Design, synthesis, and apoptotic antiproliferative action of new benzimidazole/1,2,3-triazole hybrids as EGFR inhibitors by Alshimaa A. Y. Ahmed, Anber F. Mohammed, Zainab M. Almarhoon, Stefan Bräse, Bahaa G. M. Youssif

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E-cadherin acts as a regulator of transcripts associated with a wide range of cellular processes in mouse embryonic stem cells. by Francesca Soncin, Lisa Mohamet, Sarah Ritson, Kate Hawkins, Nicoletta Bobola, Leo Zeef, Catherine L R Merry, Christopher M Ward

“…We further show that Ecad-/- ES cells maintain a functional β-catenin pool that is able to induce β-catenin/TCF-mediated transactivation but, contrary to previous findings, do not display endogenous β-catenin/TCF-mediated transactivation. …”
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Impact of symmetry in local learning rules on predictive neural representations and generalization in spatial navigation. by Janis Keck, Caswell Barry, Christian F Doeller, Jürgen Jost

“…Here, when exposed repeatedly to a linear track, neurons in our model in CA3 show less shift of the centre of mass than those in CA1, in line with existing empirical findings. Investigating the functional benefits of such symmetry, we employ a simple reinforcement learning agent which may learn symmetric or classical successor representations. …”
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The Use of Language Models to Support the Development of Cartographic Descriptions of a Building’s Interior by Krzysztof Lipka, Dariusz Gotlib, Kamil Choromański

“…The development and popularization of navigation applications are increasing expectations for their quality and functionality. Users need continuous navigation not only outdoors, but also indoors. …”
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Corporate Social Responsibility Legal Framework in Southeast Asia: Comparing Indonesia, Malaysia, and Thailand by Martono Anggusti, Fitri Yanni Dewi Siregar, Ruetaitip Chansrakaeo

“…Milton Friedman's thinking about profit as the primary goal of business and John Elkington's concept of the "triple bottom line" also influenced the development of CSR. CSR functions as the moral responsibility of companies towards society and the environment, implemented through transparency, ethics, and responsible business decisions. …”
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Allelic Variation at the Rht8 Locus in a 19th Century Wheat Collection by Linnéa Asplund, Matti W. Leino, Jenny Hagenblad

“…The use of WMS261 and other functional markers for analyses of historical specimens and characterization of historic crop traits is discussed.…”
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THE ROLE OF PRIMARY GLOBAL PUBLIC GOODS IN INFORMATION SOCIETY by L. N. Shcerbakova

“…The information society leans against a new basis: the new base resources, new structure of a society, global character of the functioning, new collective reason. Expansion of a circle of the global public blessings can become one of possible ways of formation of the given society. …”
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Large-scale discovery of promoter motifs in Drosophila melanogaster. by Thomas A Down, Casey M Bergman, Jing Su, Tim J P Hubbard

“…Analysis of sequence conservation and motif positioning suggested that the great majority of these discovered motifs are predictive of functional elements in the genome. Many motifs showed associations with specific patterns of gene expression in the D. melanogaster embryo, and we were able to obtain confident annotation of expression patterns for 25 of our motifs, including eight of the novel motifs. …”
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Features of angiotensin II expression in the arcuate nucleus of the hypothalamus of experimental rats with arterial hypertension of various etiology by S. V. Tishсhenko

“…The important role of the arcuate nucleus (ArC) both as the intrahypothalamic regulator of the functional activity of its nuclear structures, and the coordinator over the suprasegmental and segmental centers of blood pressure regulation is proved. …”
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A novel unsupervised analysis of electrophysiological signals reveals new sleep substages in mice. by Vasiliki-Maria Katsageorgiou, Diego Sona, Matteo Zanotto, Glenda Lassi, Celina Garcia-Garcia, Valter Tucci, Vittorio Murino

