A real-world study on the clinicopathological profile, treatment outcomes and health-related quality of life, anxiety and depression among patients with desmoid tumor at two tertia... by Ghazal Tansir, Aparna Sharma, Bivas Biswas, Suryadev Narayan Sah, Somnath Roy, S. V. S. Deo, Sandeep Agarwala, Shah Alam Khan, Sameer Bakhshi, Deepam Pushpam

“…Extremity (n=100, 50%) and abdomen (n=65, 32.5%) were commonest primary sites and median of 2 (1–4) lines of treatment were received. First-line included surgery (n=116, 58%), systemic therapy (n=67, 33.5%), radiotherapy (10, n=5%) and active surveillance (n=7, 3.5%). …”
Get full text

circRNA circ_102049 Implicates in Pancreatic Ductal Adenocarcinoma Progression through Activating CD80 by Targeting miR-455-3p by Jie Zhu, Yong Zhou, Shanshan Zhu, Fei Li, Jiajia Xu, Liming Zhang, Hairong Shu

“…Additionally, the circRNA_102049 was upregulated in PDAC cell lines. Functionally, the knockdown of circRNA_102049 by siRNAs inhibited cell growth, inflammatory factors, and migratory and invasive potential and promoted cell apoptosis. …”
Get full text

<i>Vvmrp1, Vvmt1</i>, and <i>Vvmt2</i> Co-Expression Improves Cadmium Tolerance and Reduces Cadmium Accumulation in Rice by Hongjuan Han, Yu Wang, Cen Qian, Quanhong Yao, Qiaoquan Liu

Get full text

Development of a novel radioiodinated compound for amyloid and tau deposition imaging in Alzheimer's disease and tauopathy mouse models by Xiyan Rui, Xinran Zhao, Nailian Zhang, Yuzhou Ding, Chie Seki, Maiko Ono, Makoto Higuchi, Ming-Rong Zhang, Yong Chu, Ruonan Wei, Miaomiao Xu, Chao Cheng, Changjing Zuo, Yasuyuki Kimura, Ruiqing Ni, Mototora Kai, Mei Tian, Chunyan Yuan, Bin Ji

Get full text

DNA Tweezers with Replaceable Clamps for the Targeted Degradation of Cell Membrane Proteins by Yang Sun, Yichen Huang, Daiquan Chen, Shangjiu Hu, Tao Pan, Yuanding Liu, Ruowen Wang, Weihong Tan

“…<b>Results</b>: Lysis was verified in different tumor cell lines and the antitumor activity was confirmed in zebrafish. …”
Get full text

Eribulin in Metastatic Breast Cancer: Actual Clinical Practice by A. V. Sultanbaev, K. V. Menshikov, Sh. I. Musin, I. A. Menshikova, N. I. Sultanbaeva, E. V. Popova, V. E. Askarov

“…A wide variety of patients with a number of comorbidities and lower functional status are treated in actual clinical practice. …”
Get full text

Topoisomerase IIIα controls alternative lengthening of telomeres by Prashant Khandagale, Yilun Sun, Daiki Taniyama, Sourav Saha, Liton Kumar Saha, Yves Pommier

“…Taken together, these observations uncover unexplored functions of TOP3A at ALT telomeres and suggest the potential of developing an ALT-specific cancer therapeutic strategy targeting TOP3A.…”
Get full text

Critical Analysis of the Content of French Textbooks in the First and Second Year of Educational Guidance for Iranian Students from the Perspective of Language and Culture Educati... by Hoda Khayat

“…Intercultural skills training is one of the important functions of the educational system. The aim of this study was to describe and critically analyze the content of French books in the seventh and eighth years of Intermediate 1 in terms of addressing the categories of language and culture education and interculturalism. …”
Get full text

Translational efficiency across healthy and tumor tissues is proliferation‐related by Xavier Hernandez‐Alias, Hannah Benisty, Martin H Schaefer, Luis Serrano

“…The distribution of such tRNA pools over the whole cellular translatome affects the subsequent translational efficiency, which functionally determines a condition‐specific expression program both in healthy and tumor states. …”
Get full text

Circulating Tumor Cells Shed Shearosome Extracellular Vesicles in Capillary Bifurcations That Activate Endothelial and Immune Cells by Angelos Vrynas, Salime Bazban‐Shotorbani, Sara Arfan, Karishma Satia, Brian Cunningham, Gauhar Sagindykova, Mymuna Ashna, Aoyu Zhang, Diana Visan, Aisher Chen, Teige Matthews‐Palmer, Mathew Carter, Fiona Blackhall, Kathryn L. Simpson, Caroline Dive, Paul Huang, Sam H. Au

