UPR-induced intracellular C5aR1 promotes adaptation to the hypoxic tumour microenvironment by Tatsuya Suwa, Kelly SW. Lee, Ian J. Chai, Heather O. L. Clark, David J. MacLean, Nicole Machado, Gonzalo Rodriguez-Berriguete, Lolita Singh, Geoff S. Higgins, Ester M. Hammond, Monica M. Olcina

“…C5aR1 was traditionally thought to be primarily expressed on the cell membrane, although recent reports indicate the importance of intracellular C5aR1 expression for the inflammatory effector functions of various cell types. However, the mechanisms regulating C5aR1 expression and localisation remain unclear. …”
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Generation and characterization of induced pluripotent stem cells of small apes by Yusuke Hamazaki, Hiroto Akuta, Hikaru Suzuki, Hideyuki Tanabe, Kenji Ichiyanagi, Takuya Imamura, Masanori Imamura, Masanori Imamura, Masanori Imamura

“…This study positions small ape iPSCs as a transformative tool for advancing functional genomics and evolutionary developmental biology. …”
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BIN1 inhibited tumor growth, metastasis and stemness by ALDH1/NOTCH pathway in bladder carcinoma by Si-yu Chen, Ya-long Zhang, Xiao-ran Li, Ji-rong Wang, Kun-peng Li, Shun Wan, Jian-wei Yang, Hao Wang, Jin-long Cao, Chen-yang Wang, Xin-peng Fan, Sheng-jun Fu, Li-yun Ding, Tuan-jie Che, Li Yang

“…However, its specific functions and underlying molecular mechanisms in BLCA development and progression remain poorly understood. …”
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Designing wind turbines for profitability in the day-ahead market by M. K. Mehta, M. Zaaijer, D. von Terzi

“…The goal of this study is to optimize the design for a new set of objective functions and analyze how various day-ahead market conditions and objectives drive turbine design. …”
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Prostate tumor neuroendocrine differentiation via EMT: The road less traveled by Haley Dicken, Patrick J. Hensley, Natasha Kyprianou

“…In this review, we discuss the functional contribution of EMT dynamic changes to the development of the neuroendocrine phenotype—the newly characterized pathological feature of prostate tumors in the context of the tumor microenvironment-navigated cell lineage changes and the role of this neuroendocrine phenotype in metastatic progression and therapeutic resistance. …”
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Variations of five eIF4E genes across cassava accessions exhibiting tolerant and susceptible responses to cassava brown streak disease. by Shanshan Shi, Xiuchun Zhang, M Alejandra Mandel, Peng Zhang, Yuliang Zhang, Morag Ferguson, Teddy Amuge, Steve Rounsley, Zhixin Liu, Zhongguo Xiong

“…Both have a (+)-sense single-stranded RNA genome with a 5' covalently-linked viral protein, which functionally resembles the cap structure of mRNA, binds to eukaryotic translation initiation factor 4E (eIF4E) or its analogues, and then enable the translation of viral genomic RNA in host cells. …”
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Comparative assessment of macrophage responses and antileishmanial efficacy in dynamic vs. Static culture systems utilizing chitosan-based formulations. by Alaa Riezk, Alec O'Keeffe, Katrien Van Bocxlaer, Vanessa Yardley, Simon L Croft

“…Similarly, macropinocytosis decreased by approximately 40.7% and 62.2% in PEMs, 34.8% and 60.9% in BMMs, and 33.3% and 59.3% in THP-1 cell line under this same conditions. In this study, we further assessed the impact of medium perfusion on drug efficacy and macrophage functions using a Leishmania major amastigote-macrophage assay. …”
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Interaction of STIL with FOXM1 regulates SF3A3 transcription in the hepatocellular carcinoma development by Haijun Zhang, Lin Zhang, Ziqi Wu

“…Here, we investigated the functional role of SF3A3 in hepatocellular carcinoma (HCC). …”
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Visual biofeedback for paradoxical vocal fold motion (PVFM) by Rachelle Alyce LeBlanc, Daniel Aalto, Caroline C. Jeffery

“…The condition is thought to be primarily functional, with behavioural therapy considered mainstay in the non-acute setting. …”
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Performance evaluation and optimization of triple cascode operational transconductance amplifiers using GNRFET technology for low power smart devices by Faraz Hashmi, M Nizamuddin, Syed Umar Amin

“…Insights into critical design parameters such as dimer lines ( N ), number of GNRs ( n _Rib ), and ribbon spacing ( W _SP ) are provided, emphasizing their impact on circuit performance. …”
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IgE Immune Complexes Mitigate Eosinophilic Immune Responses through NLRC4 Inflammasome by Ece Oylumlu, Goksu Uzel, Lubeyne Durmus, Ceren Ciraci

