Association between Life's Crucial 9 and Cardiorenal syndrome: the mediating role of weight-adjusted-waist index by Huanjie Fu, Zhichao Liu, Hao Yu, Yisheng Zhao, Yongkang Gan, Jinhong Chen, Eryue Liu

“…Tertile analysis of LC9 and WWI demonstrated consistent patterns, with significant p-values for trends < 0.001. …”
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Thoracic dysfunction in whiplash associated disorders: A systematic review. by Nicola R Heneghan, Richard Smith, Isaak Tyros, Deborah Falla, Alison Rushton

“…<h4>Results</h4>Thirty eight studies (n>50,000) which were conducted across a range of countries were included. …”
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Common and distinct neural underpinnings of the association between childhood maltreatment and depression and aggressive behavior by Yuan Li, Ting Zhang, Xin Hou, Xiaoyi Chen, Yu Mao

“…First, we employed Network-Based Statistics (NBS) on resting-state functional magnetic resonance imaging (fMRI) data to identify functional connectivity (FC) patterns associated with depression and aggression. …”
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Economic growth and urban metamorphosis: A quarter century of transformations within the metropolitan area of Bucharest by Cristian Tosa, Andrei Mitrea, Hitomi Sato, Tomio Miwa, Takayuki Morikawa

“…This paper concentrates explicitly on examining the structural and functional transformations occurring within the metropolitan area of Bucharest, resulting from sustained economic growth during the past quarter century, by conducting a time analysis, spanning the entire period since the fall of the communist regime in late 1989. …”
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ABBA+BraiAn, an integrated suite for whole-brain mapping, reveals brain-wide differences in immediate-early genes induction upon learning by Nicolas Chiaruttini, Carlo Castoldi, Linda Maria Requie, Carmen Camarena-Delgado, Beatrice Dal Bianco, Johannes Gräff, Arne Seitz, Bianca A. Silva

“…Summary: Unbiased characterization of whole-brain cytoarchitecture is crucial for understanding brain function, requiring precise mapping of 2D histological sections onto 3D brain atlases. …”
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CCT8 drives colorectal cancer progression via the RPL4-MDM2-p53 axis and immune modulation by Yangyang Teng, Hao Lin, Zijian Lin, Xichen Li, Yejiao Ruan, Binhui Pan, Jinlin Ge, Yuesheng Zhu, Daopo Lin, Qingji Ying, Zhenzhai Cai, Xuanping Xia

“…Functional assays, including CCK-8, transwell, wound-healing, and flow cytometry, were conducted using DLD-1 and HCT116 cell lines to assess the effects of CCT8 on cell proliferation, migration, invasion, and apoptosis. …”
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Isokinetic Evaluation of Quadriceps and Hamstring Muscle Performance in the Rehabilitation Phase after ACL Reconstruction by Nicolae Stanciu, Razvan Marian Melinte, Mark Slevin, Octav Marius Russu, Cristian Trâmbițaș, Cezara Ilinca Stanciu, Elena Georgiana Bălănescu, Dan Avrămiuc, Gabriel Koszoruș, Klara Brînzaniuc

“…Subgroup analyses were conducted based on sex and athletic background to explore differences in muscle performance and recovery patterns.…”
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Effects of water and fertilizer management on soil bacterial communities, enzyme activities, and nutrient availability in greenhouse tomatoes. by Xiaona Lyu, Hasnuri Mat Hassan, Yaling Zan, Jiongrui Tan

“…Microbial communities under I2 (PCo1 = 11.13%) showed greater homogeneity while preserving treatment-specific patterns, suggesting slight deficit irrigation balances stability and functional differentiation. …”
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Pan-cancer characterization of m6A-mediated regulation of T cell exhaustion dynamics and clinical relevancies in human cancers by Weiping Ji, Ye Fang, Liwei Chen, Yitong Zheng, Yifei Pei, Changqiu Mei, Meng Zhou

“…The role of N6-methyladenosine (m6A) modification in regulating immune cell function has been recognized, but its impact on TEX dynamics across cancer types and clinical outcomes remains unclear. …”
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Multi-omic analyses reveal PTPN6’s impact on tumor immunity across various cancers by Yuchen Zhong, Weiyuan Zhang, Chaojing Zheng, Hongyu Wu, Jun Luo, Ziming Yuan, Hao Zhang, Chunlin Wang, Haiyang Feng, Meng Wang, Qian Zhang, Haixing Ju, Guiyu Wang

“…We analyzed PTPN6 expression data from open access databases using various statistical techniques, including survival analysis, genetic heterogeneity analysis, immune profiling, single-cell analysis, drug sensitivity analysis, and protein interaction analysis. We also conducted in vitro experiments utilizing colorectal cancer cell lines to validate PTPN6’s functional role. …”
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Restrictive Cardiomyopathies: The Importance of Noninvasive Cardiac Imaging Modalities in Diagnosis and Treatment—A Systematic Review by Aidonis Rammos, Vasileios Meladinis, Georgios Vovas, Dimitrios Patsouras

