Isolation, Structure Elucidation and Biological Evaluation of Lomaiviticins F–H, Dimeric Benzofluorene Glycosides from Marine-Derived <i>Micromonospora</i> sp. Bacterium by Fan Zhang, Wenhui Wang, Doug R. Braun, Gene E. Ananiev, Weiting Liao, Mary Kay Harper, Scott R. Rajski, Tim S. Bugni

“…These findings emphasize the utility of IFS in expediting natural product discovery while providing valuable insights into structural and functional characterizations of bioactive compounds.…”
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<i>Vitis vinifera</i> L. Leaves as a Source of Phenolic Compounds with Anti-Inflammatory and Antioxidant Potential by Nuria Acero, Jorge Manrique, Dolores Muñoz-Mingarro, Isabel Martínez Solís, Francisco Bosch

“…These results pointed out <i>V. vinifera</i> leaves as a powerful functional food with a high content of biologically active compounds. …”
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TMSB10 drives prostate cancer aggressiveness via immune microenvironment regulation by Haoran Xia, Jiaxin Ning, Xiaoxiao Guo, Hongchen Song, Xuanhao Li, Xuan Wang

“…Pan-cancer analysis from The Cancer Genome Atlas (TCGA) revealed that TMSB10 is upregulated across multiple cancer types, particularly in prostate cancer, where high TMSB10 expression correlates with poorer patient outcomes. Functional assays using prostate cancer cell lines LNCaP and DU145 showed that TMSB10 silencing suppresses cell proliferation, migration, and invasion, while overexpression enhances these oncogenic processes. …”
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Unlocking the potential of antibody-drug conjugates in cervical cancer: emerging targets and clinical trials by Yue Zhang, Yao Ding, Yiran Liao, Jin Shu, Yi Gong

“…This review outlines promising tumor-associated antigens (TAAs) for ADC targeting in cervical cancer and their biological functions, such as human epidermal growth factor receptor 2 (HER2), trophoblast cell surface antigen 2 (Trop-2), mesothelin, nectin cell adhesion molecule 4 (Nectin-4). …”
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Image-based identification and isolation of micronucleated cells to dissect cellular consequences by Lucian DiPeso, Sriram Pendyala, Heather Z Huang, Douglas M Fowler, Emily M Hatch

“…Our MN segmentation modules overcome a significant challenge with reproducible MN quantification, and, joined with visual cell sorting, enable the application of powerful functional genomics assays to a wide-range of questions in MN biology.…”
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Identification of Y-box binding protein 1 as a core regulator of MEK/ERK pathway-dependent gene signatures in colorectal cancer cells. by Karsten Jürchott, Ralf-Jürgen Kuban, Till Krech, Nils Blüthgen, Ulrike Stein, Wolfgang Walther, Christian Friese, Szymon M Kiełbasa, Ute Ungethüm, Per Lund, Thomas Knösel, Wolfgang Kemmner, Markus Morkel, Johannes Fritzmann, Peter M Schlag, Walter Birchmeier, Tammo Krueger, Silke Sperling, Christine Sers, Hans-Dieter Royer, Hanspeter Herzel, Reinhold Schäfer

“…To identify regulators of transcriptome alterations, we used an integrated approach combining transcriptional profiling of colorectal cancer cell lines treated with inhibitors targeting the receptor tyrosine kinase (RTK)/RAS/mitogen-activated protein kinase pathway, computational prediction of regulatory elements in promoters of co-regulated genes, chromatin-based and functional cellular assays. …”
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The Fusion Gene <i>BPI-LY</i>, Encoding Human Bactericidal/Permeability-Increasing Protein Core Fragments and Lysozyme, Enhanced the Resistance of Transgenic Tomato Plants to Bacte... by Lei Ni, Yue Zhang, Yafei Qin, Mei Wang, Daodao Tang, Liantian Chen, Xing Ding, Yilin Zheng, Yu Pan, Jinhua Li, Xingguo Zhang

