Cathepsin L in Lung Adenocarcinoma: Prognostic Significance and Immunotherapy Response Through a Multi Omics Perspective by Jianming Lu, Jiaqi Liang, Gang Xiao, Zitao He, Guifang Yu, Le Zhang, Chao Cai, Gao Yi, Jianjiang Xie

“…The in vitro studies corroborated these findings, revealing notable suppression of tumor proliferation following CTSL knockout in cell lines, particularly in LUAD. Functional enrichment revealed that CTSL activated pathways associated with tumor progression, such as angiogenesis and Transforming growth factor beta (TGF-beta) signaling, and inhibited pathways such as apoptosis and DNA repair. …”
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Alteration in ATR protein level does not account for the inherent radiosensitivity of HPV-positive head and neck squamous cell carcinoma by Sibylla Kohl, Florentine S.B. Subtil, Vanessa Climenti, Houmam Anees, Ann C. Parplys, Rita Engenhart-Cabillic, Sebastian Adeberg, Ekkehard Dikomey, Ulrike Theiß

“…If there is a contribution of ATR to the radiosensitivity of HPV-positive cells remains unclear, and this in-vitro study tested a functional involvement of ATR expression. Methods: The study was performed with six HPV-negative and six HPV-positive HNSCC cell lines. …”
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Silver Nanoparticle Production by Ruta graveolens and Testing Its Safety, Bioactivity, Immune Modulation, Anticancer, and Insecticidal Potentials by Hamed A. Ghramh, Essam H. Ibrahim, Mona Kilnay, Zubair Ahmad, Sadeq K. Alhag, Khalid Ali Khan, Ramadan Taha, Fawziah M. Asiri

“…The extract contained many functional groups as indicated by FT-IR. The extract alone inhibited the growth of normal rat splenic cells, while the extract containing AgNPs stimulated its growth. …”
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Scalable Manufacturing Method for Model Protein-Loaded PLGA Nanoparticles: Biocompatibility, Trafficking and Release Properties by Selin Akpinar Adscheid, Marta Rojas-Rodríguez, Salma M. Abdel-Hafez, Francesco S. Pavone, Marc Schneider, Akif E. Türeli, Martino Calamai, Nazende Günday-Türeli

“…We tested the biocompatibility of the NPs in living RPMI 2650 and neuroblastoma cell lines, as well as their trafficking and uptake. Release kinetics of the encapsulated proteins were investigated through confocal microscopy and in vitro release studies, providing insights into the stability and functionality of the released proteins. …”
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A novel avenue in the successful synthesis of Schiff base macromolecules via innovative plasma and classical approaches by Rawda M. Okasha, Abdel-Aleam H. Mohamed, Ahmed A. Elhenawy, Mosa H. Alsehli, Wael H. Alsaedi, Fawzia F. Alblewi, Eman A. Assirey, Majed O. Alawad, Faizah S. Aljohani, Zainab Hrytani, Israa Ibrahim, Tarek H. Afifi

“…Moreover, the complexation of polymer 4b with various metal moieties, Ru (II), Co (II), Cu (II), and Ni (II), has been executed in order to have a comparative study of their antitumor activity against MCF-7, HCT-116, and HepG-2 cell lines. Furthermore, the density functional theory was exploited to optimize the polymers and their complexes, and their HOMO-LUMO and energy gap were calculated, which was utilized to examine the inter/intra molecular charge transfer. …”
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Orofacial Myofunctional Therapy: Investigating a Novel Therapeutic Approach for Pediatric Obstructive Sleep Apnea in Children with and Without Down Syndrome—A Study Protocol by Jolien Verbeke, Iris Meerschman, Karlien Dhondt, Els De Leenheer, Julie Willekens, Kristiane Van Lierde, Sofie Claeys

“…Results: OMT is expected to improve orofacial functions, reduce OSA severity and symptoms, and enhance quality of life in both non-syndromic and syndromic children. …”
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Pathway activation model for personalized prediction of drug synergy by Quang Thinh Trac, Yue Huang, Tom Erkers, Päivi Östling, Anna Bohlin, Albin Osterroos, Mattias Vesterlund, Rozbeh Jafari, Ioannis Siavelis, Helena Backvall, Santeri Kiviluoto, Lukas Orre, Mattias Rantalainen, Janne Lehtiö, Soren Lehmann, Olli Kallioniemi, Yudi Pawitan, Trung Nghia Vu