“…Sleep science is entering a new era, thanks to new data-driven analysis approaches that, combined with mouse gene-editing technologies, show a promise in functional genomics and translational research. However, the investigation of sleep is time consuming and not suitable for large-scale phenotypic datasets, mainly due to the need for subjective manual annotations of electrophysiological states. …”
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Motif of Hunting in M. M. Prishvin’s “Mystical” Stories of the 1900s and the Novel The Chain of Kashchey: Epistemological Aspect by Elena Anatolyevna Khudenko

“…The aim of this paper is to show that the functioning of the hunting motif in Prishvin’s texts is based on an ontological motif: hunting is conceptualised as a way of “getting” and learning the truth (through a Platonic perspective), while unsuccessful hunting is viewed as the loss of man’s integral (kinship) ties with the world. …”
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Regulators of Trypanosoma brucei cell cycle progression and differentiation identified using a kinome-wide RNAi screen. by Nathaniel G Jones, Elizabeth B Thomas, Elaine Brown, Nicholas J Dickens, Tansy C Hammarton, Jeremy C Mottram

“…Thus, the RNAi kinome library provides a valuable asset for functional analysis of cell signalling pathways in African trypanosomes as well as drug target identification and validation.…”
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A subcellular sampling instrument allows spatial resolution of amyloid deposit-derived organelle-specific effects in microglia by Robert Subirana Slotos, Tinh Thi Nguyen, Ledjona Fiska, Kristina Friedland, Kristina Endres

“…This allows for a much better spatial and functional characterization of, for example, the deterioration of cells within a tissue in response to noxae. …”
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Background of standardization and regulation of training and use of pharmaceutical regular resource potential in XI–XVI centuries by M. S. Ponomarenko, O. S. Soloviov, T. M. Krasnianska, Yu. M. Grygoruk

“…The basic steps of transformation and delimitation of professional functions pharmacist-physician have been set. Pharmacy Education; History of Medisine; Pharmacists…”

Annexin A3 Knockdown Suppresses Lung Adenocarcinoma by Ying-Fu Liu, Qing-Qing Liu, Yue-Hua Zhang, Jing-Hua Qiu

“…However, the biological functions of Anxa3 in LADC are not fully clear. In this study, in vitro and in vivo assays were performed to investigate the effects of Anxa3 downregulation on the growth, migration, invasion, metastasis, and signaling pathway activation of LADC cells. …”
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Determinants of general health perception among individuals with chronic low back pain overtime: structural equation modeling. by Owis Eilayyan, Line Enjalbert-Auneau, Sara Ahmed

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Potential benefits of male diploidy and female triploidy for parasitoid wasps used as biological control agents: A case study in Nasonia by Kelley Leung

“…However, this is only possible in species for which polyploidy does not impair essential biological functions, as in for instance species with Complementary Sex Determination (CSD), where inbreeding drives sterile diploid male production and extinction risk. …”
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PTK6 promotes cancer migration and invasion in pancreatic cancer cells dependent on ERK signaling. by Hiroaki Ono, Marc D Basson, Hiromichi Ito

“…Therefore in this study, we evaluated the functional role of PTK6 on pancreatic cancer invasion. …”
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Neurobiological emergentism: sentience as an emergent process and the experiential gap by Todd E. Feinberg

“…One of the most controversial and debated problems regarding the nature of sentience, is how to integrate the biology and neurobiology of sentience with the problem of the “explanatory gaps” that are proposed to arise between the functions of the nervous system as objectively and scientifically explained and sentience—or more generally consciousness—as it is subjectively experienced. …”
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Repression of varicella zoster virus gene expression during quiescent infection in the absence of detectable histone deposition. by Jiayi Wang, Nadine Brückner, Simon Weissmann, Thomas Günther, Shuyong Zhu, Carolin Vogt, Guorong Sun, Rongrong Guo, Renzo Bruno, Birgit Ritter, Lars Steinbrück, Benedikt B Kaufer, Daniel P Depledge, Adam Grundhoff, Abel Viejo-Borbolla

“…In this study, we addressed whether the neuroblastoma-derived cell line SH-SY5Y could serve as a model to investigate the mechanisms that lead to repression of VZV gene expression followed by reactivation. …”
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