“…In this study, we constructed a fusion gene <i>BPI-LY</i> by combining the gene encoding the lipophilic functional domains of human bactericidal/permeability-increasing protein (BPI) with the gene of human lysozyme (LY). …”
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Inhibition of class IIa HDACs reduces mutant HTT aggregation by affecting RNA stability by Annika Reisbitzer, Cecilia Hollitzer, Adriana Geraci, Jessye Schaefer, Maximilian Burghaus, Jonas Bruns, Joachim Urban, Thomas Kurz, Sybille Krauß

“…Patients suffer from progressive impairment in cognitive and motor functions. Transcriptional dysregulation is a major molecular disease mechanism of HD. …”
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A Cognitive Radio Enabled RF/FSO Communication Model for Aerial Relay Networks: Possible Configurations and Opportunities by Eylem Erdogan, Ibrahim Altunbas, Nihat Kabaoglu, Halim Yanikomeroglu

“…Finally, for an air-to-ground channel, a hybrid RF/FSO communication system is employed, where the RF communication functions as a backup for the FSO communication in the presence of adverse weather conditions. …”
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Effect of Cooling Rate on the Secondary Dendritic Spacing of a Horizontally Solidified 6xxx Series Aluminum Alloy by Luane P. Marques, Suanny Q. Mesquita, André C. Maciel, Rogério B. Costa, Raquel S. França, Otavio L. Rocha, Ivaldo L. Ferreira

“…The experimental relationships for SDAS as functions of TR and local solidification time (tSL) are expressed with the equations: SDAS = constant × (TR)(-1/3) and SDAS = constant × (tSL)(1/3). …”
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Mangrove Habitat Structure of Mud Crabs (Scylla serrata and S. olivacea) in the Bee Jay Bakau Resort Probolinggo, Indonesia by Audina Putri, Dietriech Geoffrey Bengen, Neviaty Putri Zamani, Ummu Salma, Novian Prahandhy Kusuma, Nanda Tiara Diningsih, Sonja Kleinertz

“…Accordingly, an analysis of the functional relationships between Scylla spp. abundance and the respective mangrove habitat have to be carried out. …”
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Coenzyme Q10 alleviates neurological deficits in a mouse model of intracerebral hemorrhage by reducing inflammation and apoptosis by Xiaoqing Yang, Yi Zhao, Sisi Yu, Lihui Chi, Yeyan Cai

“…In line with the part of CoQ10 in attenuating the inflammatory response, CoQ10 also suppressed cell apoptosis in the ICH-injured brain, which partly accounts for its neuroprotective effect. …”
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Reduced Levels of miR-145-3p Drive Cell Cycle Progression in Advanced High-Grade Serous Ovarian Cancer by Eva González-Cantó, Mariana Monteiro, Cristina Aghababyan, Ana Ferrero-Micó, Sergio Navarro-Serna, Maravillas Mellado-López, Sarai Tomás-Pérez, Juan Sandoval, Antoni Llueca, Alejandro Herreros-Pomares, Juan Gilabert-Estellés, Vicente Pérez-García, Josep Marí-Alexandre

“…Further investigation confirmed that DNA methylation controls <i>MIR145</i> expression. Functional assays showed that overexpression of miR-145-3p significantly reduced cell migration and induced G0/G1 cell cycle arrest by modulating the cyclin D1-CDK4/6 pathway. …”
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Identification of the Cold-Related Genes COLD11 and OsCTS11 via BSA-seq and Fine Mapping at the Rice Seedling Stage by Bian Wu, Minghui Fu, Jinghua Du, Mengjing Wang, Siyue Zhang, Sanhe Li, Junxiao Chen, Wenjun Zha, Changyan Li, Kai Liu, Huashan Xu, Huiying Wang, Shaojie Shi, Yan Wu, Peide Li, Aiqing You, Lei Zhou

“…According to the reported functional variation of COLD11, Nipponbare (TCG + 3GCG)×2 presented more GCG repeats in the 1st exon than WD16343 (TCG + 3GCG), partially explaining the difference in cold tolerance between the parents. …”
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Life Cycle Assessment of Biofuel Production from Sugarcane Bagasse by Nasri Nurul Farhana, Mohd Hanafiah Marlia, Harun Siti Norliyana, Chong Jing Wen, Hassan Faez M.