“…However, roles of antigen (Ag)-specific-IgE ICs in regulating human eosinophil responses remain elusive; therefore, this study builts upon the mechanism of which ovalbumin (Ova)-IgE ICs affects eosinophilic responses utilizing human EoL-1 cell line as a model. Eosinophils are granulocytes functioning through pattern recognition receptors (PRRs) and destructive granule contents in allergic inflammation and parasitic infections. …”
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Development of differentiated surgical technique for treating patients with multilevel degenerative diseases of cervical spine by V. A. Byvaltsev, A. A. Kalinin, M. A. Aliyev, V. V. Shepelev, B. R. Yusupov, B. M. Aglakov

“…Differential use of dorsal decompressive-stabilizing techniques based on a comprehensive assessment of disease duration, configuration of the cervical spine, spinal cord condition and volume of segmental movements allows to reduce neurological symptoms, improve the level of pain and improve the functional status of patients, as well as significantly reduce the number of adverse outcomes associated with the progression of kyphotic deformity, deterioration of neurological symptoms and revision on-line decompressive-stabilizing interventions.…”
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Breeding French bulldogs so that they breathe well-A long way to go. by Eva-Marie Ravn-Mølby, Line Sindahl, Søren Saxmose Nielsen, Camilla S Bruun, Peter Sandøe, Merete Fredholm

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Method of investigating thermal fluctuation processes in problems of diagnostics and prediction of insulating materials by Marina N. Dubyago, Nikolay K. Poluyanovich, Vyacheslav Kh. Pshikhopov

“…At that, different charging modes of operation and functions of the cable current variation are investigated. …”
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Parametric Inference in Biological Systems in a Random Environment by Manuel Molina-Fernández, Manuel Mota-Medina

“…We now continue this research line focusing the attention on the estimation of such reproductive parameters under a parametric statistical setting. …”
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Sericin/polyvinyl alcohol hydrogel optimization for enhanced angiogenesis: a promising strategy for treating chronic osteomyelitis. by Chayanee Noosak, Pavarish Jantorn, Suvimol Surassmo, Sittichat Chukaew, Jirut Meesane, Dennapa Saeloh Sotthibandhu

“…In a previous study, we demonstrated the potential of sericin/polyvinyl alcohol (PVA) hydrogel as a functional biomaterial carrier for osteomyelitis treatment. …”
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Targeting DNA Topoisomerase IIα in Retinoblastoma: Implications in EMT and Therapeutic Strategies by Wei Q, Lin N, Wang L

“…Qingquan Wei, Nan Lin, Li Wang Department of Ophthalmology, Tong Ren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of ChinaCorrespondence: Li Wang, Department of Ophthalmology, Tong Ren Hospital, Shanghai Jiao Tong University School of Medicine, 1111 Xianxia West Road, Shanghai, People’s Republic of China, Email WL1249@shtrhospital.comBackground: This study investigates the role of DNA topoisomerase IIα (TOP2A) in retinoblastoma (RB), focusing on its involvement in epithelial-mesenchymal transition (EMT) and the potential of TOP2A inhibition as a therapeutic strategy.Methods: We analyzed TOP2A expression in RB tissues using public gene expression databases (GSE97508, GSE110811, and GSE172170) and conducted functional assays in human RB cell lines (Y79 and WERI-Rb-1) modified to knock down or overexpress TOP2A. …”
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Development and validation of liquid–liquid phase separation-associated prognostic biomarkers in gastric cancer by Donghui Liu, Mingzhu Liu, Juan Du

“…Abstract Objective Liquid–liquid phase separation (LLPS) is the membrane-less formation of functional assemblies from specific molecules. It plays a key role in tumor growth by governing gene expression. …”
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Preclinical characterization of INCB053914, a novel pan-PIM kinase inhibitor, alone and in combination with anticancer agents, in models of hematologic malignancies. by Holly Koblish, Yun-Long Li, Niu Shin, Leslie Hall, Qian Wang, Kathy Wang, Maryanne Covington, Cindy Marando, Kevin Bowman, Jason Boer, Krista Burke, Richard Wynn, Alex Margulis, Gary W Reuther, Que T Lambert, Valerie Dostalik Roman, Ke Zhang, Hao Feng, Chu-Biao Xue, Sharon Diamond, Greg Hollis, Swamy Yeleswaram, Wenqing Yao, Reid Huber, Kris Vaddi, Peggy Scherle

“…The three PIM kinase isozymes (PIM1, PIM2, and PIM3) share similar downstream substrates with other key oncogenic kinases and have differing but mutually compensatory functions across tumors. This supports the therapeutic potential of pan-PIM kinase inhibitors, especially in combination with other anticancer agents chosen based on their role in overlapping signaling networks. …”
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¿Pierde atractivo el Mercado Bursátil Nacional? by Isabel Barrientos Blanco, Herla Pineda Segura, Carlos Alberto Valverde Brealey

“…The fact that since 2001, 24 companies have chosen to un-register in the stock market as debt bond issuers and many others currently registered have not issued bonds recently seems to show that something is not functioning properly. The opinion of businessmen, experts and stock market administrators collected by field work uniformly agree in most of the causes stated, going from excessive requirements that doesn’t stimulate issuers, to a loss of competitiveness to other financial options like the financing options offered by banks (corporate credit, credit lines, factoring, etc.) …”
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