Pre-therapeutic efficacy of the CDK inhibitor dinaciclib in medulloblastoma cells by Marta Buzzetti, Sonia Morlando, Dimitrios Solomos, Ammara Mehmood, Alexander W. I. Cox, Mattia Chiesa, Yuri D’Alessandra, Michela Garofalo, Caroline H. Topham, Gianpiero Di Leva

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CD81-guided heterologous EVs present heterogeneous interactions with breast cancer cells by Elena Gurrieri, Giulia Carradori, Michela Roccuzzo, Michael Pancher, Daniele Peroni, Romina Belli, Caterina Trevisan, Michela Notarangelo, Wen-Qiu Huang, Agata S. A. Carreira, Alessandro Quattrone, Guido Jenster, Timo L. M. Ten Hagen, Vito Giuseppe D’Agostino

“…The capacity to entrap heterogeneous molecular cargoes and target specific cell populations through EV functionalization promises advancements in biomedical applications. …”
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Does the tail show when the nose knows? Artificial intelligence outperforms human experts at predicting detection dogs finding their target through tail kinematics by George Martvel, Giulia Pedretti, Teddy Lazebnik, Anna Zamansky, Yuri Ouchi, Tiago Monteiro, Nareed Farhat, Ilan Shimshoni, Dan Grinstein, Yuval Michaeli, Paola Valsecchi, Nathaniel Hall, Sarah Marshall-Pescini

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The state of public health emergency preparedness and response capacity among countries in the ECOWAS region by Mahmood Dalhat, Margaret Yaa Lartey

“…In terms of coordination, the absence of functional national public health institutes in some member states and consequently the lack of a dedicated budget line will grossly affect the capacities of some member countries to address health security challenges. …”
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NRF2 maintains redox balance via ME1 and NRF2 inhibitor synergizes with venetoclax in NPM1-mutated acute myeloid leukemia by Jiayuan Hu, Zihao Yuan, Yan Shu, Jun Ren, Jing Yang, Lisha Tang, Xingyu Wei, Yongcan Liu, Fangfang Jin, Qiaoling Xiao, Xinyi Chen, Nan Wu, Wen Zhao, Ziwei Li, Ling Zhang

“…The high NRF2 expression levels were at least partially induced by fat mass and obesity-associated protein (FTO) via m6A modification. Functionally, NRF2 exerts its antioxidant effects by transcriptionally upregulating malic enzyme 1 (ME1) expression and enhancing its activity. …”
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Targeting the <i>ZMYM2-ANXA9</i> Axis with <i>FLT3</i> Inhibitor G749 Overcomes Oxaliplatin Resistance in Colorectal Cancer by Dezheng Lin, Yucheng Xu, Huanmiao Zhan, Yufan Liang, Riyun Liu, Jun Liu, Dandong Luo, Xiaochuan Chen, Jiawei Cai, Yifeng Zou

“…The expression of <i>ANXA9</i> was evaluated in oxaliplatin acquired-resistant CRC cell lines via qPCR and Western blot. Functional studies, including RNA interference, colony formation, apoptosis assays, and drug sensitivity testing, were performed in vitro and in vivo to assess the role of <i>ANXA9</i>. …”
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YY1 drives PARP1 expression essential for PARylation of NONO in mRNA maturation during neuroblastoma progression by Chunhui Yang, Jiaying Qu, Yang Cheng, Minxiu Tian, Zhijie Wang, Xiaolin Wang, Xinyue Li, Shunchen Zhou, Bosen Zhao, Yanhua Guo, Liduan Zheng, Qiangsong Tong

“…Poly(ADP-ribose) polymerase 1 (PARP1), a key enzyme catalyzing polyADP-ribosylation (PARylation), plays critical roles in various cellular processes, and contributes to tumorigenesis and aggressiveness. However, the functions and regulatory mechanisms of PARP1 in NB progression still remain to be determined. …”
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Efficacy and safety of combination therapy with lenvatinib and pembrolizumab in elderly patients with advanced endometrial cancer by M. V. Volkonskiy, A. A. Akopyan, T. A. Zhelezkova, R. S. Zhikhorev, E. P. Krasnorutskaya, N. R. Abidova, T. A. Makarkina, M. O. Skorina, V. M. Filippova, I. A. Luev, Yu. V. Vasilyeva, G. D. Malina, L. P. Veshkina, B. L. Nersesyan

“…Additional studies are required to evaluate the efficacy and safety of the combination therapy of lenvatinib and pembrolizumab in patients with a more severe functional status.…”
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Co-Highly Expressed SLC17A9 and KCNH1 as Potential Prognostic Biomarkers and Therapeutic Targets in Clear Cell Renal Cell Carcinoma by Zongpan Ke, Zhiwang Tang, Deyun Shen, Yixun Liu, Yawei Shu, Xiangyu Mu, Zexuan Li, Ping Xiang, Bing Zhong, Xuechun Hu, Ruoyun Tan, Jun Xiao

“…Leveraging The Cancer Genome Atlas (TCGA) database, we predicted the clinical relevance of these cancer-associated genes and validated their expression profiles through multiple experimental methodologies. Functional assays were conducted to assess the impact of these genes on renal cancer cell lines. …”
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Identification and validation of a prognostic signature of drug resistance and mitochondrial energy metabolism-related differentially expressed genes for breast cancer by Tiankai Xu, Chu Chu, Shuyu Xue, Tongchao Jiang, Ying Wang, Wen Xia, Huanxin Lin