“…Echocardiography reveals normal or hypertrophied ventricles, preserved systolic function, marked biatrial enlargement, and impaired diastolic function, often with restrictive filling pattern. …”
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Microbial Influences on Amyotrophic Lateral Sclerosis: The Gut–Brain Axis and Therapeutic Potential of Microbiota Modulation by Victòria Ayala, Laia Fontdevila, Santiago Rico-Rios, Mònica Povedano, Pol Andrés-Benito, Pascual Torres, José C. E. Serrano, Reinald Pamplona, Manuel Portero-Otin

“…Of note, different studies do not agree on common patterns of microbiota being linked to ALS, supporting the need for further, more extensive studies. …”
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Kinesin-related genes stratified the prognosis and immune responses of clear cell renal cell carcinoma by Wenchong Zang, Luqi Ge, Xiaoping Hu, Tong Xu, Zhentao Zhang, Yiwen Zhang, Feifeng Song

“…Validation studies involving immunohistochemical staining, malignant phenotype assays, and immunofluorescence were conducted to assess the expression and function of these signature genes. …”
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Histidine metabolism drives liver cancer progression via immune microenvironment modulation through metabolic reprogramming by Pengcheng Liu, Fuxin Huang, Peixu Lin, Jiayao Liu, Pincheng Zhou, Jie Wang, Huanhuan Sun, Fan Xing, Haiqing Ma

“…In vivo and in vitro experiments were conducted to validate how histidine treatment affects macrophage and T-cell function. …”
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Seasonal Self-Purification Process of Nutrients Entering Coastal Water from Land-Based Sources in Tieshan Bay, China: Insights from Incubation Experiments by Fang Xu, Peng Zhang, Yingxian He, Huizi Long, Jibiao Zhang, Dongliang Lu, Chaoxing Ren

“…Nutrients function as essential biological substrates for coastal phytoplankton growth and serve as pivotal indicators in marine environmental monitoring. …”
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Cardiovascular and renal comorbidities among saudi patients with type 2 diabetes: A cross-sectional observational study. by Syed Irfan Karim, Kamran Sattar, Tauseef Ahmad, Mustafa Kamal Memon, Abdulfattah S Alqahtani, Abdulrahman M Alsubiheen, Fahad Abdulaziz Alrashed

“…<h4>Methods</h4>A cross-sectional observational study was conducted across three research locations in Riyadh, Saudi Arabia. …”
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Parental kynurenine 3-monooxygenase genotype in mice directs sex-specific behavioral outcomes in offspring by Snezana Milosavljevic, Maria V. Piroli, Emma J. Sandago, Gerardo G. Piroli, Holland H. Smith, Sarah Beggiato, Norma Frizzell, Ana Pocivavsek

“…Behavioral assessments were conducted on wild-type offspring from two parental groups: (i) WT-Control from WT-Control parents, (ii) wild-type Kmo (WT-Kmo +/+) from Kmo heterozygous parents (HET-Kmo +/–). …”
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A comprehensive transcriptome based meta-analysis to unveil the aggression nexus of oral squamous cell carcinoma by Soujanya J. Vastrad, Ganesan Rajalekshmi Saraswathy, Jagadish B. Dasari, Gouri Nair, Ashok Madarakhandi, Dominic Augustine, S.V. Sowmya

“…However, the drivers of this aggressive phenotype remain unclear due to the variability in gene expression patterns. To address this, an integrative meta-analysis of six publicly available transcriptomic profiles, categorized by lymph nodal status, is conducted. …”
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Comprehensively characterize the soybean CAM/CML gene family, as it provides resistance against both the soybean mosaic virus and Cercospora sojina pathogens by Chunlei Zhang, Yanbo Wang, Yanbo Wang, Ruiping Zhang, Rongqiang Yuan, Kezhen Zhao, Xiulin Liu, Xueyang Wang, Fengyi Zhang, Sobhi F. Lamlom, Sobhi F. Lamlom, Bixian Zhang, Honglei Ren

“…Gene structure analysis, cis-acting element identification, and expression profiling were conducted to examine functional diversification and pathogen response patterns.ResultsPhylogenetic analysis revealed 14 distinct groups with evidence of both ancient and recent gene duplication events contributing to family expansion. …”
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Unraveling the Mechanistic Links Between Species Diversity and Infection Risk From Zoonotic Pathogens With Direct Transmission Among Reservoir Hosts: Rodent‐Orthohantavirus Systems... by Andreas Eleftheriou, Angela D. Luis

“…ABSTRACT To explain patterns between anthropogenic loss of species diversity and the rise in the number of novel zoonotic diseases, the “dilution effect” hypothesis predicts that with lower species diversity, infection risk will increase. …”
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