The Pregnane-X receptor regulates steroid synthesis in mouse Leydig cells by Emmanuelle Martinot, Hélène Holota, Angélique de Haze, Claude Beaudoin, David H. Volle

“…Pxr was shown to be expressed in human, mouse, rat and pig testis, however its roles in the regulation of testicular functions have been little explored so far.MethodsTo determine the potential involvement of PXR in the regulation of steroidogenesis, experiments were performed on a wild type (MLTC-1WT) and a Pxr knock-down (MLTC-1PxrKD) mouse Leydig cell line (MLTC-1 cells), treated with a PXR agonist (SR-12813) in acute and chronic conditions. …”
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Indisulam synergizes with melphalan to inhibit Multiple Myeloma malignancy via targeting TOP2A. by Chengyu Wu, Chao Wu, Jia Liu, Mingyuan Jia, Xinyi Zeng, Ze Fu, Ziqi He, Wenbin Xu, Hua Yan

“…Functional experiments revealed that silencing TOP2A inhibited cell proliferation and induced apoptosis and DNA damage. …”
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A predictive in vitro model of the impact of drugs with anticholinergic properties on human neuronal and astrocytic systems. by Elizabeth K Woehrling, H Rheinallt Parri, Erin H Y Tse, Eric J Hill, Ian D Maidment, G Christopher Fox, Michael D Coleman

“…In this preliminary study we employed a co-culture of human-derived neurons and astrocytes (NT2.N/A) derived from the NT2 cell line. NT2.N/A cells possess much of the functionality of mature neurons and astrocytes, key cholinergic phenotypic markers and muscarinic acetylcholine receptors (mAChRs). …”
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3D nanoprinted fiber-interfaced hollow-core waveguides for high-accuracy nanoparticle tracking analysis by Diana Pereira, Torsten Wieduwilt, Walter Hauswald, Matthias Zeisberger, Marta S. Ferreira, Markus A. Schmidt

“…Abstract The integration of functional components into flexible photonic environments is a critical area of research in integrated photonics and is essential for high-precision sensing. …”
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Cytotoxic Activity and Antibiofilm Efficacy of Biosynthesized Silver Nanoparticles against Methicillin-Resistant Staphylococcus aureus Strains Colonizing Cell Phones by Abderrahmen Merghni, Mohamed Ali Lassoued, Emira Noumi, Ramzi Hadj Lajimi, Mohd Adnan, Maha Mastouri, Mejdi Snoussi

“…Dynamic light scattering spectroscopy and Fourier transform infrared spectroscopy analyses further characterized nanoparticles confirming their stability and the presence of functional groups. The biological properties of biosynthesized AgNPs were subsequently investigated. …”
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Toward a synthesis of Paleoamerican fluted point cultures in the Carolinas by I. Randolph Daniel, Albert C. Goodyear, Christopher R. Moore, David K. Thulman, Joseph E. Wilkinson

“…We speculate that this morphological distinction is a functional one related to proboscidean extinction. Spatial distributions of these point types across the state, when combined with similar point distributions across South Carolina, reveal distinct geographic patterns. …”
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Towards complexity in de Sitter space from the doubled-scaled Sachdev-Ye-Kitaev model by Sergio E. Aguilar-Gutierrez

“…Later, we define the query complexity in the LdS2 model as the number of steps in an algorithm computing n-point correlation functions of boundary operators of the corresponding antipodal points in SdS3 space. …”
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Accurate distinction of pathogenic from benign CNVs in mental retardation. by Jayne Y Hehir-Kwa, Nienke Wieskamp, Caleb Webber, Rolph Pfundt, Han G Brunner, Christian Gilissen, Bert B A de Vries, Chris P Ponting, Joris A Veltman

“…In this study we developed and validated a novel computational method for differentiating between benign and MR-associated CNVs using structural and functional genomic features to annotate each CNV. In total 13 genomic features were included in the final version of a Naïve Bayesian Tree classifier, with LINE density and mouse knock-out phenotypes contributing most to the classifier's accuracy. …”
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MED8 is related to tumor immunity and has predictive value in the prognosis and treatment of glioma by Jingyi Yang, Bin Li, Xinghai Zhang, Yufeng Li, Hao Yuan

“…The expression of MED8 in cell lines was studied by qPCR. Results Studies show increased expression of MED8 is associated with poor prognosis in glioma. …”
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Let-7b-5p sensitizes breast cancer cells to doxorubicin through Aurora Kinase B. by Murat Kaya, Asmaa Abuaisha, Ilknur Suer, Selman Emiroglu, Semen Önder, Evren Onay Ucar, Mustafa Nuri Yenerel, Sukru Palanduz, Kivanc Cefle, Sukru Ozturk, Zeyneb Kurt

