Immunomodulatory and anticancer effects of moringa polyherbal infusions: potentials for preventive and therapeutic use by Wamidh H. Talib, Wamidh H. Talib, Hadeel Shaher Al Junaidi, Heba K. Alshaeri, Moudi M. Alasmari, Moudi M. Alasmari, Rawan W. Hadi, Ahmad Riyad Alsayed, Douglas Law

“…The Nitro Blue Tetrazolium Assay and Neutral Red Method were used to assess the effects of each extract on macrophage phagocytic and pinocytosis functions. Lymphocyte proliferation was also tested.ResultsThe anti-proliferative activity of Moringa-saffron showed the strongest anti-proliferative effect on T47-D and EMT6/P, with IC50 values of 1.14 ± 0.05 and 1.65 ± 0.27 mg/ml, respectively. …”
Get full text

Long-read RNA sequencing enables full-length chimeric transcript annotation of transposable elements in lung adenocarcinoma by Yang Li, Yahui Liu, Yingxin Xie, Yaxuan Wang, Jing Wang, Huan Wang, Lin Xia, Dan Xie

“…To assess the functional roles of a specific TCTs, cell migration and cell proliferation assays were performed. …”
Get full text

Synthesis of a novel mitochondrial fluorescent probe - killing cancer cells in vitro and in vivo by Xiaowen Yang, Yiting Zhan, Yifei Li, Yifei Li, Xinzhuang Shen, Xinzhuang Shen, Yuqiu Ma, Zongjun Liu, Zongjun Liu, Yipeng Liu, Chengjin Liang, Xiaoyuan Zhang, Yehao Yan, Wenzhi Shen

“…Specifically, MPM-1 significantly reduced the proliferation and migration of lung cancer cell lines A549 and H1299, as well as colon cancer cell lines SW480 and LOVO, with IC50 values of 4.900, 7.376, 8.677, and 7.720 µM, respectively, while also promoting apoptosis. …”
Get full text

A novel oncolytic Vaccinia virus armed with IL-12 augments antitumor immune responses leading to durable regression in murine models of lung cancer by Lijuan Chen, Lijuan Chen, Pengju Wang, Carmela Di Gioia, Ming Yuan, Zhe Zhang, Jinxin Miao, Wenli Yan, Guanghao Zhao, Yangyang Jia, Na Wang, Zhongxian Zhang, Haoran Guo, Giulia Marelli, Louisa Chard Dunmall, Nicholas R. Lemoine, Nicholas R. Lemoine, Yaohe Wang, Yaohe Wang

“…Synergy with α-PD1 or a VV armed with soluble PD-1 (VV-sPD1) was investigated and functional mechanisms behind efficacy probed. Tumor-targeted VVL-m12 replicated to high levels, was cytotoxic in lung cancer cell lines. …”
Get full text

Isolation and molecular characterization of the FLOWERING LOCUS C gene promoter sequence in radish (Raphanus sativus L.) by Yuan-yuan XU, Jing WANG, Shan-shan NIE, Dan-qiong HUANG, Yan WANG, Liang XU, Rong-hua WANG, Xiao-bo LUO, Li-wang LIU

“…FLOWERING LOCUS C (FLC) plays a key role in plant flowering by functioning as a repressor. Two genomic DNA sequences, a 3 046-bp from an early- and a 2 959-bp from a late-bolting radish line were isolated and named as RsFLC1 and RsFLC2, respectively, for they share approximately 87.03% sequence identity to the FLC cDNA sequences. …”
Get full text

Pan-cancer analysis identified CD248 as a potential target for multiple tumor types by Li Guo, Yan Liao, Xuyang Zhang, Rongjuan Guo, Zheng Wang, Deqin Yang, Deqin Yang, Deqin Yang

“…CD248 plays a crucial role in tumor cells’ functions, including invasion, migration, and proliferation. …”
Get full text

DKK1 promotes migration and invasion of non–small cell lung cancer via β-catenin signaling pathway by Jing Zhang, Xintong Zhang, Xiaoting Zhao, Mei Jiang, Meng Gu, Ziyu Wang, Wentao Yue

“…Disregulation of dickkopf-related protein 1 (DKK1) has been reported in a variety of human cancers. However, how DKK1 functions in Non-small cell lung cancer has not been revealed. …”
Get full text

Novel Sonoguided Digital Palpation and Ultrasound-Guided Hydrodissection of the Long Thoracic Nerve for Managing Serratus Anterior Muscle Pain Syndrome: A Case Report with Technica... by Nunung Nugroho, King Hei Stanley Lam, Theodore Tandiono, Teinny Suryadi, Anwar Suhaimi, Wahida Ratnawati, Daniel Chiung-Jui Su, Yonghyun Yoon, Kenneth Dean Reeves

