Upregulation of transferrin receptor-1 induces cholangiocarcinoma progression via induction of labile iron pool by Wassana Jamnongkan, Raynoo Thanan, Anchalee Techasen, Nisana Namwat, Watcharin Loilome, Piyapharom Intarawichian, Attapol Titapun, Puangrat Yongvanit

“…Additionally, the levels of labile iron pool and the functions of transferrin receptor-1 on cholangiocarcinoma development were also identified. …”
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Legal regulation of the system of public administration entities providing the administrative and legal regime of special economic zones by O. A. Lakaev

“…It is necessary to bring the Federal Law “On Special Economic Zones in the Russian Federation” into line with the new provisions of the Russian Constitution on public authority. …”
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ALKBH5 Promotes Breast Cancer Stemness Through Regulating Wnt/β-Catenin Signaling by Wang K, Wang K

“…The N6-methyladenylate methylation (m6A) demethylase alpha-ketoglutarate-dependent dioxygenase alkB homolog 5 (ALKBH5) decreases modification of RNA, while its role in regulating breast cancer development remains unclear.Methods: ALKBH5-silenced breast cancer cell-line MCF-7 was constructed to investigate its functional impact. …”
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IDH1 Mutation Impacts DNA Repair Through ALKBH2 Rendering Glioblastoma Cells Sensitive to Artesunate by Olivier Switzeny, Stefan Pusch, Markus Christmann, Bernd Kaina

“…The mutation found in different cancers is functionally active, causing, instead of α-KG, the formation of 2-hydroxyglutarate (2-HG), which inhibits α-KG-dependent enzymes. …”
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Cell-targeted PD-1 agonists are potent NK-cell inhibitors by Harriet C. Pope, Harriet C. Pope, Ana L. Chiodetti, Alice Newey, Guillaume Rieunier, David X. Overton, Eduardo Mateos-Diaz, Tara M. Mahon, Giovanna Bossi, Hussein Al-Mossawi, Charlotte Viant

“…Of note, NK cells can upregulate PD-1 expression upon activation and their effector functions can be modulated by the PD-1 signalling pathway.MethodsWe have generated a novel bispecific inhibitory molecule, comprised of a targeting domain highly specific for a pre-pro-insulin peptide presented by the HLA-A*02 molecules on the cell surface of pancreatic β-cells and a PD-1 agonist effector domain. …”
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DISCRETE DEFORMATION WAVE DYNAMICS IN SHEAR ZONES: PHYSICAL MODELLING RESULTS by S. A. Bornyakov, I. A. Panteleev, A. A. Tarasova

“…Directions and magnitudes of displacements of the cells were determined from displaced maximums of cross-correlation functions (…”
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Exploring the involvement of serine proteases in neutrophil extracellular traps: a review of mechanisms and implications by Aleksandra Korba-Mikołajczyk, Katarzyna Dominika Służalska, Paulina Kasperkiewicz

“…Recently, the role of NSPs during NET formation and their extracellular functions have received increased attention from researchers. …”
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Temporal Transcriptome Analysis Reveals Core Pathways and Orphan Gene <i>EARLY FLOWERING 1</i> Regulating Floral Transition in Chinese Cabbage by Hong Lang, Yuting Zhang, Shouhe Zhao, Kexin Li, Xiaonan Li, Mingliang Jiang

“…A total of 7092 differentially expressed genes (DEGs) were identified, exhibiting distinct expression trajectories during the transition. Moreover, functional enrichment analyses revealed strong associations with plant hormone signaling, MAPK pathways, and developmental regulation processes. …”
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Assessment of the capacity of health facilities in preventing and managing non-communicable diseases in selected regions of Somaliland by Opeolu O. Ojo, Omar O Hersi, Ayodele A Falobi, Nura Ali, Lawrence Tan, Yusuf A. Ali

“…Where available, they were either not functional or there is a lack of expertise for effective utilization. …”
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Effective antistress ligands lithium new generation by K. S. Ostrenko, V. A. Galochkin, O. A. Gromova, V. V. Rastashanskii, I. Yu. Torshin

“…To increase stress tolerance it is necessary to maintain the body's balance functions of the nervous, immune, endocrine and antioxidant systems of the monooxygenase. …”
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Optimized Design of Cultural Space in Wuhan Metro: Analysis and Reflection Based on Multi-Source Data by Zhengcong Wei, Yangxue Hu, Yile Chen, Tianjia Wang

