Integrated Cytological, Physiological, and Comparative Transcriptome Profiling Analysis of the Male Sterility Mechanism of ‘Xinli No.7’ <i>Pear</i> (<i>Pyrus</i> sp.) by Hao Li, Xiangyü Li, Yüjia Luo, Quanhui Ma, Zhi Luo, Jiayuan Xuan, Cuiyun Wu, Fenfen Yan

“…Comparative transcriptomics identified 283 co-expressed differentially expressed genes (DEGs). Functional enrichment linked these DEGs to ROS-scavenging pathways: galactose metabolism, ascorbate and aldarate metabolism, arginine and proline metabolism, fatty acid degradation, pyruvate metabolism, and flavonoid biosynthesis. qRT-PCR validated the expression patterns of key DEGs in these pathways. …”
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Association of predicted basal metabolic rate and insulin resistance in a Chinese general population by Linghuan Wang, Tingting Lu, Peixin Wu, Kang Chen, Yiming Mu

“…Covariates included sex, age, smoking status, alcohol consumption, glycemic and lipid profiles, liver and kidney function, and anthropometric indices. Sensitivity analyses using inverse probability weighting and restricted cubic spline regression were conducted to verify the robustness of the findings. …”
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Transcriptomic analysis of mammary gland tissues in lactating and non-lactating dairy goats reveals miRNA-mediated regulation of lactation, involution, and remodeling by Yanan Peng, Xinhua Duan, Linfan Zhang, Yiyi Guo, Jinlin Cao, Weiping Ao, Rong Xuan

“…Differential expression analysis, miRNA clustering, Gene Ontology (GO) annotation, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment were performed to predict the functions of target genes. A miRNA-mRNA regulatory network associated with mammary gland development was constructed, and functional validation experiments were conducted to confirm key regulatory relationships.ResultsA total of 1,120 miRNAs were identified, including 408 known and 712 newly predicted miRNAs. …”
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The m6A modification of LINC01133 suppresses ER+ breast cancer progression by modulating IGF2BP2 protein stability via a ubiquitination-dependent mechanism by Mai-dong Li, Mai-dong Li, Ben-jie Shan, Lei Wang, Shuang Gao, Li Hao, Hai-yang Yu, Yue-yin Pan, Yue-yin Pan

“…Functionally, LINC01133 inhibited migration and invasion in vitro and metastasis in vivo of ER+ breast cancer cells. …”
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Does the audiogram shape influence the intracochlear recording of Electrocochleography during and after cochlear implantation? by Sabine Haumann, Sabine Haumann, Max E. Timm, Max E. Timm, Andreas Büchner, Andreas Büchner, Thomas Lenarz, Thomas Lenarz, Rolf B. Salcher, Rolf B. Salcher

“…During cochlear implant (CI) surgery, it is desirable to perform intraoperative measurements such as Electrocochleography (ECochG) to monitor the inner ear function and thereby to support the preservation of residual hearing. …”
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Genomic and Transcriptomic Analysis to Explore the Biological Characteristics of <i>Cyclocybe chaxingu</i> by Qiang Yang, Haiyan Song, Ge Su, Xuncheng Wang, Haijing Hu, Zhijun Zhai, Minghui Chen, Jianping Zhou, Hua Yin, Yang Gao, Dianming Hu

“…Transcriptomic analysis revealed distinct gene expression patterns in mycelia, stipe, and cap, reflecting their functional specialization. …”
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Arthroscopic all-inside ACL reconstruction with anterolateral tendon fixation: a prospective cohort study on restoring rotational stability in high-grade tibial shift by Haoran Gu, Aifang Niu, Jingrui Ji, Miao He, Ying Yang, Junxia Lu, Jianghong Lv, Yongdong Yi, Hui Zhou, Wuping Zhou

“…Early outcomes demonstrate promising functional recovery and objective stability at short-term follow-up, suggesting that this technique may offer biomechanical benefits for managing severe instability patterns. …”
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New biomarkers of Kawasaki disease identified by gingival crevicular fluid proteomics by Xue Fan, Ying Li, Yuehao Xu, Jianqing Lin, Xin Guo, Jinwen Liao, Mingguo Xu

“…DEPs were identified and subjected to functional enrichment analysis using KEGG and GO. Protein–protein interaction (PPI) analysis was conducted for all detected DEPs. …”
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Effect of Chlorhexidine and Benincasa Hispida Pretreatment on Microshear Bond Strength of Universal Adhesive System on Dentin: A Pilot Study by Girija S Sajjan, Manda Sri Swathi, P Arun Bhupathi, Madhu Varma Kanumuri, Rajulapati Kalyan Satish, Rama Krishna Alla, Tippireddy Srija, Ch Uma Shalini

“…Benincasa hispida is a natural plant-based functional food containing minerals and vitamins that help prevent osteoporosis and improve bone health. …”
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Characterization and Application of Different Types of Pineapple Leaf Fibers (PALF) in Cement-Based Composites by Julianna M. da Silva, Adilson Brito de Arruda Filho, Lidianne do N. Farias, Everton Hilo de Souza, Fernanda V. D. Souza, Cláudia F. Ferreira, Paulo R. L. Lima

