Genotype–phenotype analysis and functional study of three novel LRP6 variants in non-syndromic oligodontia by Yunyun Yuan, Ya Zhao, Lingqiang Meng, Shuyun Zheng, Hui Li, Jiabao Ren, Beibei Li, Chenyun Dou, Yan Hou, Wenjing Chen, Jing Zhang, Jing Zhang, Yulin Ding, Yulin Ding, Wenjing Shen

“…Herein we aimed to identify novel LRP6 variants in patients with non-syndromic oligodontia (NSO) and perform functional analyses of these variants.Methods:Whole-exome sequencing (WES) was conducted on probands and their first-degree relatives to identify potential pathogenic variants. …”
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Association patterns of work-family balance, perceived stress and turnover intentions among female medical workers in China (2022–2023): integration network and pathway analysis by Yin Lin, Jia li

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Integrative Genomic and Functional Approaches Identify FUOM as a Key Driver and Therapeutic Target in Cervical Cancer by Wenzhi Jiao, Shanshan Liu, Jianwei Shi, Minmin Yu

“…Objective This study integrates Mendelian randomization (MR) and single‐cell RNA sequencing (scRNA‐seq) to identify causal eQTL‐related genes and explore their roles in tumorigenesis. Functional experiments were conducted to validate key findings. …”
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Training protocol characteristics in studies comparing functional versus traditional training: systematic review of controlled trials by Jader Alfredo Beck, Jean Marlon Machado, Amandda de Souza, Cristiano Gomes Sanchotene, Fábio Hech Dominski, Caroline Ruschel

“… Introduction: Functional training and traditional training are widely used in rehabilitation and strength training, but their methodological differences remain debated. …”
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Comparison of resting-state alpha frequency and prefrontal cortex activation patterns between elite retired amateur boxers and healthy individuals: an fNIRS and EEG study by Muhammed Sıddık Çemç, Murat Kaldırımcı

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Physical, Cognitive, Social, and Functional Health Correlates of Major Depressive Disorder Subtypes: A Systematic Review by Jen E. McKeough, Christopher F. Sharpley, Kirstan A. Vessey, Vicki Bitsika, Rebecca J. Williams, G. Lorenzo Odierna, Ian D. Evans

“…This systematic review examined the methods used to define several MDD subtypes and their associations with physical, cognitive, social, and functional health outcomes. Methods: A systematic search of PubMed was conducted in accordance with PRISMA 2020 guidelines to identify peer-reviewed studies published in English between 2014 and 2025. …”
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Novel epidermal–cortical pattern and root apical silencing of VcCPC promoter activity in Arabidopsis might suggest a joint contribution to hairless roots in blueberry by Youyin Zhu, Ke Li, Yu Zong, Yongqiang Li, Weidong Guo

“…This distinctive epidermal cell pattern, which differs from the three known patterns observed in other plant species, is classified as type IV. …”
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Assessment of the Short-Term Effectiveness of Kinesiotaping and Trigger Points Release Used in Functional Disorders of the Masticatory Muscles by Danuta Lietz-Kijak, Łukasz Kopacz, Roman Ardan, Marta Grzegocka, Edward Kijak

“…Latent trigger points located in the muscles can interfere with muscular movement patterns, cause cramps, and reduce muscle strength. …”
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Identification and functional characterization of the RPP13 gene family in potato (Solanum tuberosum L.) for disease resistance by Baoqi Yuan, Chuang Li, Qingfeng Wang, Qi Yao, Xiaowei Guo, Yuhang Zhang, Zhongwei Wang

“…The RPP13 gene family is known to play a pivotal role in plant disease resistance responses; however, its specific functions in potato remain unclear. In this study, we conducted the first comprehensive identification and analysis of 28 RPP13 gene family members in potato, examining their gene structures, chromosomal locations, expression patterns, and functional characteristics. …”
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Developing an early warning land degradation indicator based on geostatistical analysis of Ecosystem Functional Types dynamics by Cristina Domingo-Marimon, Małgorzata Jenerowicz-Sanikowska, Lluís Pesquer, Marek Ruciński, Michał Krupiński, Edyta Woźniak, Anna Foks-Ryznar, Mohammad Abdul Quader

“…This study evaluates the effectiveness of Ecosystem Functional Attributes (EFAs) and Ecosystem Functional Types (EFTs) as early warning indicators of ecosystem degradation. …”
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Influence of exercise interventions on functional movement screen scores in athletes: a systematic review and meta-analysis by Ali Asghar Maleki, Seyed Hamed Mousavi, Mohamad Ali Biabangard, Hooman Minoonejad

“…Abstract The functional movement screen (FMS) is a widely recognized tool for evaluating movement patterns and identifying potential injury risks in athletes. …”
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Evaluating traditional Chinese medicine diagnostic instruments for functional dyspepsia: A systematic review on measurement properties by Leonard TF Ho, Vincent CH Chung, Charlene HL Wong, Irene XY Wu, Kun Chan Lan, Darong Wu, Jerry WF Yeung, Nevin L Zhang, Ting Hung Leung, Justin CY Wu

