Natural killer T cell immunotherapy combined with IL-15-expressing oncolytic virotherapy and PD-1 blockade mediates pancreatic tumor regression by Simon Gebremeskel, Adam Nelson, Brent Johnston, Brian D Lichty

“…Enhanced tumor control was associated with increased immune cell infiltration and anti-tumor effector functions (cytotoxicity and cytokine production). While ineffective as a monotherapy, the addition of blocking PD-1 antibodies to the combined protocol sustained immune cell activation and effector functions, resulting in prolonged tumor regression and complete tumor clearance in 20% of mice. …”
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Investigation of the role of miRNA variants in neurodegenerative brain diseases by Alexandros Frydas, Alexandros Frydas, Rita Cacace, Rita Cacace, Julie van der Zee, Julie van der Zee, Christine Van Broeckhoven, Christine Van Broeckhoven, Eline Wauters, Eline Wauters

“…These variants are also predicted to strongly downregulate mature miR885 levels, in line with what is reported for MIR885 in the context of AD.DiscussionFunctional investigation of miRNAs/variants described in this study could propose novel miRNA-mediated molecular cascades in FTD and AD pathogenicity. …”
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Satisfied with the worst health outcomes or unsatisfied with the best: explaining the divergence between good patient-reported outcomes and low satisfaction and vice versa among kn... by Lukas Schöner, Viktoria Steinbeck, Reinhard Busse, Carlos J. Marques

“…Conclusion Addressing individual health concerns, e.g. through expectation management, and assessing alternative treatment options might improve satisfaction in line with functional improvements. A closer evaluation at which physical impairment level surgery is beneficial could help to improve the care of Satisfied Non-Achievers.…”
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Nature-aligned Education Technologies as the Basis of Forming an Individual Noospheric Consciousness by Natalya V. Maslova, Natalia V. Antonenko, Oksana A. Alekseeva

“…It is shown that the introduction of noospheric consciousness into the realization of individual basic functions displays his/her ability to self-awareness of an integrated system of structural-functional dynamics of the psyche. …”
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FCGBP promotes ovarian cancer progression via activation of IL-6/JAK-STAT signaling pathway by Zhiqin Fu, Kelie Chen, Fang Zheng, Wangang Gong, Ding Chao, Chao Lu

“…FCGBP expression was validated in ovarian cancer tissues using quantitative PCR, western blotting, and immunohistochemistry. Functional assays, including proliferation, migration, invasion, and colony formation, were conducted in SKOV3 and ES-2 ovarian cancer cell lines with FCGBP knockdown. …”
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The phenomenon of therapeutic resistance in the treatment of schizophrenia: the possibilities of modern diagnostics and methods of anti-resistant effects by V. V. Stanovaya, Z. T. Guseynova, M. V. Ivanov, E. V. Bigday

“…The reasons for the formation of resistance identified to date are diverse and can be associated with both biological changes due to violations of the functioning of various neurotransmitter systems. so it is with non-compliance with the regimen of taking medications (drug noncompliance). …”
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A ROMANIAN PERSPECTIVE ON DETERMINING THE COMPETENT COURT FOR THE SHARING-OUT OF THE ESTATE IN THE LIGHT OF REGULATION (EU) NO. 650/2012 by Silviu-Dorin ŞCHIOPU

“…The Treaty on the Functioning of the European Union provides that the Union shall develop judicial cooperation in civil matters having cross-border implications and, for this purpose, the European Parliament and the Council shall adopt measures for the proper functioning of the internal market, aimed at ensuring the compatibility of the rules applicable in the Member States concerning conflict of laws and of jurisdiction. …”
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The oncogenic lncRNA MIR503HG suppresses cellular senescence counteracting supraphysiological androgen treatment in prostate cancer by Julia Kallenbach, Mahdi Rasa, Mehdi Heidari Horestani, Golnaz Atri Roozbahani, Katrin Schindler, Aria Baniahmad