“…An anatomical analysis of the leaves was conducted to identify fiber distribution and structural function. …”
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Genome-Wide Identification and Expression Analysis of <i>NAC</i> Gene Family Members in Seashore Paspalum Under Salt Stress by Xuanyang Wu, Xiaochen Hu, Qinyan Bao, Qi Sun, Pan Yu, Junxiang Qi, Zixuan Zhang, Chunrong Luo, Yuzhu Wang, Wenjie Lu, Xueli Wu

“…This study established a theoretical basis for understanding the molecular functions and regulatory mechanisms of the <i>NAC</i> gene family in seashore paspalum under salt stress.…”
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A novel NFKB1 agonist remodels tumor microenvironment and activates dendritic cells to promote anti-tumor immunity in colorectal cancer by Ying Chen, Qiaoming Li, Zixiang Wang, Ling V. Sun, Steven X. Hou

“…We then performed functional validation using a mouse colorectal cancer graft tumor model established with the CT26 cell line characterized by its high content of CSCs. …”
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Dynamics of cerebral blood flow following sertraline treatment in adolescent depression by Wenyu Ren, Wenyu Ren, Xiao Liu, Zhiwei Zhang, Xiaoqin Zhang, Wei Wu, Xingyu Wang, Zhihui Yu, Chuan Liu, Renqiang Yu

“…Among the depressed cohort, 25 participants adhered to the treatment protocol and completed MRI scans. Resting-state functional MRI (rs-fMRI) scans were conducted for all participants, with a subsequent scan for the depression group after 8 weeks of sertraline therapy. …”
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Navigating Nepal's health financing system: A road to universal health coverage amid epidemiological and demographic transitions. by Resham B Khatri, Pratik Khanal, Dipendra Singh Thakuri, Prabesh Ghimire, Mihajlo Jakovljevic

“…Policies and content related to the health financing system were reviewed to understand the status, issues and challenges of health financing functions, and UHC . A framework-guided deductive content analysis approach was employed, and findings were interpreted using the three UHC components: service coverage, population coverage, and financial coverage.…”
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Identification and Mechanistic Studies of Key Genes in Thalamic Hemorrhage Pain by Multi-omics by Chen Yang, Ju Gao, Yaqun Li, Yinggang Xiao, Tianfeng Huang

“…Multi-omics analyses yielded distinct profiles of DEGs, single-cell DEGs, DEPs, RF-DEGs, and DEMs, which were functionally annotated through enrichment strategies. …”
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The novel diagnostic markers for systemic lupus erythematosus and periodontal disease by Xuedi Cheng, Jinfeng Zhang, Jiali Hou, Xiaocui Han, Bin Han, Jun Zhou, Zhongjun Wang, Junzheng Wang

“…Protein-protein interaction (PPI) network analysis was conducted to explore relationships between hub genes. …”
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NAP1L5 in acute myeloid leukemia: a prognostic biomarker and potential therapeutic target by Meng Wang, Meng Wang, Zhibin Xie, Yuanyuan Tan, Yan Zhou, Tingting Zhang, Yuqing Du, Huan Wu, Lili Zhou, Jian Ge

“…To elucidate the functional role of NAP1L5, we conducted Gene Set Enrichment Analysis (GSEA) and Gene Ontology (GO) analysis, which revealed its involvement in specific signaling pathways and biological processes. …”
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The Role of Values and Emotions in Accepting Fake Political News in the Post-Truth Era by Amir Mollaee Mozaffari, Ali Ashraf Nazari

“…A preliminary survey was conducted with 370 participants, resulting in the identification of 10 emotionally charged fake news items that had been widely accepted by audiences.Next, semi-structured interviews were conducted with 12 ordinary Iranians, using these 10 fake news items (intermixed with legitimate news stories) as discussion prompts. …”
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Impact assessment of differential chlormequat chloride exposure on soil fungal community dynamics by Qiujun Lin, Qiujun Lin, Xianxin Wu, Xianxin Wu, Lina Li, Lina Li, Tianshu Peng, Tianshu Peng, Xun Zou, Xun Zou, Guang Li, Guang Li, Jianzhong Wang, Jianzhong Wang, Chunjing Guo, Chunjing Guo

“…The significant shifts observed in key functional guilds, particularly the decline in pathogens and proliferation of saprophytes, highlight the impact of CC application on soil fungal ecological functions.…”
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SMYD2 epigenetically activates BMP4/SMAD1/5/8/ID3 axis to enhance cancer stem cell properties and drive sorafenib resistance in hepatocellular carcinoma by Shanshan Wang, Weicheng Wu, Zhen Shi, Mei Bin, Fengwei Zhang, Long Cai, Kaiqing Lin, Zhihui Li

“…To investigate the biological functions of SMYD2, we conducted a series of functional assays in vitro and in vivo. …”
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