Investigating the Role of Osteopontin (OPN) in the Progression of Breast, Prostate, Renal and Skin Cancers by Gautam Kundu, Selvakumar Elangovan

“…<b>Methods</b>: In this study, we conducted a further examination of the transcriptomic expression profile of SPP1 (Osteopontin) during the progression of cancer in four human tissues, breast, prostate, renal and skin, in order to understand the circumstances conducive to its activation and dysregulation, the biological pathways and other mechanisms involved as well as differences in its splicing patterns influencing its expression and functionality. …”
Get full text

Identification of hub genes in myocardial infarction by bioinformatics and machine learning: insights into inflammation and immune regulation by Juan Yang, Xiang Li, Li Ma, Jun Zhang

“…These genes were then subjected to functional enrichment analysis, including Kyoto Encyclopedia of Genes and Genomes (KEGG), Gene Ontology (GO), and Gene Set Enrichment Analysis (GSEA). …”
Get full text

Epigenetic regulation of TNNT1 in gastrointestinal cancers prognostic implications and clinical significance by Jin Xie, Xin-Yang Qu, Rui-Min Wu, Jie Liu, Fan Cheng, Yu Zhang, Xu-Sheng Liu

“…The impact of TNNT1 expression on patient prognosis was evaluated through Cox regression analyses. Furthermore, functional enrichment analysis was conducted to explore the biological pathways involved, alongside promoter methylation and mutation analyses, to elucidate its regulatory mechanisms. …”
Get full text

Single-cell RNA sequencing technology was employed to construct a risk prediction model for genes associated with pyroptosis and ferroptosis in lung adenocarcinoma by Longfei Ji, Binyu Wang, Danfei Shi, Weiyun Shen, Xinmin Li, Yong Li

“…Method This study integrated single-cell RNA sequencing (scRNA seq), bulk transcriptome data, and clinical information to comprehensively analyze the expression patterns and functional roles of pyroptosis related genes (PRGs) in LUAD. …”
Get full text

Circulating Plasma Proteins as Biomarkers for Immunotherapy Toxicity: Insights from Proteome-Wide Mendelian Randomization and Bioinformatics Analysis by Liansha Tang, Wenbo He, Handan Hu, Jiyan Liu, Zhike Li

“…Circulating plasma proteins, dynamically accessible and functionally linked to immunity, may predict and offer novel targets for irAEs. …”
Get full text

Analysis of the structural changes in domestic consumption of FUEL and energetic resources of Moscow by L. G. Moiseykina, E. S. Darda

“…The fuel and energy complex of Moscow is one of the largest in Russia. A feature of its functioning is the concentrated consumption of gas, fuel, electricity, heat energy and other energy resources. …”
Get full text

Exploration of biomarkers associated with histone lactylation modification in spinal cord injury by Yisong Sun, Jie Gao, Juehua Jing

“…Inter-cluster comparisons were conducted to examine Hallmark pathways, HLA genes, and immune functions. …”
Get full text

Expressing the Author's Position in the English-Language Network Film Review by I. V. Kononova, T. A. Klepikova, E. A. Klenova

“…The authors proceed from the position that the methods of subject verbalization are determined by functional characteristics of discourse. The relevance of the study is due to the interest of modern linguistics in the study of the subject factor in “personal” types of discourse. …”
Get full text

Placental whole transcriptome expression profile in patients with early-onset, late-onset preeclampsia and gestational diabetes mellitus by Zhuo Chen, Li Yang, Li Geng, Xinwen Zhang, Mingyu Du, Yonghu Sun, Lin Zhao, Bing Bai, Xiaohong Li

“…The results revealed dysregulation of key pathways in early-onset-PE (OE-PE), including Wnt signaling, PI3K-Akt signaling, MAPK signaling, FoxO signaling, and TNF signaling, along with downregulation of genes related to Ca2 + conduction and hormone pathways. In late-onset-PE (LO-PE) and GDM, abnormalities were observed in immune pathways including chemokine signaling pathway and IL-17 signaling pathway, with differing immune cell infiltration patterns. …”
Get full text

A Low-Power Electrothermal Flexible Actuator with Independent Heating Control for Programmable Shape Deformation by Shen Dai, Zhiyao Ling, Han Gong, Kunwei Zheng

“…Compared to traditional actuators, the proposed design offers significant improvements in bending angle, response speed, and voltage requirements. By optimizing the conductive silver paste pattern and voltage input strategy, this work develops a low-voltage, highly controllable, multi-mode programmable actuator with potential for applications in flexible robotics and space-deformable antennas.…”
Get full text