“…Functional assays reveal that MIR503HG promotes PCa cell proliferation and inhibits SAL-mediated cellular senescence, partly through miR-424-5p. …”
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Integration of single-cell transcriptomics and bulk transcriptomics to explore prognostic and immunotherapeutic characteristics of nucleotide metabolism in lung adenocarcinoma by Kai Zhang, Kai Zhang, Luyao Wang, Huili Chen, Lili Deng, Mengling Hu, Ziqiang Wang, Yiluo Xie, Chaoqun Lian, Xiaojing Wang, Xiaojing Wang, Jing Zhang

“…In addition, patients of different subtypes showed significant differences in genomic mutation and functional enrichment and exhibited different anti-tumor immune profiles. …”
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SRSF1-mediated alternative splicing regulates bladder cancer progression and cisplatin sensitivity through HIF1A/BNIP3/mitophagy axis by Qikai Wu, Hao Yu, Huanyou Sun, Jiancheng Lv, Juntao Zhuang, Lingkai Cai, Lingjing Jiang, Yuhan Chen, Yiran Tao, Kexin Bai, Haiwei Yang, Xiao Yang, Qiang Lu

“…However, the specific functions and potential mechanisms of SRSF1 in advancing bladder cancer (BCa) progression and influencing chemosensitivity remain largely unexplored. …”
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EBV-Derived miR-BART20-3p Influences Proliferation and Migration in EBV-Positive Gastric Cancer Models by Suppressing PPARα by Qiong Wu, Guiying Ye, Xiazhen Xu, Xianchang Zeng, Biyun Wu, Fan Xin, Lu Zhang, Xu Lin, Xinjian Lin, Wannan Chen

“…Epstein–Barr virus (EBV) is the first oncogenic DNA virus known to encode microRNAs (miRNAs) and has been implicated in the pathogenesis of multiple malignancies, including a distinct subset of gastric cancers (EBV-associated gastric cancer, EBVaGC). However, the functional roles of individual EBV-encoded miRNAs in EBVaGC remain poorly defined. …”
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A prognostic signature of Glutathione metabolism-associated long non-coding RNAs for lung adenocarcinoma with immune microenvironment insights by Junxi Hu, Junxi Hu, Shuyu Tian, Shuyu Tian, Qingwen Liu, Qingwen Liu, Jiaqi Hou, Jiaqi Hou, Jun wu, Jun wu, Xiaolin Wang, Xiaolin Wang, Yusheng Shu, Yusheng Shu

“…A prognostic model was built with Cox and Least Absolute Shrinkage and Selection Operator (LASSO) methods and validated by Kaplan-Meier analysis, Receiver Operating Characteristic (ROC) curves, and Principal Component Analysis (PCA). Functional analysis revealed immune infiltration and drug sensitivity differences. …”
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Novel Potent and Selective Dopamine D4 Receptor Piperidine Antagonists as Potential Alternatives for the Treatment of Glioblastoma by Federica Matteucci, Pegi Pavletić, Alessandro Bonifazi, Rian Garland, Hideaki Yano, Consuelo Amantini, Laura Zeppa, Emanuela Sabato, Giulio Vistoli, Valerio Mammoli, Loredana Cappellacci, Fabio Del Bello, Gianfabio Giorgioni, Riccardo Petrelli, Alessia Piergentili, Wilma Quaglia, Alessandro Piergentili

“…<b>Methods</b>: All the new compounds <b>9–20</b> were evaluated for their radioligand binding affinity at D2-like receptor subtypes and the results were rationalized by docking studies and molecular dynamics (MD) simulations. The functional profiles of the most interesting derivatives were assessed at D4R Go and Gi protein and β-arrestin by BRET assay and their potential anticancer activity was determined in GBM cell lines. …”
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Drought-induced transposon expression reveals complex drought response mechanisms in Brassica napus by Manyi Chen, Dan Luo, Hanzhao Kong, Yan Lv, Chunsheng Li, Yongguo Zhao, Qian Huang, Guangyuan Lu, Guangyuan Lu

“…Functional annotation was performed for protein-coding TE transcripts located in intergenic regions to predict their involvement in biological processes. …”
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COMMD3 Regulates Copper Metabolism via the ATOX1-ATP7A-LOX Axis to Promote Multiple Myeloma Progression by Yajun Wang, Bo Zhang, Fengjuan Fan, Fei Zhao, Jian Xu, Yuhuan Zheng, Chunyan Sun, Yu Hu