“…Physical examination revealed tenderness along the anterior axillary line and a positive hyperirritable spot at the mid axillary line at the 5th rib level. …”
Get full text

Joint Genomic and Transcriptomic Analysis Reveals Candidate Genes Associated with Plumage Color Traits in Matahu Ducks by Pengwei Ren, Liu Yang, Muhammad Zahoor Khan, Yadi Jing, Meixia Zhang, Chao Qi, Xin Zhang, Xiang Liu, Zhansheng Liu, Shuer Zhang, Mingxia Zhu

“…The functional enrichment of these genes revealed several key signaling pathways, including those related to cGMP-PKG, cAMP, PI3K-Akt, and MAPK. …”
Get full text

Predicting hypoglycemia in elderly inpatients with type 2 diabetes: the ADOCHBIU model by Rui-Ting Zhang, Yu Liu, Chao Sun, Quan-Ying Wu, Hong Guo, Gong-Ming Wang, Ke-Ke Lin, Jing Wang, Xiao-Yan Bai

“…BackgroundHypoglycemic episodes cause varying degrees of damage in the functional system of elderly inpatients with type 2 diabetes mellitus (T2DM). …”
Get full text

Analysis of Characteristics of Bovine-Derived Non-Enterotoxigenic <i>Bacteroides fragilis</i> and Validation of Potential Probiotic Effects by Dong Wang, Long Zhao, Jingyi Lin, Yajing Wang, Haihui Gao, Wenhui Liu, Qirui Li, Liang Zhang, Xiaodong Kang, Kangkang Guo

“…A non-toxigenic <i>Bacteroides fragilis</i> (NTBF) was isolated and identified by 16S rRNA high-throughput sequencing and named BF-1153; genome composition and genome functional analyses were carried out to reflect the biological characteristics of the BF-1153 strain. …”
Get full text

Introducing Angle B: A Novel Quantitative Approach for Sagittal Alignment Reduction in Atlanto-Axial Dislocation Surgery by Cui S, Wang X, Li K, Feng H, Liu Z, Jian F, Wang K

“…Shengyu Cui,1– 4 Xinyu Wang,1– 5 Kang Li,1– 4 Hailong Feng,6 Zhenlei Liu,1– 4 Fengzeng Jian,1– 4 Kai Wang1– 4 1Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Spine Center, China International Neuroscience Institute (CHINA-INI), Beijing, People’s Republic of China; 3Research Center of Spine and Spinal Cord, Beijing Institute of Brain Disorders, Capital Medical University, Beijing, People’s Republic of China; 4Lab of Spinal Cord Injury and Functional Reconstruction, China International Neuroscience Institute (CHINA-INI), Xuanwu Hospital, Capital Medical University, Beijing, People’s Republic of China; 5Baylor College of Medicine, Huston, TX, USA; 6Department of Neurosurgery, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, Chengdu, People’s Republic of ChinaCorrespondence: Fengzeng Jian; Kai Wang, China International Neuroscience Institute (CHINA-INI), Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing, 100053, People’s Republic of China, Tel +86-1083198277, Email jianfengzeng@xwh.ccmu.edu.cn; sammas1883@sina.comObjective: This study aims to establish a quantitative relationship between cervical lordosis (CL) and the rotation angle of the axis for the surgical reduction of atlantoaxial dislocation (AAD) and to explore the potential applications of this relationship in preoperative planning and selection of surgical techniques.Methods: To construct the correlation between horizontal gaze and location of axis, we introduced the angle B, defined as the angle between the Frankfort horizontal line and the extension line of the posterior edge of the axis, and explored its application in surgical planning. …”
Get full text

Biological properties of macroporous cryostructurate based on extracellular matrix components by A. M. Grigoriev, Yu. B. Basok, A. D. Belova, N. P. Shmerko, A. M. Subbot, V. K. Kulakova, V. I. Lozinsky, V. I. Sevastianov

“…Biocompatibility of the macroporous carrier was studied on cultures of human adipose tissue-derived mesenchymal stromal cells (AD-MSC), human hepatocellular carcinoma cell line HepG2 and human umbilical vein endothelial cell line EA.hy926. …”
Get full text

Targeting HVEM-GPT2 axis: a novel approach to T cell activation and metabolic reprogramming in non-small cell lung cancer therapy by Yuanshan Yao, Chunji Chen, Bin Li, Wen Gao