“…We show evidence that higher synergy is associated with higher functional interaction between the drug targets, and this functional interaction information is captured by PAS. …”
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HJURP modulates cell proliferation and chemoresistance via the MYC/TOP2A transcriptional axis in gastric cancer by Xu Li, Xu Li, Xiwen Li, Yanlin Ren, Ling Wang, Zehao Mao, Shikun Gao, Shikun Gao, Peng Ma, Junjie Chen, Junjie Chen

“…Functional experiments were carried out on the AGS and HGC-27 GC cell lines. …”
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Transferrin conjugated pH/NIR-responsive black phosphorus nanoplatform: A novel multimodal approach for breast cancer theranostics by Soji Soman, Sanjay Kulkarni, Jeena John, Milan Paul, Krishnadas Nandakumar, Swati Biswas, Sajan D. George, Srinivas Mutalik

“…The exfoliated BPNSs were surface loaded with an anticancer drug, doxorubicin (DOX), functionalized with a photo-responsive polymer, polydopamine (PDA), and conjugated with a protein-based ligand, transferrin (TF). …”
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Machine learning for discrimination of phase‐change chalcogenide glasses by Qundao Xu, Meng Xu, Siqi Tang, Shaojie Yuan, Ming Xu, Wei Zhang, Xian‐Bin Li, Zhongrui Wang, Xiangshui Miao, Chengliang Wang, Matthias Wuttig

“…Abstract Chalcogenides, despite their versatile functionality, share a notably similar local structure in their amorphous states. …”
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NEK2 promotes colorectal cancer progression by activating the TGF-β/Smad2 signaling pathway by Hai Qin, Manqin Yuan, Yaqin Yuan, Fengqiong Xia, Yonghong Yang

“…This study aimed to investigate the impact of NEK2 on CRC cell functionality and its interaction with the TGF-β/Smad signaling pathway. …”
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An electroactive microfluidic platform integrated with AM-pDEP focusing and side-counter design for selective cell sorting and single-cell quantification by Zuyuan Tian, Mohamed Shaheen, Tianxiang Jiang, Shaoxi Wang, Xihua Wang, Jie Chen

“…Recent advances in label-free microfluidic techniques have attempted to overcome these limitations but often suffer from reduced reliability and throughput when integrating multiple functions. Here, we demonstrate an electroactive microfluidic platform that integrates functions of selective concentration, particle focusing, and single-cell level quantification without introducing additional complex physical microstructures. …”
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An exploratory study of the relevance of therapy format and therapist’ training in individual cognitive behavioral therapy for psychosis by Oda Skancke Gjerdalen, Manuela Zucknick, Manuela Zucknick, Ingvild Tvedt Westlie, Helen Bull, Stig Evensen, Erik Falkum, Marit Grande, Marit Grande, Roger Hagen, Roger Hagen, Roger Hagen, Kristin Lie Romm, Kristin Lie Romm, Lene Hunnicke Jensen, Petter Andreas Ringen, Petter Andreas Ringen, Olivia Schjøtt-Pedersen, Nasrettin Sönmez, Torill Ueland, Torill Ueland, Tiril Østefjells, Jan Ivar Røssberg, Jan Ivar Røssberg, June Ullevoldsæter Lystad, June Ullevoldsæter Lystad, June Ullevoldsæter Lystad

“…Using a series of mixed effects models for repeated measurements, we examined differences between the groups in terms of general functioning and psychiatric symptom severity. Emphasis was placed on potential differences between the two groups receiving CBTp, considering both average differences across assessment points and trajectories over time.ResultsIn line with expectations, all groups demonstrated overall improvements in functioning and symptom levels. …”
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Review Article: Diagnostic Paradigm Shift in Spine Surgery by Aras Efe Levent, Masato Tanaka, Chetan Kumawat, Christian Heng, Salamalikis Nikolaos, Kajetan Latka, Akiyoshi Miyamoto, Tadashi Komatsubara, Shinya Arataki, Yoshiaki Oda, Kensuke Shinohara, Koji Uotani

