Engineering of a chitin deacetylase to generate tailor-made chitosan polymers. by Martin Bonin, Antonia L Irion, Anika Jürß, Sergi Pascual, Stefan Cord-Landwehr, Antoni Planas, Bruno M Moerschbacher

“…In addition, molecular dynamics simulations were conducted to get an in-depth view of crucial interactions along the binding site. …”
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Exploring the c.406 C > T variant in TNNI3 gene: pathogenic insights into restrictive cardiomyopathy by Tannaz Masoumi, Hamed Hesami, Majid Maleki, Samira Kalayinia

“…Methods Whole exome sequencing (WES) was conducted on the proband, followed by Sanger sequencing for variant confirmation and familial segregation analysis. …”
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Transcriptomic and metabolomic analyses for the mechanism underlying anthocyanin synthesis during the growth and development of purple eggplant (Solanum melongena L) by Ting Yang, Wanping Lv, Runjie Zhuang, Shiyu Wang, Shuqi Fan, Yongxian Wen, Yongxian Wen

“…This study aimed to elucidate the dynamics of anthocyanin accumulation and identify key regulatory genes across three developmental stages of eggplant fruit peel (S1: white, S2: light purple, S3: dark purple).MethodsIntegrated metabolomic and transcriptomic analyses were conducted to investigate anthocyanin profiles and gene expression patterns during fruit development. …”
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Improved smart city security using a deep maxout network-based intrusion detection system with walrus optimization by Wahid Rajeh, Majed Aborokbah, Manimurugan S., Umar Albalawi, Ahamed Aljuhani, Osama Shibl Abdalghany Younes, Karthikeyan Periyasami

“…The DMN is configured with an architecture that includes multiple layers with maxout activation functions. These layers are capable of capturing complex patterns in the data, making the DMN particularly effective for identifying anomalies in IoT network traffic. …”
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<i>DBI</i> as a Novel Immunotherapeutic Candidate in Colorectal Cancer: Dissecting Genetic Risk and the Immune Landscape via GWAS, eQTL, and pQTL by Ting Tian, Huan Han, Jingtao Huang, Jun’e Ma, Ruoxi Ran

“…Further validation was performed using The Cancer Genome Atlas (TCGA) to assess gene expression patterns and prognostic significance. Additionally, immune infiltration analysis was conducted to characterize the tumor immune microenvironment. …”
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Study on the Wind Pressure Distribution in Complicated Spatial Structure Based on k-ε Turbulence Models by Jing Wang, Shixiong Zhou, Hui Liu, Shixing Zhao, Fei He, Lei Zhao

“…Both wind tunnel test and CFD simulations are conducted to analyze the wind pressure distribution on building surface. …”
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Identification and characterization of soybean phytochrome-interacting factors and their potential roles in abiotic stress by Dewei Mu, Zhaowei Shui, Haoyu Guo, Hengke Jiang, Yuhan Liu, Liqiu Luo, Yanpeng Zhang, Xinxin Zhang, Jiaxin Yu, Shulin Liao, Liang Yu, Chunyan Liu, Junbo Du

“…Nevertheless, research on PIFs in soybean is relatively scarce. In this study, we conducted a comprehensive analysis of the gene structure, chromosomal location, conserved motifs, phylogenetic relationships, and expression patterns of the Glycine max PIF (GmPIF) genes. …”
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Real-world safety of carboplatin in non-small cell lung cancer: a retrospective signal detection and subgroup analysis based on the FAERS database by Lei Wang, Kunpeng Yang, Kunpeng Yang, Hui Zhao, Peiyun Lv, Chenglun Cai, Zhe Wang, Bao Wang, Bao Wang, Bao Wang

“…Subgroup analyses revealed distinct patterns: males exhibited increased infection-related events, whereas females were more prone to gastrointestinal and hepatic complications. …”
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Transcriptome profiling and co-expression network analysis of 96 Haematococcus pluvialis samples by Bin Hu, Kai Liu, Feichao Du, Hailiang Xing, Xiaoyuan Su, Tao Hu, Feng Chen, Yujie Qin, Zhaozhen Dong, Xue Sun, Liuquan Zhang, Jagroop Pandhal, Nianjun Xu, Chaoyang Hu

“…Additionally, the re-annotation process provided functional descriptions for 8,598 previously uncharacterized genes. …”
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Information Propagation in Hypergraph-Based Social Networks by Hai-Bing Xiao, Feng Hu, Peng-Yue Li, Yu-Rong Song, Zi-Ke Zhang

