Resveratrol Protects against Sepsis-Associated Encephalopathy and Inhibits the NLRP3/IL-1β Axis in Microglia by Da-ming Sui, Qun Xie, Wen-jing Yi, Sahil Gupta, Xi-ya Yu, Jin-bao Li, Jun Wang, Jia-feng Wang, Xiao-ming Deng

“…Spatial learning memory functions were evaluated by Morris water maze testing. …”
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Differences in Surgical Management of Corneal Perforations, Measured over Six Years by Katarzyna Krysik, Dariusz Dobrowolski, Anita Lyssek-Boron, Judyta Jankowska-Szmul, Edward A. Wylegala

“…To report the surgical approach, anatomical and functional results, and complications in the group of patients with corneal perforation. …”
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Tumor suppressor miR-29c regulates radioresistance in lung cancer cells by Elena Arechaga-Ocampo, Cesar Lopez-Camarillo, Nicolas Villegas-Sepulveda, Claudia H Gonzalez-De la Rosa, Isidro X Perez-Añorve, Reynalda Roldan-Perez, Ali Flores-Perez, Omar Peña-Curiel, Oscar Angeles-Zaragoza, Rosalva Rangel Corona, Juan A Gonzalez-Barrios, Raul Bonilla-Moreno, Oscar del Moral-Hernandez, Luis A Herrera, Alejandro Garcia-Carranca

“…Deregulation of microRNAs contributes to the molecular mechanism underlying resistance to radiotherapy in cancer cells. Although the functional roles of microRNAs have been well described in lung cancer, their functional roles in radioresistance are largely unclear. …”
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Sea food by-products valorization for biomedical applications: evaluation of their wound regeneration capabilities in an Ex vivo skin model by Giulia Zivelonghi, Luca Melotti, Anna Carolo, Andrea Venerando, Margherita Roncoroni, Giordana Martinelli, Lisa Maccatrozzo, Stefania Marzorati, Michela Sugni, Marco Patruno

“…IntroductionThe skin is often exposed to harmful stimuli that might compromise its integrity and functionality. After an injury, the skin has a limited capability to restore its complex structure, and in the case of severe skin damage, surgical operations and rapid application of wound dressings are often required to promote optimal wound healing. …”
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Dysfunction of ATP7B Splicing Variant Caused by Enhanced Interaction With COMMD1 in Wilson DiseaseSummary by Donghu Zhou, Huaduan Zi, Xiaoxi Yang, Xiaojin Li, Yanmeng Li, Anjian Xu, Bei Zhang, Wei Zhang, Xiaojuan Ou, Jidong Jia, Jian Huang, Hong You

“…The ATP7B knockout HuH-7 cell line and Atp7b-/- mice were created, and the functional consequence of the mutant ATP7B were evaluated in vitro and in vivo. …”
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Antioxidant, cytotoxicity, and antibacterial potential of eugenol- and carvacrol-entrapped silver-zinc oxide nanocomposites against multi-drug resistant non-typhoidal Salmonella an... by K.A. Deepika Roy, Shivaprasad Shivappa Desai, Padikkamannil Abishad, A.K. Ahalya, Rahul Krishnan, Valil Kunjukunju Vinod, Asha Karthikeyan, Kavitha Rajagopal, Renuka Nayar, Sukhadeo Baliram Barbuddhe, Deepak Bhiwa Rawool, Jess Vergis

“…Overall, this study indicated that Ag/ZnO-E and Ag/ZnO-R were effective antioxidant and antibacterial agents against MDR foodborne pathogens, suggesting their potential use in functionalized packaging to enhance the shelf life of food.…”
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GG-NER’s role in androgen receptor signaling inhibitor response for advanced prostate cancer by Chuanfan Zhong, Jiaxing Wang, Hangyang Peng, Jianming Lu, Zining Long, Zhuoyuan Lin, Guo Chen, Chao Cai, Shilong Cheng, Zhongjie Chen, Le Zhang, Weibo Zhong, Rujun Mo, Xiangming Mao

