B Cell Activating Factor Induces Drug Resistance in Hairy Cell Leukemia Variant by Claire Fritz, Daniel Feinberg, Akshaya Radhakrishnan, Kayla Klatt, E. Ricky Chan, Philip Rock, Richard Burack, Reshmi Parameswaran

“…Conversely, in the Bonna-12 cell line, we observed constitutive activation of the nonclassical NF-κB pathway. …”
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The Remarkable and Selective In Vitro Cytotoxicity of Synthesized Bola-Amphiphilic Nanovesicles on Etoposide-Sensitive and -Resistant Neuroblastoma Cells by Silvana Alfei, Paolo Giannoni, Maria Grazia Signorello, Carola Torazza, Guendalina Zuccari, Constantinos M. Athanassopoulos, Cinzia Domenicotti, Barbara Marengo

“…Triphenyl phosphonium salts (TPPs) are mitochondria-targeting compounds that exert anticancer effects, impair mitochondria functions, and damage DNA at the same time. Despite several biochemical applications, TPP-based bola-amphiphiles self-assembling nanoparticles (NPs) in water have never been tested as antitumor agents. …”
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CD151 Promotes Cancer Progression in Triple-Negative Breast Cancer by Inducing EMT through the MAPK Signaling Pathway by Lv H, Zhang B, Weng X, Li Y, Deng C, Wang R, Shi L, Yin Y

“…However, the specific functions of CD151 in triple-negative breast cancer (TNBC) remain unclear. …”
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Exploring Autophagy-Related Gene Expression in Hepatocellular Carcinoma via TCGA, GEPIA2, and HPA Databases: Implications for Prognosis by Gu X, Chen Y, Hu X, Li Y, Zhu R, Li H, Yuan Z, Wang Y

“…RT-qPCR analysis further confirmed significant upregulation of mRNA expression levels of randomly selected BAG3, EIF2AK2, KIF5B, and RAB24 in HCC cell lines, consistent with the bioinformatics analysis findings.Conclusion: This study showed that the 41 obtained ARGs, such as ATG16L1, ATG4B, BAG3, KIF5B, MAPK1, RAB24, and SOGA1, these findings suggest that ARGs may serve as prognostic biomarkers for HCC, warranting further validation in clinical cohorts and functional studies.Keywords: hepatocellular carcinoma, bioinformatics, autophagy, prognostic markers, TCGA…”
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The transcription factor PbeNAC83 positively regulates the Valsa canker resistance in apple and pear by DOU Zhiqi, CAI Minrui, DU Chenglong, HU Huanhuan, ZUO Cunwu

“…PbeNAC83 was transfected into the DuliG03 suspension cells, and three wellgrown overexpression cell lines were obtained. Functional analysis demonstrated that PbeNAC83-OE cells were more resistant to Vp and VpM compared to the control. …”
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Fluidic-manipulation-enabled multiplexed dose delivery of RONS by a CAP chip for dose optimization enhancement by Fang Wang, Liangyu Zhou, Wei Guo, Haisong Lin, Ruotong Zhang, Shaolong Kuang, Yuan Liu, Xiaoxue Fan, Yau Kei Chan, Hui Deng, Ho Cheung Shum

“…Leveraging multiplexed treatment, we capably optimize the CAP dose to effectively eradicate the liver cancer cell line of Huh7 and bacteria of S. aureus within one exposure. …”
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Lipid droplet-associated hydrolase (LDAH) knockdown enhances TAG hydrolysis and promotes ovarian cancer progression and chemoresistance by Bhawna Deswal, Sameera Nallanthighal, Elahe Nikpayam, Zenab Minhas, Antoni Paul, Young-Hwa Goo, Dong-Joo Cheon

“…Consistently, knockdown (KD) of LDAH in human ovarian cancer cell lines increased tumor cell proliferation but decreased endoplasmic reticulum (ER) stress and apoptosis upon cisplatin treatment. …”
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Silencing of SCEL promotes progression of oral squamous cell carcinoma via activating TGF-β/Smad pathway by Danping Li, Limei Li, Shu Wu, Jun Zhao, Haishan Zhang, Qiaoli Chen, Yingxi Mo, Liudmila Matskova, Ping Li, Xiaoying Zhou

“…Methods mRNA and protein expression of SCEL in OSCC cell lines and patient tissues were examined by qRT-PCR and IHC. …”
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RBOHD, GLR3.3, and GLR3.6 cooperatively control wounding hypocotyl-induced systemic Ca2+ signals, jasmonic acid, and glucosinolates in Arabidopsis leaves by Che Zhan, Na Xue, Zhongxiang Su, Tianyin Zheng, Jianqiang Wu

“…We show that wounding hypocotyls rapidly activated both Ca2+ and ROS signals in leaves. RBOHD, which functions to produce ROS, along with two glutamate receptors GLR3.3 and GLR3.6, but not individually RBOHD or GLR3.3 and GLR3.6, in hypocotyls regulate the dynamics of systemic Ca2+ signals in leaves. …”
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Synthesis, Characterization, HSA/DNA Binding, and Cytotoxic Activity of [RuCl₂(η⁶-<i>p</i>-cymene)(bph-κ<i>N</i>)] Complex by Stefan Perendija, Dušan Dimić, Thomas Eichhorn, Aleksandra Rakić, Luciano Saso, Đura Nakarada, Dragoslava Đikić, Teodora Dragojević, Jasmina Dimitrić Marković, Goran N. Kaluđerović

