DNMT3B promotes the progression of pheochromocytoma by mediating the hypermethylation of LRP1B promoter by Min Sun, Yanrong Ma, Jing Wan, Bingli Zheng, Zhenfeng Shi, Jiuzhi Li

“…LRP1B or DNMT3B were knock-down in Pheo cell line by shRNAs. Functional experiments including clonal formation, migration, and in vivo transplantation were performed to evaluate the regulation of LRP1B or DNMT3B on tumor growth. …”
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RETRACTED ARTICLE: Sulforaphane induces S-phase arrest and apoptosis via p53-dependent manner in gastric cancer cells by Yuan Wang, Huazhang Wu, Nannan Dong, Xu Su, Mingxiu Duan, Yaqin Wei, Jun Wei, Gaofeng Liu, Qingjie Peng, Yunli Zhao

“…The Bax and cleaved-caspase-3 genes involved in apoptosis executive functions were significantly increased in a dose-dependent manner in BGC-823 and MGC-803 cells. …”
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The Vitamin A Derivative All-Trans Retinoic Acid Repairs Amyloid-β-Induced Double-Strand Breaks in Neural Cells and in the Murine Neocortex by Emmanuelle Gruz-Gibelli, Natacha Chessel, Clélia Allioux, Pascale Marin, Françoise Piotton, Geneviève Leuba, François R. Herrmann, Armand Savioz

“…This phenomenon would remain functional up to a point when Aβ increase and RA decrease probably lead to a pathological state.…”
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Botulinum toxin type A for amyotrophic lateral sclerosis lower limb spasm: two case reports by Qiang Duan, Chao Li, Chunxia Wei, Qian Wang, Bo Wang, Liangwen Sun, Yongjing He, Junxia Qin, Xiaoqun Huang

“…Botulinum toxin type A (BTX-A) is a first-line drug for spastic management. However, there are limited reports on its effectiveness in reducing muscle tone among ALS patients, with scarcely any related research conducted in China. …”
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MergeBot: A platform of semi-structured merge conflict resolution for C/C++ code by Hua He, Xiaofan Liu, Lei Xu, Guanghui Mei, Jifeng Xuan

“…The semi-structured merge combines structural merge of program entities (e.g., functions, classes) with unstructured merge of code lines. …”
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ATAD2 Overexpression Identifies Colorectal Cancer Patients with Poor Prognosis and Drives Proliferation of Cancer Cells by Yang Luo, Guang-Yao Ye, Shao-Lan Qin, Min-Hao Yu, Yi-Fei Mu, Ming Zhong

“…Kaplan-Meier method suggested that higher ATAD2 protein expression significantly associated with the overall survival (OS) of CRC patients (P<0.001) and was an independent predictor of poor OS. Functional studies showed that suppression of ATAD2 expression with siRNA could significantly inhibit the growth in SW480 and HCT116 cells. …”
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PPAR-γ in Melanoma and Immune Cells: Insights into Disease Pathogenesis and Therapeutic Implications by Vladimir Sobolev, Ekaterina Tchepourina, Anna Soboleva, Elena Denisova, Irina Korsunskaya, Alexandre Mezentsev

“…As a transcription factor, PPAR-γ is crucial in functions like fatty acid storage and glucose metabolism. …”
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Descriptive and temporal analysis of the mortality rate and average hospital stay due to burns and corrosion in the elderly in Brazil between 2010 and 2019 by Arthur Antunes Coimbra Pinheiro Pacífico, Ester Saraiva Carvalho Feitosa, Anna Letícia Silveira Parnaíba, Pedro Lucena de Aquino, Amanda de Andrade Cavalcante, Thalia de Souza Bezerra, Leandro Dantas Rolim, Samy Lima Carneiro

“…Introduction: Aging leads to physical and cognitive limitations and decreased functional capacity. Therefore, there is a greater risk, a higher rate of complications and death in elderly patients from burns. …”
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Fine-grained hardware resource optimization and design for FPGA-based real-time simulation of large-scale renewable energy generations by Yanfei Li, Zhiying Wang, Xiaopeng Fu, Peng Li, Ligang Zhao, Xiaoshan Wu

“…A detailed hardware design and automatic hardware description language generation method are proposed to rapidly generate the functional hardware modules for the REG control system solution. …”
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OPTIMIZATION OF HEALTHCARE FOR CHILDREN WITH RHEUMATIC DISEASES IN EPOCH OF TREATMENT WITH GENETICALLY ENGINEERED BIOLOGICAL AGENTS (BY THE EXAMPLE OF THE REPUBLIC OF BASHKORTOSTAN... by G. A. Shebaev, R. M. Shakirova, V. A. Malievskii, R. Z. Akhmetshin