“…The LCA was performed using SimaPro version 9.0 software, utilizing the ReCiPe 2016 methodology in a ’cradle-to-gate’ framework. The functional unit in this study was 252 kg of bioethanol produced from 1 ton of sugarcane bagasse. …”
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The MEK inhibitor trametinib is effective in inhibiting the growth of canine oral squamous cell carcinoma by William P. Katt, Cheryl E. Balkman, Scott D. Butler, Michael Byron, Patrick C. Carney, Amy B. Todd-Donato, Matthew E. Drozd, Gerald E. Duhamel, Jacquelyn M. Evans, Nadine Fiani, Jordan C. Ford, Jennifer K. Grenier, Jessica J. Hayward, Kristiina Heikinheimo, Kelly R. Hume, Elizabeth S. Moore, Rishi Puri, Skylar R. Sylvester, Sydney L. Warshaw, Suzin M. Webb, Andrew C. White, Alexandra L. Wright, Richard A. Cerione, Santiago Peralta

“…Here, we demonstrate that the MEK inhibitor trametinib, an FDA-approved drug for human cancers, substantially inhibits the growth of six COSCC cell lines established from current patient tumor samples. …”
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USP21-EGFR-Lyn axis drives NSCLC progression and therapeutic potential of USP21 inhibition by Ji Hye Shin, Ji Young Kim, Mi-Jeong Kim, Yeeun Kang, Bongkum Choi, Dohee Kwon, Yoolim Sung, Seo Hyun Kim, Ha-Jeong Lee, Chaeeun Lee, Kyeong Kyu Kim, Jae-Hyuck Shim, Duk-Hwan Kim, Eunyoung Chun, Ki-Young Lee

“…Gene Set Enrichment Analysis (GSEA) of NSCLC patient datasets revealed a strong correlation between USP21 overexpression and poor prognosis. Functional studies using USP21-knockout (USP21-KO) lung cancer cell lines demonstrated reduced proliferation, migration, colony formation, and tumor spheroid growth. …”
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miR-5100 Overexpression Inhibits Prostate Cancer Progression by Inducing Cell Cycle Arrest and Targeting E2F7 by An Zhang, Wen Deng, Haojie Shang, Jian Wu, Yucong Zhang, Qianyuan Zhuang, Cuntai Zhang, Yuan Chen

“…By using RT-qPCR, we observed lower miR-5100 expression in PCa cell lines than in benign prostate cells. Functional assays demonstrated that miR-5100 overexpression significantly suppressed PCa cell proliferation, migration, and invasion. …”
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The Transcription Factor ZNF395 Is Required for the Maximal Hypoxic Induction of Proinflammatory Cytokines in U87-MG Cells by Christine Herwartz, Paola Castillo-Juárez, Linda Schröder, Blanca L. Barron, Gertrud Steger

“…The transcription factor ZNF395 was found to be overexpressed in various tumors including glioblastomas particularly in the network of a hypoxic response pointing to a functional role of ZNF395. On the other hand, ZNF395 was suggested to have tumor suppressor activities which may rely on its repression of proinflammatory factors. …”
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Construction of reliable QSPR models for predicting the impact sensitivity of nitroenergetic compounds using correlation weights of the fragments of molecular structures by Shahram Lotfi, Shahin Ahmadi, Alla P. Toropova, Andrey A. Toropov

“…Four target functions (TF0, TF1, TF2, and TF3) were used to generate robust models. …”
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