“…Wuhan, located in central China, has many subway lines and its engineering construction has set several national firsts, which is a typical sample of urban subway development in China. …”
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Development of a Novel KCNN4-Related ceRNA Network and Prognostic Model for Renal Clear Cell Carcinoma by Hengtao Bu, Qiang Song, Jiexiu Zhang, Yuang Wei, Bianjiang Liu

“…Finally, quantitative real-time polymerase chain reaction and western blot were conducted for KCNN4 expression detection in cell lines and clinical samples. Small interfering RNA was employed to knock down KCNN4, and corresponding functional experiments were conducted on ccRCC cells as well. …”
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Reforms in the Field of Statistics of the Republic of Uzbekistan: Results and Development Prospects by B. A. Begalov, O. T. Mamadaliev

“…The purpose of this article is to highlight the ongoing reforms in the field of statistics of the Republic of Uzbekistan, as well as to determine the prospects for further development in the context of the formation of a digital economy for the effective functioning of the statistical sphere in the unified socio-economic system of the country.Materials and methods. …”
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TRIM26 as a dual regulator of ferroptosis and chemoresistance in gastric cancer through HSF1 ubiquitination and exosomal miR-24-3p signaling by Nouf S. Al-Abbas

“…TRIM26, an E3 ubiquitin ligase with emerging tumor-suppressive functions, has been implicated in various malignancies; however, its precise role in GC has not been fully elucidated. …”
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INDUCED PLURIPOTENT STEM CELL-DERIVED MICROGLIA TO STUDY NLRP3 INFLAMMASOME ACTIVATION IN ALZHEIMER’S DISEASE by Aslı Erdoğan, Cira Dansokho, Jari Koıstınaho, Sarka Lehtonen, Seyhun Solakoğlu, Michael Thomas Heneka

“…The expression of proteins associated with the NLRP3 pathway was investigated by Western blot. For functional analysis, cytokine release was assessed by Enzyme-linked immunosorbent assay (ELISA) upon NLRP3 inflammasome activators (lipopolysaccharide (LPS), Aβ) and inhibitor (cytokine release inhibitory drug 3, CRID3) treatments. …”
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Genetic analysis of completely sequenced disease-associated MHC haplotypes identifies shuffling of segments in recent human history. by James A Traherne, Roger Horton, Anne N Roberts, Marcos M Miretti, Matthew E Hurles, C Andrew Stewart, Jennifer L Ashurst, Alexey M Atrazhev, Penny Coggill, Sophie Palmer, Jeff Almeida, Sarah Sims, Laurens G Wilming, Jane Rogers, Pieter J de Jong, Mary Carrington, John F Elliott, Stephen Sawcer, John A Todd, John Trowsdale, Stephan Beck

“…Certain coding sequences vary significantly between different haplotypes, making them candidates for functional and disease-association studies. Analysis of the two DR3 haplotypes allowed delineation of the shared sequence between two HLA class II-related haplotypes differing in disease associations and the identification of at least one of the sites that mediated the original recombination event. …”
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The Relation between Fatigue Level and Nurses’ Caring Behavior in The Orthopedic Department by Yasmin F. M. AbdElazeem, Rasha F. Ahmed, Eman F. A. M. Aly

“…It may significantly interfere with functioning and may persist despite periods of rest. …”
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“They knew how to take care of people”: a qualitative study on older adults with chronic low back pain perspectives of an exercise plus education program by Fabianna Resende de Jesus-Moraleida, Ana Carla Lima Nunes, Crislaine Silva Costa, Lara Figueiredo Vasconcelos, Nathalia Costa

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Study of phenotypic and cytotoxic properties of erythroid cells of the spleen under hematopoiesis-stimulating effects by Yu. A. Shevchenko, K. V. Nazarov, S. V. Sennikov

“…In recent years, research has revealed a wide variety of erythroid cell functions, including modulation of innate and adaptive immune responses. …”
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Unraveling the anti-tumor effects of midazolam in non-small cell lung cancer through the lncRNA XLOC_010706/miR-520d-5p/STAT3/autophagy pathway by Jinghua Jiao, Yifang Tang, Lu Ye, Yaru Yang, Zhenghua Liu

“…Within the signaling pathway, lncRNA XLOC_010706 functioned as a competing endogenous RNA (ceRNA) targeting miR-520d-5p, with STAT3 identified as a functional target gene for miR-520d-5p in NSCLC. …”
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