“…Formation of regional registry of children with juvenile arthritis has been performed in the Republic of Bashkortostan since 2003, regional component of the federal on-line registry has been functioning since 2011. The prevalence of juvenile arthritis, its social and economic consequences and the «costs of the disease» were established. …”
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SPON2 facilitates osteosarcoma development by inducing M2 macrophage polarization through activation of the NF-κB/VEGF signaling axis by Xinchang Lu, Xueping Zhang, Fengzhen Zhang, Wenhao Wang, Ruijie Liu, Yubao Hou, Weiye Shi, Jiazhen Li, Changliang Peng

“…SPON2 is significantly upregulated in OS tissues and cell lines and correlates with shorter patient survival. …”
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Automation of Optimization Synthesis for Modular Technological Equipment by Zaleta O. M., Povstyanoy O. Yu., Ribeiro L. F., Redko R. G., Bozhko T. Ye., Chetverzhuk T. I.

“…Technological equipment design based on functionally modular methods is widely used in various technical fields. …”
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Engineering hydrophobicity and manufacturability for optimized biparatopic antibody–drug conjugates targeting c-MET by Andreas Evers, Simon Krah, Deniz Demir, Ramona Gaa, Desislava Elter, Christian Schroeter, Stefan Zielonka, Nicolas Rasche, Julia Dotterweich, Christine Knuehl, Achim Doerner

“…Optimized variants showed high stability, strongly reduced hydrophobicity, retained affinities supporting the desired functionality and enhanced producibility. The resulting biparatopic anti-c-MET ADCs were comparably active on c-MET expressing tumor cell lines as REGN5093 exatecan DAR6 ADC. …”
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Mimicking Axon Growth and Pruning by Photocatalytic Growth and Chemical Dissolution of Gold on Titanium Dioxide Patterns by Fatemeh Abshari, Moritz Paulsen, Salih Veziroglu, Alexander Vahl, Martina Gerken

“…Biological neural circuits are based on the interplay of excitatory and inhibitory events to achieve functionality. Axons form long-range information highways in neural circuits. …”
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Multispanning membrane protein SIDT2 increases knockdown activity of gapmer antisense oligonucleotides by Kohshi Kusumoto, Kiyomi Sasaki, Yasunori Uchida, Ayaka Utsumi, Tokuyuki Yoshida, Satoshi Obika, Takao Inoue, Keiichiro Okuhira

“…By inducing SIDT1 or SIDT2 expression in human cell lines, we demonstrated that SIDT2 enhanced the knockdown activity of gapmer ASOs and potentially promoted their endosomal escape into the cytosol. …”
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Genomic Landscape and Potential Regulation of RNA Editing in Drug Resistance by Xu Zhou, Ramkrishna Mitra, Fei Hou, Shunheng Zhou, Lihong Wang, Wei Jiang

“…In addition, it is determined that the functions of genes enriched with DESs are associated with drug resistance, such as apoptosis, drug metabolism, and DNA synthesis involved in DNA repair. …”
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Design, Synthesis, and Biological Evaluation of New Analogs of Aurein 1.2 Containing Non-Proteinogenic Amino Acids by Nora Angelova, Ivan Iliev, Veronica Nemska, Tatyana Dzimbova, Nelly Georgieva, Dancho Danalev, Emilia Naydenova

“…Aurein 1.2 (GLFDIIKKIAESF-NH2) was demonstrated to have broad spectrum bi-functionality against bacterial and cancer cells. The Solid Phase Peptide Synthesis (Fmoc-strategy) was used for the synthesis of new analogs of aurein 1.2. …”
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Controlled Synthesis of TiB2-TiC Composite: Substantiation of the Homogenizing Joule Thermostatting Efficiency and Improvement of SHS-Compaction Technology in a Vacuum by Gigo Jandieri, David Sakhvadze

“…For this purpose, an improved technological approach is proposed, which is based on the known method of SHS-compacting but differs by the possibility of controlled Joule influence on the synthesis products, which is achieved by the use of a special electrothermal vacuum press-mold functioning according to a particular control algorithm. …”
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Efficacy and aesthetic outcomes of photodynamic therapy for basal cell carcinoma in aesthetic-sensitive facial regions: A case series study by Xu Ji, Li Ma, Yu Xin Ding, Jin Chi Zhang, Ming Kai Ji

“…., nasal, periocular) risks disfiguring scars and functional deficits, particularly for elderly patients with surgical contraindications or extensive lesions where complete tumor clearance proves challenging. …”
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Inhaled pH-Responsive polymyxin B-loaded albumin nanoparticles against pneumonia caused by carbapenem resistant Klebsiella pneumoniae by Ziling Li, Huiling Lei, Jiannan Hu, Tong Zhou, Shuaiqi Yuan, Xinyue Ma, Yunfei Zhu, Chao Liu, Decai Wang, Yuzhou Wu, Shuyun Xu

“…An acid-responsive functional molecule (PEBA) and NH2-PEG-SH are linked to the surface of human serum albumin (HSA) via the conjugation reaction. …”
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