“…Although cancer cells can maintain viability independently of mitochondrial energy metabolism, they remain reliant on mitochondrial functions for the synthesis of new DNA strands. This dependency underscores a potential link between mitochondrial energy metabolism and drug resistance. …”
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Persistence of activated anti‐mesothelin hYP218 chimeric antigen receptor T cells in the tumour is associated with efficacy in gastric and colorectal carcinomas by Sameer Mir, Abhilash Venugopalan, Jingli Zhang, Nishanth Ulhas Nair, Manjistha Sengupta, Manakamana Khanal, Chaido Stathopoulou, Qun Jiang, Raffit Hassan

“…Mesothelin expression in gastric and colorectal cancer cell‐lines (n = 5) was analysed using flow cytometry. …”
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Design and Analysis of an Electric Integrated Work Vehicle for Corn Intertillage Fertilization and Pesticide Spraying by Dongdong Gu, Jiahan Zhang, Yijie Ding, Yongzhen Wang, Jie Yang, Ge Shi, Bin Li, Junqiang Zhao

“…In response to the situation in the Huanghuai region, where corn fertilization and pesticide application primarily rely on manual methods such as hand broadcasting fertilizer and using manual backpack sprayers, resulting in low levels of mechanization, this study designed an electric integrated work vehicle in line with the trend of developing new energy. The vehicle is powered by six 12 V, 100 Ah lead-acid batteries and integrates the functions of fertilization and pesticide spraying. …”
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Single-cell RNA sequencing reveals the role of GTF2F2 in ovarian cancer oncogenesis and progression by Haiyang Du, Gao Si, Jiqing Si, Xuejie Song, Fuchun Si

“…This study aimed to utilize single-cell RNA sequencing to investigate the heterogeneity of malignant epithelial cells in ovarian cancer, focusing on their potential functions and the implications for treatment and prognosis. …”
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A Proteome-Level Investigation Into Plasmodiophora brassicae Resistance in Brassica napus Canola by Dinesh Adhikary, Devang Mehta, R. Glen Uhrig, Habibur Rahman, Nat N. V. Kav

“…Proteins play a crucial role in many biological functions and the identification of differentially abundant proteins (DAP) using proteomics is a suitable approach to understand plant–pathogen interactions to assist in the development of gene specific markers for developing clubroot resistant (CR) cultivars. …”
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Cilostazol for secondary stroke prevention: systematic review and meta-analysis by Leonard LL Yeo, Choon Han Tan, Ching-Hui Sia, Aloysius ST Leow, Vijay Kumar Sharma, Benjamin YQ Tan, Andrew GR Wu, Bernard PL Chan

“…Cilostazol did not significantly decrease mortality (RR=0.90, 95% CI 0.64 to 1.25) or increase the rate of good functional outcome (Modified Rankin Scale score of 0–1; RR=1.07, 95% CI 0.95 to 1.19). …”
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A structured investigation on the site supervisory traits in applying science and technology related fundamental concepts in construction operations by Kesavan Manoharan, Pujitha Dissanayake, Chintha Pathirana, Dharsana Deegahawature, Renuka Silva

“…This may result in constructive benefits to upgrading the current functions associated with urbanisation, sustainability and society. …”
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Machine learning-enhanced discovery of tsRNA-mRNA regulatory networks: identifying novel diagnostic biomarkers and therapeutic targets in breast cancer by Zhongling Ma, Rui Wang, Ming Yuan, Bo Wang, Li Li, Tianfu Zhao, Xinhan Zhao

“…Comprehensive multi-omics analyses including survival, immune infiltration, drug sensitivity, and pathway enrichment were performed for identified targets. Functional validation was conducted in breast cancer cell lines.ResultsWe identified 297 differentially expressed tsRNAs and developed a four-tsRNA signature (tRF-21-FSXMSL73E, tRF-20-XSXMSL73, tRF-23-FSXMSL730H, tRF-23-YJE76INB0J) achieving AUC of 0.98 in discovery and 0.82 in validation cohorts. tRF-21-FSXMSL73E showed strong correlation with FAM155B expression. …”
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A bacterial membrane-disrupting protein stimulates animal metamorphosis by Kyle E. Malter, Tiffany L. Dunbar, Carl Westin, Emily Darin, Josefa Rivera Alfaro, Nicholas J. Shikuma

“…Although this host-microbe interaction is critical to establishing and maintaining marine animal populations, the functional activity of bacterial products and how they activate the host’s metamorphosis program has not yet been defined for any animal. …”
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Low fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) diet improves symptoms in adults suffering from irritable bowel syndrome (IBS) compared to sta... by Péter Varjú, Nelli Farkas, Péter Hegyi, András Garami, Imre Szabó, Anita Illés, Margit Solymár, Áron Vincze, Márta Balaskó, Gabriella Pár, Judit Bajor, Ákos Szűcs, Orsolya Huszár, Dániel Pécsi, József Czimmer

“…<h4>Background</h4>Irritable bowel syndrome (IBS) and functional digestive tract disorders, e.g. functional bloating, carbohydrate maldigestion and intolerances, are very common disorders frequently causing significant symptoms that challenge health care systems. …”
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Modernization of local heat distribution stations of city heat supply system by Yu. A. Gorinov, P. N. Anisimov, E. V. Egoshin

“…The article considers the issues of functioning of district heating systems with open water intake. …”
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