Patient-derived pancreatic tumor bacteria exhibit oncogenic properties and are recognized by MAIT cells in tumor spheroids by Poojabahen Tajpara, Michał Jacek Sobkowiak, Michał Jacek Sobkowiak, Katie Healy, Sabrina Naud, Beate Gündel, Asif Halimi, Asif Halimi, Zara Ahmad Khan, Giorgio Gabarrini, Sylvie Le Guyader, Gabriela Imreh, Julie A. Reisz, Marco Del Chiaro, Angelo D’Alessandro, Rainer Heuchel, J Matthias Löhr, Volkan Özenci, Margaret Sällberg Chen, Margaret Sällberg Chen, Margaret Sällberg Chen

“…IntroductionTumor-residing microbiota poses a new challenge in cancer progression and therapy; however, the functional behavior of patient tumor-derived microbes remains poorly understood. …”
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Electrical addressing of exceptional points in compact plasmonic structures by Jeong Hoon Yeub, Lim Yeonsoo, Han Jungho, An Soo-Chan, Jun Young Chul

“…Electrically addressable EPs in compact plasmonic structures may provide exciting opportunities for highly functional and tunable elements in integrated device platforms.…”
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Experimental Investigation on the Machining Behaviour, Surface Integrity and Tool Wear Analysis in Environment Friendly Milling of Inconel 825 by D. Nathan, T. Ramkumar, M. Selvakumar

“…Prediction of surface roughness by ANOVA linear model for MQL condition was found functionally adequate with R2 = 89.25% which fits with the experimental values. …”
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Increasing the reliability and speed of data transmission in the rayleigh channel through the use of combining intermittent data transmission with diversity reception with optimal... by I. M. Andrianov, I. G. Kiselev, M. N. Andrianov

“…The applicability of the method is shown not only for radio range systems, but also for quantum data transmission devices, in particular in the infrared range, operating under conditions of fluctuations of the tropospheric channel, on the communication line between a spacecraft and a ground tracking station. …”
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Innovative Approaches in the Synthesis and Optimization of Copper Complexes for Antitumor Therapies: A Comprehensive Review by Clara Maria Faria Silva, Ricardo Campos Lino, Mariana Cristina Teixeira de Moura, Anna Paula de Sá Borges, Robson José de Oliveira Júnior

“…Recently, Cu complexes have been studied owing to their biological functions and effects on tumor angiogenesis. In this review, we examined 23 types of cancer and revealed the use of cell lines. …”
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ZNF146 accelerates lung adenocarcinoma progression through MDM2/p53 and PHGDH/ferroptosis by Junkan Zhu, Shencheng Ren, Yanjun Yi, Zhiyao Wu, Han Lin, Guangyao Shan, Xiaolong Huang, Binyang Pan, Zhengyang Hu, Qihai Sui, Cheng Zhan, Shuai Wang, Jiaqi Liang

“…Results Through an extensive analysis of expression data from over a thousand LUAD samples, we identified zinc finger protein 146 (ZNF146) as a transcription factor significantly overexpressed in LUAD, closely associated with poor patient outcomes. Functional studies using knockout and re-expression experiments in LUAD cell lines confirmed that ZNF146 robustly promotes cell proliferation. …”
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Genetic assessment and Identification of genes related to characterization of Guangdong local goose breeds based on modern and historical genomes by Xing Zhang, Guiling Qiu, Dechun Huang, Zheng Ma, Jixiang Wei, Richeng Zhong, Ruirui Li, Miaoxing Huang, Junwei Gou, Fei Ye, Qiqiong Zhang, Qingyou Liu, Hai Xiang, Hua Li