“…Patient CTCs, CTC‐derived explant cells, and numerous cancer cell lines shed nuclei‐free fragments in a cell size‐ and bifurcation‐dependent manner. …”
Get full text

VPS4B orchestrates response to nuclear envelope stress by regulating ESCRT-III dynamics in glioblastoma by Zuqian Wu, Issei Omura, Atsushi Saito, Kazunori Imaizumi, Yasunao Kamikawa

“…Our functional analysis demonstrated that insufficient VPS4B triggers an inadequate response to NE stress and that VPS4B regulates the dynamics of ESCRT-III, uncovering the mechanism underlying the NE stress response in GBM.…”
Get full text

Adult Neural Stem Cells: Basic Research and Production Strategies for Neurorestorative Therapy by E. M. Samoilova, V. A. Kalsin, N. M. Kushnir, D. A. Chistyakov, A. V. Troitskiy, V. P. Baklaushev

“…Over many decades, constructing genetically and phenotypically stable lines of neural stem cells (NSC) for clinical purposes with the aim of restoring irreversibly lost functions of nervous tissue has been one of the major goals for multiple research groups. …”
Get full text

Elucidating essential kinases of endothelin signalling by logic modelling of phosphoproteomics data by Alexander Schäfer, Enio Gjerga, Richard WD Welford, Imke Renz, Francois Lehembre, Peter MA Groenen, Julio Saez‐Rodriguez, Ruedi Aebersold, Matthias Gstaiger

“…We investigated phosphoproteomic changes caused by endothelin B receptor (ENDRB) activation in the melanoma cell lines UACC257 and A2058 and built an integrated model of EDNRB signalling from the phosphoproteomics data. …”
Get full text

Local Self-Government in Kosovo: The Impact of International Agreements on the Association of Municipalities with a Major Serb Population by Bashkim Rrahmani, Majlinda Belegu

“…This paper aims to explain the organisation and functioning of local governance based on the legal infrastructure of Kosovo and the efforts of its institutions to accommodate international pressure under the existing legal infrastructure, which was specifically created according to international law and international demands. …”
Get full text

Structure stability of (U, Pu) C and (U, Pu) N compositions by William A. Watson, Sophie Cooper, Matthew Horton, Robin W. Grimes

“…Abstract Atomic scale computer simulations based on density functional theory (DFT) are used to calculate the formation energies and structures associated with phases in the U–N, Pu–N, U–C and Pu–C systems. …”
Get full text

Placental weight percentile curves in a Danish population by Simon Foged Victor, Maria Jeppegaard, Steen Christian Rasmussen, Marie Høygaard Larsen, Lone Krebs

“…Abstract Introduction The role of the placenta is to transport oxygen and nutrients to the fetus, and a well‐functioning placenta is vital to fetal health. Our aim was to develop placental weight percentile curves adjusted by gestational age, and stratified by major maternal comorbidities. …”
Get full text

The inner nuclear membrane protein, Banf1, has an essential role in triple negative breast cancer cell proliferation and survival by Maddison Rose, Joshua T. Burgess, Chee Man Cheong, Iain Richard, Amila Suraweera, Mark N. Adams, Pascal H. G. Duijf, Kenneth J. O’Byrne, Derek J. Richard, Emma Bolderson

“…These findings highlight the significant overexpression and functional involvement of Banf1 in TNBC progression and suggests that it may have potential as a novel anti-cancer target, supporting further investigation.…”
Get full text

OTUD4 inhibits ferroptosis by stabilizing GPX4 and suppressing autophagic degradation to promote tumor progression by Jinglian Chen, Chengqing Huang, Jiale Mei, Qiuhua Lin, Wenbo Chen, Jiali Tang, Xinjie Wei, Caixia Mo, Yueyan Zhang, Qi Zeng, Xianwei Mo, Weizhong Tang, Tao Luo

“…This investigation concentrates on the deubiquitinase OTUD4, scrutinizing its functional and molecular implications in ferroptosis within tumor cells. …”
Get full text

SADS-CoV nsp5 Inhibits Interferon Production by Targeting Kinase IKKε by Gaoli She, Chunhui Zhong, Yue Pan, Zexin Chen, Jingmin Li, Mingchong Li, Yufang Liu, Yongchang Cao, Xiaona Wei, Chunyi Xue

“…As a 3C-like protease, SADS-CoV nsp5 functioned as an interferon inhibitor by interacting with IKKε, reducing its protein abundance, and inhibiting its phosphorylation. …”
Get full text

Participation of steamships of the Solovetsky monastery in the defense of the Russian North in 1914–1917 by Sozont Singh

“…The monastery, being far from the fighting on the front line, found itself in the thick of events unfolding in the Arctic Ocean. …”
Get full text