Ryan Rodriguez, Thomas Yamashita, John Kioko, Christian Kiffner

“…Modelling habitat linkages for wildlife is based on several modelling steps (each involving multiple choices), and in the case of multi-species corridors, an approach to optimize single species corridors to few or a single functional corridor for multiple species. To model robust corridors for multiple species and simultaneously evaluate the impact of methodological choices, we develop a multi-method approach to delineate corridors that effectively capture movement of multiple wildlife species, while limiting the area required. …”
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Minor abnormalities of testis development in mice lacking the gene encoding the MAPK signalling component, MAP3K1. by Nick Warr, Debora Bogani, Pam Siggers, Rachel Brixey, Hilda Tateossian, Asha Dopplapudi, Sara Wells, Michael Cheeseman, Ying Xia, Harry Ostrer, Andy Greenfield

“…We discuss the significance of these data for the functional interpretation of sex-reversing MAP3K1 mutations in humans.…”
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Genome-wide association study for charcoal rot resistance in soybean harvested in Kazakhstan by A. Zatybekov, S. Abugalieva, S. Didorenko, A. Rsaliyev, A. Maulenbay, C. Fang, Y. Turuspekov

“…Candidate genes within the identified genomic regions were explored for their functional annotations and potential roles in plant defense responses. …”
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Health system governance cooperation with unrecognised health authorities: a political economy analysis in Afghanistan and Northwest Syria by Anna Paterson, Jennifer Palmer, Egbert Sondorp

“…In Northwest Syria, on the other hand, establishing health governance bodies that were strongly technical in focus and claimed functional independence from sanctioned ruling militias significantly boosted cooperation and protected the health system. …”
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Dietary Epigallocatechin-3-Gallate (EGCG) Improves Nonspecific Immune Response of Chinese Rice Field Eel (Monopterus albus) by Haichao Deng, Huamei Yue, Rui Ruan, Huan Ye, Zhong Li, Chuangju Li

“…Epigallocatechin-3-gallate (EGCG) has been recognized as a potential additive for aquafeeds due to its beneficial biological functions. In order to evaluate the potential application of EGCG in Chinese rice field eel (Monopterus albus), six isonitrogenous and isolipidic diets containing 0, 25, 50, 100, 200, and 400 mg/kg EGCG were formulated and were fed to Monopterus albus (M. albus) for 9 weeks. …”
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Enhancing Creativity and Validation in Explanatory Deep Learning-Based Symbolic Music Generation: A Hybrid Approach With LSTM and Genetic Algorithms by Ahmad Zainul Fanani, Arry Maulana Syarif, Ika Novita Dewi, Abdul Karim

“…The model successfully generates new bars and lines with notation sequences not found in the original dataset, indicating creative variation. …”
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Lack of GAGA protein in Trl mutants causes massive cell death in Drosophila spermatogenesis and oogenesis by N. V. Dorogova, A. E. Zubkova, E. V. Fedorova, E. U. Bolobolova, E. M. Baricheva

“…Drosophila protein GAGA (GAF) is a factor of epigenetic transcription regulation of a large group of genes with a wide variety of cellular functions. GAF is encoded by the Trithorax-like (Trl) gene, which is important for the formation of various organs and tissues at all stages of ontogenesis. …”
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