“…A multitude of genes have been identified as related to various functional phenotypes in different Guangdong geese, such as fat deposition (ACER3), feather color (ACTA2), skin pigmentation (GDA), and body growth and development (ARHGAP21), collectively defining the distinctive attributes of indigenous breeds. …”
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BUB1 an Overexpressed Kinase in Sarcoma: Finding New Target Therapy for Osteosarcoma, Liposarcoma, Synovial Sarcoma, and Leiomyosarcoma by Mercedes Olvera-Valencia, Fernando Luna-Maldonado, Joselyn Juarez-Reyes, Alejandro Lopez-Saavedra, Jossimar Coronel-Hernandez, Oliver Millan-Catalan, Daniel Guzman-Gomez, Frida Rodríguez-Izquierdo, Luis A. Herrera, David Francisco Cantú-De León, Carlos Perez-Plasencia, Eloy-Andres Pérez-Yepez

“…Moreover, the role of this kinase was further validated through molecular and functional assays, including pharmacological inhibition in cell lines derived from the four sarcoma subtypes. …”
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Methylation-induced suppression of BEX1 activates AKT/ERK/STAT3 signaling pathways regulating cell cycle and apoptosis in glioma by Li-Zhi Xiao, Shi Feng, Zhen He, Rui Mao, Kai Qian, Zhi-Ying Zhou, Huabao Cai, Mengyu Zhao, Cunzhi Wang, Tianhang Yu, Zi-Yu Zhao, Jie Li

“…We conducted bioinformatics analyses to assess BEX1 expression differences in glioma using tissue samples, followed by validation through Western blot and qRT-PCR. Functional assays in glioma cell lines were performed, employing gene transfection and small molecule inhibitors to further explore BEX1’s role in the AKT/ERK/STAT3 signaling pathways. …”
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Teager–Kaiser Energy Operator-Based Short-Circuit Fault Localization Method for Multi-Circuit Parallel Cables by Zhichao Li, Jian Mao, Changhao Luo, Yuangang Sun, Chuanjian Zheng, Zhenfei Chen

“…Traditional fault localization methods, such as the traveling wave method using wavelet transform to process fault signals, suffer from wavefront distortion due to inter-line reflections and noise interference in multi-circuit systems, because wavelet-based techniques are limited by preset basis functions and environmental noise. …”
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A health management system for large vertical mill by Sugai Han, Ansheng Li, Hongchao Wang, Xiaoyun Gong, Liangwen Wang, Yixiang Huang, Yanming Li, Wenliao Du

“…As large vertical mill always works in severe conditions, the on-line monitoring, timely fault diagnosis, and trend prediction are very important guarantees for the safe service and saving maintaining costs. …”
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New Phase Space Calculations for β-Decay Half-Lives by Sabin Stoica, Mihail Mirea, Ovidiu Niţescu, Jameel-Un Nabi, Mavra Ishfaq

“…To obtain the electron/positron wave functions, we develop a code for solving accurately the Dirac equation with a nuclear potential derived from a realistic proton density distribution in the nucleus. …”
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The Transcription Axes ERK-Elk1, JNK-cJun, and JAK-STAT Promote Autophagy Activation and Proteasome Inhibitor Resistance in Prostate Cancer Cells by Georgios Kalampounias, Kalliopi Zafeiropoulou, Theodosia Androutsopoulou, Spyridon Alexis, Argiris Symeonidis, Panagiotis Katsoris

“…In this study, a Bortezomib-resistant prostate cancer cell line is created by using the PC-3 cell as a prostate carcinoma model of high metastatic potential. …”
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Development of the Italian clinical practice guideline on diagnosing and treating obesity in adults: scope and methodological aspects by Rocco Barazzoni, Silvio Buscemi, Luca Busetto, Paolo Sbraccia, Simona Bo, Emanuele Cereda, Marco Chianelli, Sonja Chiappetta, Riccardo Dalle Grave, Walter de Caro, Giovanni Docimo, Giuseppe Galloro, Primiano Iannone, Frida Leonetti, Fabrizia Lisso, Maria Caterina Manca, Gerardo Medea, Manuela Merli, Anna Maria Moretti, Giuseppe Navarra, Uberto Pagotto, Barbara Paolini, Giovanni Papa, Nicola Perrotta, Andrea Pession, Vincenzo Pilone, Vincenzo Provenzano, Cecilia Ricciardi Rizzo, Maurizio Santomauro, Cristina Segura Garcia, Federico Spandonaro, Samir Sukkar, Patrizia Todisco, Dario Tuccinardi, Andrea Vania, Valentina Vanzi, Riccardo Williams, Iris Zani, Benedetta Ragghianti, Giovanni Antonio Silverii, Matteo Monami, the panel and Evidence Review Team for the Italian Guidelines on Surgical Treatment of Obesity