“…Expression analysis via quantitative PCR confirmed that let-7b-5p was downregulated and AURKB was upregulated in breast cancer tissue samples. Later, functional studies conducted with MCF-10A, MCF-7, and MDA-MB-231 cell lines demonstrated that let-7b-5p inhibits cancer cells through AURKB and sensitizes them to Dox resistance. …”
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Retrovolution: HIV-driven evolution of cellular genes and improvement of anticancer drug activation. by Paola Rossolillo, Flore Winter, Etienne Simon-Loriere, Sarah Gallois-Montbrun, Matteo Negroni

“…In evolution strategies aimed at isolating molecules with new functions, screening for the desired phenotype is generally performed in vitro or in bacteria. …”
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Stability Analysis of Power Systems with High Penetration of State-of-the-Art Inverter Technologies by Sayan Samanta, Bowen Yang, Gab-Su Seo

“…Four types of inverter controls are considered: two grid-following (GFL) controls, with or without grid support functions; droop-based grid-forming (GFM) controls; and virtual oscillator control-based GFM. …”
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Cyclization of small forms of Balkar prose by Asiyat D. Atabieva

“…During the analysis the relevant material, various types of prose cycles are revealed: author’s (originally written according to the writer’s plan), editorial (compiled to the publication of collections of works by an individual author, based on a single problem) and composite (multi-component texts, within which autonomous works are transformed into a cyclical unity, based on meaningful overlap, repeatability of plot lines and dominant images). The result of the study is the conclusion that the novelistic cycle has become a very effective form in national prose with its functionality and scope of application, allowing the most complete reflection of the dynamically changing reality.…”
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Effects of Material Rheology and Die Walls Translational Motions on the Dynamics of Viscous Flow during Equal Channel Angular Extrusion through a Segal 2θ-Die: CFD 2D Solution of a... by Alexander V. Perig, Nikolai N. Golodenko

“…Theoretical CFD-derived plots with computational flow lines, dimensionless flow and curl functions, flow velocities, and tangential stresses for viscous material flow through the stated die geometries have been generated and described. …”
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Multiobjective Reactive Power Optimization Planning for Medium Voltage Distribution Networks Based on Improved Genetic Algorithm by Min Li, Juncheng Zhang, Jing Tan, Xiaohong Tan, Lingjie Tang

“…Establish a mathematical model for medium voltage distribution network planning based on the multiobjective functions of active power loss, total voltage deviation of system nodes, and minimum total compensation amount of system compensation devices. …”
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Honey bee behaviours within the hive: Insights from long-term video analysis. by Paul Siefert, Nastasya Buling, Bernd Grünewald

“…With our unique video method, we are able to bring the processes of a fully functioning social insect colony into classrooms and homes, facilitating ecological awareness in modern times. …”
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Transcriptomic characterization of cancer-testis antigens identifies MAGEA3 as a driver of tumor progression in hepatocellular carcinoma. by Amanda J Craig, Teresa Garcia-Lezana, Marina Ruiz de Galarreta, Carlos Villacorta-Martin, Edgar G Kozlova, Sebastiao N Martins-Filho, Johann von Felden, Mehmet Eren Ahsen, Erin Bresnahan, Gabriela Hernandez-Meza, Ismail Labgaa, Delia D'Avola, Myron Schwartz, Josep M Llovet, Daniela Sia, Swan Thung, Bojan Losic, Amaia Lujambio, Augusto Villanueva

“…Further analysis of CTAs in larger patient cohorts revealed high CTA expression related to worse overall survival and several other markers of poor prognosis. Functional analysis of MAGEA3 was performed in human HCC cell lines by gene silencing and in a genetic mouse model by overexpression of MAGEA3 in the liver. …”
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Analysis of TRPV channel activation by stimulation of FCεRI and MRGPR receptors in mouse peritoneal mast cells. by A Solís-López, U Kriebs, A Marx, S Mannebach, W B Liedtke, M J Caterina, M Freichel, V V Tsvilovskyy

“…So far, immortalized mast cell lines and nonspecific TRPV blockers have been employed to characterize the role of TRPV channels in MC. …”
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The Efficiency of The Interest Channel in The Context of Monetary Policy in Developed Countries by Taner Taş, Kubilay Çağrı Yılmaz

“…Within the framework of the panel VAR model established in line with the results obtained from these tests, the efficiency of the interest channel was investigated with the impulse-response functions and variance decomposition methods. …”
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Copy number-based quantification assay for non-invasive detection of PVT1-derived transcripts. by Gargi Pal, Olorunseun O Ogunwobi

“…PVT1 gives rise to multiple transcripts which may have different functions. Here, we describe a real-time quantitative polymerase chain reaction (qPCR)-based assay for copy number-based quantitation of PVT1 exons 4A, 4B, and 9 to enable accurate, reproducible, and quantifiable detection.…”
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