“…Social networks, functioning as core platforms for modern information dissemination, manifest distinctive user clustering behaviors and state transition mechanisms, thereby presenting new challenges to traditional information propagation models. …”
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Evaluating the effects of climate-induced heatwaves on the thermal dynamics and water quality of a deep reservoir in Portugal by Manuel Almeida, Senlin Zhu, Rita M. Cardoso, Pedro M.M. Soares, Pedro Coelho

“…The study also underscores the importance of hydrodynamic forcing functions, such as inflow temperature and atmospheric variability, in shaping thermal stratification and circulation patterns. …”
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Sex differences in schizophrenia: symptomatology, treatment efficacy and adverse effects by Ivi Moniem, Vasilios Kafetzopoulos

“…Men typically experience illness onset approximately 3–5 years earlier than women, with more severe negative symptoms, worse social functioning, and higher rates of comorbid substance use disorders. …”
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Relational, Ethical, and Care Challenges in ALS: A Systematic Review and Qualitative Metasynthesis of Nurses’ Perspectives by Giovanna Artioli, Luca Guardamagna, Nicole Succi, Massimo Guasconi, Orejeta Diamanti, Federica Dellafiore

“…Background: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that leads to severe functional decline and death, imposing significant physical, emotional, and ethical burdens on patients and healthcare providers. …”
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Anoikis in hepatocellular carcinoma: genetic alterations and immune microenvironment insights from single-cell and computational analysis by Bing Zhou, Jialing Zhang, Mingfeng Guo

“…Key findings were validated using qPCR on clinical samples, and functional assays using shRNA-mediated knockdown of KPNA2 were conducted in Hep-3B cell lines to assess changes in proliferation and migration. …”
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Exploring the interplay between LDHA and ABCC1 in breast cancer using computational approach by Bader Alshehri

“…GeneMANIA and STRING databases were used to explore gene–gene and protein–protein interaction networks, while KM Plotter evaluated survival correlations. Functional enrichment and pathway analyses were conducted using Enrichr for Gene Ontology (GO) and KEGG pathways. …”
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Antibiotic use for digestive system diseases (ICD-10: K00-K93) at an Indonesian government teaching hospital in 2021 by Rahmah Inasiyyah, Ikhwan Yuda Kusuma, Fauziah Fauziah, Fiqih Nurkholis, Khamdiyah Indah Kurniasih

“…Acute appendicitis (n = 416), inguinal hernia (n = 250), and functional dyspepsia (n = 169) were the leading diagnoses. …”
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Integrative computational approaches identify haptoglobin inhibitors to modulate erythrocyte sedimentation rate in trauma-linked inflammatory and haematological malignancies by Abdulaziz H. Al Khzem, Shaban Ahmad

“…The study also included Density Functional Theory computations and pharmacokinetic profiling to assess these compounds’ suitability further, revealing promising results. …”
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Microbial community composition and co-occurrence network analysis of the rhizosphere soil of the main constructive tree species in Helan Mountain of Northwest China by Yuze Yang, Yue Li, Ke Hao, Yujia Zhao, Min Li, Yongjun Fan

“…By analyzing the response of rhizosphere microbial communities of major tree species in Helan Mountain to nutrient dynamics and pH changes, we can deepen our understanding of the role of microorganisms in regulating ecosystem functions and provide theoretical basis for soil improvement and ecological restoration strategies.…”
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Elucidating the role of brassinosteroid signaling genes and their promoters in Arabidopsis revealed regulatory mechanisms in plant development and responses to different abiotic st... by Sunny Ahmar, Muhammad Sohaib Shafique, Marcin Rapacz, Ewa Pociecha

“…Therefore, the present study was designed to conduct detailed and comprehensive analysis of BR signaling genes, promoter regions, and their encoded proteins in Arabidopsis. …”
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Research trends of protein palmitoylation in cancer from 2004 to 2024: a bibliometric and visualization analysis by Yufeng Peng, Kewei Peng, Yi Wang, Luyao Li, Yuefei Lu

“…Palmitoylation involves the covalent attachment of palmitic acid (C16) to cysteine residues, altering the protein’s hydrophobicity and thereby affecting its membrane localization, stability, and functional activity. Recently, palmitoylation has been closely associated with the development and progression of various cancers, making it a key factor in cancer biology research.MethodsThis study conducted a systematic bibliometric analysis using the Web of Science Core Collection (WoSCC) as the data source. …”
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