“…Activated T cells, particularly from the Jurkat cell line, significantly inhibited NSCLC progression, reducing both proliferation and invasion capabilities of A549 and H1299 lung cancer cell lines. …”
Get full text

Regulatory role of lnc-MAP3K13-3:1 on miR-6894-3p and SHROOM2 in modulating cellular dynamics in hepatocellular carcinoma by Kuai Chen, Manqin Zhu, Qinghua Hu, Hui Huang, Ka Chen, Xia Shuai, Jinshi Huang, Qiang Tao, Zhibin Guo

“…Methods Quantitative PCR (qPCR) was initially employed to measure the expression levels of lnc-MAP3K13-3:1 and miR-6894-3p in three HCC cell lines: HepG2, HuH-7, and Li-7. Based on these initial assessments, two cell lines were selected for further experimentation. …”
Get full text

Prognostic value of Osteopontin (SPP1) in colorectal carcinoma requires a personalized molecular approach by Mourad Assidi, Wafaey Gomaa, Mohammad Jafri, Mehenaz Hanbazazh, Mahmoud Al-Ahwal, Peter Pushparaj, Asia Al-Harbi, Mohammed Al-Qahtani, Abdelbaset Buhmeida, Jaudah Al-Maghrabi

“…SPP1 has several isoforms, tissue localizations and molecular functions, signaling pathways, and downstream molecular functions. …”
Get full text

Intensive 7-day internet-delivered cognitive behaviour therapy for social anxiety disorder: study protocol for a randomised controlled trial by Kayla R. Steele, Emily Upton, Monique Holden, Amy Regan, Matthew J. Coleshill, Sophie Li, Amy E. Joubert, Alison E. J. Mahoney, Michael Millard, Jill M. Newby

“…Abstract Background Social anxiety disorder (SAD) is a serious mental health disorder that when left untreated can lead to significant social, occupational, educational, and functional impairment. Cognitive behaviour therapy (CBT) is the recommended first-line psychological treatment for SAD and has been shown to be efficacious in face-to-face and online formats. …”
Get full text

Social Relations and Interpersonal Dialogue among Couples: A Study in the City of Yazd Based on the Grounded Theory by Lida Hatefi rad, Mehraban Parsamehr, Ali Ruhani

“…It assumes distinct roles and functions and addresses a range of human needs. Central to family life and functioning are the relationships among family members. …”
Get full text

ADI-270: an armored allogeneic gamma delta T cell therapy designed to target CD70-expressing solid and hematologic malignancies by Jie Zhang, Jyothi Sethuraman, Marissa Herrman, Pranav Murthy, Ramandeep Kaur, Jonathan T S Wong, Kevin P Nishimoto, Smitha R Y Gundurao, Arun Bhat, Blake T Aftab, Shon Green, Aruna Azameera, Morgan Smith-Boeck, Michael Salum, Yvan Chanthery, Melinda Au, Amy Doan, Christopher J Rold, Swapna Panuganti, Helen Budworth, Gauri Lamture, Alexander G Teague, Yogendra Verma, Elizabeth B Speltz, Katherine M Wang, Dishant Bhatwala, Ana Giner-Rubio, Pavan Puligujja, Aya Jakobovits

“…ADI-270 is also double-armored to mitigate the immunosuppressive effects of TGFβ and reduce the potential for allogeneic rejection.Methods Vδ1 T cells engineered to express an anti-CD70 CAR and dominant negative TGFβ receptor II (dnTGFβRII) were expanded from healthy donor human PBMCs. The phenotype and functional characterization of ADI-270 were assessed with in vitro cell culture assays and in vivo tumor xenograft models.Results ADI-270 exhibited high levels of in vitro cytotoxicity against a panel of cancer cell lines and displayed a favorable inflammatory cytokine profile compared with reference scFv-based anti-CD70 CAR αβ T cells. …”
Get full text

The neuropeptide sulfakinin is a peripheral regulator of insect behavioral switch between mating and foraging by Hong-Fei Li, Bao Dong, Yuan-Yuan Peng, Hao-Yue Luo, Xiao-Lan Ou, Zheng-Lin Ren, Yoonseong Park, Jin-Jun Wang, Hong-Bo Jiang

“…Further analysis of the mutant flies revealed that sets of odorant receptor (OR) genes were differentially expressed. Functional characterization of the differentially expressed ORs suggested that sulfakinin directly suppresses the expression of ORs that respond to opposite-sex hormones while enhancing the expression of ORs that detect food volatiles. …”
Get full text