“…This high-risk group exhibited elevated TP53 mutation frequencies and significant enrichment in key pathways such as ribosome and mitochondrial functions, as well as MYC and E2F signaling. Experimental validation confirmed that targeting the GG-NER pathway or its key gene, ACTL6A, significantly reduces enzalutamide resistance in resistant cell lines and increases γH2AX expression. …”
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CD19.CAR T-cell–derived extracellular vesicles express CAR and kill leukemic cells, contributing to antineoplastic therapy by Paola Lanuti, Francesco Guardalupi, Giulia Corradi, Rosalba Florio, Davide Brocco, Serena Veschi, Elsa Pennese, Domenico De Bellis, Francesca D’Ascanio, Anna Piro, Laura De Lellis, Pasquale Simeone, Maria Concetta Cufaro, Serena Pilato, Isabella D’Amario, Ida Villanova, Barbara Di Francesco, Lucia Di Re, Fabio Verginelli, Damiana Pieragostino, Prassede Salutari, Fabrizia Colasante, Annalisa Natale, Maria Vittoria Mattoli, Simone Vespa, Antonella Fontana, Raffaella Giancola, Bianca Fabi, Stefano Baldoni, Stella Santarone, Francesco Restuccia, Nicola Tinari, Piero Del Boccio, Alessandro Cama, Mauro Di Ianni

“…Here, a cohort of 22 patients who received infusion with CD19 CAR T cells were monitored for the presence of circulating CD19 CAR+ T-cell–derived EVs (CD19.CAR+EVs), which were then separated and functionally characterized for their killing abilities. …”
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What are the effects of dry cupping therapy combined with the McKenzie method on clinical outcomes in chronic low back pain? A protocol for a randomized, sham-controlled trial by Kimberly Moreira Pereira da Silva, Hugo Jario Almeida Silva, André Pontes-Silva, Josimari Melo DeSantana, Mariana Arias Avila, Germanna Medeiros Barbosa, Marcelo Cardoso de Souza

“…Objective To evaluate the effects of dry cupping therapy with the McKenzie method (MDT) on disability and functional outcomes in people with non-specific CLBP. …”
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Meso-macro analysis of microwave-assisted double-indenter impact on rock-like materials by Peng WANG, Zhongwen YUE, Shengnan XU, Dan GAO, Meng REN, Akang LI, Weijun LIU

“…Without microwave radiation, the final fracture path of the concrete specimen is basically consistent with the direction of the line connecting the dual indenters. With microwave radiation, the final fracture path forms a larger angle with the direction of the line connecting the dual indenters, and multiple macroscopic cracks may occur. …”
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LncRNA SNHG15 targets miR-200a-3p affects the proliferation, apoptosis, migration, and invasion of cervical cancer cells by Songtao Han, Yajuan Qin, YuJiao He, Ming Li, Jing Ma, Ning Luo, Yishan Huo, Xinling Meng, Yunmei Liu

“…SNHG15 has been found and proven to have important functions in many cancers. Related studies have shown that miR-200a-3p plays an important role in tumor development. …”
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IgSF11–RAP1 signaling promotes cell migration and invasion of cutaneous melanoma by Yasuyuki Kobayashi, Kotaro Sugimoto, Minaka Ishibashi, Makoto Kobayashi, Shohei Igari, Shigeki Kitamura, Toshiyuki Yamamoto, Yuko Hashimoto, Hideki Chiba

“…The immunoglobulin superfamily 11 (IgSF11) functions as a cell adhesion protein and is overexpressed in several types of cancer, including high-grade glioma. …”
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Dopamine-driven increase in IL-1β in myeloid cells is mediated by differential dopamine receptor expression and exacerbated by HIV by Stephanie M. Matt, Rachel Nolan, Samyuktha Manikandan, Yash Agarwal, Breana Channer, Oluwatofunmi Oteju, Marzieh Daniali, Joanna A. Canagarajah, Teresa LuPone, Krisna Mompho, Kaitlyn Runner, Emily Nickoloff-Bybel, Benjamin Li, Meng Niu, Johannes C. M. Schlachetzki, Howard S. Fox, Peter J. Gaskill