“…Risk of bias assessment was conducted using the COSMIN Risk of Bias Checklist. …”
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Phytoplankton functional group dynamics and environmental drivers in a tropical monomictic lake (Lake Yambo, Philippines) by Dimple May Gianne Q. Dumaguit, Maxine A.D. Mowe, Rey Donne S. Papa

“…This study examined vertical and seasonal variations in environmental conditions and phytoplankton functional group composition in Lake Yambo to assess how seasonal stratification and mixing affect functional groups’ vertical structure. …”
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Effects of plant functional group removal on caterpillars (Gynaephora alpherakii) performance and plant production in an alpine meadow by Rui Cao, Han Chen, Jingran Cai, Chen Hang, Ziyu Zhang, Yingchun Miao, Peng Xie

“…To elucidate these, we conducted a series of experiments consisting of (1) a two-factor field experiment, where we manipulated the forb abundance and caterpillar presence to assess their interactive effects on plant productivity and caterpillar performance, (2) a field complementary shelter addition experiment, designed to isolate and evaluate the effects of microclimatic changes resulting from forb removal, and (3) a confirmatory microcosm experiment to validate the field findings under controlled by monitoring the herbivory patterns. …”
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RNA editing-induced structural and functional adaptations of NAD9 in Triticum aestivum under drought stress by Nermin G. Mohamed, Ahmed M. Ramadan, Ahmed M. Ramadan, Marwa Amer, Yasser Morsy, Yasser Morsy, Rasha A. Mohamed, Osama A. M. Said, Afnan A. Alnufaei, Mona I M. Ibrahim, Sameh E. Hassanein, Sameh E. Hassanein, Hala F. Eissa, Hala F. Eissa

“…Protein models were generated using AlphaFold, with functional predictions and structure verification conducted using various bioinformatics tools to investigate the effect of RNA editing on protein level.ResultsThe results showed significant RNA editing events, especially C-to-T conversions, in the nad9 gene across different drought exposure times. …”
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Diversity and functional roles of endophytic and rhizospheric microorganisms in Ophioglossum vulgatum L.: implications for bioactive compound synthesis by Xian-Nv Long, Xian-Nv Long, Xian-Nv Long, Xing-Kai Zhang, Yue Wu, Shu-Shuang Tang, Tai-Xiong Zheng, Di Chen, Guan-Hua Cao, Guan-Hua Cao, Guan-Hua Cao, Xu-Hong Zhou, Sen He, Sen He, Sen He

“…Alpha/beta diversity analyses showed higher microbial richness in rhizosphere soil than in plant tissues. Functional predictions (PICRUSt2/FUNGuild) linked endophytic and rhizospheric bacteria to metabolism, human diseases, and biological systems. …”
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Cognitive functions in patients suffering from hypertension and hypothyroidism with retrospective evaluation of control over disease compensation. by M. I. Lesiv

“…A detailed analysis of the patterns of the ACE-R scale revealed that patients in Group I had a significantly lower score in the memory domain (22.68±0.96, p=0.037); patients in Group II had a low score in the concentration domain (15.85±1.14, p=0.045) and executive functions domain (11.62±8.63, p=0.041). …”
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Species and Functional Diversity of Bird Communities in Different Habitats in Shiquan River National Wetland Park, Tibet by Yang Wei, Jingshan Wang, Yi Guo, Chen Huang, Xu Li

“…Finally, the functional dispersion (FDis) results demonstrated a pattern of grass land > marsh land > bare land > water bodies, indicating a greater number of species with similar functional traits in grass habitats. …”
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Silent but significant: Functional elucidation of a synonymous ATP7B mutation in Wilson’s disease pedigrees by Qi Zhang, Qi Zhang, Xiaoming Xie, Hairong Li, Yulei Li, Hongyao Huang, Hongyao Huang

“…Bioinformatics tools (HSF, SpliceAI and ESEfinder 3.0) were used to predict the impact of mutations on the splicing function of precursor mRNA. The in vitro minigene experiment was conducted to verify the impact of the mutation on the splicing function of the precursor mRNA.ResultsWhole-exome sequencing of the proband identified a synonymous variant c.2145C>T (p. …”
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The Impact of Physical Activity on Metabolic Health and Cognitive Function in Postmenopausal Women: A Cross-Sectional Study by Kinga Mruczyk, Rafał W. Wójciak, Marta Molska, Ewa Śliwicka, Tomasz Podgórski, Aleksandra Skoczek-Rubińska, Anna Borowiecka, Angelika Cisek-Woźniak

“…<b>Background</b>: This study aimed to evaluate the impact of physical activity levels on selected biochemical markers (glucose, insulin, cholesterol, triglycerides, interleukin-6 [IL-6]), brain-derived neurotrophic factor (BDNF), cognitive functions, and additional macronutrient intake in postmenopausal women. …”
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