“…Methods: Comprehensive bioinformatics analyses were conducted on bone marrow and extramedullary samples to determine the expression of COMMD3, which was validated through in vitro and in vivo functional assays. The MM cell lines RPMI8226 and MM1S underwent lentiviral transfection for COMMD3 overexpression and knockdown. …”
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The interaction of β-arrestin1 with talin1 driven by endothelin A receptor as a feature of α5β1 integrin activation in high-grade serous ovarian cancer by Ilenia Masi, Flavia Ottavi, Danila Del Rio, Valentina Caprara, Cristina Vastarelli, Sara Maria Giannitelli, Giulia Fianco, Pamela Mozetic, Marianna Buttarelli, Gabriella Ferrandina, Giovanni Scambia, Daniela Gallo, Alberto Rainer, Anna Bagnato, Francesca Spadaro, Laura Rosanò

“…As demonstrated in primary HG-SOC cells and SOC cell lines, ET-1 increased Intβ1 and downstream FAK/paxillin activation. …”
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RNA silencing response in chloroplast-replicating viroid siRNA biogenesis in plants by Pengcheng Zhang, Xinlian Zhang, Atef M. Mohamed, Leizhen Wang, José-Antonio Daròs, Shifang Li, Mahmut Tör, Yiguo Hong

“…In plants, a combined functionality of DCL2 and DCL3 is crucial for their synergistic defence against whilst DCL4 is required for nucleus-replicating viroid. …”
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A domain-based framework for cognitive profile identification in Parkinson’s disease across diverse samples by Elvira Andújar-Castillo, Carla Carrillo-Molina, Fernando Alonso, Fernando Alonso, Clara Villanueva-Iza, Clara Villanueva-Iza, Gustavo Fernández-Pajarín, Gustavo Fernández-Pajarín, Angel Sesar, Angel Sesar, Isabel Jiménez-Martín, Isabel Jiménez-Martín, Juan Francisco Martín-Rodriguez, Juan Francisco Martín-Rodriguez, Juan Francisco Martín-Rodriguez, Maria Jesús Lama, Pablo Mir, Pablo Mir, Pablo Mir, Elena Perez-Hernandez, Cristina Nombela Otero

“…Five cognitive domains were constructed, addressing attention/working memory, executive functions, memory, visuospatial abilities, and language, using composite z-scores derived from standardized neuropsychological tests.ResultsLatent Cluster Analysis identified three distinct cognitive profiles: (1) a fronto-striatal profile characterized by mild deficits in executive and attention functions and intact visuospatial abilities, (2) a posterior cortical profile marked by severe memory and visuospatial impairments but strong language performance, and (3) a preserved profile displaying mild deficits across multiple domains. …”
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Effects of the <i>Agrobacterium rhizogenes rolC</i> Gene Insertion on Secondary Metabolites Profile and In Vitro Biological Activity of <i>Acmella oleracea</i> (L.) R.K. Jansen by Priscilla Paola Bettini, Martina Imbesi, Patrizia Bogani, Valentina Maggini, Filippo Firenzuoli, Fabio Firenzuoli, Domenico Trombetta, Antonella Smeriglio

“…These findings highlight <i>rolC</i>’s role in modulating secondary metabolite synthesis, influencing both the phytochemical composition and functional properties of <i>A. oleracea</i> extracts.…”
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GABA, Glx, and GSH in the cerebellum: their role in motor performance and learning across age groups by Shanti Van Malderen, Shanti Van Malderen, Shanti Van Malderen, Melina Hehl, Melina Hehl, Melina Hehl, Melina Hehl, Stefanie Verstraelen, Robbe Breugelmans, Georg Oeltzschner, Stephan P. Swinnen, Stephan P. Swinnen, Koen Cuypers, Koen Cuypers, Koen Cuypers

“…Instead, volumetric decline and changes in structural and functional connectivity in the aging cerebellum may play a more significant role in motor decline as compared to neurochemical alterations. …”
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