“…Abstract The catecholamine neurotransmitter dopamine is classically known for regulation of central nervous system (CNS) functions such as reward, movement, and cognition. …”
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SIGMAR1 screened by a GPCR-related classifier regulates endoplasmic reticulum stress in bladder cancer by Jingming Zhuang, Yang Wang, Xinyong Wu, Zijing Peng, Zhengnan Huang, Chao Zhao, Bing Shen

“…The sigma-1 receptor (SIGMAR1), although not a classical GPCR, has similar functions and is associated with the regulation of ER stress. …”
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Diagnostic Advances in Leptospirosis: A Comparative Analysis of Paraclinical Tests with a Focus on PCR by Elena Ciurariu, Catalin Prodan-Barbulescu, Diana-Maria Mateescu, Paul Tutac, Virgiliu-Bogdan Sorop, Monica Susan, Norberth-Istvan Varga

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Synergistic effect of rhenium and tungsten in nickel-based model single crystal superalloys by Wei Tan, Tingting He, Xiaona Zhang, Bingquan Lin, Hongxian Xie, Tao Yu, Chaochao Shi, Yumo Wen, Chongyu Wang, Ze Zhang

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PLCH1 overexpression promotes breast cancer progression and predicts poor prognosis through the ERK1/2-EGR1 axis by Jing Li, Fenge Jiang, Congcong Wang, Ping Sun, Lei Song, Jiannan Liu

“…PLCH1 expression was strongly correlated with the expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) in breast cancer tissues, further linking PLCH1 to poor prognosis and adverse patient outcomes. Functional studies revealed that PLCH1 was highly expressed in breast cancer cell lines, and PLCH1 knockdown significantly inhibited cell proliferation, induced cell cycle arrest, and reduced cyclin-dependent kinase 1 (CDK1) expression in BT-474 cells. …”
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STAT1β modulates the tumor immune microenvironment to improve prognosis in ovarian cancer: a comprehensive study of transcriptional and protein expression differences by Ning Lan, Xintong Li, Yifan Qiao, Siyi Zhang, Min Chen, Xiaofeng Yang, Yuliang Zou, Juan Ren, Meili Pei

“…Abstract Objectives As a central regulator of the JAK/STAT signaling pathway, STAT1 generates functionally distinct α and β protein isoforms through alternative splicing. …”
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A minority of proliferating human CD4+ T cells in antigen-driven proliferation assays are antigen specific by Pushpak Bhattacharjee, Miha Pakusch, Matthew Lacorcia, Chris Y. Chiu, Xin Liu, Xin Liu, Eleonora Tresoldi, Abby Foster, Laura King, Fergus J. Cameron, Fergus J. Cameron, Fergus J. Cameron, Stuart I. Mannering, Stuart I. Mannering, Stuart I. Mannering, Stuart I. Mannering, Stuart I. Mannering

“…The TCRs expressed by antigen-responsive CD4+ T cells were sequenced, and their antigen specificity was tested functionally by expressing them in a reporter T-cell line. …”
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RNA-seq approach to discriminate gene expression profiles in RIXI-overexpressing transgenic rice by PENG Yaoyao, HOU Chunxiao, ZHAN Yihua, HUANG Yingying, SUN Xiangyu, WENG Xiaoyan

“…To investigate whether RIXI-overexpressing transgenic plants influence the expression of other genes, we analyzed transcriptomic changes between R7 (RIXI-overexpression transgenic line 7) plants and WT (wild-type) plants using deep RNA sequencing combined with digital gene expression profile analysis. …”
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