“…Obesity-associated complications and comorbid conditions include metabolic, cardiovascular, renal, liver and respiratory diseases, cancers, and functional limitations, leading to higher all-cause and cardiovascular mortality, and incident disability. …”
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LIN28B promotes the progression of endometrial cancer through upregulating MYC and correlates with immune microenvironment by Yuchao Diao, Xiangkun Li, Chang Wang, Jinwen Jiao, Dongmei Gao, Weifang Mao, Xinping Yu, Hongjuan Yang

“…Survival outcomes associated with LIN28B were analyzed using the Kaplan-Meier methodology. Functional validation was conducted in HEC-1A, HEC-1B, and KLE cell lines through siRNA-mediated LIN28B knockdown. …”
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Discovery of a novel 4-pyridyl SLC-0111 analog targeting tumor-associated carbonic anhydrase isoform IX through tail-based design approach with potent anticancer activity by Hamada Hashem, Shadwa Abdelfattah, Hesham M. Hassan, Ahmed Al-Emam, Mohammed Alqarni, Ghallab Alotaibi, Ibrahim Taha Radwan, Kirandeep Kaur, Devendra Pratap Rao, Stefan Bräse, Abdullah Alkhammash

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Revealing the impact of Pseudomonas aeruginosa quorum sensing molecule 2’-aminoacetophenone on the human bronchial-airway epithelium and pulmonary endothelium using a human airway-... by Shifu Aggarwal, Shifu Aggarwal, Arijit Chakraborty, Arijit Chakraborty, Arijit Chakraborty, Vijay K. Singh, Stephen Lory, Katia Karalis, Laurence G. Rahme, Laurence G. Rahme, Laurence G. Rahme

“…BackgroundPseudomonas aeruginosa (PA) causes severe respiratory infections utilizing multiple virulence functions. Previous findings on the PA secreted quorum sensing (QS)-regulated small molecule, 2’-aminoacetophenone (2-AA), revealed its impact on immune and metabolic functions, favouring a long-term presence of PA in the host. …”
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Malignant epithelial cell marker–driven risk signature enables precise stratification in esophageal cancer by Hao Zhang, Hao Zhang, Shizhao Cheng, Shizhao Cheng, Yijun Xu, Yijun Xu

“…Additionally, qRT-PCR was conducted to quantify the expression levels of model genes in ESCC tissue samples, further evaluating their biological relevance. Functional roles of the key gene HMGB3 were validated in vitro through CCK-8 proliferation assays, Transwell invasion assays, and colony formation assays following gene knockdown in ESCC cell lines.ResultsAt the single-cell level, we identified ten major cell types and six distinct malignant epithelial subclusters, which exhibited pronounced heterogeneity in cell cycle states, transcriptional regulatory networks, and differentiation trajectories. …”
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The antimicrobial peptide Angie 5 inhibits TcdA and TcdB from Clostridioides difficile by Stefanie Lietz, Lena-Marie Sokolowski, Katrin Lindner, Armando A. Rodríguez, Ludger Ständker, Verena Vogel, Barbara Spellerberg, Steffen Stenger, Daniel Alpízar-Pedraza, Katharina Ernst, Panagiotis Papatheodorou, Holger Barth

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Breaking barriers: Strength training feasibility in McArdle syndrome – A systematic review by Danielle N. Ribeiro, Adelino S.R. da Silva, Ana Paula Pinto

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