Multidimensional Burden of Moderate-to-Severe Atopic Dermatitis in Adolescent and Adult Patients from Portugal and Greece: Results from the Global Cross-Sectional Study MEASURE-AD by Pedro Mendes-Bastos, Elisavet Lazaridou, Tiago Torres, Charalampos Aggelakopoulos, Ioannis Katsantonis, Pantelis Aronis, Dimitrios Rigopoulos, Filomena Azevedo, Felicidade Santiago, Markos Papakonstantis, Paulo Varela, Vera S. G. Ribeiro, Aikaterini Kollia, Evaggelia Papadavid

“…Methods MEASURE-AD was a global, cross-sectional observational study in adolescents and adults with moderate-to-severe AD, conducted to describe disease burden, treatment patterns, and healthcare resource utilization. …”
Get full text

Distinct steps of neural induction revealed by Asterix, Obelix and TrkC, genes induced by different signals from the organizer. by Sonia Pinho, Pamela R Simonsson, Katherine E Trevers, Matthew J Stower, William T Sherlock, Mohsin Khan, Andrea Streit, Guojun Sheng, Claudio D Stern

“…To define signals and responses during the first 5 hours of node signals, a differential screen was conducted. Here we describe three early response genes: two of them, Asterix and Obelix, encode previously undescribed proteins of unknown function but Obelix appears to be a nuclear RNA-binding protein. …”
Get full text

Influence of seasonal variation on in vitro fertilization success. by Michal Kirshenbaum, Alon Ben-David, Eran Zilberberg, Tal Elkan-Miller, Jigal Haas, Raoul Orvieto

“…<h4>Methods & materials</h4>A total of 5,765 IVF cycles conducted in Sheba medical center between 2013 and 2016 were retrospectively analyzed. …”
Get full text

Iris Microcirculation After Selective Laser Trabeculoplasty: A Pilot Optical Coherence Tomography Angiography Study by Dmitrii S. Maltsev, Alexey N. Kulikov, Alina A. Kazak

“…OCTA examination of the iris was performed before SLT and one day and seven days after SLT using RTVue-XR with a 3 mm scan pattern and follow-up function. Iris vascularity was calculated with ImageJ software (version 1.53k) as vessel density on binarized images. …”
Get full text

Morphometric and Genetic Characterization of Dominant Fish Species in Progo River, Yogyakarta, Indonesia by null Mulyasari, null Subaryono, Bagus Sediadi Bandol Utomo, Imam Taufik, Irin Iriana Kusmini, null Yosmaniar

“…A study on the morphology and genetics of the three species of dominant wader that live in the Progo River has been conducted. This study aimed to identify the three kinds of dominant waders in the Progo River, their morphology, and their genetics to ensure their right identity. …”
Get full text

Identification of Attention Deficit Hyperactivity Disorder Using Parent-teacher Administered ADHD Rating Scale-IV among Pre-school Children of Belagavi City by Deepa C. Metgud, Vinanti Sanjay Makasare

“…Background: Attention deficit hyperactivity disorder (ADHD) is a developmental disorder with a persistent pattern of distractibility, hyperactivity, restlessness, and other disturbances of executive function. …”
Get full text

Optimal Charging Current Protocol with Multi-Stage Constant Current Using Dandelion Optimizer for Time-Domain Modeled Lithium-Ion Batteries by Seongik Han

“…A composite objective function that incorporates both charging time and charging temperature was constructed to facilitate the use of DO in obtaining the OCP. …”
Get full text

ZmHsp18 screened from the ZmHsp20 gene family confers thermotolerance in maize by Ming Xue, Yiwen You, Luyao Zhang, Jinming Cao, Mingliang Xu, Saihua Chen

Get full text

Alcohol vs. Cocaine: Impulsivity and Alexithymia in Substance Use Disorder by Alessio Mosca, Giovanna Bubbico, Clara Cavallotto, Stefania Chiappini, Rita Allegretti, Andrea Miuli, Carlotta Marrangone, Nicola Ciraselli, Mauro Pettorruso, Giovanni Martinotti

“…Group comparisons were conducted using non-parametric tests, and logistic regression models were applied to control for demographic covariates. …”
Get full text

Digital Storytelling for People With Cognitive Impairment Using Available Mobile Apps: Systematic Search in App Stores and Content Analysis by Di Zhu, Abdullah Al Mahmud, Wei Liu, Dahua Wang

“…The reviewed apps featured capture memory, save, reminisce, and share functions, which are critical in supporting cognitive functions and enhancing user engagement. …”
Get full text