“…Traditional radiographic methods such as conventional and functional X-rays and CT scans are still the first line in the diagnosis of spinal disorders due to their low cost and accessibility. …”
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Identification of the first plant caffeoyl-quinate esterases in Cichorium intybus by Antoine Mallavergne, David Mathiron, Roland Molinié, Jean-Louis Hilbert, David Gagneul

“…Since CiCQE1 and CiCQE3 catalyze similar reactions using 5-CQA as substrate, these enzymes may represent a novel route for 5-CQA remobilization in chicory roots. Further functional characterization of the role of these genes using mutant lines is still required to fully understand their role in planta.…”
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Decoding chromosomal instability insights in CRC by integrating omics and patient-derived organoids by Federica Papaccio, Manuel Cabeza-Segura, Blanca García-Micó, Francisco Gimeno-Valiente, Sheila Zúñiga-Trejos, Valentina Gambardella, María Fernanda Gutiérrez‐Bravo, Carolina Martinez‐Ciarpaglini, Pilar Rentero‐Garrido, Tania Fleitas, Susana Roselló, Juan Antonio Carbonell-Asins, Marisol Huerta, David Moro-Valdezate, Desamparados Roda, Noelia Tarazona, Manuel M. Sánchez del Pino, Andrés Cervantes, Josefa Castillo

“…We integrated the RNA-seq and mass spectrometry-based proteomics data from PDOs in a functional interaction network to identify the significantly dysregulated processes in CIN. …”
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Inhibition of SIRT3 by a specific inhibitor induces cellular senescence and growth arrest of ovarian granulosa cell tumor via p53 and NF-κB axis by Jingxin Ma, Sailing Lin, Chuimian Zeng, Wenhao Wu, Qi Zhang, Guli Zhu, Qi Zhang, Qiongfang Fang, Lijun Fan, Shunichi Takeda, Xiaoyu Li, Xiaoyu Li, Xiushen Li, Yu Zhou, Xueqing Wu

“…SIRT3, an NAD + -dependent deacetylase, is upregulated in GCTs and implicated in tumorigenesis, yet its functional role and underlying mechanisms remain poorly understood. …”
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Elite Alleles of EPE1 Identified via Genome-wide Association Studies Increase Panicle Elongation Length in Rice by Hao Sun, Qiqi Yao, Mei Hai, Tianhu Li, Jinghan Sun, Zhengbo Liu, Yang Ang, Yingying Zhao, Yanan Zhang, Xianping Cheng, Tao Huang, Yinping Chang, Mingyu Du, Erbao Liu

“…Mining genes controlling PEL in rice (Oryza sativa L.) has great practical significance in breeding cytoplasmic male sterility (CMS) lines with increased PEL and simplified, high-efficiency seed production. …”
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Preliminary study of the mechanism of isolinderalactone inhibiting the malignant behavior of bladder cancer by Qun Wang, Wenkai Xu, Lu Ying, Hongjin Shi, Yuxin Sun, Wei Feng, Haole Xu, Jun Xie, Hairong Wei, Zhao Yang, Haifeng Wang

“…Isolinderalactone (ILL), extracted from the dried tubers of Linderae aggregate, has multiple functions, such as antioxidation, antitumor, and anti-infection effects. …”
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Genomic characterization of Leishmania (V.) braziliensis associated with antimony therapeutic failure and variable in vitro tolerance to amphotericin B by Laura Natalia Gonzalez-Garcia, Aura María Rodríguez-Guzmán, Carolina M. Vargas-León, Samanda Aponte, Liliana A. Bonilla-Valbuena, J. Manuel Matiz-González, Ana M Clavijo-Vanegas, Germán Andrés Duarte-Olaya, Catherine Aguilar-Buitrago, Daniel Alfonso Urrea, Jorge Duitama, Maria C. Echeverry

“…The main mutations associated with AmB resistance previously reported in experimental cell lines from L. (L.) infantum, L. (L.) mexicana, and L. …”
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