“…A novel ruthenium(II) complex, [RuCl₂(η⁶-<i>p</i>-cymene)(bph-κ<i>N</i>)] (<b>1</b>), was synthesized and structurally characterized using FTIR and NMR spectroscopy. Density functional theory (DFT) calculations supported the proposed geometry and allowed for comparative analysis of experimental and theoretical spectroscopic data. …”
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SMARCB1 orchestrates cellular plasticity and oncogenic pathways in typical and chondroid chordomas by Weihai Liu, Moksada Regmi, Shikun Liu, Ying Xiong, Yuwei Dai, Yingjie Wang, Jun Yang, Chenlong Yang

“…SMARCB1 knockdown experiments were conducted in chordoma cell lines, followed by comprehensive transcriptome analysis. …”
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HLA-E: Presentation of a Broader Peptide Repertoire Impacts the Cellular Immune Response—Implications on HSCT Outcome by Thomas Kraemer, Alexander A. Celik, Trevor Huyton, Heike Kunze-Schumacher, Rainer Blasczyk, Christina Bade-Döding

“…The HLA-E locus encodes a nonclassical class Ib molecule that serves many immune functions from inhibiting NK cells to activating CTLs. …”
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Study on Antiviral Activity and Pharmacological Safety of Double-Stranded Ribonucleic Acid for Intranasal Administration by S. G. Gamaley, G. G. Shimina, E. S. Tsyplenkova, O. V. Simakova, M. O. Skarnovich, M. A. Skarnovich, L. N. Shishkina, O. S. Taranov, O. S. Ivanova, G. M. Levagina, E. D. Danilenko

“…Interferon inducers are of interest as the first line of defense against viral infections, including influenza. …”
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Metformin blocks BIK1-mediated CPK28 phosphorylation and enhances plant immunity by Yazhou Bao, Qian Zhang, Hai Zhu, Yong Pei, Yaning Zhao, Yixin Li, Peiyun Ji, Dandan Du, Hao Peng, Guangyuan Xu, Xiaodan Wang, Zhiyuan Yin, Gan Ai, Xiangxiu Liang, Daolong Dou

“…Despite its well-documented benefits in mammalian cellular processes, its functions and underlying mechanisms in plants remain unclear. …”
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An intraoral approach to minimize morbidity in a pediatric trauma case by Bima Baskara, Lucas Pedro Bernardo, Poerwati Soetji Rahajoe, Bramasto Purbo Sejati, Erdananda Haryosuwandito

“…A CT scan disclosed more than two fracture lines that involved the mandibular symphysis and a basal triangle fracture. …”
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Nonmuscle Myosin-2B Regulates Apical Cortical Mechanics, ZO-1 Dynamics and Cell Size in MDCK Epithelial Cells by Marine Maupérin, Niklas Klatt, Thomas Glandorf, Thomas Di Mattia, Isabelle Méan, Andreas Janshoff, Sandra Citi

“…These results extend our understanding of the functions of NM2B by describing its role in the regulation of the mechanical properties of the apical membrane cortex and cell size and validate our model about the role of cingulin–NM2B interaction in the regulation of ZO-1 dynamics.…”
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Aptamer-Enhanced Surface Decontamination: A Novel Approach for Neutralizing Peanut Allergens and Preventing Cell-Degranulation by Mohamad Ammar Ayass, Trivendra Tripathi, Natalya Griko, Ramya Ramankutty Nair, Tutku Okyay, Jin Zhang, Kevin Zhu, Victor Pashkov, Lina Abi-Mosleh

“…To mitigate this risk, we developed AYA22AR321, a novel aptamer with selective, high-affinity binding to these allergens (Kd values: 0.5 nM for Ara h1, 14.5 nM for Ara h2, and 6.6 nM for crude peanut extract). Functional assays using RBL-2H3 (rat basophilic leukemia cell line) cells showed that AYA22AR321 significantly reduces IgE-mediated degranulation, indicating its potential to attenuate allergic responses. …”
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Selective depletion of metastatic stem cells as therapy for human colorectal cancer by María Virtudes Céspedes, Ugutz Unzueta, Anna Aviñó, Alberto Gallardo, Patricia Álamo, Rita Sala, Alejandro Sánchez‐Chardi, Isolda Casanova, María Antònia Mangues, Antonio Lopez‐Pousa, Ramón Eritja, Antonio Villaverde, Esther Vázquez, Ramón Mangues

“…Colorectal cancer (CRC) cells overexpressing CXCR4 display trafficking functions and metastasis‐initiating capacity. We assessed the antimetastatic activity of a nanoconjugate (T22‐GFP‐H6‐FdU) that selectively delivers Floxuridine to CXCR4+ cells. …”
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The Effect of Physiotherapy on Arthrogenic Muscle Inhibition After ACL Injury or Reconstruction: A Systematic Review by Maria Paço, Maxence Peysson, Elona Dumont, Mário Correia, Anna Quialheiro, Paula Chaves

“…Arthrogenic muscle inhibition (AMI) following ACL injury or reconstruction is a common issue that affects muscle activation and functional recovery. Thus, the objective of this study was to systematize the literature on the effects of physiotherapy interventions in the rehabilitation of AMI after ACL injury or reconstruction. …”
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Upregulation of TREM2 expression in M2 macrophages promotes Brucella abortus chronic infection by Jingyu Wang, Zhirong Yan, Weiyu Zhang, Xiaofeng Liu, Jun Wang, Qisheng Peng

“…In a mouse model, the predominance of alternatively activated macrophages (also known as M2) plays an essential role in sustaining chronic infection. The underlying functional mechanism by which M2 sustains chronic infection remains unclear. …”
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